scholarly journals Drug-induced parkinsonism: A case report

2017 ◽  
Vol 7 (2) ◽  
pp. 65-68 ◽  
Author(s):  
Brianna D. Morabito ◽  
Barbara Paulison
Keyword(s):  
Temporal Relationship ◽  
Psychiatric History ◽  
Loading Dose ◽  
Drug Induced ◽  
Cyclothymic Disorder ◽  
Long Term Consequences ◽  
Long Acting ◽  
Pharmaceutical Agents ◽  
Relationship Of

Abstract Drug-induced parkinsonism is defined as the appearance of parkinsonism on treatment with pharmaceutical agents. Symptoms typically manifest within a few days, and 90% of cases emerge within 3 months. The patient was a 68-year-old white man with a past psychiatric history significant for bipolar I versus cyclothymic disorder. The patient presented with pressured speech, flight of ideas, distractibility, delusions, and disorganized thinking. He was started on risperidone and, due to a subclinical response, was cross-tapered from risperidone to olanzapine, and divalproex was started. The patient was then given paliperidone 234 mg long-acting injection (LAI) and a second loading dose of 156 mg 1 week later. The patient's cognitive and functional status subsequently declined, all neuroleptics were discontinued, and he was diagnosed with drug-induced parkinsonism. After a complicated hospital course the patient died approximately 5 months after the administration of paliperidone LAI. Although there are several confounding factors, due to the temporal relationship of events it is likely that paliperidone LAI was a contributing factor for the development of severe parkinsonism. Practitioners should be cognizant of the potential long-term consequences of paliperidone LAI.

scholarly journals Traumatic brain injury may not increase the risk of Alzheimer disease

Neurology ◽  
2017 ◽  
Vol 89 (18) ◽  
pp. 1923-1925 ◽  
Author(s):  
Michael W. Weiner ◽  
Paul K. Crane ◽  
Thomas J. Montine ◽  
David A. Bennett ◽  
Dallas P. Veitch
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Alzheimer Disease ◽  
Epidemiologic Studies ◽  
Increased Risk ◽  
Military Populations ◽  
Long Term Consequences ◽  
Relationship Of ◽  
The Relationship

Traumatic brain injury (TBI) commonly occurs in civilian and military populations. Some epidemiologic studies previously have associated TBI with an increased risk of Alzheimer disease (AD). Recent clinicopathologic and biomarker studies have failed to confirm the relationship of TBI to the development of AD dementia or pathologic changes, and suggest that other neurodegenerative processes might be linked to TBI. Additional studies are required to determine the long-term consequences of TBI.

Accountability in morphological borrowing: Analyzing a linguistic subsystem as a sociolinguistic variable

2008 ◽  
Vol 20 (2) ◽  
pp. 225-253 ◽  
Author(s):  
Tara Sanchez
Keyword(s):  
Social Factors ◽  
Language Contact ◽  
Verbal Morphology ◽  
Language Variation And Change ◽  
Contact Data ◽  
Long Term Consequences ◽  
Theory Of Language ◽  
Relationship Of ◽  
The Relationship

ABSTRACTPrinciples of structural borrowing have been proposed, relating to structures of the languages involved and sociodemographic circumstances of their respective societies. This article quantitatively evaluates the roles of both linguistic and social factors in structural borrowing via examination of language contact data from Aruba and Curaçao, where creole Papiamentu is in contact with Spanish, Dutch, and English. Variationist methods, rooted in Labov's Principle of Accountability, are applied in a novel way to the system of verbal morphology to flesh out factors promoting borrowing. Linguistic factors are found to be quantitatively stronger, and only one nonlinguistic factor was found to promote borrowing. Results are discussed in light of prevailing theories of language contact. Findings contribute to our understanding of the long-term consequences of language contact and the relationship of contact-induced change to a more general sociolinguistic theory of language variation and change.

Effect in antipsychotic-induced hyperprolactinemia after switching to long-acting injectable aripiprazole: A 1-year study

2017 ◽  
Vol 41 (S1) ◽  
pp. s815-s816
Author(s):  
M. Juncal Ruiz ◽  
B. Fernández-Abascal Puente ◽  
O. Porta Olivares ◽  
M. Gómez Revuelta ◽  
R. Landera Rodríguez ◽  
...  
Keyword(s):  
Side Effects ◽  
Sexual Dysfunction ◽  
Clinical Improvement ◽  
Drug Induced ◽  
Oral Olanzapine ◽  
Competing Interest ◽  
One Year ◽  
Long Acting ◽  
Almost All

IntroductionAntipsychotic-induced hyperprolactinemia is associated with relevant side effects: short-term as hypogonadism, gynecomastia, amenorrhoea, sexual dysfunction and galactorrhoea; long-term as cardiovascular disease, bone demineralization and breast and prostate tumors.AimsTo evaluate the effect of switching to long-acting injectable aripiprazole on long-lasting antypsychotic-induced hyperprolactinemia.MethodsThis was a prospective observational 1-year study carried out in 125 outpatients with schizophrenia who were clinically stabilized but a switching to another antipsychotic was indicated. We measured the basal prolactine at the start of the study and 1 year after switching to long acting injecatable (LAI) aripiprazole.ResultsIn basal analytic, 48% had hyperprolactinemia (21.8–306.2 ng/mL) and 66.5% of them described side effects: 78% sexual dysfunction (72% men), 11% galactorrhoea (100% women), 5.5% amenorrhoea and 5.5% bone pain (100% women). In 48% of patients with hyperprolactinemia, the previous antipsychotics comprised: LAI-paliperidone (65,7%), oral-risperidone (7%), oral-olanzapine (6.1%), oral-paliperidone (5.2%), LAI-risperidone (4%) and others (12%). One year after switching to LAI-aripiprazole, prolactine levels were lower in all patients and in 85% prolactine levels were normalized. Overall, 72% described a clinical improvement, especially in terms of sexual dysfunction.ConclusionsSeveral studies have described an improvement of drug-induced hyperprolactinemia after switching to or adding oral aripiprazole. In our study, we observed that levels of prolactine were normalized in 85% of patients with a clinical improvement in almost all of cases. These findings suggest that switching to LAI aripiprazole may be an effective alternative for managing antipsychotic-induced hyperprolactinemia due to its partial agonism in D2 brain receptors, especially in tuberoinfundibular pathway.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Long-Acting Growth Hormone Preparations – Current Status and Future Considerations

2019 ◽  
Vol 105 (6) ◽  
pp. e2121-e2133 ◽  
Author(s):  
Bradley S Miller ◽  
Eric Velazquez ◽  
Kevin C J Yuen
Keyword(s):  
Current Status ◽  
Term Therapy ◽  
Efficacy And Safety ◽  
Short Term ◽  
Randomized Controlled Clinical Trials ◽  
Serum Peak ◽  
Igf I ◽  
Long Acting ◽  
Relationship Of

Abstract Context Long-acting GH (LAGH) preparations are currently being developed in an attempt to improve adherence. The profile of GH action following administration of LAGH raises practical questions about clinical monitoring and long-term safety and efficacy of these new therapeutic agents. Methods Recent literature and meeting proceedings regarding LAGH preparations are reviewed. Results Multiple LAGH preparations are currently at various stages of development, allowing for decreased GH injection frequency from daily to weekly, biweekly, or monthly. Following administration of LAGH, the serum peak and trough GH and IGF-I levels vary depending upon the mechanism used to prolong GH action. Randomized, controlled clinical trials of some LAGH preparations have reported non-inferiority compared with daily recombinant human GH (rhGH) for improved growth velocity and body composition in children and adults with GH deficiency (GHD), respectively. No significant LAGH-related adverse events have been reported during short-term therapy. Conclusion Multiple LAGH preparations are proceeding through clinical development with some showing promising evidence of short-term clinical efficacy and safety in children and adults with GHD. The relationship of transient elevations of GH and IGF-I following administration of LAGH to efficacy and safety remain to be elucidated. For LAGH to replace daily rhGH in the treatment of individuals with GHD, a number of practical questions need to be addressed including methods of dose adjustment, timing of monitoring of IGF-I, safety, efficacy, and cost-effectiveness. Long-term surveillance of efficacy and safety of LAGH preparations will be needed to answer these clinically relevant questions.

Barriers to Physical Activity in Adolescents

2015 ◽  
Vol 23 (2) ◽  
pp. 47-59 ◽  
Author(s):  
Nadine Langguth ◽  
Tanja Könen ◽  
Simone Matulis ◽  
Regina Steil ◽  
Caterina Gawrilow ◽  
...  
Keyword(s):  
Physical Activity ◽  
Leisure Activities ◽  
Outcome Expectations ◽  
Multidimensional Approach ◽  
Factor Analyses ◽  
Physical And Mental Health ◽  
Tailored Interventions ◽  
Long Term Consequences ◽  
Age Range

During adolescence, physical activity (PA) decreases with potentially serious, long-term consequences for physical and mental health. Although barriers have been identified as an important PA correlate in adults, research on adolescents’ PA barriers is lacking. Thus reliable, valid scales to measure adolescents’ PA barriers are needed. We present two studies describing a broad range of PA barriers relevant to adolescents with a multidimensional approach. In Study 1, 124 adolescents (age range = 12 – 24 years) reported their most important PA barriers. Two independent coders categorized those barriers. The most frequent PA barriers were incorporated in a multidimensional questionnaire. In Study 2, 598 adolescents (age range = 13 – 21 years) completed this questionnaire and reported their current PA, intention, self-efficacy, and negative outcome expectations. Seven PA barrier dimensions (leisure activities, lack of motivation, screen-based sedentary behavior, depressed mood, physical health, school workload, and preconditions) were confirmed in factor analyses. A multidimensional approach to measuring PA barriers in adolescents is reliable and valid. The current studies provide the basis for developing individually tailored interventions to increase PA in adolescents.

Responding to Immediate and Long-Term Consequences of Terror

2008 ◽  
Author(s):  
Mary Fabri ◽  
Amber Gray ◽  
Jeannette Uwineza
Keyword(s):  
Long Term Consequences
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