Spatial Patterns of the Urban Agglomeration of the Yellow River Ji-Shaped Bend Based on Space of Multiple Flows

Previous studies on the space of flows have mainly focused on a single flow element and have given less consideration to the joint effect of complex correlations among multiple flows. To fill this gap, in the context of the coordinated development of the urban agglomeration of the Yellow River Ji-shaped bend (UAYB), in this study, three flows, namely population flow, logistics flow, and information flow, are selected to research the spatial patterns of the UAYB. The results show the following: (1) The information flow among cities in the UAYB is the strongest, followed by logistics flow and population flow. (2) Hohhot, Ordos, Yinchuan, and Taiyuan are the core cities and have attracted more flows to converge there; different flows have formed different central features. (3) Regarding the correlation of the three flows, information flow has a strong correlation with the other two flows. (4) From the perspective of the joint effects of the three flows considered, the hierarchy of UAYB is dominated by Hohhot and Taiyuan and sub-dominated by Yinchuan and Ordos; four prominent city groups have been formed with these four cities as the center. On the basis of our results, we put forward some recommendations on the integrated development of cities at various levels within the UAYB to provide a reference for its spatial optimization strategy.

Low kV Computed Tomography of Parenchymal Abdominal Organs—A Systematic Animal Study of Different Contrast Media Injection Protocols

Objectives: To evaluate multiphase low kV computed tomography (CT) imaging of the abdomen with reduced contrast media (CM) dose using different injection protocols. Methods: Two injection protocols were evaluated for use with low kV (80 kV) multiphase abdominal imaging in comparison to the standard procedure acquired at 120 kV (500 mgI/kg; 5 mL/s). This evaluation was conducted in a highly standardized animal study (5 Goettingen minipigs). The low kV protocols consisted of (a) a single-flow (SF) injection with 40% reduced CM dose and injection rate (300 mgI/kg; 3 mL/s) and (b) a DualFlow (DF) injection protocol consisting of 60%/40% contrast to saline ratio administered at 5 mL/s. Dynamic CT was first performed within representative liver regions to determine optimal contrast phases, followed by evaluation of the three protocols in multiphase abdominal CT imaging. The evaluation criteria included contrast enhancement (CE) of abdominal organs and vasculature. Results: The 80 kV DF injection protocol showed similar CE of the abdominal parenchymatous organs and vessels to the 120 kV reference and the 80 kV SF protocol. Hepatic parenchyma showed comparable CT values for all contrast phases. In particular, in the portal venous parenchymal phase, the 80 kV DF protocol demonstrated higher hepatic parenchymal enhancement; however, results were statistically non-significant. Similarly, CE of the kidney, pancreas, and abdominal arterial/venous vessels showed no significant differences between injection protocols. Conclusions: Adapted SF and DF injection protocols with reduced IDR/iodine load offer the potential to calibrate optimal CM doses to the tube voltage in abdominal multiphase low kV CT imaging. The data suggest that the DF approach allows the use of predefined injection protocols and adaption of the contrast to saline ratio to an individualized kV setting and yields the potential for patient-individualized CM adaption.

Scour Hole Development in Natural Cohesive Bed Sediment around Cylinder-Shaped Piers Subjected to Varying Sequential Flow Events

Scour evolution and propagation around a cylinder in natural cohesive sediment was uniquely investigated under multi-flow event varying sequentially by velocity magnitudes. This flume study differs from others that only used test sediment with commercially available clays for single flow. The objective of this study was to explore the potential differences in scour hole development in natural riverbed sediments subjected to varying flow velocity scenarios, advancing our understanding from existing studies on scour. The study consisted of 18 experimental runs based on: velocity, flow duration, and soil bulk density. Scour hole development progressed initially along the cylinder sides, and maximum depths also occurred at these lateral locations. Scour hole depths were less for higher soil bulk densities (≥1.81 g/cm3) compared with lower densities, and erosion rates were slower. It was observed with all flow sequences that scour depths were similar at the end of each experimental run. However, scour initiation was observed to be time dependent for soils with higher bulk density (1.81–2.04 g/cm3) regardless of flow velocity sequences. The observed time dependency suggests a process feedback with the scour hole development initiated at the cylinder sides, which influence local 3D hydraulics as the scour hole depth progresses.

An Arbitrary Hybrid Turbulence Modeling Approach for Efficient and Accurate Automotive Aerodynamic Analysis and Design Optimization

The demand in solving complex turbulent fluid flows has been growing rapidly in the automotive industry for the last decade as engineers strive to design better vehicles to improve drag coefficients, noise levels and drivability. This paper presents the implementation of an arbitrary hybrid turbulence modeling (AHTM) approach in OpenFOAM for the efficient simulation of common automotive aerodynamics with unsteady turbulent separated flows such as the Kelvin–Helmholtz effect, which can also be used as an efficient part of aerodynamic design optimization (ADO) tools. This AHTM approach is based on the concept of Very Large Eddy Simulation (VLES), which can arbitrarily combine RANS, URANS, LES and DNS turbulence models in a single flow field depending on the local mesh refinement. As a result, the design engineer can take advantage of this unique and highly flexible approach to tailor his grid according to his design and resolution requirements in different areas of the flow field over the car body without sacrificing accuracy and efficiency at the same time. This paper presents the details of the implementation and careful validation of the AHTM method using the standard benchmark case of the Ahmed body, in comparison with some other existing models, such as RANS, URANS, DES and LES, which shows VLES to be the most accurate among the five examined. Furthermore, the results of this study demonstrate that the AHTM approach has the flexibility, efficiency and accuracy to be integrated with ADO tools for engineering design in the automotive industry. The approach can also be used for the detailed study of highly complex turbulent phenomena such as the Kelvin–Helmholtz instability commonly found in automotive aerodynamics. Currently, the AHTM implementation is being integrated with the DAFoam for gradient-based multi-point ADO using an efficient adjoint solver based on a Sparse Nonlinear optimizer (SNOPT).

Determinants of intracranial aneurysm retreatment following embolization with a single flow-diverting stent

Purpose Flow diverting stents have revolutionized the treatment of intracranial aneurysms through endoluminal reconstruction of the parent vessel. Despite this, certain aneurysms require retreatment. The purpose of this study was to identify clinical and radiologic determinants of aneurysm retreatment following flow diversion. Methods A multicenter flow diversion database was evaluated to identify patients presenting with an unruptured, previously untreated aneurysm with a minimum of 12 months’ clinical and angiographic follow-up. Univariate and multivariate logistic regression modeling was performed to identify determinants of retreatment. Results We identified 189 aneurysms treated in 189 patients with a single flow-diverting stent. Mean age was 54 years, and 89% were female. Complete occlusion was achieved in 70.3% and 83.6% of patients at six and 12 months, respectively. Aneurysm retreatment with additional flow-diverting stents occurred in 5.8% of cases. Univariate analysis revealed that dome diameter [Formula: see text]10 mm ( p = 0.012), pre-clinoid internal carotid artery location ( p = 0.012), distal > proximal parent vessel diameter ( p = 0.042), and later dual antiplatelet therapy (DAPT) discontinuation ( p < 0.001) were predictive of retreatment. Multivariate analysis identified discontinuation of DAPT [Formula: see text]12 months ( p = 0.003) as a strong determinant of retreatment with dome diameter [Formula: see text]10 mm trending toward statistical significance ( p = 0.064). Large aneurysm neck diameter, presence of aneurysm branch vessels, patient age, smoking history, and hypertension were not determinant of retreatment on multivariate analysis. Conclusions Prolonged DAPT is the most important determinant of aneurysm retreatment following single-device flow diversion. Abbreviating DAPT duration to only six months should be a consideration in this population, especially for patients with a large aneurysm dome diameter.

Identification and quantification of chimeric sequencing reads in a highly multiplexed RAD-seq protocol

Highly multiplexed approaches have become a common practice in genomic studies. They have improved the cost-effectiveness of genotyping hundreds of individuals by using combinatorially-barcoded adapters. These strategies, however, can potentially misassign reads to incorrect samples. Here we used a modified quaddRAD protocol to analyse the occurrence of index hopping and PCR chimeras in a series of experiments with up to a 100 multiplexed samples per sequencing lane (total n = 639). We created two types of sequencing libraries: four libraries of Type A, where PCR reactions were run on individual samples before multiplexing, and three libraries of Type B, where PCRs were run on pooled samples. We used fixed pairs of inner barcodes to identify chimeric reads. Type B libraries show a higher percentage of misassigned reads (1.15%) compared to Type A libraries (0.65%). We also quantify the commonly undetectable chimeric sequences that occur whenever multiplexed groups of samples with different outer barcodes are sequenced together on a single flow cell. Our results suggest that these types of chimeric sequences represent up to 1.56% and 1.29% of reads in Type A and B libraries, respectively. We review the source of such errors, provide recommendations for developing highly-multiplexed RAD-seq protocols and analysing the resulting data to minimise the generation of chimeric sequences, allow their quantification, and provide finer control over the number of PCR cycles necessary to generate enough input DNA for library preparation.

Experimental investigation of hydrodynamic phenomena in vertical-upward adiabatic two-phase flow conditions

In order to investigate hydrodynamic phenomena in two-phase flow conditions in nuclear safety analysis, a series of two-phase flow experiments were conducted using a single flow channel in which air and water were simultaneously injected into the test section. The experiments under atmospheric pressure conditions were carried out with the water velocity and the air velocity covering the ranges from 0.2 to 1.5 m/s and 0.05 to 0.2 m/s, respectively. The technique of two-sensor conductivity probe was used for the measurement of bubble parameters. The experimental results presented and analyzed in this study are the local time-averaged void fraction and bubble velocities at three axial positions L/D = 14.4, 51.2 and 71.3.

Design and fabrication of a vigorous “cavitation-on-a-chip” device with a multiple microchannel configuration

Hydrodynamic cavitation is one of the major phase change phenomena and occurs with a sudden decrease in the local static pressure within a fluid. With the emergence of microelectromechanical systems (MEMS), high-speed microfluidic devices have attracted considerable attention and been implemented in many fields, including cavitation applications. In this study, a new generation of ‘cavitation-on-a-chip’ devices with eight parallel structured microchannels is proposed. This new device is designed with the motivation of decreasing the upstream pressure (input energy) required for facile hydrodynamic cavitation inception. Water and a poly(vinyl alcohol) (PVA) microbubble (MB) suspension are used as the working fluids. The results show that the cavitation inception upstream pressure can be reduced with the proposed device in comparison with previous studies with a single flow restrictive element. Furthermore, using PVA MBs further results in a reduction in the upstream pressure required for cavitation inception. In this new device, different cavitating flow patterns with various intensities can be observed at a constant cavitation number and fixed upstream pressure within the same device. Moreover, cavitating flows intensify faster in the proposed device for both water and the water–PVA MB suspension in comparison to previous studies. Due to these features, this next-generation ‘cavitation-on-a-chip’ device has a high potential for implementation in applications involving microfluidic/organ-on-a-chip devices, such as integrated drug release and tissue engineering.