Uric acid in  hypertension – a marker of cardiovascular risk related to body composition

A significant number of epidemiological studies have shown that hyperuricemia is highly associated with the risk of developing cardiovascular disease, chronic kidney disease, and diabetes. In this connection, increased attention is required to monitor serum uric acid levels in patients, not only from a rheumatological point of view, but also with regard to reducing cardiovascular and renal risks. This article is a review of studies on the association of hyperuricemia with cardiovascular risk and a new consensus for the management of patients with hyperuricemia and high cardiovascular risk, published in december 2019 by a group of experts of the Russian Medical Society for Arterial Hypertension, which, among other things, includes a management algorithm of this category of patients.

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Effects of 60-Day Saccharomyces boulardii and Superoxide Dismutase Supplementation on Body Composition, Hunger Sensation, Pro/Antioxidant Ratio, Inflammation and Hormonal Lipo-Metabolic Biomarkers in Obese Adults: A Double-Blind, Placebo-Controlled Trial

Nutrients ◽

10.3390/nu13082512 ◽

2021 ◽

Vol 13 (8) ◽

pp. 2512

Author(s):

Mariangela Rondanelli ◽

Niccolò Miraglia ◽

Pietro Putignano ◽

Ignazio Castagliuolo ◽

Paola Brun ◽

...

Keyword(s):

Vitamin D ◽

Superoxide Dismutase ◽

Body Composition ◽

Uric Acid ◽

Fat Mass ◽

Intervention Group ◽

Saccharomyces Boulardii ◽

Homa Index ◽

Obese Adults ◽

Hunger Sensation

In animals it has been demonstrated that Saccharomyces boulardii and Superoxide Dismutase (SOD) decrease low-grade inflammation and that S. boulardii can also decrease adiposity. The purpose of this study was to evaluate the effect of a 60-day S. boulardii and SOD supplementation on circulating markers of inflammation, body composition, hunger sensation, pro/antioxidant ratio, hormonal, lipid profile, glucose, insulin and HOMA-IR, in obese adults (BMI 30–35 kg/m2). Twenty-five obese adults were randomly assigned to intervention (8/4 women/men, 57 ± 8 years) or Placebo (9/4 women/men, 50 ± 9 years). Intervention group showed a statistically significant (p < 0.05) decrease of body weight, BMI, fat mass, insulin, HOMA Index and uric acid. Patients in intervention and control groups showed a significant decrease (p < 0.05) of GLP-1. Intervention group showed an increase (p < 0.05) of Vitamin D as well. In conclusion, the 60-day S. boulardii-SOD supplementation in obese subjects determined a significant weight loss with consequent decrease on fat mass, with preservation of fat free mass. The decrease of HOMA index and uric acid, produced additional benefits in obesity management. The observed increase in vitamin D levels in treated group requires further investigation.

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Correction to: Cardiovascular risk factors and body composition in adults with achondroplasia

Genetics in Medicine ◽

10.1038/s41436-021-01201-1 ◽

2021 ◽

Author(s):

Svein O. Fredwall ◽

Jennifer Linge ◽

Olof Dahlqvist Leinhard ◽

Lisa Kjønigsen ◽

Heidi Beate Eggesbø ◽

...

Keyword(s):

Risk Factors ◽

Body Composition ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors

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Could uric acid reduction by specific xanthine oxidase inhibition improve vascular function and reduce cardiovascular risk?

Journal of Clinical Hypertension ◽

10.1111/jch.13693 ◽

2019 ◽

Vol 21 (11) ◽

pp. 1721-1723

Author(s):

Jamario Skeete ◽

Emily Ridley ◽

Donald J. DiPette

Keyword(s):

Uric Acid ◽

Cardiovascular Risk ◽

Xanthine Oxidase ◽

Vascular Function ◽

Oxidase Inhibition ◽

Xanthine Oxidase Inhibition ◽

Acid Reduction

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Uric acid is associated with adiposity factors, especially with fat mass reduction during weight loss in obese children and adolescents

Nutrition & Metabolism ◽

10.1186/s12986-020-00500-9 ◽

2020 ◽

Vol 17 (1) ◽

Author(s):

Yang Niu ◽

Xue-lin Zhao ◽

Hui-juan Ruan ◽

Xiao-meng Mao ◽

Qing-ya Tang

Keyword(s):

Weight Loss ◽

Body Composition ◽

Uric Acid ◽

Children And Adolescents ◽

Body Fat ◽

Fat Mass ◽

Dietary Control ◽

Obese Children ◽

Fat Percentage ◽

Before And After

Abstract Background Current adult studies suggest that uric acid (UA) is associated with body fat, but the relationship in obese children is unclear. Thus, we aim to evaluate the association between uric acid and body composition of obese children. Methods A total of 79 obese children were included in this study, and 52 children (34 boys and 18 girls) underwent a 6-week weight loss camp, including 34 boys and 18 girls. Six-week weight-loss interventions were performed on all participants through aerobic exercise and appropriate dietary control. Laboratory tests and body composition were collected before and after the intervention. Results Before the intervention, correlation analysis demonstrated that uric acid was positively correlated with height, weight, body mass index (BMI), waist circumference, hip circumference, fat mass (FM), and free fat mass (FFM) with adjusting for age and gender (P < 0.05). After 6 weeks of intervention, the participants gained 3.12 ± 0.85 cm in height, body fat percentage decreased by 7.23 ± 1.97%, and lost 10.30 ± 2.83 kg in weight. Univariate and multivariate analysis indicated that uric acid at baseline was associated with FM reduction during weight loss (P < 0.05). Conclusions This study is the first report that uric acid is associated with BMI and FM, and may play an important role in the reduction of FM during weight loss in obese children and adolescents. The interaction between UA and adiposity factors and its underlying mechanisms need to be further explored. Trial registration This study was registered in Clinical Trials.gov (NCT03490448) and approved by the Ethics Committee of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.

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