scholarly journals Recent Advances in Biodistribution, Preclinical and Clinical Applications of Radiolabelled Iodine

2021 ◽  
Author(s):  
Khaled Soliman ◽  
Ahmed Alenezi ◽  
Abdullah Alrushoud ◽  
Salman Altimyat ◽  
Mousa Bakkari ◽  
...  
Keyword(s):  
The Body ◽  
Radiation Physics ◽  
Medical Practitioners ◽  
Factors Affecting ◽  
Reference Guide ◽  
Pharmaceutical Therapy ◽  
Recent Advances ◽  
Key Factor ◽  
Medical Physicists ◽  
Preclinical And Clinical Studies

Adequate understanding of radiopharmaceutical distribution in the body of the patient has both spatial and temporal characteristics and they are the key factor to consider when planning successful radio pharmaceutical therapy, because they are an integral part of the radiation dosimetry calculations of any proposed personalized treatment. In this chapter we will focus on radioiodine therapy for thyroid cancer patients since it is a widely known practice in clinical oncology. Factors affecting the radioiodine organs’ distribution will be examined in sufficient details using the available published research in the scientific literature. The literature will be reviewed extensively and summarized in this chapter. Another aim is to provide the medical practitioners with a quick reference guide to this clinically important area of expertise; often mastered by medical physicists with background in radiation physics, mathematics and medical imaging analysis. This chapter will cover recent advances in the area of radioiodine biodistribution modeling with applications in preclinical and clinical studies.

Interactive Agencies and Digitalization Readiness

2017 ◽  
Vol 8 (4) ◽  
pp. 48-64
Author(s):  
Leila Behboudi
Keyword(s):  
Organizational Culture ◽  
The Body ◽  
Critical Factors ◽  
Key Factors ◽  
Technology Infrastructure ◽  
Factors Affecting ◽  
Global Trend ◽  
Key Factor ◽  
Financial Infrastructure ◽  
Management Participation

This study presents primarily factors affecting interactive agencies in Iran. There is a kind of unwillingness among Iranian ad agencies to execute online ad campaign in compare to the global trend and the advantage of use of online ad makes it imperative to find the key factors affecting interactive agencies behavior. Accordingly, the body of literature was analyzed and eight critical factors including “Management participation,” “Organizational culture,” “Size of the organization,” “The level of organization technology,” “Communication infrastructure,” “Financial infrastructure,” “Technology infrastructure” and “Electronic readiness,” were extracted. The expert questionnaire was designed to validate the gathered factors. By analyzing 294 questionnaires, the type of management was found as key factor in adopting online ad campaign execution.

Use of Hemoglobin for Delivering Exogenous Carbon Monoxide in Medicinal Applications

2020 ◽  
Vol 27 (18) ◽  
pp. 2949-2963 ◽  
Author(s):  
Kazuaki Taguchi ◽  
Toru Maruyama ◽  
Masaki Otagiri
Keyword(s):  
Carbon Monoxide ◽  
The Body ◽  
Stable Form ◽  
Oxygen Carriers ◽  
Positive Effects ◽  
Pharmaceutical Therapy ◽  
Low Concentrations ◽  
Artificial Oxygen Carriers ◽  
Literature Evidence ◽  
Preclinical And Clinical Studies

Carbon Monoxide (CO), at low concentrations, can have a variety of positive effects on the body including anti-apoptosis, anti-inflammatory, anti-oxidative and anti-proliferative effects. Although CO has great potential for use as a potent medical bioactive gas, for it to exist in the body in stable form, it must be associated with a carrier. Hemoglobin (Hb) represents a promising material for use as a CO carrier because most of the total CO in the body is stored associated with Hb in red blood cells (RBC). Attempts have been made to develop an Hb-based CO carrying system using RBC and Hb-based artificial oxygen carriers. Some of these have been reported to be safe and to have therapeutic value as a CO donor in preclinical and clinical studies. In the present review, we overview the potential of RBC and Hb-based artificial oxygen carriers as CO carriers based on the currently available literature evidence for their use in pharmaceutical therapy against intractable disorders.

Dziedinošās darbības un to veicēji folkloras un valodas liecībās

2020 ◽  
pp. 372-389
Author(s):  
Ieva Ančevska
Keyword(s):  
General Term ◽  
Spoken Word ◽  
The Body ◽  
Folk Healing ◽  
Medical Practitioners ◽  
Medical Terms ◽  
Healing Tradition

This article summarizes the various healing-related activities used in the Latvian healing tradition. To explain these activities and describe their performers and specialization, folklore sources and linguistic materials were used. The aim of this article is to demonstrate the diversity of folk healing activities and their names, while also clarifying their nature and use as much as possible. The linguistic and etymological analysis was used to investigate the healing activities and the names of their performers, but folklore examples were used for clarifying the meanings. By studying the healing tradition, the names of medical practitioners were collected from various sources, adding up to over 60 labels. When compiling the report, the representatives of the healing activities were divided into conditional groups according to the type of their main medical activities. Thus, the following groups of healing activities were formed: healing activities using the body, actions with spoken word and blowing, ritual and magic activities, defense techniques and liberating rituals. In addition to the medicinal practitioners who were active in healing, there were also counselors who sought out the causes of diseases through various means and searched for their best remedies. The survey in the article shows that the healing tradition uses diverse and specialized medical terms. However, as the examples show, most of them have used a combination of different practices. The name of the healer in question usually described the skills that were particularly developed and had been used most frequently. During tradition bans, names of healers became more general, and tabooed names were used instead. The general term “healer” has only been naturalized into society after the restoration of national independence.

scholarly journals Optimize Design of Run-Flat Tires by Simulation and Experimental Research

Materials ◽  
2021 ◽  
Vol 14 (3) ◽  
pp. 474
Author(s):  
Huaqiao Liu ◽  
Yiren Pan ◽  
Huiguang Bian ◽  
Chuansheng Wang
Keyword(s):  
Stress Distribution ◽  
Energy Loss ◽  
Successful Implementation ◽  
Performance Tests ◽  
Key Factors ◽  
Heat Accumulation ◽  
Factors Affecting ◽  
Structural Rigidity ◽  
Key Factor ◽  
Durability Testing

In this study, the two key factors affecting the thermal performance of the insert rubber and stress distribution on the tire sidewall were analyzed extensively through various performance tests and simulations to promote the development of run-flat tires. Four compounds and two structures of insert rubber were designed to investigate the effects of heat accumulation and stress distribution on durability testing at zero pressure. It was concluded that the rigidity and tensile strength of the compound were negatively correlated with temperature. The deformation was a key factor that affects energy loss, which could not be judged solely by the loss factor. The stress distribution, however, should be considered in order to avoid early damage of the tire caused by stress concentration. On the whole, the careful balance of mechanical strength, energy loss, and structural rigidity was the key to the optimal development of run-flat tires. More importantly, the successful implementation of the simulations in the study provided important and useful guidance for run-flat tire development.

scholarly journals Exploring the Effects of Problematic Internet Use on Adolescent Sleep: A Systematic Review

2021 ◽  
Vol 18 (2) ◽  
pp. 760
Author(s):  
Ioulia Kokka ◽  
Iraklis Mourikis ◽  
Nicolas C. Nicolaides ◽  
Christina Darviri ◽  
George P. Chrousos ◽  
...  
Keyword(s):  
Internet Use ◽  
Educational Interventions ◽  
The Body ◽  
Problematic Internet Use ◽  
Affecting Factors ◽  
Physical And Mental Health ◽  
Adolescent Sleep ◽  
Key Factor ◽  
Parental Educational Level ◽  
The Impact

Adolescent suse internet via several devices to gather information or communicate. Sleep, as a key factor of adolescents’ development, contributes to their physical and mental health. Over the past decades insufficient sleep among adolescents has been wide spread, and one of its attributing factors is the increased availability of technology. This review aims to investigate the body of evidence regarding the impact of problematic internet use on adolescent sleep. Extensive search of databases was performed according to PRISMA guidelines for studies published within the last decade, regarding subjects aged 10–19. The final step of the search yielded 12 original studies. The quality of extracted data was evaluated with the AXIS tool, in order to estimate the risk of bias. All studies showed a negative correlation between adolescent sleep and problematic internet use. It was found to affect sleep quality and quantity and provoke insomnia symptoms. Interestingly, adolescent’s sex, parental educational level, type of family and use for leisure or academic reasons appeared as affecting factors of the problematic internet use-sleep relationship. Problematic internet use has several effects on adolescents’ sleep. Results of relevant studies should be embedded in educational interventions addressed to adolescents as well as parents, to eliminate the negative outcomes of problematic internet use on sleep and adolescence’s health in general.

scholarly journals Ecological and Physiological Factors Affecting Brood Patch Area and Prolactin Levels in Arctic-Nesting Geese

The Auk ◽  
2006 ◽  
Vol 123 (2) ◽  
pp. 405-418 ◽  
Author(s):  
Jón Einar Jónsson ◽  
Alan D. Afton ◽  
Ray T. Alisauskas ◽  
Cynthia K. Bluhm ◽  
Mohamed E. El Halawani
Keyword(s):  
Body Condition ◽  
The Body ◽  
Nest Size ◽  
Patch Area ◽  
Physiological Factors ◽  
Factors Affecting ◽  
Chen Caerulescens ◽  
Brood Patch ◽  
Snow Geese ◽  
Ross's Geese

AbstractWe investigated effects of ecological and physiological factors on brood patch area and prolactin levels in free-ranging Lesser Snow Geese (Chen caerulescens caerulescens; hereafter “Snow Geese”) and Ross's Geese (C. rossii). On the basis of the body-size hypothesis, we predicted that the relationships between prolactin levels, brood patch area, and body condition would be stronger in Ross's Geese than in the larger Snow Geese. We found that brood patch area was positively related to clutch volume and inversely related to prolactin levels in Ross's Geese, but not in Snow Geese. Nest size, nest habitat, and first egg date did not affect brood patch area in either species. Prolactin levels increased as incubation progressed in female Snow Geese, but this relationship was not significant in Ross's Geese. Prolactin levels and body condition (as indexed by size-adjusted body mass) were inversely related in Ross's Geese, but not in Snow Geese. Our findings are consistent with the prediction that relationships between prolactin levels, brood patch area, and body condition are relatively stronger in Ross's Geese, because they mobilize endogenous reserves at faster rates than Snow Geese.Factores Ecológicos y Fisiológicos que Afectan el Área del Parche de Incubación y los Niveles de Prolactina en Gansos Nidificantes del Ártico

Metabolic adjustments to breath holding in higher vertebrates

1989 ◽  
Vol 67 (12) ◽  
pp. 3024-3031 ◽  
Author(s):  
P. J. Butler
Keyword(s):  
Marine Mammals ◽  
Lactate Production ◽  
Weddell Seal ◽  
Specific Dynamic Action ◽  
The Body ◽  
Breath Holding ◽  
Reduced Body ◽  
Key Factor ◽  
Reduced Rate ◽  
Anaerobic Production

There is substantial behavioural and physiological evidence to suggest that most feeding dives by aquatic birds and mammals are aerobic in nature, with no net production of lactate. Any increase in lactate production is matched by increased removal. This does not mean, however, that there are no cardiovascular adjustments associated with such dives. Nonactive parts of the body (including the large pectoral muscles in diving ducks) may be hypoperfused and consume oxygen at a reduced rate. For example, in marine mammals, such as the Weddell seal, reduced perfusion of the gut during a feeding period (which can last for up to 12 h) would reduce the energy expenditure associated with the digestion and assimilation of food (specific dynamic action). Reperfusion during the nonfeeding period would contribute to an unusually high "resting" oxygen uptake. Although some tissues in seals at least can tolerate periods of ischaemia, there is no evidence to suggest that enhanced anaerobic production of ATP is a key factor in the survival of marine mammals during unusually long periods underwater. There may, in fact, be an overall reduction in the ATP requirements of certain tissues, possibly as a result of a reduction in the permeability of cell membranes to some ions, but most certainly as a result of reduced body temperature. During relatively long dives, lactate production eventually exceeds its rate of removal and it accumulates. Precisely what occurs in the muscles is not known. One suggestion is that periods of vasoconstriction are interrupted by vasodilatation, when the oxygen stores are replaced.

MICROSCOPIC CHANGES IN THE INTERNAL ORGANS OF WHITE MICE DURING EXPERIMENTAL IRON (IV) CLATHROCHELATE TOXICOSIS

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
B. V. Borysevych ◽  
◽  
V. V. Lisova ◽  
I. M. Derkach ◽  
S. S. Derkach ◽  
...  
Keyword(s):  
Biological Response ◽  
Organ Damage ◽  
The Body ◽  
New Drugs ◽  
Laboratory Animals ◽  
Internal Organs ◽  
Experimental Drug ◽  
Liver And Kidney ◽  
Preclinical And Clinical Studies ◽  
First Time

Iron (IV) clathrochelate based on a macrobicyclic ligand of the hexahydrazide type is a unique compound that contains iron in a rare high valence IV. Preclinical and clinical studies of this complex, which were started for the first time in Ukraine, have an important theoretical and practical consequence as this complex can be recommended as an active substance in iron-containing drugs with antianemic action. In conducting preclinical studies of new drugs, pathomorphological studies are important because they are a necessary step in studying the biological response of animals to the action of test substances. It was found that some pathological changes develop in the body of white mice under conditions of experimental acute and chronic iron (IV) clathrochelate intoxication. They correlated with the dose of the test compound. During chronic intoxication, the microscopic changes in the liver and kidney of white mice treated with iron (IV) clathrochelate at a dose of 1/10 DL50 were similar to the microscopic changes in the liver and kidney of mice treated with the experimental drug at a dose of 1/5 DL50. However, the severity of these changes was lower, reflecting a lower degree of organ damage. In the myocardium of mice treated with iron (IV) clathrochelate at a dose of 1/5 DL50 on the 10th day, as in acute iron (IV) clathrochelate poisoning, only edema was recorded. The prospects for further research are the study of microscopic changes in the organs of laboratory animals of other species during experimental iron (IV) clathrochelate toxicosis.

Mixed qualitative–quantitative approach for bidding decisions in construction

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Emad Mohamed ◽  
Parinaz Jafari ◽  
Ahmed Hammad
Keyword(s):  
Expert System ◽  
Expert Knowledge ◽  
The Body ◽  
Decision Makers ◽  
Quantitative Approach ◽  
Rule Based ◽  
Content Type ◽  
Factors Affecting ◽  
Qualitative And Quantitative ◽  
Mixed Approach

PurposeThe bid/no-bid decision is critical to the success of construction contractors. The factors affecting the bid/no-bid decision are either qualitative or quantitative. Previous studies on modeling the bidding decision have not extensively focused on distinguishing qualitative and quantitative factors. Thus, the purpose of this paper is to improve the bidding decision in construction projects by developing tools that consider both qualitative and quantitative factors affecting the bidding decision.Design/methodology/approachThis study proposes a mixed qualitative-quantitative approach to deal with both qualitative and quantitative factors. The mixed qualitative-quantitative approach is developed by combining a rule-based expert system and fuzzy-based expert system. The rule-based expert system is used to evaluate the project based on qualitative factors and the fuzzy expert system is used to evaluate the project based on the quantitative factors in order to reach the comprehensive bid/no-bid decision.FindingsThree real bidding projects are used to investigate the applicability and functionality of the proposed mixed approach and are tested with experts of a construction company in Alberta, Canada. The results demonstrate that the mixed approach provides a more reliable, accurate and practical tool that can assist decision-makers involved in the bid/no-bid decision.Originality/valueThis study contributes theoretically to the body of knowledge by (1) proposing a novel approach capable of modeling all types of factors (either qualitative or quantitative) affecting the bidding decision, and (2) providing means to acquire, store and reuse expert knowledge. Practical contribution of this paper is to provide decision-makers with a comprehensive model that mimics the decision-making process and stores experts' knowledge in the form of rules. Therefore, the model reduces the administrative burden on the decision-makers, saves time and effort and reduces bias and human errors during the bidding process.

scholarly journals Recent advances in managing systemic sclerosis

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 88
Author(s):  
Martin Aringer ◽  
Anne Erler
Keyword(s):  
Systemic Sclerosis ◽  
Treatment Options ◽  
The Body ◽  
Therapeutic Options ◽  
Recent Advances ◽  
Main Components ◽  
Near Future

How the main components in systemic sclerosis—namely autoimmunity, vasculopathy, and fibrosis—fit together is still not sufficiently clear. However, vascular treatment options are well established, the body of evidence for the efficacy of immunomodulatory approaches is increasing, and now at least one hopeful substance that may directly interfere with fibrosis is being tested. Although we still wait for important breakthroughs, there is grounds for hope that better therapeutic options will be available in the near future.

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