These papers describe the status, challenges and opportunities of spices production in Ethiopia. It has the highest potential to produce a lot of spice crops. The country mainly produces; Korarima, chillies, turmeric, ginger, black pepper, cumin, fenugreek, coriander and so forth. In spite of the fact that the country has great potential for various spices production, the subsector of spices had remained and neglected and subsequently the level of production and share of spice crops of the total export earning of the country is at considerably low level. Hence, it is essential to describe the status, challenges and opportunities of spices sector in Ethiopia, for best uses of the potential and used spice crop resources. Among the various spices crops, chilli/hot pepper is the most commonly produced spices in Ethiopia. Similarly, the Ethiopian spice productions have showed a declining trend from 2013 onwards. This is mainly due to the disease that considerably affects ginger production and the rapid increasing domestic demand of spices. Therefore, intervention and provide awareness for spices growers on using improved production and processing technology, training across all production and productivity, formulating strong marketing regulations and proclamation is of paramount importance to increase the production, profits and productivity.