scholarly journals HEPATOPROTECTIVE ACTIVITY OF BAUHINIA RACEMOSA ROOTS EXTRACTS

2021 ◽  
Vol 12 (1) ◽  
pp. 29-32
Author(s):  
P Aravanan ◽  
S Jayakumari
Keyword(s):  
Biochemical Parameters ◽  
Molecular Level ◽  
Ethanolic Extract ◽  
Chloroform Extract ◽  
Hepatoprotective Activity ◽  
Extensive Literature ◽  
Negative Effects ◽  
Pharmacological Activities ◽  
Ethanolic Extracts

Of all types of plants, we come across everyday every plant is useful some more than other. Our predecessors left an ocean of knowledge regarding the usage of natural sources for medicinal purposes all that we need is, to work on the molecular level to better understand how to avoid negative effects. In the present study Chloroform and Ethanolic extracts of Bauhinia racemosa obtained by soxhlation were used in the determination of Hepatoprotective activity using Paracetamol induced hepatotoxicity method. Oral administration of Bauhinia racemosa Chloroform extract and Bauhinia racemosa Ethanolic Extract showed significant decrease in biochemical parameters such as the ALT, AST, ALP. Animals treated with Ethanolic extract at dose level of 200 mg/kg & 400 mg/kg b.w, p.o in Hepatotoxicity induced rats exhibited a significant reduction of ALP (178.2±1.65 & 169.1±1.88), AST (123.5±1.87 & 115.7±1.25), ALT (115.2±0.94 & 111.4±1.29) respectively. Extensive literature review showed that Bauhinia racemosa is capable of several pharmacological activities and the present study sheds light on the hepatoprotective nature of the selected plant.

Evaluation of Phytochemicals and Pharmacological Activities of Ben-Cha-Lo-Ka-Wi-Chian Remedy

2019 ◽  
Vol 891 ◽  
pp. 52-59
Author(s):  
Chanai Noysang ◽  
Teerarat Pummarin
Keyword(s):  
Antioxidant Activity ◽  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Propionibacterium Acnes ◽  
Ethanolic Extract ◽  
Inhibition Zone ◽  
Inhibitory Effect ◽  
Pharmacological Activities ◽  
Ethanolic Extracts ◽  
Reaction Test

Benchalokawichian (BLW) remedy is a Thai traditional medicine that has been notified in the List of Medicine Products of the National List of Essential Drugs A.D. 2006 and has long been used as an antipyretic. The phytochemicals of the 70% and 95% ethanolic extracts of were studied by color reaction test and HPTLC analysis. The BLW remedy showed a highest amounts of 70% ethanolic extractives (ca. 3.99 ± 0.60% of dry material weight). The several ethanolic extracts showed similar qualitative phytochemicals. The major of phytochemicals identified in these extracts were alkaloids, flavonoids, tannins, and polyphenols. The antioxidant activity was assessed using the 2,2-diphenyl-1-picrylhydrazyl assay. The analysed 70% ethanolic extract showed a highest antioxidant activity at IC50= 526.09 µg/ml and both extracts not showed tyrosinase inhibitory effect. The 95% ethanolic extract showed the greatest anti-propionibacterium acnes activity with inhibition zone of 10.10 ± 0.45 mm and minimum inhibitory concentration (MIC) was 5.05 mg/ml

scholarly journals Determination of Functional Properties of Sri Lankan Ambarella (Spondias dulcis Forst. syn. Spondias cytherea Sonn.) Fruit and Development of Vacuum Dried Ambarella Fruit Powder and Incorporated Soup Mix

2021 ◽  
pp. 113-122
Author(s):  
N. P. G. D. Navoda ◽  
M. D. W. Samaranayake ◽  
S. L. Liyanage ◽  
H. M. T. Herath ◽  
J. M. J. K. Jayasinghe
Keyword(s):  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Antioxidant Potential ◽  
Alpha Amylase ◽  
Total Phenolic ◽  
Sri Lankan ◽  
Antioxidant Power ◽  
Ethanolic Extracts ◽  
Fruit Powder

Objective: To develop vacuum dried (VD) Ambarella fruit powder and Ambarella fruit incorporated soup mix from large and miniature Ambarella and investigation of antioxidants and anti-diabetic properties. Methods: Ethanolic extracts of two Ambarella varieties were analyzed for antioxidant potential in terms of total phenolic content (TPC), total flavonoid content (TFC), ferrous reducing antioxidant power (FRAP), radical scavenging activities of DPPH and ABTS and α-amylase inhibitory activity. Results: Fresh dwarf Ambarella showed a significantly (p<0.05) high TPC (3.35±0.10 mgGAE/g) while fresh large Ambarella showed a significantly (p<0.05) high FRAP (0.71±0.13 mgTE/g) and DPPH (3.57±0.31 mg TE/g). In comparison of ethanolic extracts of VD Ambarella powders, a significantly (p<0.05) higher antioxidant potential in terms of FRAP (4.19±0.06 mgTE/g) exhibited in dwarf variety while significantly (p<0.05) higher ABTS (4.03±0.27 mgTE/g) and DPPH (3.00±0.49mgTE/g) exhibited in large Ambarella. Alpha amylase inhibition activities of fresh fruits of large and dwarf were 46.30±4.07% and 49.55±3.18% where as in VD powders were 27.59±5.03% and 15.58±5.86% respectively. An instant soup mixture was developed incorporating 20% of VD powder from large variety due its abundance. The antioxidant potential of ethanolic extract of the soup mixture in terms of TPC, TFC, ABTS, and FRAP were 0.55±0.00 mgGAE/g, 0.04±0.00 mgQE/g, 1.65±0.06 mgTE/g, and 0.04±0.15 mgTE/g. Alpha amylase inhibition activity of soup mixture was 39.49±0.29%. Conclusion: The both types of fresh fruits exhibited higher antioxidant potential except FRAP and higher anti-amylase inhibition than VD Ambarella powder.

Evaluation of Hepatoprotective activity of Ethanolic Extract of Garuga pinnata Roxburgh leaves against Carbon tetrachloride induced Hepatotoxicity in rats.

2021 ◽  
pp. 2375-2380
Author(s):  
Sandeep Chavan ◽  
Remeth Dias ◽  
Chandrakant Magdum
Keyword(s):  
Carbon Tetrachloride ◽  
Biochemical Parameters ◽  
Histopathological Examination ◽  
Liquid Paraffin ◽  
Ethanolic Extract ◽  
Serum Levels ◽  
Hepatoprotective Activity ◽  
Antioxidant Defense Enzymes ◽  
Serum Glutamate

In this study we investigated the in vivo Hepatoprotective activity of ethanolic extract of Garuga pinnata (EEGP) leaves in Carbon tetrachloride (CCl4) induced hepatotoxicity using wistar rats of either sex as model. Hepatotoxicity was induced by the administration of CCl4 intraperitoneally (0.125ml CCl4 in liquid paraffin (1:1) per 100g body weight). Garuga pinnata leaves extract at different dose levels (200 and 400mg/kg, p.o.) showed the dose dependant hepatoprotective effect and was compared with well known standard hepatoprotective Silymarain (100mg/kg). When groups were treated with CCl4, significant increase in serum biochemical parameters such as Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), Alkaline phosphate (ALP), Acid Phosphate (ACP), Creatinine and alteration of tissue biochemical parameters such as reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), lipid peroxidation (LPO), and the total proteins were observed. The histopathological examination of the CCl4 treated groups showed sinusoidal congestion, centrilobular necrosis, marked vacuolations and congestion. However, pretreatment with extract of leaves of Garuga pinnata significantly reduced the increased serum levels of biochemical parameters and restored antioxidant defense enzymes level to its normal. Moreover, histopathology of leaves extract treated groups showed normal architecture with minimal sinusoidal congestion. Taken together, our study concludes that EEGP to be a more potential agent for caring liver from CCl4 induced damage.

Subacute oral toxicity evaluation of the ethanolic extract of Hydnophytum formicarum Jack. tubers in Phu Quoc, Vietnam

MedPharmRes ◽  
2020 ◽  
Vol 4 (1) ◽  
pp. 1-6
Author(s):  
Mai Nguyen Ngoc Trac ◽  
Pham Thu Ha ◽  
Do Thi Hong Tuoi
Keyword(s):  
Biochemical Parameters ◽  
Ethanolic Extract ◽  
Hepatoprotective Activity ◽  
The Body ◽  
Oral Toxicity ◽  
Analgesic Effects ◽  
Significant Difference ◽  
Body Weights ◽  
Health Products ◽  
Hematological And Biochemical Parameters

The tubers of Hydnophytum formicarum Jack. have been used for the treatment of rheumatism, liver and intestinal diseases in the traditional medicine of Vietnam. The 50% ethanolic extract of H. formicarum (EEHF) has been proved anti-inflammatory and analgesic effects as well as hepatoprotective activity at the oral doses of 100 and 200 mg/kg in Swiss albino mice. The aim of this work was to study on the subacute oral toxicity of the EEHF at the doses of 100 and 200 mg/kg for 30 and 60 consecutive days in both sexes of mice. The observations were undertaken on the mortality, the body weights, the toxic signs, hematological and biochemical parameters. At the end of the experiment, the histopathology of liver and kidneys was studied. The results showed that the 100 mg/kg of EEHF did not cause any toxic signs in mice. There was no significant difference of hematological and biochemical parameters between the treated animals and the controls. Histopathological examinations of livers and kidneys showed no significant difference suggesting no morphological disturbances in treated mice. In conclusion, the results indicated that the EEHF did not cause any subacute toxicity in mice at the dose of 100 mg/kg, providing the evidence of the safety of health products from this medicinal plant.

scholarly journals HYPOGLYCEMIC ACTIVITY OF TEN MEDICINAL PLANTS EXTRACT IN GLUCOSE INDUCED MICE

2017 ◽  
Vol 10 (14) ◽  
pp. 14 ◽  
Author(s):  
Ahmad Muhtadi ◽  
Yola Irenka ◽  
Wulan Chandra Ayu ◽  
Rini Hendriani ◽  
Ade Zuhrotun
Keyword(s):  
Glucose Level ◽  
Ethanolic Extract ◽  
Hypoglycemic Activity ◽  
Blood Samples ◽  
Activity Test ◽  
Ethanolic Extracts ◽  
Glucose Meter ◽  
Potential Use ◽  
Plants Extract

Objective: To evaluate and compare the hypoglycemic activity of ten medicinal plantsextract that are used empirically to treat hyperglycemia in Indonesia, in order to determineplant with the most potential as a hypoglycemic agent.Methods: Activity test was conducted in Swiss Webster glucose induced mice with glucosetolerance test. The ethanolic extracts of Mangiferaindica L. leaves, Perseaamericana Mill.leaves, Acoruscalamus L. rhizome, Phyllanthusniruri L. herb, Syzigiumcumini (L.) skeelsbark, Zingiberofficinale Roscoe rhizome, Moringaoleifera Lam. leaves, TamarindusindicaL. seed, Momordicacharantia L. fruits and Azadirachtaindica A. juss leaves, which weregiven orally at the same dose of 300 mg/kg bw. The blood samples wereused for determination of glucose level examination using glucose meter and test strips (AccuChek).Results: The ethanolic extract of Mangiferaindica L. leaves has the best activity in reductionof blood glucose level in mice, followed by Zingiberofficinale Roscoe rhizome,Acoruscalamus L. rhizome, Tamarindusindica L. seed.,MomordicacharantiaL. fruit., Syzigiumcumini (L.) skeels bark, Phyllanthusniruri L. herb., Perseaamericana Mill. leaves, andAzadirachtaindica A. juss leaves.Conclusion: Results of the present study suggest the potential use of Mangiferaindica L.leaves extract in therapy of hyperglycemia. 

scholarly journals Antidiabetic Activity of Aqueous and Ethanolic Extracts of Stem Barks from Trichilia emetica (Meliaceae) in Alloxan-Induced Diabeticalbinos Rats

2020 ◽  
pp. 17-24
Author(s):  
Djoupo Agnon Prisca ◽  
Dere Kwadjo Anicet Luc ◽  
Manhan Kahissié ◽  
Yapi Houphouet Félix ◽  
Tiahou Gnomblesson Georges
Keyword(s):  
Blood Pressure ◽  
Blood Glucose ◽  
Biochemical Parameters ◽  
Diabetes Management ◽  
Ethanolic Extract ◽  
Good Alternative ◽  
Antidiabetic Activity ◽  
Insulin Levels ◽  
Ethanolic Extracts ◽  
Antidiabetic Effects

Aims: This study was designed to evaluate the antidiabetic effects of aqueous and ethanolic extracts of Trichilia emetica (TE) stem bark in albinos rats. Methodology: 24 rats of comparable weight were divided into 2 lots, including a control lot of 3 rats and a test lot of 21 rats. Diabetes was induced by injecting Alloxan® intraperitoneally (125 mg/kg bw) for 7 days. After the onset of diabetes, the animals were divided into several groups and given the extracts of Trichilia emetica and Diastabol® orally for 6 days according to the following protocol: Normal Control (NC) received normal saline, group diabetic control (DC) it consists of untreated diabetic, group DD10 and DD20 was comprised of diabetic animals treated  with Diastabol® at a doses of 10  and 20 mg/kg bw respectively , group DTEE100 and DTEE200 it consists of diabetic animals treated with ethanolic extract at a doses of 100 and 200 mg/kg bw respectively, group DTEA100 and DDTEA 200 was comprised of diabetic animals treated with aqueous extract at a same dose (100 and 200 mg/kg bw). At the end of experimentation, some blood was collected for the determination of some biochemical parameters such as insulin, blood glucose, AST, ALT, urea and creatinine. Systolic blood pressure (SBP), diastolic blood pressure (DBP), cardiac frequency (CF) were also recorded.  Results: The results showed a significant (P<0.05) decrease in insulin levels in diabetic rats compared with NC. In addition, diabetes caused a significant increase (P<0.05) in blood glucose, urea, creatinine levels, transaminase activity, and in blood pressure numbers (DBP, SBP and CF) still in comparison with NC. However, the treatment of sick animals with the extracts and the Diastabol at the doses listed above significantly (P <0.05) increased insulin levels and reduced the sames biochemical parameters levels as well as the blood pressure numbers compared with DC. Conclusion: The data obtained showed that this part of the plant would have antidiabetic effects with ethanolic extract at the dose of 200 mg/kg bw had the highest pronounced effect and could be used as a good alternative for diabetes management, thus justifying its use in traditional medicine.

Biochemical Activities of Propolis Extracts. I. Standardization and Antioxidative Properties of Ethanolic and Aqueous Derivatives

1993 ◽  
Vol 48 (11-12) ◽  
pp. 851-857 ◽  
Author(s):  
Regina Volpert ◽  
Erich F Elstner
Keyword(s):  
Indole Acetic Acid ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Water Soluble ◽  
Biochemical Activity ◽  
Ethanolic Extracts ◽  
Ancient Times ◽  
Radical Scavenging Properties ◽  
Catalyzed Oxidation

Abstract Ethanolic extracts of Propolis are used as antiinflammatory and wound healing drugs since ancient times. In order to facilitate a comparison of different extracts, the standardization on the basis of quantitative determination of prominent components of these extracts has been substituted for simple biochemical “activity” tests. One of these activity tests bases on the in­ hibition of peroxidase-catalyzed oxidation of indole acetic acid indicating the presence of a defined mixture of monophenolic and diphenolic compounds. Other tests (diaphorase-catalyzed reductions and xanthine oxidase-catalyzed oxidations) demonstrate significant radical scavenging properties. Water-soluble extracts of propolis exhibit higher antioxidative and inhibitory activities as compared to the ethanolic extract.

scholarly journals COMPARATIVE STUDY OF BUTANOLIC AND ETHANOLIC EXTRACTS OF TRIBULUS TERRESTRIS FRUITS IN 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED HEPATOTOXICITY IN RATS

2018 ◽  
Vol 11 (6) ◽  
pp. 258
Author(s):  
Rajeswary Hari ◽  
Muralidharan P
Keyword(s):  
Plant Extracts ◽  
Biochemical Parameters ◽  
Elevated Serum ◽  
Ethanolic Extract ◽  
Treated Group ◽  
Hepatoprotective Activity ◽  
Serum Marker ◽  
Tribulus Terrestris ◽  
Marker Enzymes ◽  
Tetrachlorodibenzo P Dioxin

Objective: To compare hepatoprotective activity of ethanol and butanol fraction of Tribulus terrestris fruits against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced hepatic damage in albino rats.Methods: The degree of liver protection was assessed in terms of biochemical parameters, liver marker enzymes, and lipid peroxidation (LPO) in drug-treated and TCDD-intoxicated rats.Results: The results revealed that the elevated serum marker enzymes and biochemical parameters in TCDD-treated rats were significantly reduced toward normal levels in saponin rich fraction of T. terrestris drug-treated animals when comparable to ethanolic extract of T. terrestris drug-treated group. The plant extracts have got a notable inhibitory activity on the formation of LPO products in the basal as well as in the presence of inducers.Conclusion: The plant extracts hindered oxidative damage that occurred to the hepatocytes during TCDD toxicity may be responsible for the hepatoprotective activity in the present study.

scholarly journals Mycochemical Analysis and Prediction of Pleurotus Tuber-Regium’s (Pleurotaceae) Pharmacological Activities, A Food and Medicinal Fungi from Gabon

2021 ◽  
Vol 4 (3) ◽  
pp. 99-107
Author(s):  
Eyi-Ndong H.C. ◽  
Iwangou G. ◽  
Orango-Bourdette J.O.
Keyword(s):  
Reducing Sugars ◽  
Therapeutic Potential ◽  
Ethanolic Extract ◽  
Pharmacological Activities ◽  
Total Polyphenols ◽  
Chemical Screening ◽  
Ethanolic Extracts ◽  
Medicinal Fungi ◽  
Medicinal Properties ◽  
Chemical Groups

Pharmaceutical activities of a fungus depend on its bioactive compounds composition. Pleurotus tuber-regium (paleotropical species) is a fungus used in Gabon and throughout tropical Africa for its culinary and medicinal properties. The aim of this study was to predict the therapeutic potential of this species, in particular of its carpophore and its sclerotia, based on the main chemical groups highlighted during the chemical screening of aqueous, hydro-ethanolic and ethanolic extracts. Chemical screening revealed that the three extracts (aqueous, hydro-ethanolic and ethanolic) prepared from the carpophore are rich in total polyphenols, alkaloids, coumarins and proanthocyanidins. Aqueous and hydro-ethanolic extracts are moderately rich in tannins and coumarins while the ethanolic extract is very rich in reducing sugars. About the sclerotia, the three extracts are rich in total polyphenols, alkaloids, reducing sugars and proanthocyanidins. Aqueous and hydro-ethanolic extracts are moderately rich in tannins, total flavonoids and coumarins. The dosage of phenolic compounds carried out on aqueous and hydro-ethanolic extracts confirmed the richness of this fungus in total polyphenols and proanthocyanidins, as well as its deficiency in flavonoids and tannins. The chemical groups thus identified in the carpophore and the sclerotium of P. tuber-regium allow to predict its antioxidant, antiallergic, antiplasmodial, anesthetic, analgesic, anticancer, vasodilator, anti-inflammatory and ant-mutagenic activities.

scholarly journals Evaluation of Anthelmintic Activity of Calendula officinalis Flowers Extract

2021 ◽  
Vol 11 (4) ◽  
pp. 48-50
Author(s):  
Alok Bhardwaj ◽  
Khursheed Alam ◽  
Devender Pathak ◽  
Shahid Ansari ◽  
Vandana Arora Sethi
Keyword(s):  
Anthelmintic Activity ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Chemical Investigation ◽  
Calendula Officinalis ◽  
Pharmacological Activities ◽  
Ethanolic Extracts ◽  
Level Of Significance ◽  
Dose Dependent ◽  
One Way Anova

Background: The present study is an attempt to explore the anthelmintic activity of ethanolic extract of flower of Calendula officinalis. Various doses of ethanolic extracts were evaluated for their anthelmintic activity on adult Indian earthworms, Pheretima posthuma. Calendula officinalis Linn has been widely used in homeopathic medicine for the treatment of many diseases. It has been reported to possess many pharmacological activities, which include antibacterial, antifungal, antiviral,antioxidant and anti-inflammatory. Methods: The ethanol extract of air dried flowers powder (500g) was prepared by using soxlet apparatus, concentrated and vacuum dried which gave an orange yellowish mass (60.46 g). Extract was subjected to qualitative chemical investigation of phytoconstituents such as glycosides, alkaloids, flavonoids, carbohydrates, tannins, proteins, vitamins, coumarins etc. Results: All extracts were able to show anthelmintic activity at 10mg/mL concentration. The activities are comparable with the standard drugs, piperazine citrate and albendazole. The data were found statistically significantly by using one way Anova at 5% level of significance (p< 0.05). Conclusion: All the doses of ethanolic extract of calendula officinalis showed dose dependent anthelmintic activity in comparison to standard drugs. Keywords: Calendula officinalis, Asteraceae, Anthelmintic, Piperazine citrate, Albendazole

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