scholarly journals Mitochondrial functionality in female reproduction

2017 ◽  
Vol 71 (1) ◽  
pp. 0-0
Author(s):  
Łukasz Gąsior ◽  
Regina Daszkiewicz ◽  
Mateusz Ogórek ◽  
Zbigniew Polański
Keyword(s):  
Mitochondrial Genome ◽  
Germ Cells ◽  
Germ Line ◽  
Whole Body ◽  
Female Reproduction ◽  
Normal Number ◽  
Female Germ Line ◽  
And Function ◽  
Role And Function

In most animal species female germ cells are the source of mitochondrial genome for the whole body of individuals. As a source of mitochondrial DNA for future generations the mitochondria in the female germ line undergo dynamic quantitative and qualitative changes. In addition to maintaining the intact template of mitochondrial genome from one generation to another, mitochondrial role in oocytes is much more complex and pleiotropic. The quality of mitochondria determines the ability of meiotic divisions, fertilization ability, and activation after fertilization or sustaining development of a new embryo. The presence of normal number of functional mitochondria is also crucial for proper implantation and pregnancy maintaining. This article addresses issues of mitochondrial role and function in mammalian oocyte and presents new approaches in studies of mitochondrial function in female germ cells.

SISTEM PENDUKUNG KEPUTUSAN ANALISIS KEPUASAN MAHASISWA TERHADAP PENGGUNAAN SARANA LABORATORIUM SISTEM INFORMASI

2018 ◽  
Vol 4 (2) ◽  
pp. 150
Author(s):  
Rahmadini Darwas
Keyword(s):  
Service Quality ◽  
Learning Process ◽  
Quality Of Services ◽  
Laboratory Facilities ◽  
Cold Room ◽  
And Function ◽  
And Behavior ◽  
Attitudes And Behavior ◽  
Role And Function

<p><strong><em>Abstract<br /></em></strong><em>Laboratory is one of the supporting facilities in im[roving the learning process. Problems found by students regarding the information system laboratory facilities at STMIK Indonesia Padang are</em><em> the computers that suddenly die when operated, the less cold room, display data is blurred, making the inconvenience in the learning process that causes the students less satisfied with the services provided. Students will feel satisfied if the service is expected to match the received. Therefore, a decision support system is needed to analyze the quality of services provided to the students so that it can support the role and function of the laboratory optimally and what attributes need to be improved the quality of service. The method used is Fuzzy Service Quality (Servqual) method. The results showed that the service quality received was not in accordance with the expected because there is a gap of -1.55 for tangibles dimension. Attributes that need to be improved the quality of services are laboratory space is cool and comfortable, the use of laboratories relevant to the field of science, the responsibility of laboratory assistant, the availability of professional teachers and attitudes and behavior of labor officers.<br /></em></p><p><strong><em>Abstrak<br /></em></strong>Laboratorium merupakan salah satu fasilitas pendukung dalam meningkatkan proses pembelajaran. Permasalahan yang ditemukan mahasiswa mengenai fasilitas laboratorium sistem informasi pada STMIK Indonesia Padang adalah komputer yang tiba-tiba mati saat dioperasikan, ruangan yang kurang dingin, data <em>display</em> yang buram sehingga membuat ketidaknyamanan dalam proses pembelajaran yang menyebabkan mahasiswa kurang puas terhadap layanan yang diberikan. Mahasiswa akan merasa puas apabila layanan yang diharapkan sesuai dengan yang diterima. Oleh sebab itu, diperlukan suatu sistem pendukung keputusan untuk menganalisis kualitas layanan yang diberikan kepada mahasiswa sehingga dapat mendukung peran dan fungsi laboratorium secara optimal serta atribut apa saja yang perlu ditingkatkan kualitas layanannya. Metode yang digunakan adalah metode <em>Fuzzy Service Quality </em>(<em>Servqua</em>l). Hasil penelitian menunjukkan bahwa kualitas layanan yang diterima belum sesuai dengan yang diharapkan karena terdapat <em>gap</em> sebesar -1.55 untuk dimensi <em>tangibles</em>. Atribut yang perlu ditingkatkan kualitas layanannya yaitu ruangan laboratorium yang sejuk dan nyaman, penggunaan laboratorium yang relevan dengan bidang ilmu, tanggungjawab asisten labor, tersedianya tenaga pengajar yang professional dan sikap serta perilaku petugas labor</p><p><strong><em>Kata kunci</em></strong><strong> : sistem pendukung keputusan, laboratorium, <em>fuzzy</em>, <em>servqual</em></strong></p><p><strong><em><br /></em></strong></p>

scholarly journals The Interplay between Mitochondrial Morphology and Myomitokines in Aging Sarcopenia

2020 ◽  
Vol 22 (1) ◽  
pp. 91
Author(s):  
Vanina Romanello
Keyword(s):  
Mitochondrial Dysfunction ◽  
Poor Quality ◽  
Whole Body ◽  
Fibroblast Growth Factor 21 ◽  
Mitochondrial Morphology ◽  
Mass Force ◽  
Major Mechanism ◽  
Muscle Aging ◽  
And Function

Sarcopenia is a chronic disease characterized by the progressive loss of skeletal muscle mass, force, and function during aging. It is an emerging public problem associated with poor quality of life, disability, frailty, and high mortality. A decline in mitochondria quality control pathways constitutes a major mechanism driving aging sarcopenia, causing abnormal organelle accumulation over a lifetime. The resulting mitochondrial dysfunction in sarcopenic muscles feedbacks systemically by releasing the myomitokines fibroblast growth factor 21 (FGF21) and growth and differentiation factor 15 (GDF15), influencing the whole-body homeostasis and dictating healthy or unhealthy aging. This review describes the principal pathways controlling mitochondrial quality, many of which are potential therapeutic targets against muscle aging, and the connection between mitochondrial dysfunction and the myomitokines FGF21 and GDF15 in the pathogenesis of aging sarcopenia.

scholarly journals Germline selection shapes human mitochondrial DNA diversity

Science ◽  
2019 ◽  
Vol 364 (6442) ◽  
pp. eaau6520 ◽  
Author(s):  
Wei Wei ◽  
Salih Tuna ◽  
Michael J. Keogh ◽  
Katherine R. Smith ◽  
Timothy J. Aitman ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Mitochondrial Genome ◽  
Germ Line ◽  
Population Level ◽  
Maternal Transmission ◽  
Human Mitochondrial Dna ◽  
Genetic Lineages ◽  
Selective Forces ◽  
Female Germ Line ◽  
Genomic Regions

Approximately 2.4% of the human mitochondrial DNA (mtDNA) genome exhibits common homoplasmic genetic variation. We analyzed 12,975 whole-genome sequences to show that 45.1% of individuals from 1526 mother–offspring pairs harbor a mixed population of mtDNA (heteroplasmy), but the propensity for maternal transmission differs across the mitochondrial genome. Over one generation, we observed selection both for and against variants in specific genomic regions; known variants were more likely to be transmitted than previously unknown variants. However, new heteroplasmies were more likely to match the nuclear genetic ancestry as opposed to the ancestry of the mitochondrial genome on which the mutations occurred, validating our findings in 40,325 individuals. Thus, human mtDNA at the population level is shaped by selective forces within the female germ line under nuclear genetic control, which ensures consistency between the two independent genetic lineages.

scholarly journals Perpustakaan Berbasis Inklusi Sosial

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Woro Titi Haryanti
Keyword(s):  
Lifelong Learning ◽  
Social Inclusion ◽  
Community Empowerment ◽  
Social Culture ◽  
Information And Communication ◽  
And Function ◽  
Library Transformation ◽  
Role And Function ◽  
Source Of Information

Tujuan kebijakan transformasi perpustakaan berbasis inklusi sosial adalah untuk meningkatkan literasi informasi berbasis Teknologi Informasi dan Komunikasi, meningkatkan kualitas hidup dan kesejahteraan masyarakat  memperkuat peran dan fungsi perpustakaan, agar tidak hanya sekadar tempat penyimpanan dan peminjaman buku, tapi menjadi tempat pembelajaran sepanjang hayat dan pemberdayaan masyarakat. Perpustakaan harus  memfasilitasi masyarakat dalam mengembangkan potensinya dengan melihat keragaman budaya,  keinginan menerima perubahan, serta menawarkan kesempatan  usaha, melindungi dan melestarikan budaya dan Hak Azasi Manusia dan sesuai dengan tujuan pembangunan berkelanjutan. Transformasi perpustakaan berbasis inklusi sosial merupakan wujud perpustakaan sebagai pembelajaran sepanjang hayat. Di mana perpustakaan bukan hanya sebagai pusat sumber informasi tetapi lebih dari itu sebagai tempat mentransformasikan diri sebagai pusat sosial budaya dengan memberdayakankan dan mendemokratisasi masyarakat dan komunitas lokal,  dalam upaya peningkatan kesejahteraan masyarakat.   The objective of the library transformation policy based on social inclusion is to increase information literacy based on Information and Communication Technology, improve the quality of life and welfare of the community, strengthen the role and function of the library, so that it is not just a place for storing and borrowing books, but a place for lifelong learning and community empowerment. Libraries must facilitate the community in developing their potential by looking at cultural diversity, change, and offering business opportunities, protecting and preserving culture and human rights and in accordance with the goals of sustainable development. Transforming libraries based on social inclusion is a form of library as lifelong learning. Where the library is not only as a source of information but more than that as a place to transform yourself as a center for social culture by empowering and democratizing the community and local communities, in an effort to improve the welfare of the community.

scholarly journals Peran Kepemimpinan Kepala Madrasah dalam Meningkatkan Budaya Disiplin Siswa di MAS Patra Mandiri Plaju Palembang

2021 ◽  
Vol 1 (2) ◽  
pp. 289-300
Author(s):  
Sandy Surya ◽  
Ahmad Zainuri ◽  
Sayid Habiburrahman
Keyword(s):  
Role Models ◽  
Student Attitudes ◽  
Educational Institution ◽  
Leadership Role ◽  
Educational Institutions ◽  
Disciplinary Culture ◽  
And Function ◽  
Role And Function

Discipline culture is a reflection of the quality of educational institutions. The low level of discipline is the main problem of every educational institution. The role of leadership is very much needed in overcoming this problem. This paper aims to describe the leadership role of madrasah principals in improving the disciplinary culture of students at MAS Patra Mandiri Plaju Palembang. This research uses a qualitative approach with a descriptive analytic study method. Data were collected using interview techniques, observation and documentation study. The results of this study indicate that the headmaster of MAS Patra Mandiri Plaju Palembang has played its role and function in improving the disciplinary culture of students in a fairly good category. This is supported by 2 factors, namely (1) the role models of madrasah principals in complying with school regulations; and (2) socialization of school discipline rules and sanctions for violations. The obstacles faced by madrasah principals are (1) there are still some teachers who do not exemplify student attitudes; and (2) there are still students who are not "deterred" to be given disciplinary violations.

Kualitas Pelayanan Kartu Keluarga di Bidang Pendaftaran Identitas Kependudukan di Dinas Kependudukan dan Pencatatan Sipil Kabupaten Pulang Pisau

2016 ◽  
Vol 2 (2) ◽  
pp. 15-19
Author(s):  
Indah Megawati ◽  
Erwin Dwi Prayogo
Keyword(s):  
Descriptive Study ◽  
Data Sources ◽  
Civil Registration ◽  
District Population ◽  
Technological Advances ◽  
Qualitative Descriptive ◽  
And Function ◽  
Role And Function ◽  
Registration Service

The purpose of this study was to determine the Quality of Family Card Services in the Registration of Population Identity in the Population and Civil Registration Service in Pulang Pisau District. The research used in this study was a qualitative descriptive study conducted at the Pulang Pisau District Population and Civil Registration Service specifically in the area of Population. The data sources are through interviews and observations. Data analysis is done by organizing and describing it into units, synthesizing, arranging into patterns, choosing which ones are important and which will be studied, and making conclusions that can be told to others. The results showed that the quality of service provided by the Pulang Pisau District Population and Civil Registration Service was very good in terms of transparency carried out by utilizing socialization activities by giving the task of cadres to explain to the community and take advantage of technological advances, then the performance of officers in serving the community good enough, this is indicated by the role and function of each officer and the officer is responsible for their respective duties even though the officer is still lacking in terms of disciplinary time problems. But overall the service in making a Family Card is efficient and effective. In serving the community, the value of the officer�s politeness is quite good, but there still needs to be an increase in hospitality

What Can Mass-Testing Programs Do for—and—to the Pursuit of Excellence in American Education

1964 ◽  
Vol 34 (1) ◽  
pp. 63-79 ◽  
Author(s):  
Joshua Fishman ◽  
Paul Clifford
Keyword(s):  
Educational System ◽  
Quality Of Education ◽  
American Education ◽  
Complete Understanding ◽  
And Function ◽  
Role And Function

Mass-testing is conspicuously entwined in the functioning of the American educational system. It is subject to constant criticism from those who see it as a detriment to improving the quality of education. The authors below suggest that much of this criticism may be misplaced and that a more complete understanding of the role and function of mass-testing is necessary.

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