scholarly journals Scale and Pustule on Dermoscopy of Rosacea: A Diagnostic Clue for Demodex Species

2021 ◽  
pp. e2021139
Author(s):  
Gamze Serarslan ◽  
Özlem Makbule Kaya ◽  
Emre Dirican
Keyword(s):  
Sensitivity And Specificity ◽  
Skin Surface ◽  
Noninvasive Diagnosis ◽  
Healthy Skin ◽  
Dermatological Diseases ◽  
Demodex Folliculorum ◽  
Demodex Brevis ◽  
Dermoscopic Image ◽  
Diagnostic Clue ◽  
Demodex Mites

Background: Demodex mites are highly found in the skin of patients with rosacea.The diagnosis of Demodex can be made by standardized skin surface biopsy. Dermoscopy is a tool used in the noninvasive diagnosis of various dermatological diseases. Objectives: To determine whether dermoscopic features of demodicosis are associated with the result of standardized skin surface biopsy in patients with rosacea and to compare dermoscopic features of rosacea in Demodex-positive and negative samples and Demodex type. Methods: A total of 30 patients (7 male, 23 female) were included in the study. Dermoscopic examination was performed on both the clinically most severely affected areas and adjacent healthy skin. The skin surface biopsy sample was taken from the same place from where the dermoscopic image was taken. Results: A total of 83 (lesion n = 60, non-lesion n = 23) areas were evaluated. Demodex was detected in 60.2% (n = 50) of the samples. Half of these samples revealed only Demodex folliculorum, and the remaining half revealed D folliculorum and Demodex brevis. Of theDemodex-positive samples, 88% had Demodex tails (P =0.001) and68% Demodex follicular openings (P = 0.002) on dermoscopy. In D folliculorum+D brevis-positive samples, the rate of scale and pustule was higher than D folliculorum-positive samples (P = 0.017 and P = 0032,respectively). Conclusions: The sensitivity and specificity of Demodex tail are higher than Demodex follicular opening and scale and pustule detection with dermoscopy and may indicate the coexistence of both D folliculorum and D brevis.

scholarly journals Under the lash: Demodex mites in human diseases

2009 ◽  
Vol 31 (4) ◽  
pp. 20-24 ◽  
Author(s):  
Noreen Lacey ◽  
Kevin Kavanagh ◽  
Scheffer C.G. Tseng
Keyword(s):  
Inflammatory Diseases ◽  
Human Diseases ◽  
Research Experience ◽  
Joint Research ◽  
Pathogenic Potential ◽  
Demodex Folliculorum ◽  
Demodex Brevis ◽  
Demodex Mites ◽  
Purebred Dogs ◽  
Rats And Mice

Demodex mites, class Arachnida and subclass Acarina, are elongated mites with clear cephalothorax and abdomens, the former with four pairs of legs. There are more than 100 species of Demodex mites, many of which are obligatory commensals of the pilosebaceous unit of mammals including cats, dogs, sheep, cattle, pigs, goats, deer, bats, hamsters, rats and mice. Among them, Demodex canis, which is found ubiquitously in dogs, is the most documented and investigated. In excessive numbers D. canis causes the inflammatory disease termed demodicosis (demodectic mange, follicular mange or red mange), which is more common in purebred dogs and has a hereditary predisposition in breeding kennels1. Two distinct Demodex species have been confirmed as the most common ectoparasite in man. The larger Demodex folliculorum, about 0.3–0.4 mm long, is primarily found as a cluster in the hair follicle (Figure 1a), while the smaller Demodex brevis, about 0.2–0.3 mm long with a spindle shape and stubby legs, resides solitarily in the sebaceous gland (Figure 1b). These two species are also ubiquitously found in all human races without gender preference. The pathogenic role of Demodex mites in veterinary medicine is not as greatly disputed as in human diseases. In this article, we review the key literature and our joint research experience regarding the pathogenic potential of these two mites in causing inflammatory diseases of human skin and eye. We hope that the evidence summarized herein will invite readers to take a different look at the life of Demodex mites in several common human diseases.

scholarly journals Demodicosis in humans as a current problem in dermatology and ophthalmology

2020 ◽  
Vol 3 (2) ◽  
pp. 108-121
Author(s):  
Sara Królik ◽  
Agnieszka Muth ◽  
Adriana Polańska ◽  
Ryszard Żaba ◽  
Zygmunt Adamski ◽  
...  
Keyword(s):  
Hair Follicles ◽  
Inflammatory Dermatoses ◽  
Demodex Folliculorum ◽  
Medical Library ◽  
Pubmed Database ◽  
Present Information ◽  
Demodex Brevis ◽  
Polish Language ◽  
Demodex Mites ◽  
Demodex Infestation

Introduction. Human Demodex mites (Demodex folliculorum and Demodex brevis) are ectoparasites living inside the sebaceous glands and hair follicles. In most people, their presence is of no consequence. However, several conditions or various external factors might contribute to pathological Demodex infestation resulting in demodicosis. Many different cutaneous diseases can resemble demodicosis leading to misdiagnosis.Aim. This paper aims to present information about demodicosis and provides a clear clinical portrait of demodicosis in order to distinguish it from other mimicking inflammatory dermatoses. Material and Methods. The literature search was conducted in the English and Polish language via the PubMed database and Main Medical Library. The articles regarding Demodex infestation were selected. Results. There is some evidence about the role of Demodex in the development of rosacea, blepharitis and clinical correlation between them.Conclusions. More attention should be drawn to Demodex as it plays a significant role in the development of various clinical entities in both dermatology and ophthalmology.

scholarly journals A Case Report of Human Demodicosis in a Patient Referred to a Dermatology Clinic in Tabriz, Iran

2020 ◽  
Vol 1 (1) ◽  
pp. 21-22
Author(s):  
Hesamoddin Mohebbi ◽  
Shayan Boozarjomehri Amniyeh ◽  
Parisa Mahdavi ◽  
Ali Heydari Azar Heris
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Hair Follicle ◽  
Case Presentation ◽  
Demodex Folliculorum ◽  
Dermatology Clinic ◽  
The Family ◽  
Demodex Brevis ◽  
Demodex Mites ◽  
Tabriz City

Background: The genus Demodex belongs to the order Prostigmata and the family Demodecidae that has several species of uncommon mites, some of which cause severe scabies in animals. There are two species of this mite that cause disease in humans, including Demodex folliculorum, which is known as hair follicle mite, and Demodex brevis. This disease is more common in women than in men. Case Presentation: The patient is a 36-year-old woman living in one of the villages of Tabriz city who referred to a dermatologist following severe itching and hyperkeratosis (abundant dandruff) of the cheeks. Then, she was introduced to the laboratory for preparing a slide from a sample taken from the patient’s cheeks. A large number of Demodex mites were observed in the microscopic test of the sample. Conclusion: In patients referred to skin clinics with scaling and itching, especially in the head and face, the complication may be due to Demodex infection. Therefore, it is suggested that demodicosis be considered in differential diagnosis in such patients.

Demodex folliculorum and Demodex brevis (Acari: Demodecidae) and their association with facial and non-facial pathologies

2021 ◽  
pp. 1-8
Author(s):  
Amanda Nery Pormann ◽  
Lucas Vieira ◽  
Fernanda Majolo ◽  
Liana Johann ◽  
Guilherme Liberato da Silva
Keyword(s):  
Demodex Folliculorum ◽  
Demodex Brevis

scholarly journals A Survey of Human Face Mites Demodex (Acari, Demodicidae) in Patients with Dermatological Symptoms in Baghdad, Iraq

2021 ◽  
pp. 3827-3833
Author(s):  
Basma H. Bedair ◽  
Suhaila D. Salman ◽  
Azhaar F. Abtan
Keyword(s):  
Significant Relationship ◽  
Rural Areas ◽  
Urban Areas ◽  
Personal Hygiene ◽  
Dermatological Diseases ◽  
Asymptomatic Patients ◽  
Large Numbers ◽  
Acne Rosacea ◽  
Time Of Year ◽  
Demodex Mites

Demodex spp. mites are external obligate parasites; they are transmitted between hosts through direct contact, and may induce several dermatological symptoms when found in large numbers. However, these symptoms may be similar to other commonly known diseases; this often leads dermatologists to neglect the pathogenic role of these mites. Therefore, a better diagnosis is recommended in order to avoid mistreatment. The aim of this study was to investigate the correlation between Demodex mites and dermatological diseases. Infestation rates in patients suffering from acne, rosacea, folliculitis, and psoriasis were compared with asymptomatic patients, along with the mites’ relation to gender, age, personal hygiene, time of year, and residency. These mites were mainly found in patients with rosacea (66.67%) followed by acne (64.41%), while they were only observed in 48.15% of asymptomatic patients, 40.00% in folliculitis, and 0.00% in psoriasis. The statistical analysis showed a significant relationship between infestation and the previously mentioned dermatological diseases (P<0.01). The infestation rates increased significantly with age, reaching 83.33% in patients above 60 years old, and especially during cold months with higher humidity rates. These mites were also more predominantly found in urban areas (56.10%), followed by rural areas (48.45%). However, there was no significant relationship according to gender or personal hygiene.

Udder skin surface temperature variation pre- and post- milking in dairy cows as determined by infrared thermography

2018 ◽  
Vol 85 (2) ◽  
pp. 201-203 ◽  
Author(s):  
Chunhe Yang ◽  
Gan Li ◽  
Xiaojun Zhang ◽  
Xianhong Gu
Keyword(s):  
Surface Temperature ◽  
Dairy Cows ◽  
Infrared Thermography ◽  
Sensitivity And Specificity ◽  
Milk Yield ◽  
Skin Surface ◽  
Optimal Time ◽  
Skin Surface Temperature ◽  
Infrared Images ◽  
Significant Difference

The objectives of the research reported in this Research Communication were to compare the variation of hind quarter skin surface temperature pre- and post- milking in dairy cows and to determine the optimal time to capture images by infrared thermography for improving the sensitivity and specificity of mastitis detection in dairy cows. Hind quarter infrared images of 102 Holstein dairy cows were captured from the caudal view by an infrared camera pre-milking and post-milking. The udder skin surface temperature was measured with the help of the image processing software. No significant difference was found between the left and right quarter skin surface temperature pre- and post- milking. The hind quarter skin surface temperature pre-milking was not significantly influenced by milk yield, but exhibited a rising trend along with the increase of milk yield. The hind quarter skin surface temperature post-milking was significantly influenced by milk yield. This leads us to conclude that the sensitivity and specificity of IRT in mastitis detection may be influenced by milk yield and it may be better to capture the infrared images of cow udders pre-milking.

Demodex folliculorum in patients with rheumatoid arthritis

2007 ◽  
Vol 52 (1) ◽  
Author(s):  
Ihsan Ciftci ◽  
Umit Dundar ◽  
Zafer Cetinkaya ◽  
Mustafa Kulac ◽  
Nilay Kiyildi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Disease Activity Score ◽  
Disease Duration ◽  
Demodex Folliculorum ◽  
Das 28 ◽  
Immunosuppressed Patients ◽  
The Mean ◽  
Demodex Mites ◽  
Assessment Of Disease Activity

AbstractThe objective of this study was to investigate the incidence and density of Demodex folliculorum in the patients with rheumatoid arthritis (RA). Forty-one patients with RA and twenty-seven age and sex matched healthy controls were enrolled in this study. Disease Activity Score (DAS 28) was used for the assessment of disease activity. Out of 41 patients, 33 were females and 8 males. The mean disease duration was 10.9 ± 8.2 years. The mean DAS 28 was 3.8 ± 1.2. No statistically significant differences in the incidence and density of Demodex mites were found between patients with RA and controls. Although immunosuppression is thought to be a risk factor for the D. folliculorum infestation no such correlations could be found in the 41 immunosuppressed patients with RA, therefore, further studies with larger groups are needed.

scholarly journals Prevalence of Demodex spp. in students and employees of the Pomeranian Medical University in Szczecin*

2019 ◽  
Vol 65 (3) ◽  
Author(s):  
Katarzyna Dołęgowska
Keyword(s):  
Hair Follicle ◽  
Influencing Factor ◽  
Study Participant ◽  
Hair Follicles ◽  
Infestation Rate ◽  
Sebaceous Glands ◽  
Demodex Folliculorum ◽  
Demodex Brevis ◽  
Medical University ◽  
Demodex Infestation

Introduction: Demodex folliculorum and Demodex brevis are mites living in the hair follicles and sebaceous glands of humans, with infestation usually being asymptomatic. In the present study the prevalence and number of mites, together with influencing factors of Demodex infestation, were investigated in students and personnel of the Pomeranian Medical University in Szczecin in Poland (PUM). The prevalence of 2 Demodex species, Demodex folliculorum and Demodex brevis, was compared in epilated eyelashes and skin scrapings derived from healthy volunteers.Materials and methods: The study was conducted on 217 healthy volunteers – females and males. The study group consisted of 114 students and 103 employees of PUM. From each study participant, 2–3 eyelashes from each lid were epilated. From 99 volunteers, skin scrapings and/or secretions from sebaceous glands were also obtained. Demodicosis was diagnosed when Demodex eggs, larvae or adult mites were identified under microscopic examination.Results: The infestation rate of Demodex (in epilated eyelashes and skin) among the 217 volunteers was 21%. Prevalence of hair follicle mites among personnel and students were 28% and 14% respectively. The mean number of mites among the 217 patients was 2.52 ±2.48 (3.16 ±2.9 in PUM personnel and 1.46 ±0.83 in students). The infestation rate increased with age (p = 0.0005). Demodex folliculorum infested 78% (p = 0.005) of the participants and 87.5% of epilated eyelashes (p = 0.000001). Demodex brevis was more frequent on the skin (67%; p = 0.00001). Hair follicle mites were detected more often in epilated eyelashes originating from the lower lid (p = 0.000001). Moreover, a weak correlation between the presence of selected symptoms (blepharedema, conjunctivitis, burning and itching of eyelids) and Demodex infestation was observed. There was no statistically significant association between Demodex infestation and an influencing factor: work using a microscope (p = 0.92).

scholarly journals Role of Adenosine Deaminase in Patients with Erythematotelan-giectatic Rosacea and Demodex folliculorum Positivity

2020 ◽  
Author(s):  
Serpil SENER ◽  
Ulku KARAMAN ◽  
Tugba Raika KIRAN ◽  
Cemil COLAK ◽  
Ali ASLAN ◽  
...  
Keyword(s):  
Adenosine Deaminase ◽  
Close Contact ◽  
Acne Vulgaris ◽  
Skin Surface ◽  
Control Group ◽  
Purine Nucleotides ◽  
Demodex Folliculorum ◽  
Significant Difference ◽  
The Mean ◽  
And Gender

Background: Adenosine deaminase (ADA) is an aminohydrolase involved in the catabolism of purine nucleotides and irreversibly deaminizes adenosine and deoxyadenosine to inosine and deoxyinosine. ADA enzyme deficiency results in the loss of functional properties of B and T lymphocytes. Demodex species have been reported to be transmitted between humans through close contact and to play a role in the pathogenesis of rosacea, acne vulgaris, perioral dermatitis, seborrhoeic dermatitis, micropapillary-pruritic dermatitis and blepharitis. The present study aimed to compare serum ADA levels in D. folliculorum positive patients with the healthy control individuals. Methods: Serum ADA levels were examined for 30 patients diagnosed with erythematotelangiectatic rosacea and 40 healthy individuals in Malatya Inonu University in 2017. Standardized skin surface biopsy (SSSB) method was used to diagnose D. folliculorum. A significant decrease was found in the ADA levels of Demodex-positive rosacea patients when compared to the control group. Results: ADA levels were decreased in the Demodex-positive group. The mean ADA level in patient group was significantly lower than the mean in the control group (P<0.001). There was no significant difference between the patient and control groups in terms of age and gender. Conclusion: During and after treatment of Demodex-positive rosacea patients, determination of ADA levels may give more detailed information on the immune mechanisms.

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