scholarly journals Study of Morphofunctional Parameters of Blood Cells in Ischemic Stroke Using a Genome-wide Research

2021 ◽  
pp. 70-75
Author(s):  
Ulyana Viktorovna Matveeva ◽  
Malika Ruslanovna Askhanova ◽  
Shamsi Aisayevich Saydaev ◽  
Alina Said-Alvievna Bakasheva ◽  
Diana Magomedovna Nauruzova ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Early Diagnosis ◽  
Brain Tissue ◽  
Tissue Damage ◽  
Blood Cells ◽  
Risk Of Death ◽  
Apolipoprotein Ciii ◽  
Genome Wide ◽  
A Genome ◽  
Brain Tissue Damage

Biomarkers can play many useful roles in modern neurology. Early diagnosis and immediate therapy are important factors for reducing the degree of brain tissue damage in ischemic stroke, reduces the risk of death from stroke. In the current study, apolipoprotein CIII (ApoCIII), a biomarker of ischemic stroke, was found.

scholarly journals GAMBARAN FAKTOR RISIKO PADA PENDERITA STROKE ISKEMIK YANG DIRAWAT INAP NEUROLOGI RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JULI 2012 - JUNI 2013

e-CliniC ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Glen Y. C. R. Kabi ◽  
Rizal Tumewah ◽  
Mieke A. H. N. Kembuan
Keyword(s):  
Risk Factors ◽  
Blood Flow ◽  
Ischemic Stroke ◽  
Brain Tissue ◽  
Tissue Damage ◽  
Medical Records ◽  
Clinical Signs ◽  
Stroke Patients ◽  
Brain Tissue Damage ◽  
The Brain

Abstract: Ischemic stroke is a clinical sign of dysfunction or brain tissue damage caused by lack of blood flow to the brain that disrupts the need for blood and oxygen to the brain. WHO defines stroke as a rapidly developing clinical signs of focal brain due to interference (or global) with symptoms - that last for 24 hours or more- and can cause death without any other obvious cause other than vascular. This study aimed to obtain an overview of risk factors in ischemic stroke patients in the Inpatient Neurology Department of Prof. Dr. R. D. Kandou Hospital Manado period July 2012 - June 2013. Data were taken by collecting data of ischemic stroke patients medical records. There were 60 patients during that period. Patients affected by stroke were aged between 51 - 65 years and had histories of hypertension.Keywords: risk factors, ischemic stroke.Abstrak: Stroke iskemik adalah tanda klinis disfungsi atau kerusakan jaringan otak yang disebabkan kurangnya aliran darah ke otak sehingga mengganggu kebutuhan darah dan oksigen di otak. WHO mendefiniskan stroke merupakan suatu tanda klinis yang berkembang cepat akibat gangguan otak fokal (atau global) dengan gejala - gejala yang berlangsung selama 24 jam atau lebih dan dapat menyebabkan kematian tanpa adanya penyebab lain yang jelas selain vaskuler. Penelitian ini bertujuan untuk mendapatkan gambaran tentang faktor resiko pada pasien stroke iskemik di rawat inap Neurologi RSUP Prof. Dr. R. D. Kandou Manado periode Juli 2012 - Juni 2013. Penelitian dilakukan dengan cara mengumpulkan data pasien yang terkena stroke iskemik di bagian rekam medik RSUP Prof. Dr. R. D. Kandou Manado. Didapatkan 60 pasiem selama periode Juli 2012 – Juni 2013. Berdasarkan hasil yang didapat maka disimpulkan bahwa pasien yang sering terkena stroke adalah pasien yang berumur antara 51-65 tahun, dan pasien yang memiliki riwayat hipertensi.Kata kunci: faktor risiko, stroke iskemik

Abstract P629: Genome-Wide Association Study of Individuals of Native Hawaiian Ancestry Reveals Unique Genetic Risk Factors for Stroke and Myocardial Infarction

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Stacy C Brown ◽  
Cameron Both ◽  
Julian N Acosta ◽  
Natalia Szejko ◽  
Victor Torres ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Ischemic Stroke ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Native Hawaiian ◽  
European Ancestry ◽  
Intronic Region ◽  
Genome Wide ◽  
A Genome ◽  
Risk Locus

Background: Several genetic susceptibility risk loci for ischemic stroke have been identified. However, the relative dearth of genetic data from populations of non-European ancestry has the potential to create disparities in access to genomics-based precision medicine strategies. Individuals of Native Hawaiian ancestry represent a particularly understudied group in stroke genomics research despite facing high rates of cerebrovascular disease. Hypothesis: Genetic variants associated with stroke differ between Native Hawaiians and previously studied groups of predominantly European ancestry. Methods: We conducted a genome-wide (GW) association study of stroke and myocardial infarction (MI) in an adult population of Native Hawaiian ancestry, using data from the Multiethnic Cohort study (MEC). Genetic information was ascertained via genome-wide array genotyping using the AB OpenArray and TaqMan platforms followed by imputation to 1000 Genomes reference panels. We pursued replication of variants that were GW significant (p<5x10 -8 ) or yielded suggestive associations (p<5x10 -7 ) in the prior stroke GW association study MEGASTROKE. Results: We identified 2,104 individuals (1,089 [51.8%] female) of Native Hawaiian ancestry, including 173 cases and 1,931 controls. We identified one novel susceptibility risk locus at a narrow intronic region located at chromosome q26.2 (top associated SNP 3:169096251, OR 2.48, 95%CI 1.81-3.41; p=1.93x10 -8 ), overlying the MECOM gene. We also identified 9 other suggestive risk loci at p<5x10 -7 . When replicating in MEGASTROKE, q26.2 did not have available counterpart variants to analyze, and 3 out of 9 suggestive signals were associated with ischemic stroke subtypes at p<0.05. Conclusions: We report the first GW association study of ischemic stroke and myocardial infarction in a Native Hawaiian population. We identified one susceptibility risk locus at q26.2, located in a narrow intronic region of MECOM, a gene that codes for a histone-lysine N-methyltransferase that has transcriptional regulation and oncoprotein functions. The lack of available replication data for this locus in the large MEGASTROKE collaboration emphasizes the importance of developing genomic resources across ancestral groups.

MR Spectroscopic Evaluation of Brain Tissue Damage After Treatment for Pediatric Brain Tumors

2009 ◽  
pp. 183-186 ◽  
Author(s):  
Sławomir Blamek ◽  
Dawid Larysz ◽  
Kornelia Ficek ◽  
Maria Sokół ◽  
Leszek Miszczyk ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Brain Tissue ◽  
Tissue Damage ◽  
Pediatric Brain Tumors ◽  
Brain Tissue Damage ◽  
Pediatric Brain

MONOPHASIC BUT NOT BIPHASIC PULSES INDUCE BRAIN TISSUE DAMAGE DURING MONOPOLAR HIGH-FREQUENCY DEEP BRAIN STIMULATION

Neurosurgery ◽  
2009 ◽  
Vol 64 (1) ◽  
pp. 156-163 ◽  
Author(s):  
Brigitte Piallat ◽  
Stéphan Chabardès ◽  
Annaelle Devergnas ◽  
Napoleon Torres ◽  
Marjolaine Allain ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Tissue ◽  
Brain Stimulation ◽  
Tissue Damage ◽  
High Frequency ◽  
Brain Tissue Damage ◽  
Deep Brain

scholarly journals Acetaldehyde Induces Cytotoxicity of SH-SY5Y Cells via Inhibition of Akt Activation and Induction of Oxidative Stress

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Tingting Yan ◽  
Yan Zhao ◽  
Xia Zhang
Keyword(s):  
Oxidative Stress ◽  
Brain Tissue ◽  
Cognitive Dysfunction ◽  
Tissue Damage ◽  
Heavy Drinking ◽  
Mitogen Activated Protein Kinase ◽  
Toxic Metabolite ◽  
Excessive Alcohol Consumption ◽  
Brain Tissue Damage ◽  
Induced Apoptosis

Excessive alcohol consumption can lead to brain tissue damage and cognitive dysfunction. It has been shown that heavy drinking is associated with an earlier onset of neurodegenerative diseases such as Alzheimer’s disease. Acetaldehyde, the most toxic metabolite of ethanol, is speculated to mediate the brain tissue damage and cognitive dysfunction induced by the chronic excessive consumption of alcohol. However, the exact mechanisms by which acetaldehyde induces neurotoxicity are not totally understood. In this study, we investigated the cytotoxic effects of acetaldehyde in SH-SY5Y cells and found that acetaldehyde induced apoptosis of SH-SY5Y cells by downregulating the expression of antiapoptoticBcl-2andBcl-xLand upregulating the expression of proapoptoticBax. Acetaldehyde treatment led to a significant decrease in the levels of activated Akt and cyclic AMP-responsive element binding protein (CREB). In addition, acetaldehyde induced the activation of p38 mitogen-activated protein kinase (MAPK) while inhibiting the activation of extracellular signal-regulated kinases (ERKs, p44/p42MAPK). Meanwhile, acetaldehyde treatment caused an increase in the production of reactive oxygen species and elevated the oxidative stress in SH-SY5Y cells. Therefore, acetaldehyde induces cytotoxicity of SH-SY5Y cells via promotion of apoptotic signaling, inhibition of cell survival pathway, and induction of oxidative stress.

Piezosurgery prevents brain tissue damage: an experimental study on a new rat model

2011 ◽  
Vol 40 (8) ◽  
pp. 840-844 ◽  
Author(s):  
G. Pavlíková ◽  
R. Foltán ◽  
M. Burian ◽  
E. Horká ◽  
S. Adámek ◽  
...  
Keyword(s):  
Experimental Study ◽  
Brain Tissue ◽  
Rat Model ◽  
Tissue Damage ◽  
Brain Tissue Damage

The effect of common carotid artery occlusion on delayed brain tissue damage in the rat double subarachnoid hemorrhage model

2011 ◽  
Vol 154 (1) ◽  
pp. 11-19 ◽  
Author(s):  
Erdem Güresir ◽  
Nikos Vasiliadis ◽  
Santosh Dias ◽  
Peter Raab ◽  
Volker Seifert ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Carotid Artery ◽  
Brain Tissue ◽  
Common Carotid Artery ◽  
Tissue Damage ◽  
Artery Occlusion ◽  
Carotid Artery Occlusion ◽  
Brain Tissue Damage ◽  
Common Carotid Artery Occlusion

scholarly journals A genome-wide study of DNA methylation in white blood cells and asthma in Latino children and youth

Epigenetics ◽  
2020 ◽  
pp. 1-9
Author(s):  
Yale Jiang ◽  
Erick Forno ◽  
Yueh-Ying Han ◽  
Zhongli Xu ◽  
Donglei Hu ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Blood Cells ◽  
White Blood Cells ◽  
Children And Youth ◽  
Latino Children ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Study
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