scholarly journals Evaluation of Salivary Interleukin-1 Beta in Covid Recovered Patients

Author(s):  
Harini Palani ◽  
Palati Sinduja ◽  
R. Priyadharshini ◽  
V. Meghashree

Introduction: The COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The epidemic started in Wuhan in mid-December 2019 and quickly spread across the world as a pandemic. Saliva is emerging as a promising alternative to nasopharyngeal/oropharyngeal swabs for COVID-19 diagnosis and monitoring. Aim: To evaluate the Interleukin-1 Beta in the salivary samples of COVID-recovered patients and healthy controls. Materials and Methods: An observational study on saliva samples of COVID recovered patients. The study was non-invasive and easy to perform without much inconvenience to patients. The samples were obtained from patients who came to the clinics of Saveetha Dental College and Hospitals. A total of 20 saliva samples were collected from recruited patients 10 of whom were healthy controls and 10 were collected from patients who had made complete recovery from covid infection at least three months ago Student T  test were performed using Statistical Package for the Social Sciences (IBM SPSS statistics for windows version 23.0, Armonk, NY: IBM Corp. Released 2015). Values were expressed as Mean and SD. An observational study on saliva samples of COVID recovered patients.The salivary Interleukin-1 levels were analyzed using ELISA. Results: Within the limitations of the study, we conclude that salivary Interleukin-1 level is increased in COVID recovered patients. The difference was statistically significant proving that in spite of complete uneventful recovery from COVID infection the individual’s inflammatory markers are seen to be at our rise. Conclusion: Salivary Interleukin-1 levels are increased in COVID recovered patients. Further prospective studies with the limited sample size of the salivary levels of IL-1  can effectively assess disease severity and predict outcome in patients with COVID-19.This study illustrates the group of healthy controls and COVID recovered patients.

Author(s):  
Soorya Ganesh ◽  
Palati Sinduja ◽  
. Priyadharshini ◽  
V. Meghashree

Introduction: The acute phase reactant synthesized by the liver. CRP is an annular (ring- shaped) metameric protein set up in plasma, whose circulating immersion rise in response to inflammation. The idea of the study is to estimate the C-reactive protein situations in the salivary samples of COVID- 19 recovered cases and healthy controls. Materials and Methods: An experimental study on salivary samples of COVID recovered cases. The study was non-invasive and easy to perform without important vexation to cases. The samples were acquired from cases who came to the clinics of Saveetha Dental College and Hospitals. An aggregate of 20 saliva samples was collected from recruited cases 10 of whom were healthy controls and 10 were collected from cases who had made complete recovery from COVID infection. Results: C-reactive protein (CRP) could be generally used as a biomarker of systemic inflammation, routinely measured in serum blood samples. Still salivary samples offer a non-invasive and simply accessible preference which might upgrade point of care (POC) testing for inflammation. This study illustrates the group of healthy controls and COVID recovered cases. Conclusion: Within the limitations of our study, we were capable to interpret the difference of CRP levels between COVID recovered cases and healthy individualities.


2017 ◽  
Vol 8 (2) ◽  
pp. 85-88
Author(s):  
Afrose Ahmed ◽  
Shamim Ara ◽  
KM Monjurul Alom ◽  
Saida Rashed ◽  
Sadia Rahman ◽  
...  

Background: Dermtoglyphics are the lines and ridges forming a skin pattern, especially on the palm of the hands, fingertips and soles of feet. Differentiations of dermal ridges in early life are genetically determined1. Any disturbance by genetic factors causes development of unusual dermatoglyphics. On the other hand, deficiency of Mannose binding protein (MBP) gene and Interleukin-1 (IL-1) gene cause spread of pulmonary tuberculosis2. The dermatoglyphic pattern in patient with pulmonary tuberculosis can represent an anatomical, non-invasive, inexpensive tool for screening high-risk population, and facilitates early prediction of vulnerable population of PTB.Materials and Methods: A Cross-sectional, analytical type of study was conducted in Department of Anatomy, Dhaka Medical College, Dhaka, from January 2012 to December 2012. The study was performed in 100 patients suffering from pulmonary tuberculosis and 100 healthy individuals.Results: There was significant reduction in mean±SD of atd angle in pulmonary tuberculosis patients in comparison to control subjects. Mean±SD of atd angle was 37.87±3.403 in pulmonary tuberculosis patients and 49.77±4.628 in the control subjects. The difference was highly significant (P<0.001).Conclusion: The atd angle was found significantly narrower in the study group compared to the control subjects.Anwer Khan Modern Medical College Journal Vol. 8, No. 2: Jul 2017, P 85-88


Crisis ◽  
2020 ◽  
Vol 41 (6) ◽  
pp. 422-428 ◽  
Author(s):  
Masatsugu Orui

Abstract. Background: Monitoring of suicide rates in the recovery phase following a devastating disaster has been limited. Aim: We report on a 7-year follow-up of the suicide rates in the area affected by the Great East Japan Earthquake, which occurred in March 2011. Method: This descriptive study covered the period from March 2009 to February 2018. Period analysis was used to divide the 108-month study period into nine segments, in which suicide rates were compared with national averages using Poisson distribution. Results: Male suicide rates in the affected area from March 2013 to February 2014 increased to a level higher than the national average. After subsequently dropping, the male rates from March 2016 to February 2018 re-increased and showed a greater difference compared with the national averages. The difference became significant in the period from March 2017 to February 2018 ( p = .047). Limitations: Specific reasons for increasing the rates in the recovery phase were not determined. Conclusion: The termination of the provision of free temporary housing might be influential in this context. Provision of temporary housing was terminated from 2016, which increased economic hardship among needy evacuees. Furthermore, disruption of the social connectedness in the temporary housing may have had an influence. Our findings suggest the necessity of suicide rate monitoring even in the recovery phase.


2017 ◽  
Vol 8 (1) ◽  
pp. 10
Author(s):  
Narendra Kumar Singh ◽  
Nishant Goyal

Background: Schizophrenia is associated with a high familial, social and economic burden. Schizophrenia is also associated with a high level of disability which may create impediments on the social and economic areas of the patients as well as on their respective family networks. Families with schizophrenia may encounter problems such as impairment of health and well being of other family members, restriction of social activities of the family members and shrinking of support from the social network. Aims: The present study examined the difference in perceived social support and burden of care between the male and female caregivers of patients with schizophrenia. Methods: This was a cross-sectional study examining the difference in perceived social support and burden of care between the male and female caregivers of patients with schizophrenia. The sample consisted of 60 (30 male and 30 female) caregivers of the patients with the diagnosis of schizophrenia as per ICD-10-DCR. Results and Conclusion: This study revealed that male caregivers perceived more social support and less burden of care as compared to female caregivers. Key words: Gender, social support, burden


Author(s):  
S.A. Kirillina ◽  
A.L. Safronova ◽  
V.V. Orlov

Аннотация В статье изучены общие и специфические черты идейных воззрений, пропагандистской риторики и политических действий представителей халифатистского движения на Ближнем Востоке и в Южной Азии. В ретроспективном ключе прослеживается эволюция представлений о сущности и необходимости возрождения института халифата в трудах исламских идеологов, реформаторов и политиков Джамал ад-Дина ал-Афгани, Абд ар-Рахмана ал-Кавакиби, Мухаммада Рашида Риды, Абул Калама Азада. Внимание авторов сосредоточено на общественно-политических дискуссиях 2030-х годов XX столетия, а также на повестке дня халифатистских конгрессов и конференций этого периода. На них вырабатывались первые представления современников о пост-османском формате мусульманского единства и идейно-политической роли будущего халифата. Авторы демонстрируют различие между моделями реакции мусульман Ближнего Востока и Южной Азии на упразднение османского халифата республиканским руководством Турции. Установлена многоаспектная взаимосвязь между халифатистскими ценностями, проосманскими настроениями и формами самоотождествления, которые сложились в арабских и южноазиатских обществах. Отдельно намечено соотношение между подъемом халифатистских настроений и радикализацией антиколониальных действий мусульман Индостана.Abstract The article deals with analysis of common and specific features of ideas, propaganda, rhetoric and political actions taken by representatives of the movement for defense of the Caliphate in the Middle East and South Asia. The retrospection showing the transformation of conception of the Caliphate and the necessity of its revival in the works of eminent ideologists and politicians of the Muslim world Jamal al-Din al-Afghani, Abd al-Rahman al-Kawakibi, Muhammad Rashid Rida and Abul Kalam Azad, is also given in the article. The authors also focus on the social and political discussions of the 1920s 1930s, as well as on the agenda of Caliphatist congresses and conferences of this period. They helped to elaborate the early representations of post-Ottoman pattern of the Muslim unity and the ideological and political role of the future Caliphate. The authors demonstrate the difference between the forms of reaction of Muslims in the Middle East and South Asia to the repudiation of the Caliphate by the Republican leaders of Turkey. The article establishes a multi-aspect interaction between the Caliphatist values and forms of self-identification, emerged in Arab and South Asian societies. The correlation between the rise of Caliphatist attitudes and radicalization of anti-colonial actions of South Asian Muslims is also outlined.


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