The article is devoted to the study of foreign policy strategies of the main actors of the world politics, represented by the USA and the countries of the European Union, regarding the Middle East and the Syrian Arab Republic. The interest in this topic is explained by the particular attractiveness of the Middle East region for the above-mentioned actors, since it has significant economic and transport potential and a favorable geographical position, which opens up opportunities for establishing strong partnership trade and economic ties between the US and the EU on the one hand and Middle Eastern states on the other. At the same time, the Middle East, as a region of increased military-political and social tension, directly influences peace and security situation in the entire world, and because of that the most developed countries of the world seek to establish control over the internal politics in the Middle East and spread their influence on its territory. The author pays great attention to the study of factors that have contributed to the formation of certain US and EU foreign policy courses in respect of the entire Middle East and Syria in particular, and comes to the conclusion that all of them can conditionally be divided into several large groups that equally affect the development process strategies. Their comparison allowed us to establish that in general both the USA and the countries of the European Union have similar perspective goals and objectives, however, they use different methods and forms of implementing their strategies. This explains the difference in the results achieved: while the United States successfully implement their geopolitical aspirations and gradually strengthen their presence in the Middle East, the EU countries are faced with a number of problems that impede their participation in the current regional events. Nevertheless, despite the successes and failures, the importance of the Middle East region for both the United States and the EU is beyond doubt.