Background: The stigma of cancer as a deadly disease greatly affects the patient’s perspective in shaping self-concept, which impacts on hopes and influences the stability of psychological well-being. The purpose of this study was to prove that the self-concept influences the hopes and psychological well-being of cancer survivors. Methods: This was a cross-sectional study. Samples were 90 cancer survivors from three public health centers in Surabaya, Indonesia taken by simple random sampling. All participants completed the instruments of the Tennessee Self-Concept Scale, Herth Hope Index, and Ryff’s Psychological Well-Being Scale. All the instruments were valid and reliable based on the test. Ethical feasibility has been conducted. The Pearson Product-Moment Correlation Test was applied to analyze the data with P < .05. Results: The demographic characteristics of cancer survivors include the age majority of 46-65 years (53%), female sex (80%), married (61%), having stage-III cancer (44%), diagnosed of cancer for 1–6 years (56%), having support system from nuclear families (73%), and actively involved in the community (66%). The mean score of self-concept is 78.2, hope 38.2, and psychological well- being 76.3. Self-concept had a significant effect on hope (r = .783, P = .000) and psychological well-being (r = .611, P = .000) Conclusions: Cancer survivors who had positive self-concepts are more likely to accept themselves, which triggers the formation of high hope for recovery and the achievement of positive psychological well-being.