Effect of Chrysanthemum indicum Aqueous Extract on Some Biochemical and Haematological Parameters in Albino Rats

2018 ◽  
Vol 22 (4) ◽  
pp. 1-8
Author(s):  
B Hussaini ◽  
M Tula ◽  
G Onyeje ◽  
G Memi ◽  
U Nne
Keyword(s):  
Aqueous Extract ◽  
Haematological Parameters ◽  
Albino Rats ◽  
Chrysanthemum Indicum

Hormonal profile and haematological parameters of Wistar albino rats treated with methanolic and aqueous leaf extracts of Schleichera oleosa

2021 ◽  
Author(s):  
Sophy Jose ◽  
M. P. Sinha
Keyword(s):  
Aqueous Extract ◽  
Low Dose ◽  
Methanolic Extract ◽  
Haematological Parameters ◽  
Albino Rats ◽  
High Dose ◽  
Corpuscular Haemoglobin ◽  
Hormonal Profile ◽  
Schleichera Oleosa ◽  
Wistar Albino Rats

Abstract Background: The present study aims to study the Hormonal profile and haematological parameters of Wistar albino rats treated with methanolic and aqueous extracts of Schleichera oleosa.Result: The amount of RBC was found to be 9.6±0.057106/mm3, 9.7±0.0125, 106/ 9.5±0.003, 106/mm3 9.5±0.012 106/mm3 and 9.5±0.023 106/mm3. The amount of WBC was found to be 13.5±0.058 103/mm3,13.6±0.0113 103/mm3,13.7±0.021 103/mm3, 9.5±0.012 103/mm3 and 9.5±0.023 103/mm3. Platelets, 396±0.577 103/mm3, 395±0.03 103/mm3 , 397±0.042103/mm3 , 398±0.020103/mm3, and 397±0.011103/mm3 for controlled group, low dose of methanolic extract, high dose of methanolic extract, low dose of aqueous extract and high dose of aqueous extract respectively. The packed cell volume, haemoglobin, mean corpuscular volume, mean corpuscular haemoglobin, corpuscular haemoglobin concentration and amount of neutrophils, Eosinophils, Lymphocytes, Basophils and Monocytes were measured and no significant change was noticed. The amount of testosterone showed significant increase from 0.75± 0.024 pg/ mL (control) 2.96± 0.088 pg/ mL, 3.9± 0.14pg / mL, 1.85± 0.076 pg/ mL and 2.85± 0.074 pg/ mL.Conclusions: The study suggests that the prolonged treatment of Wistar rats with both low dose and high dose of methanolic as well as the aqueous extract of Schleichera oleosa is not toxic and they increased the amount of testosterone in the blood which is indicative of their testosterone enhancement.

scholarly journals Effect of Aqueous Extract of Senna occidentalis Leaves on Haematological and Liver Biochemical Parameters in Wistar Rats

2017 ◽  
Vol 6 (2) ◽  
Author(s):  
OWOLARAFE TAJUDEEN ALOWONLE
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Weight Ratio ◽  
Haematological Parameters ◽  
Histological Evaluation ◽  
Albino Rats ◽  
Body Weight Ratio ◽  
Glutamyl Transferase

This study evaluated the effect of aqueous extract of Senna occindentalis leaves on some biochemical parameters in Wistar rats. Twenty albino rats equally divided into four experimental groups were used. One group served as control and received the carrier solvent treatment. Three test groups were treated with S. occidentalis extract at 500, 1000 and 1500 mg/kg body weight respectively. The experiment lasted for 14 days after which the rats were sacrificed and blood collected for biochemical and haematological evaluation. Liver-body weight ratio was computed and liver histoarchitecture was investigated. The results showed that all haematological parameters were significantly (P<0.05) affected except the mean corpuscular haemoglobin concentration and mean corpuscular volume. There were also significant (P<0.05) alterations in the activities of gamma-glutamyl transferase, alanine aminotransferase, and aspartate aminotransferase, as well as the levels of total protein, albumin and globulin in the serum. No significant (P>0.05) alterations were observed in the computed liver-body weight ratio but marked alterations in histoarchitecture of the liver cells were present. These alterations in the haematological parameters, liver function enzymes and histological evaluation suggest a selective toxicity of the extract on the animals.

scholarly journals Prevention of peptic ulcer by aqueous extract of Aegle marmelos leaf in rats

2018 ◽  
Vol 12 (1) ◽  
pp. 11-14
Author(s):  
Sharmin Rahman ◽  
Mohammad Rezaul Quader ◽  
Md Ismail Khan
Keyword(s):  
Body Weight ◽  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Aqueous Extract ◽  
Protective Efficacy ◽  
Albino Rats ◽  
Ulcer Formation ◽  
Aegle Marmelos ◽  
Rat Stomach ◽  
Dose Dependent

Background and objectives: Aegle marmelos (Bael), a medicinal plant, has been widely used indigenously to treat many diseases in Bangladesh and other countries. The present study was carried out to evaluate the efficacy of A. marmelos leaf to prevent ethanol induced gastric ulcer in a rat model.Methods: Thirty two Wister albino rats of either sex, weighing between 100-150g, were fed 200 mg/kg or 400 mg/kg aqueous extract of A. marmelos leaves one hour prior to oral administration of 90% ethanol (1 ml/200 gm body weight) to induce gastric ulcer. The animals were sacrificed after one hour and ulcer scores and index were determined. The protective efficacy of A. marmelos aqueous extract was expressed as percentage protection of ulcer.Results: Aqueous extract exhibited significant (p<0.05) dose dependent protection against gastric ulcer formation by ethanol in rat stomach. Percentage protection of ulcer with 200 mg/kg and 400 mg/kg of aqueous extract of A. marmelos leave were 19.3% and 37.2% respectively compared to standard anti-peptic ulcer drug omeprazole (50.4%).Conclusion: Thus, crude extracts of A. marmelos leave have been shown to have potential ability to prevent experimentally induced peptic ulcer formation in animal model.IMC J Med Sci 2018; 12(1): 11-14

scholarly journals A STUDY OF THE EFFECT OF THE PHYTOCHEMICAL CONTENT OF P. AMERICANALEAF ON HEMATOLOGICAL SYSTEM OF ALBINO RATS

2021 ◽  
Vol 9 (04) ◽  
pp. 464-467
Author(s):  
Ngozi a ◽  
◽  
N. Omeke ◽  
Haruna M. Ndahi ◽  
◽  
...  
Keyword(s):  
Adverse Effect ◽  
Experimental Study ◽  
Aqueous Extract ◽  
Leaf Extract ◽  
Control Group ◽  
Albino Rats ◽  
Phytochemical Content ◽  
Other Substances ◽  
And Control ◽  
Experimental Group

Given the medicinal importance of the avocado plant in alternative medicine,the present study aimed to study the effect of the phytochemical content of P. americana leaf extract on the hematological system of albino rats. Albino rats were obtained andclustered into sixgroups,with five rats per groupsimultaneously were assigned experimental and control. The rats in the experimental group were administered with varying doses of the prepared aqueous extract of P. americanawithin the period of the study. The rats in the control group were administered with other substances such as water and feed for the study period.The hematological system of the experimental animal was assessed after the administration of the extract, and it was observed that the aqueous extract of P. americana leaf recorded no significant adverse effect on the hematology system of the experimental study animal.

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