Ultrasonographic Analysis of Optimal Needle Placement for Extensor Indicis

Objective To determine the most optimal needle insertion point of extensor indicis (EI) using ultrasound.Methods A total 80 forearms of 40 healthy volunteers were recruited. We identified midpoint (MP) of EI using ultrasound and set MP as optimal needle insertion point. The location of MP was suggested using distances from landmarks. Distance from MP to medial border of ulna (MP-X) and to lower margin of ulnar head (MP-Y) were measured. Ratios of MP-X to Forearm circumference (X ratio) and MP-Y to forearm length (Y ratio) were calculated. In cross-sectional view, depth of MP (Dmp), defined as middle value of superficial depth (Ds) and deep depth (Dd) was measured and suggested as proper depth of needle insertion.Results Mean MP-X was 1.37±0.14 cm and mean MP-Y was 5.50±0.46 cm. Mean X ratio was 8.10±0.53 and mean Y ratio was 22.15±0.47. Mean Dmp was 7.63±0.96 mm.Conclusion We suggested that novel optimal needle insertion point of the EI. It is about 7.6 mm in depth at about 22% of the forearm length proximal from the lower margin of the ulnar head and about 8.1% of the forearm circumference radial from medial border of ulna.

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Can Cytokines be used as an Activation Marker in Rheumatoid Arthritis?

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530320666201019115030 ◽

2020 ◽

Vol 20 ◽

Author(s):

Fatih Öner Kaya ◽

Yeşim Ceylaner ◽

Belkız Öngen İpek ◽

Zeynep Güneş Özünal ◽

Gülbüz Sezgin ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Healthy Volunteers ◽

Venous Blood ◽

Cross Sectional Study ◽

Joint Disease ◽

Control Group ◽

Cross Sectional ◽

Positive Correlation ◽

Das 28 ◽

Tnf Α

Aims: The etiopathogenesis of Rheumatoid Arthritis (RA) is not clearly understood. However, the role of the cytokines takes an important part in this mechanism. We aimed to bring a new approach to the concept of 'remission' in patients with RA. Background: RA is a chronic, autoimmune, inflammatory disease that involves small joints in the form of symmetrical polyarthritis and progresses with exacerbations and remissions. Pain, swelling, tenderness and morning stiffness are typical of the joints involved. Although it is approached as a primary joint disease, a wide variety of extra-articular involvements may also occur. It is an interesting pathophysiological process, the exact cause of which is still unknown, with many environmental, genetic and potentially undiscovered possible factors in a chaotic manner. Objective: In this cross-sectional study, sedimentation rate (ESR), C- Reactive protein (CRP), Tumor necrosis factor (TNF)-α, soluble-TNF-α receptor (TNF-R), Interleukin (IL)-1B and IL-10 were measured in three groups which were healthy volunteers, patients with RA in the active period, and patients with RA in remission. Disease activity score-28 (DAS-28) was calculated in active RA and RA in remission. Methods: This study included 20 healthy volunteers, 20 remission patients with RA and 20 active RA patients. Venous blood samples were collected from patients in both healthy and RA groups. Results: RA group consisted 43 (71.6%) female and 17 (28.4%) male. Control group consisted 11 (55%) female and 9 (45%) male. TNF-R was significantly high only in the active group according to the healthy group (p=0.002). IL-10 was significantly high in active RA according to RA in remission (p=0.03). DAS-28 was significantly high in active RA according to RA in remission (p=0.001). In the active RA group, ESR and TNF-R had a positive correlation (r:0.442; p=0.048). In the active RA group, there was also a positive correlation between TNF-R and CRP (r:0.621; p=0,003). Both healthy and active RA group had significant positive correlation between ESR and CRP (r: 0.481; p=0.032 and r: 0,697; p=0,001 respectively). Conclusion: TNF-R can be the main pathophysiological factor and a marker showing activation. TNF-R can be very important in revealing the effect of TNF on the disease and the value of this effect in the treatment and ensuring the follow-up of the disease with CRP instead of ESR in activation.

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Abstract P354: Circulating Interleukin 17 A In Patients With Acute And Chronic Coronary Syndrome

Circulation Research ◽

10.1161/res.129.suppl_1.p354 ◽

2021 ◽

Vol 129 (Suppl_1) ◽

Author(s):

Dinaldo C Oliveira ◽

Edivaldo Mendes Filho ◽

Mariana Barros ◽

Carolina Oliveira ◽

Joao Vitor Cabral ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Healthy Volunteers ◽

Clinical Characteristics ◽

Serum Levels ◽

Cross Sectional Study ◽

Interleukin 17 ◽

Cross Sectional ◽

Coronary Syndrome ◽

Artery Disease

Introduction: Interleukin L-17 is produced by Th 17 cells and other cells. There is a debate if IL 17 is atherogenic or atheroprotective. The true role of this interleukin during the development and progression of the coronary artery disease is not known. Objective: To evaluate if there are differences between the IL17 A serum levels according to clinical presentation of the coronary artery disease. Methods: This is a cross sectional study which enrolled 101 patients with acute coronary syndrome (ACS), 100 patients with chronic coronary syndrome (CCS) and 100 healthy volunteers. Blood samples were taken from patients ( at admission) and controls to analysis the level of IL17A. Clinical characteristics were collected through questionnaires. This research was approved by ethical committee. Results: Comparisons of the clinical characteristics between patients with ACS and CCS revealed: mean age ( 62 ± 12.4 vs 63.3 ± 9.8, p = 0.4 ), male (63.4% vs 58%, p = 0.4) hypertension (85.1% vs 79%, p = 0.1) , disyipidemia (48% vs 31%, p =0.01), Diabetes Mellitus (47.5% vs 41%, p = 0.3), previous myocardial infarction (57.4% vs 40%, p = 0,01), smoking (29.7% vs 38%, p = 1). The peripheral concentrations of IL17A according to ACS, CCS and controls were: 5.36 ± 8.83 vs 6.69 ± 17.92 vs 6.26 ± 11.13, p = 0.6. Besides, the comparison between ACS and CCS showed: 5.36 ± 8.83 vs 6.69 ± 17.92, p = 0.3. Conclusion: The main finding os this study was that the circulating IL 17 concentrations were similar in patients with ACS, CCS and healthy volunteers). Besides, there was no difference between patients with ACS and CCS. Therefore, our hypothesis is that in patients with ACS and CCS the circulating IL 17 A concentrations are low or undetectable.

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The Relationship between Body Composition, Dietary Intake, Physical Activity, and Pulmonary Status in Adolescents and Adults with Cystic Fibrosis

Nutrients ◽

10.3390/nu14020310 ◽

2022 ◽

Vol 14 (2) ◽

pp. 310

Author(s):

Kevin J. Scully ◽

Laura T. Jay ◽

Steven Freedman ◽

Gregory S. Sawicki ◽

Ahmet Uluer ◽

...

Keyword(s):

Physical Activity ◽

Cystic Fibrosis ◽

Body Composition ◽

Dietary Intake ◽

Healthy Volunteers ◽

Clinical Outcomes ◽

Body Fat ◽

Lean Mass ◽

Cross Sectional ◽

Adolescents And Adults

Measures of body fat and lean mass may better predict important clinical outcomes in patients with cystic fibrosis (CF) than body mass index (BMI). Little is known about how diet quality and exercise may impact body composition in these patients. Dual X-ray absorptiometry (DXA) body composition, 24-h dietary recall, and physical activity were assessed in a cross-sectional analysis of 38 adolescents and adults with CF and 19 age-, race-, and gender-matched healthy volunteers. Compared with the healthy volunteers, participants with CF had a lower appendicular lean mass index (ALMI), despite no observed difference in BMI, and their diets consisted of higher glycemic index foods with a greater proportion of calories from fat and a lower proportion of calories from protein. In participants with CF, pulmonary function positively correlated with measures of lean mass, particularly ALMI, and negatively correlated with multiple measures of body fat after controlling for age, gender, and BMI. Higher physical activity levels were associated with greater ALMI and lower body fat. In conclusion, body composition measures, particularly ALMI, may better predict key clinical outcomes in individuals with CF than BMI. Future longitudinal studies analyzing the effect of dietary intake and exercise on body composition and CF-specific clinical outcomes are needed.

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TSH-deficiency is associated with a lower thyroid gland volume in hypopituitaric patients compared to healthy volunteers: a cross-sectional study

Endocrine Abstracts ◽

10.1530/endoabs.32.p1005 ◽

2013 ◽

Author(s):

Daniele Santi ◽

Giulia Brigante ◽

Valentina Gnarini ◽

Bruno Madeo ◽

Vincentis Sara De ◽

...

Keyword(s):

Thyroid Gland ◽

Healthy Volunteers ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Gland Volume ◽

Thyroid Gland Volume ◽

Tsh Deficiency

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Measurement of Anal Cross-Sectional Area and Pressure during Anal Distension in Healthy Volunteers

Digestion ◽

10.1159/000200674 ◽

1991 ◽

Vol 48 (2) ◽

pp. 61-69 ◽

Cited By ~ 8

Author(s):

H. Gregersen ◽

S. Sørensen ◽

S.M. Sørensen ◽

S. Rittig ◽

A.J. Andersen

Keyword(s):

Healthy Volunteers ◽

Cross Sectional Area ◽

Sectional Area ◽

Cross Sectional

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Moderate use of alcohol is associated with lower levels of C reactive protein but not with less severe joint inflammation: a cross-sectional study in early RA and healthy volunteers

RMD Open ◽

10.1136/rmdopen-2017-000577 ◽

2018 ◽

Vol 4 (1) ◽

pp. e000577 ◽

Cited By ~ 5

Author(s):

Lukas Mangnus ◽

Hanna W van Steenbergen ◽

Wouter P Nieuwenhuis ◽

Monique Reijnierse ◽

Annette H M van der Helm-van Mil

Keyword(s):

Healthy Volunteers ◽

Joint Inflammation ◽

Cross Sectional Study ◽

Sectional Study ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Early Ra

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Validity and reliability of smartphone use in assessing balance in patients with chronic ankle instability and healthy volunteers: A cross-sectional study

Gait & Posture ◽

10.1016/j.gaitpost.2020.08.116 ◽

2020 ◽

Vol 82 ◽

pp. 26-32

Author(s):

Nadia Abdo ◽

Basma ALSaadawy ◽

Eman Embaby ◽

Aliaa Rehan Youssef

Keyword(s):

Healthy Volunteers ◽

Ankle Instability ◽

Cross Sectional Study ◽

Chronic Ankle Instability ◽

Sectional Study ◽

Validity And Reliability ◽

Cross Sectional ◽

Smartphone Use

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PDB66 ASSESSMENT OF RISK OF TYPE 2 DIABETES IN HEALTHY VOLUNTEERS USING SIMPLIFIED INDIAN DIABETES RISK SCORE TOOL: A CROSS-SECTIONAL STUDY IN NORTH INDIA

Value in Health ◽

10.1016/j.jval.2019.04.615 ◽

2019 ◽

Vol 22 ◽

pp. S151-S152

Author(s):

M. Mahmood Asrar ◽

S. Deepak ◽

D. Bansal

Keyword(s):

Type 2 Diabetes ◽

Healthy Volunteers ◽

Risk Score ◽

Cross Sectional Study ◽

Diabetes Risk ◽

North India ◽

Sectional Study ◽

Cross Sectional ◽

Diabetes Risk Score

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Igg Subclasses in Capd Patients

Peritoneal Dialysis International ◽

10.1177/089686089601600310 ◽

1996 ◽

Vol 16 (3) ◽

pp. 288-294 ◽

Cited By ~ 9

Author(s):

Raymond T. Krediet ◽

Ger C.M. Koomen ◽

Arjen Vlug ◽

Dirk G. Struijk ◽

Barbara Buis ◽

...

Keyword(s):

Healthy Volunteers ◽

Interleukin 2 ◽

Hemodialysis Patients ◽

Igg Subclasses ◽

University Hospital ◽

Synthesis Rate ◽

Renal Unit ◽

Cross Sectional ◽

Transport Studies ◽

Peritoneal Transport

Objective To make a comparison of serum levels of immunoglobulin G (lgG) subclasses in adult continuous ambulatory peritoneal dialysis (CAPD) patients with those in age-and sex-matched hemodialysis patients and healthy volunteers, and to analyze the contribution of removal of these proteins in peritoneal effluent to their plasma values. Design A cross-sectional study. Setting A renal unit of a university hospital. Patients Twenty-three CAPD patients, 21 hemodialysis patients, and 21 healthy volunteers. Peritoneal transport studies were done in 8 of the 23 CAPD patients. Methods IgG subclasses were measured in serum by nephelometry. For the peritoneal transport studies an ELISA method on ethylenediamine tetracetic acid plasma was used. The same method was used in seven-to ten-fold concentrated peritoneal dialysate. Results CAPD patients had lower IgG2 and IgG4 1evels than hemodialysis patients and healthy volunteers (p < 0.01). lgG2 values below 1.5 glL were present in 43% of the CAPD patients (p < 0.001 compared to healthy volunteers). Peritonitis incidence was not different between CAPD patients with low or normal IgG2 plasma levels. Peritoneal clearance of IgG3 was lower than that of the other subclasses. Evidence was obtained for a depressed synthesis of IgG2 and IgG4 in CAPD patients. The hypothesis that interleukin-2 may be involved in the low synthesis rate of IgG2 is discussed. Conclusion Low serum IgG2 and IgG4 1evels are present in stable, adult CAPD patients. These were not caused by increased peritonealloss, but by decreased synthesis.

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