scholarly journals Nutrient Composition of Cereals-based Complementary Flour and its Nutritional Adequacy in Infants Nutrition

2017 ◽  
Vol 6 (6) ◽  
pp. 45
Author(s):  
Nyabasi Makori ◽  
Neema Kassim ◽  
Joyce Kinabo ◽  
Athanasia Matemu
Keyword(s):  
Protein Content ◽  
Zinc Content ◽  
Molar Ratio ◽  
Nutritional Adequacy ◽  
Molar Ratios ◽  
Significant Difference ◽  
Iron And Zinc ◽  
The Mean ◽  
Phytate Content

Evaluation of the quality of complementary flour and its nutritional adequacy in relation to infant’s nutritional requirements was done to four different types of complementary flour (composite cereals with groundnuts, maize, millet and sorghum). The collected samples were analysed for determination of macronutrient, micronutrients and phytate content. The mean protein content in all types of complementary flour was 7.30 ± 2.52 g/100 g. A significant difference in protein content between composite cereals (p ≤ 0.001) and other types of cereals-based foods was observed. Fat and iron content were found to be inadequate in all types of complementary flours. Phytate content ranged from 59.47 - 1176.8 mg/100 g, the highest content was observed in sorghum. On the other hand, the mean iron and zinc content in all types of complementary flour was 5.25 ± 1.35 mg/100 g and 2.99 ± 1.36 mg/100 g respectively. The molar ratios of phytate:iron and phytate:zinc were at a level that would tend to inhibit bioavailability of iron and zinc in 97% and 45% of analysed samples respectively. An association between anaemia and phytate:iron molar ratio (AOR = 4.2, 95%, 1.2 - 6.9) was observed. The quality and adequacy of nutrients in cereal-based complementary flour has shown to be inadequate and likely to be compromised by the presence of phytate. 

Detection of Circulating Tissue Factor and Factor VII in a Normal Population

1996 ◽  
Vol 75 (05) ◽  
pp. 772-777 ◽  
Author(s):  
Sybille Albrecht ◽  
Matthias Kotzsch ◽  
Gabriele Siegert ◽  
Thomas Luther ◽  
Heinz Großmann ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Normal Population ◽  
Mean Value ◽  
Factor Vii ◽  
Significant Difference ◽  
Age Dependent ◽  
The Mean ◽  
Highly Correlated ◽  
And Gender

SummaryThe plasma tissue factor (TF) concentration was correlated to factor VII concentration (FVIIag) and factor VII activity (FVIIc) in 498 healthy volunteers ranging in age from 17 to 64 years. Immunoassays using monoclonal antibodies (mAbs) were developed for the determination of TF and FVIIag in plasma. The mAbs and the test systems were characterized. The mean value of the TF concentration was 172 ± 135 pg/ml. TF showed no age- and gender-related differences. For the total population, FVIIc, determined by a clotting test, was 110 ± 15% and the factor VIlag was 0.77 ± 0.19 μg/ml. FVII activity was significantly increased with age, whereas the concentration demonstrated no correlation to age in this population. FVII concentration is highly correlated with the activity as measured by clotting assay using rabbit thromboplastin. The ratio between FVIIc and FVIIag was not age-dependent, but demonstrated a significant difference between men and women. Between TF and FVII we could not detect a correlation.

Colorimetric Method for Rapid Determination of Serum Arginase

1967 ◽  
Vol 13 (10) ◽  
pp. 900-908 ◽  
Author(s):  
Brigitta Mellerup
Keyword(s):  
Rapid Determination ◽  
Colorimetric Method ◽  
Normal Range ◽  
Clinical Routine ◽  
Mean Values ◽  
Enzymatic Formation ◽  
Significant Difference ◽  
The Mean ◽  
Normal Men

Abstract A method for the determination of serum arginase is given which combines the enzymatic formation of urea with the sensitive method of Coulombe (1) for measuring this substance. This procedure allows more accurate determinations in the normal range than do previous methods described and is convenient for clinical routine. Significant difference is found between the mean values of normal men and women, 3.9 units/L. for the former and 2.9 units/L. for the latter.

scholarly journals Zero order and area under curve spectrophotometric methods for determination of Levocetirizine in pharmaceutical formulation

2015 ◽  
Vol 1 (6) ◽  
pp. 270
Author(s):  
Audumbar Digambar Mali ◽  
Ritesh Bathe ◽  
Manojkumar Patil ◽  
Ashpak Tamboli
Keyword(s):  
Area Under The Curve ◽  
Zero Order ◽  
Pharmaceutical Dosage Forms ◽  
Mean Values ◽  
Spectrophotometric Methods ◽  
Ich Guidelines ◽  
Significant Difference ◽  
Curve Method ◽  
The Mean

Simple, fast and reliable spectrophotometric methods were developed for determination of Levocetirizine in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in methanol. The quantitative determination of the drug was carried out using the zero order derivative values measured at 230 nm and the area under the curve method values measured at 227-234 nm (n=2). Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Levocetirizine using 5-25?g/ml (r=0.998 and r=0.999) for zero order and area under the curve spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Developed spectrophotometric methods in this study are simple, accurate, precise and sensitive to assay of Levocetirizine in tablets.

scholarly journals An estimate of phytate intake and molar ratio of phytate to zinc in the diet of the people in the United Kingdom

2010 ◽  
Vol 13 (9) ◽  
pp. 1380-1388 ◽  
Author(s):  
F Amirabdollahian ◽  
R Ash
Keyword(s):  
United Kingdom ◽  
Elderly Population ◽  
The Elderly ◽  
Molar Ratio ◽  
Daily Consumption ◽  
Nutrition Survey ◽  
Molar Ratios ◽  
The United Kingdom ◽  
The People ◽  
Phytate Content

AbstractObjectiveTo estimate the phytate intake and molar ratio of phytate to zinc in the diet of the people in the United Kingdom.DesignTables of the phytate content of foods were developed from twenty-eight published and unpublished studies. They were then applied to the nutrient databank of the National Diet and Nutrition Survey (NDNS). The study is a retrospective analysis of data on daily consumption of foods and drinks from the NDNS of children, adolescents, adults and the elderly based on 4–7 d weighed intakes.SubjectsA total of 6786 British participants aged 1·5 years and above, who participated in the NDNS, 1992–2001.SettingEngland, Scotland and Wales.ResultsThe median daily intakes of phytate for children, adolescents, adults and the elderly population were 496, 615, 809 and 629 mg/d, respectively. Although there were differences in phytate intakes between men and women, and for children, adolescents and elderly populations, after adjusting for differences in energy intake, there was no significant variation. The median phytate-to-zinc molar ratios for children, adolescents, adults and the elderly population were 11·8, 10·4, 9·7 and 8·7, respectively. Overall, the main sources of phytate were cereal and cereal products (e.g. breakfast cereals and breads), vegetables, potatoes and savoury snacks (e.g. chips and crisps), hot drinks and miscellaneous foods (e.g. commercial toddler foods and drinks, chocolate and soups), fruits and nuts.ConclusionsThe present study estimated the dietary intake of phytate and the phytate-to-zinc molar ratio of the diet of the UK population, which can be used for estimating the average requirement of zinc. Further research should focus on the completion and validation of the tables of phytate content of UK foods, to assess (and if necessary improve) the accuracy and precision of these findings.

scholarly journals Orexitropic Signaling Proteins in Obese Children

2007 ◽  
Vol 7 ◽  
pp. 1263-1271 ◽  
Author(s):  
Ljiljana Saranac ◽  
Bojko Bjelakovic ◽  
Hristina Stamenkovic ◽  
Borislav Kamenov
Keyword(s):  
Body Mass ◽  
Central Obesity ◽  
Energy Homeostasis ◽  
Leptin Resistance ◽  
Signaling Proteins ◽  
Obese Children ◽  
Significant Difference ◽  
The Mean ◽  
Very High

Adipose tissue is not only the main organ for energy storage, but it also has endocrine properties, producing “adipokines” responsible for energy homeostasis, insulin sensitivity, and inflammation. Leptin, produced by adipocytes, is the key hormone in appetite regulation and suppression of orexigenic, hypothalamic neuropeptide Y (NPY). We wanted to establish and compare levels of leptin and NPY in different obesity types in childhood, and to investigate their correlations with auxological parameters. Twenty-one obese children (seven girls and 14 boys), divided into two groups, were compared with 14 controls. The mean age of the study group was 10.81 ± 3.69 years and the mean puberty stage was 2.21. The mean body mass index (BMI) was 32.80 kg/m2(range 23.30– 47.02) and the mean overweight 30.73 kg (range 8.00–74.00). The mean leptin level was higher in boys and in the group with central obesity, but was not significant. Leptin/NPY ratio and leptin/BMI ratio was also higher in the central obesity group and there was a more significant difference compared with controls. We found significant correlation of the leptin level with body mass (BM), body mass excess (BME), and BMI (p < 0.05). The mean leptin level in obese children was very high (36.39 ng/ml). Leptin and NPY levels showed inverse values in two different obesity types. Results are suggestive for leptin resistance rather than leptin deficiency in our group of obese children. Orexitropic signaling proteins correlated significantly with auxological parameters. Determination of the leptin and NPY concentrations provided evidence that obesity represents disease with neuroendocrine dysfunction and high leptin/NPY ratio, which could be a useful marker for central obesity.

scholarly journals Development and Validation of Method for the Quantitative Determination of Zinc in its Chelate Complexes Using Energy Dispersive X-ray Fluorescence Spectroscopy

2021 ◽  
Vol 10 (4) ◽  
pp. 154-161
Author(s):  
А. V. Marukhlenko ◽  
Т. V. Maksimova ◽  
Т. V. Pleteneva ◽  
М. A. Morozova
Keyword(s):  
Fluorescence Spectroscopy ◽  
Aqueous Solutions ◽  
Quantitative Determination ◽  
Zinc Sulfate ◽  
Zinc Content ◽  
Chelate Complex ◽  
Molar Ratio ◽  
X Ray ◽  
Validation Parameters

Introduction. The production, standardization and quality control process of various dietary supplements containing chelated zinc requires validated quantitative assessment methods. In this work, we propose an X-ray fluorescence spectroscopy (XRF) technique for determining the zinc content in the composition of coordination compounds using the example of a synthesized chelate complex with methionine.Aim. To synthesize Zn(Met)2 chelate complex, to develop and validate a method for its quantitative analysis using the XRF method.Materials and methods. The synthesized zinc chelate complex was investigated by IR spectroscopy. The XRF method was used to develop a method for quantifying the zinc content in the synthesized complex. We used dry mixtures of zinc sulfate monohydrate and L-methionine (Met) in a molar ratio of Zn to Met – 1 : 1, 1 : 2, 1 : 4, 1 : 8 and 1 : 16 and also aqueous solutions of zinc sulfate and L-methionine in a molar ratio of Zn to Met 1 : 2 with Zn concentrations from 0.5 to 100 mmol/l as calibration standards. Complexometric titration was used as an arbitration method for the quantitative determination of zinc content in the samples under study.Results and discussion. The IR spectrum of chelate complex confirmed the presence of a donor-acceptor bond between Zn2+ and the nitrogen atom of amino group in methionine. The titration results showed chelate compounds have a composition corresponding to the stoichiometric formula Zn(Met)2. XRF analysis of dry standard mixed samples demonstrated the presence of matrix effect, that makes impossible an accurate assessment of zinc content in the chelate compound. According to the XRF spectra of aqueous solutions containing zinc sulfate and methionine in a ratio of 1 : 2 at a zinc concentration of 0.5; 1; 2; 3; 4; 5; 10; 25; 50 and 100 mmol/L, a calibration graph was constructed – the dependence of the fluorescence signal intensity for the Kα line of zinc on the concentration of zinc in the solution (r = 0.9996). The method was evaluated by the following validation parameters: specificity, linearity, correctness, precision, and analytical range. The specificity of the validated method was proven in the presence of copper, iron, and silver.Conclusion. The developed method make it possible to determine with sufficient precision and correctness the content of Zn2+ in its aqueous solutions of inorganic and organic nature by the XRF method in the concentration range from 3 to 100 mmol/l without the influence of the matrix.

scholarly journals DETERMINATION OF THE COMBINED WIDTH OF MAXILLARY ANTERIOR TEETH USING INNERCANTHAL DISTANCE WITH RESPECT TO AGE GENDER AND ETHINICITY

2021 ◽  
Vol 71 (Suppl-1) ◽  
pp. S164-69
Author(s):  
Naseer Ahmed ◽  
Maria Shakoor Abbasi ◽  
Danish Azeem Khan ◽  
Shiza Khalid ◽  
Warda Jawed ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Gender Disparities ◽  
Sectional Study ◽  
Weak Correlation ◽  
Cross Sectional ◽  
Anterior Teeth ◽  
Significant Difference ◽  
The Mean ◽  
The Relationship

Objective: To evaluate the relationship between inner canthal distance and maxillary anterior teeth width withrespect to age, gender and ethnicity. Study Design: Cross sectional study. Place and Duration of Study: Altamash Institute of Dental Medicine, Karachi, from Aug 2019 to Jan 2020. Methodology: One hundred participants from both genders with full permanent dentition, no interdental space or pathology and facial symmetry were included in this study. The measurements were carried out with digital Vernier caliper. SPSS-25 was used for statistical analysis. Results: The mean ± SD of inner canthal distance and width of maxillary anterior teeth were 2.99cm ± 0.46and 3.82cm ± 0.35 respectively. A significant difference was found between gender (p=0.037) and inner canthaldistance. The maxillary anterior teeth width and inner canthal distance varies amongst different ethnicities(p=0.01). The inner canthal distance does not vary with advancing age (p=0.87) whereas width of maxillaryanterior teeth varies (p=0.04). A weak correlation value of 0.47 was found between inner canthal distance andmaxillary anterior teeth width. Conclusion: This research suggests that there is a weak relationship between inner canthal distance and maxillary anterior teeth width. Therefore, a multiplication ratio of 1.27 is advised to get combined mesiodistal width of maxillary anterior teeth. Additionally, the value of both differs in various local ethnicities. Inner canthal distance does not vary with age though has significant gender disparities while maxillary anterior teeth width remains constant.

scholarly journals Acetylcysteine in random skin flap in rats

2005 ◽  
Vol 20 (2) ◽  
pp. 121-123 ◽  
Author(s):  
Luiz Eduardo Felipe Abla ◽  
Heitor Carvalho Gomes ◽  
Sandro Percario ◽  
Lydia Masako Ferreira
Keyword(s):  
Normal Skin ◽  
Skin Flap ◽  
Control Group ◽  
Distilled Water ◽  
Significant Difference ◽  
Group Control ◽  
The Mean ◽  
Flap Elevation ◽  
Skin Samples

PURPOSE: Analyze the ability of Acetylcysteine to reduce distal necrosis in a random skin flap, in the rat. METHODS: The present study utilized 28 adult male Wistar-EPM rats distributed, at random, in two groups of 14 animals. Control group rats (CG) received distilled water and Acetylcysteine group animals (NACG) received NAC (300 mg/kg) by oral infusion, 15 minutes before flap elevation. On the seventh postoperative day, percentage of distal necrosis was determined and skin samples collected in order to allow determination of MDA levels. RESULTS: The mean necrotic area in CG group (control) was 66 % and in NACG group (Acetylcysteine) 52 %, a statistically significant difference according to the Mann-Whitney test (U calc = 25; U crit = 45). MDA levels were lower in the CG flap skin samples than in the NACG samples (U calc = 24; U crit = 45), the oposite being true in the normal skin samples (U calc = 10; U crit = 45). CONCLUSION: Acetylcysteine was effective, according to the model used, reducing the percentage of distal necrosis in NACG rats.

Periodic measurement of N-telopeptides of type I collogen in serum (sNTx) for early diagnosis of bone metastasis in patients with lung cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e18042-e18042
Author(s):  
Koji Takeda ◽  
Shinya Tokunaga ◽  
Haruko Daga ◽  
Hideaki Okada ◽  
Koichi Taira ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Bone Metastasis ◽  
Early Diagnosis ◽  
Bone Scintigraphy ◽  
Type I ◽  
Clinical Implementation ◽  
Significant Difference ◽  
The Mean ◽  
Diagnosis Of Bone Metastasis

e18042 Background: The bone resorption biomarker sNTx has been previously shown to add value as an aid in the diagnosis of bone metastasis in patients with lung cancer. The objective of this prospective study was to determine if periodic sNTx measurements could lead to early diagnosis of bone metastasis in patients with lung cancer. Methods: Patients with newly diagnosed organ-confined lung cancer were enrolled. sNTx values were determined once each month using the OSTEOMARKTM serum NTx assay (Alere Medical). The presence or absence of bone metastasis was determined by monthly physical examination and by bone scintigraphy every 3 months for 12 months. All patients were required to provide written informed consent. Results: Forty patients were enrolled between June and December 2010. One patient withdrew early and was excluded from analysis. The mean +/- 1 SD baseline level of sNTx was 17.5 +/- 4.4 nM BCE/L. Five patients developed bone metastasis (as characterized by bone scintigraphy) during the study period. The level of sNTx in subjects with bone metastasis was slightly increased (21.6 +/- 3.2 nM BCE/L), however, in these patients, there was no statistically significant difference between sNTx values at baseline (18.2 +/- 4.2 nM BCE/L) and when metastasis was diagnosed. (p=0.176). When a cut-off value of sNTx was set to 22.0 nM BCE/L, the sensitivity and the specificity of detection of bone metastasis were 80.0% and 41.2%, respectively. Using this cut-off, the elevation of sNTx could predict bone metastasis at least one month before diagnosis by bone scintigraphy in all 5 patients, however, the specificity was relatively low for clinical implementation. Additionally, the sensitivity and the specificity of early detection of systematic spread of disease (including bone metastasis) were 70.6% and 45.5%, respectively. Conclusions: Periodic determination of sNTx in patients with organ confined lung cancer did not provide sufficient specificity for it to be used for the early diagnosis of bone metastasis or disease progression.

scholarly journals Path analysis of iron and zinc contents and others traits in cowpea

2012 ◽  
Vol 12 (4) ◽  
pp. 245-252 ◽  
Author(s):  
Jeane de Oliveira Moura ◽  
Maurisrael de Moura Rocha ◽  
Regina Lúcia Ferreira Gomes ◽  
Francisco Rodrigues Freire Filho ◽  
Kaesel Jackson Damasceno e Silva ◽  
...  
Keyword(s):  
Grain Size ◽  
Grain Yield ◽  
Path Analysis ◽  
Protein Content ◽  
Indirect Effects ◽  
Zinc Content ◽  
Direct Selection ◽  
Direct And Indirect Effects ◽  
Iron And Zinc ◽  
Positive Direct

The objective of this study was to estimate the direct and indirect effects of agronomic and culinary traits on iron and zinc contents in 11 cowpea populations. Correlations between traits were estimated and decomposed into direct and indirect effects using path analysis. For the study populations, breeding for larger grain size, higher number of grains per pod, grain yield, reduced cooking time, and number of days to flowering can lead to decreases in the levels of iron and zinc in the grain. Genetic gains for the iron content can be obtained by direct selection for protein content by indirect effects on the number of grains per pod, 100-grain weight and grain yield. The positive direct effect of grain size and protein content on the zinc content indicates the possibility of simultaneous gain by combined selection of these traits.

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