Obesity: An Evolutionary Perspective

2012 ◽  
Author(s):  
Robin I.M. Dunbar
Keyword(s):  
Body Size ◽  
Evolutionary Perspective ◽  
Long Time ◽  
Human Adults ◽  
Human Brains ◽  
Time And Energy ◽  
Post Industrial ◽  
Industrial Societies ◽  
The Brain ◽  
Late Palaeolithic

The brain consumes about 20 per cent of the total energy intake in human adults. Primates, and especially humans, have unusually large brains for body size compared with other vertebrates, and fuelling these is a significant drain on both time and energy. Larger-brained primates generally eat fruit-intense diets, but human brains are so large that a reduction in gut size is needed to free up sufficient resources to allow a larger brain to be evolved, placing further pressure on foraging. The early invention of cooking increased nutrient absorption by around 30 per cent over raw food. Increasing digestibility in this way perhaps inevitably leads to risk of obesity when food is super-abundant, as it is in post-industrial societies. However, obesity has clearly been around for a long time, as suggested by the late Palaeolithic Venus figures of Europe, so it is not a novel problem.

Inter-country inequality as a dynamic process and the problem of post-industrial development

2018 ◽  
pp. 5-29 ◽  
Author(s):  
L. M. Grigoryev ◽  
V. A. Pavlyushina
Keyword(s):  
Economic Growth ◽  
Political Institutions ◽  
Industrial Development ◽  
Modern World ◽  
New Approach ◽  
Development Level ◽  
The World ◽  
Long Time ◽  
The Difference ◽  
Post Industrial

The phenomenon of economic growth is studied by economists and statisticians in various aspects for a long time. Economic theory is devoted to assessing factors of growth in the tradition of R. Solow, R. Barrow, W. Easterly and others. During the last quarter of the century, however, the institutionalists, namely D. North, D. Wallis, B. Weingast as well as D. Acemoglu and J. Robinson, have shown the complexity of the problem of development on the part of socioeconomic and political institutions. As a result, solving the problem of how economic growth affects inequality between countries has proved extremely difficult. The modern world is very diverse in terms of development level, and the article offers a new approach to the formation of the idea of stylized facts using cluster analysis. The existing statistics allows to estimate on a unified basis the level of GDP production by 174 countries of the world for 1992—2016. The article presents a structured picture of the world: the distribution of countries in seven clusters, different in levels of development. During the period under review, there was a strong per capita GDP growth in PPP in the middle of the distribution, poverty in various countries declined markedly. At the same time, in 1992—2016, the difference increased not only between rich and poor groups of countries, but also between clusters.

scholarly journals MicroRNA profiling of the pig periaqueductal grey (PAG) region reveals candidates potentially related to sex-dependent differences

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Klaudia Pawlina-Tyszko ◽  
Maria Oczkowicz ◽  
Artur Gurgul ◽  
Tomasz Szmatoła ◽  
Monika Bugno-Poniewierska
Keyword(s):  
Expression Profiles ◽  
Differential Expression Analysis ◽  
Mirna Profile ◽  
Human Model ◽  
Periaqueductal Grey ◽  
Neurological Research ◽  
Downstream Analysis ◽  
Neuron Growth ◽  
Human Brains ◽  
The Brain

Abstract Background MicroRNAs indirectly orchestrate myriads of essential biological processes. A wide diversity of miRNAs of the neurodevelopmental importance characterizes the brain tissue, which, however, exhibits region-specific miRNA profile differences. One of the most conservative regions of the brain is periaqueductal grey (PAG) playing vital roles in significant functions of this organ, also those observed to be sex-influenced. The domestic pig is an important livestock species but is also believed to be an excellent human model. This is of particular importance for neurological research because of the similarity of pig and human brains as well as difficult access to human samples. However, the pig PAG profile has not been characterized so far. Moreover, molecular bases of sex differences connected with brain functioning, including miRNA expression profiles, have not been fully deciphered yet. Methods Thus, in this study, we applied next-generation sequencing to characterize pig PAG expressed microRNAs. Furthermore, we performed differential expression analysis between females and males to identify changes of the miRNA profile and reveal candidates underlying sex-related differences. Results As a result, known brain-enriched, and new miRNAs which will expand the available profile, were identified. The downstream analysis revealed 38 miRNAs being differentially expressed (DE) between female and male samples. Subsequent pathway analysis showed that they enrich processes vital for neuron growth and functioning, such as long-term depression and axon guidance. Among the identified sex-influenced miRNAs were also those associated with the PAG physiology and diseases related to this region. Conclusions The obtained results broaden the knowledge on the porcine PAG miRNAome, along with its dynamism reflected in different isomiR signatures. Moreover, they indicate possible mechanisms associated with sex-influenced differences mediated via miRNAs in the PAG functioning. They also provide candidate miRNAs for further research concerning, i.e., sex-related bases of physiological and pathological processes occurring in the nervous system. Graphical abstract

scholarly journals Limbic Expression of mRNA Coding for Chemoreceptors in Human Brain—Lessons from Brain Atlases

2021 ◽  
Vol 22 (13) ◽  
pp. 6858
Author(s):  
Fanny Gaudel ◽  
Gaëlle Guiraudie-Capraz ◽  
François Féron
Keyword(s):  
G Proteins ◽  
The Body ◽  
Trace Amines ◽  
Chemical Senses ◽  
Brain Areas ◽  
Genes Encoding ◽  
The Central Nervous System ◽  
Human Brains ◽  
The Brain ◽  
Brain Atlases

Animals strongly rely on chemical senses to uncover the outside world and adjust their behaviour. Chemical signals are perceived by facial sensitive chemosensors that can be clustered into three families, namely the gustatory (TASR), olfactory (OR, TAAR) and pheromonal (VNR, FPR) receptors. Over recent decades, chemoreceptors were identified in non-facial parts of the body, including the brain. In order to map chemoreceptors within the encephalon, we performed a study based on four brain atlases. The transcript expression of selected members of the three chemoreceptor families and their canonical partners was analysed in major areas of healthy and demented human brains. Genes encoding all studied chemoreceptors are transcribed in the central nervous system, particularly in the limbic system. RNA of their canonical transduction partners (G proteins, ion channels) are also observed in all studied brain areas, reinforcing the suggestion that cerebral chemoreceptors are functional. In addition, we noticed that: (i) bitterness-associated receptors display an enriched expression, (ii) the brain is equipped to sense trace amines and pheromonal cues and (iii) chemoreceptor RNA expression varies with age, but not dementia or brain trauma. Extensive studies are now required to further understand how the brain makes sense of endogenous chemicals.

Post-Industrial model of Society, Education and science in Philosophical concepts of Radical Pedagogy in the context of Globalization for the Sustainable Development

2021 ◽  
Vol 7 (1) ◽  
pp. 1-6
Author(s):  
Viktor Zinchenko ◽  
Nataliia Krokhmal ◽  
Оlha Horpynych ◽  
Nataliia Fialko
Keyword(s):  
Critical Theory ◽  
Self Determination ◽  
Theory Theory ◽  
The Sustainable Development ◽  
Security Education ◽  
Theory Of Education ◽  
Socially Excluded ◽  
Post Industrial ◽  
Industrial Societies

Critical theory of education should be based on a critical theory of society, which is conceptually analyzes the features of actually existing industrial and post-industrial societies and their relations of domination and subordination (oppression), conflict and the prospects for progressive social change and transformative practices that make projects more complete, freer life and democratic society. Criticality theory means a way of seeing and understanding, building categories, making connections, reflection and participation in practice theory, theory of withdrawal of social practice.This term contains an element of emancipation, liberation and self-determination of the oppressed and exploited masses, recognizing that people are socially excluded from the material security, education and decision-making can share vidrefleksuvaty their situation, realize that it is unauthorized again, and realize that they must organize themselves in order to change the structure of society.

scholarly journals An Evolutionary Perspective on the Importance of Community Relations for Quality of Life

2009 ◽  
Vol 9 ◽  
pp. 588-605 ◽  
Author(s):  
Bjørn Grinde
Keyword(s):  
Quality Of Life ◽  
Social Relations ◽  
Well Being ◽  
Community Relations ◽  
Western Society ◽  
Evolutionary Perspective ◽  
Human Interactions ◽  
Inherent Nature ◽  
The Brain

The evolutionary perspective is relevant for the study of quality of life in that the brain, including its capacity for positive and negative states of mind, has been shaped by the forces of evolution. The present text uses this perspective to discuss three questions related to the observation that human interactions are a particular important factor for well-being: (1) What is known about the inherent nature of our social propensities? (2) Is the present situation responsible for a suboptimal quality of life? (3) Are there alternatives to the organization of mainstream Western society? Based on this discussion, the question is raised as to whether it is possible to suggest improvements. Briefly, it seems possible to create conditions that enhance social relations and to the extent that happiness is considered an important objective, this is a relevant endeavor.

Disappointing poverty trends: is the social investment state to blame?

2011 ◽  
Vol 21 (5) ◽  
pp. 450-471 ◽  
Author(s):  
Frank Vandenbroucke ◽  
Koen Vleminckx
Keyword(s):  
Social Inclusion ◽  
Resource Competition ◽  
Social Investment ◽  
Policy Makers ◽  
The Social ◽  
Working Age ◽  
Per Se ◽  
Post Industrial ◽  
Industrial Societies ◽  
The Eu

Should we explain the disappointing outcomes of the Open Method of Co-ordination on Inclusion by methodological weaknesses or by substantive contradictions in the ‘social investment’ paradigm? To clarify the underlying concepts, we first revisit the original ‘Lisbon inspiration’ and then relate it to the idea of the ‘new welfare state’, as proposed in the literature on new risks in post-industrial societies. We then discuss two explanations for disappointing poverty trends, suggested by critical accounts of the ‘social investment state’: ‘resource competition’ and a ‘re-commodification’. We do not find these explanations convincing per se and conclude that the jury is still out on the ‘social investment state’. However, policy-makers cannot ignore the failure of employment policies to reduce the proportion of children and working-age adults living in jobless households in the EU, and they should not deny the reality of a ‘trilemma of activation’. Finally, we identify policy conditions that may facilitate the complementarity of social investment and social inclusion.

Self and Body

2012 ◽  
Author(s):  
Roberta Sassatelli
Keyword(s):  
Material Culture ◽  
Early Modern ◽  
Early Modern Period ◽  
The Body ◽  
Contemporary Society ◽  
Modern Period ◽  
Specific Configuration ◽  
Post Industrial ◽  
Industrial Societies ◽  
Late Modern

This article investigates the historical formation and specific configuration of a threefold relation crucial to contemporary society, that between the body, the self, and material culture, which, in contemporary, late modern (or post-industrial) societies, has become largely defined through consumer culture. Drawing on historiography, sociology, and anthropology, it explores how, from the early modern period, the consolidation of new consumption patterns and values has given way to particular visions of the human being as a consumer, and how, in turn, the consumer has become a cultural battlefield for the management of body and self. The article also discusses tastes, habitus, and individualization.

scholarly journals An impact of the distance on grandparental childcare: A comparative study conducted in Russia, the United States, and Brazil

2021 ◽  
pp. 139-152
Author(s):  
Olga Vladimirovna Semenova ◽  
◽  
Marina Lvovna Butovskaya ◽  
Keyword(s):  
United States ◽  
Quantitative Data ◽  
The United States ◽  
Cross Cultural ◽  
Online Surveys ◽  
R Software ◽  
Grandparental Childcare ◽  
Post Industrial ◽  
The Impact ◽  
Industrial Societies

We tested this prediction on data collected in three cultural contexts of modern post-industrial societies. Quantitative data on the frequency of grandparental involvement in childcare were collected via a set of online surveys conducted in 2019 in Russia, the United States, and Brazil (N= 1531) and analyzed in R software. The current research was also focused on the analysis of the impact of the distance between households on the frequency of kinship assistance in childcare. Results. We found significant cross-cultural universalizes: 1) the distance between households negatively affects the frequency of help; 2) the care of the maternal grandparents is significantly higher than the care of the paternal grandparents. Discussion. In this study we found that the distance between households and family kin side have stable significant impact on the grandparental help cross-culturally. At the same time, it was shown that grandparental help in childcare is significantly reduced in Brazil compared to the other two studied countries. The phenomenon of reduced kin help in Brazil is an important finding and requires further research by evolutionary psychologists, anthropologists, and sociologists.

scholarly journals ApoE4 attenuates autophagy via FoxO3a repression in the brain

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hee-Young Sohn ◽  
Seong-Ik Kim ◽  
Jee-Yun Park ◽  
Sung-Hye Park ◽  
Young Ho Koh ◽  
...  
Keyword(s):  
Genetic Risk ◽  
Late Onset ◽  
Multiple Roles ◽  
Lipid Transport ◽  
Phosphorylated Tau ◽  
Phosphorylation Level ◽  
Ε4 Allele ◽  
Human Brains ◽  
The Brain ◽  
Novel Therapeutic

AbstractApolipoprotein E (ApoE) plays multiple roles in lipid transport, neuronal signaling, glucose metabolism, mitochondrial function, and inflammation in the brain. It is also associated with neurodegenerative diseases, and its influence differs depending on the isoform. In particular, the ε4 allele of APOE is the highest genetic risk factor for developing late-onset Alzheimer’s disease (AD). However, the mechanism by which ApoE4 contributes to the pathogenesis of AD remains unclear. We investigated the effect of ApoE4 on autophagy in the human brains of ApoE4 carriers. Compared to non-carriers, the expression of FoxO3a regulating autophagy-related genes was significantly reduced in ApoE4 carriers, and the phosphorylation level of FoxO3a at Ser253 increased in ApoE4 carriers, indicating that FoxO3a is considerably repressed in ApoE4 carriers. As a result, the protein expression of FoxO3a downstream genes, such as Atg12, Beclin-1, BNIP3, and PINK1, was significantly decreased, likely leading to dysfunction of both autophagy and mitophagy in ApoE4 carriers. In addition, phosphorylated tau accumulated more in ApoE4 carriers than in non-carriers. Taken together, our results suggest that ApoE4 might attenuate autophagy via the repression of FoxO3a in AD pathogenesis. The regulation of the ApoE4-FoxO3a axis may provide a novel therapeutic target for the prevention and treatment of AD with the APOE4 allele.

scholarly journals VARIANTS OF MASTOID AND OCCIPITAL EMISSARY FORAMENS AND THEIR CLINICAL CORRELATION

2021 ◽  
Vol 27 (4) ◽  
pp. 4004-4009
Author(s):  
Ivan Maslarski ◽  
◽  
Lyudmila Belenska-Todorova ◽  
Keyword(s):  
Varicose Veins ◽  
Foramen Magnum ◽  
Clinical Correlation ◽  
Tissue Separation ◽  
Emissary Veins ◽  
Important Study ◽  
Long Time ◽  
The Brain ◽  
Standard Techniques ◽  
Dural Venous Sinuses

Purpose: Emissary foramens in the skull and emissary veins (EV), respectively, have been known for a long time, but their importance is often disregarded. In the present study, we introduce variants of occipital emissary foramens (OEF) unilaterally located on the left, close to оccipital condylе in a formation of three apertures that open together in a sinus near clivus. Material/Methods: Corpses of 30 dеad people were dissected in the Department of Anatomy, and standard techniques for soft tissue separation or maceration of the skull were used. After the removal of the calvaria, fixed bones of the skull were disarticulated. Foramens were cleaned using a double-ended probe, and depth and diameter measurements were performed using an atomical caliper. Results: We found variants of mastoid emissary foramens (MEF) situated into two groups, each of a couple of foramens. Their clinical significance is discussed, compared with existing experience and analysis of their phylogeny and embryogenesis. Conclusion: We introduce OEF and MEF to be important markers for detection of dural venous sinuses (DVS). The latter, together with EV, provide an important mechanism for decreasing intracranial pressure. This happens due to the absence of a valve apparatus in the veins of the brain, and the lack, or small amount, of muscle tissue. There is a possibility of existing varicose veins, such as those caused by arterio-venous fistulas and the pathology associated with it. We suggest the application of EV in imaging as an important study before surgery by lateral and transcondylar approach to the anterior foramen magnum.

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