SLAM CHARACTERISTICS OF A HIGH-SPEED WAVE PIERCING CATAMARAN IN IRREGULAR WAVES

Slam characteristics of a 112m INCAT wave piercing catamaran in a range of realistic irregular sea conditions are presented in this paper. Towing tank testing of a 2.5 m hydroelastic segmented catamaran model was used to gather a database of slam events in irregular seas. The model was instrumented to measure motions, centrebow surface pressures and forces, encountered wave elevations and wave elevations within the bow area tunnel arches. From these measurements characteristics of the vessel slamming behaviour are examined: in particular relative vertical velocity, centrebow immersion, archway wave elevations and slam load distributions. A total of 2,098 slam events were identified over 22 different conditions, each containing about 80 to 100 slam events. The data, although inherently scattered, shows that encounter wave frequency and significant wave height are important parameters with regard to centrebow slamming. Relative vertical velocity was found to be a poor indicator of slam magnitude and slams were found to occur before the centrebow arch tunnel was completely filled, supporting the application of a two-dimensional filling height parameter as a slam indicator.

Electrophysiological Consequences of Cardiac Fibrosis

For both the atria and ventricles, fibrosis is generally recognized as one of the key determinants of conduction disturbances. By definition, fibrosis refers to an increased amount of fibrous tissue. However, fibrosis is not a singular entity. Various forms can be distinguished, that differ in distribution: replacement fibrosis, endomysial and perimysial fibrosis, and perivascular, endocardial, and epicardial fibrosis. These different forms typically result from diverging pathophysiological mechanisms and can have different consequences for conduction. The impact of fibrosis on propagation depends on exactly how the patterns of electrical connections between myocytes are altered. We will therefore first consider the normal patterns of electrical connections and their regional diversity as determinants of propagation. Subsequently, we will summarize current knowledge on how different forms of fibrosis lead to a loss of electrical connectivity in order to explain their effects on propagation and mechanisms of arrhythmogenesis, including ectopy, reentry, and alternans. Finally, we will discuss a histological quantification of fibrosis. Because of the different forms of fibrosis and their diverging effects on electrical propagation, the total amount of fibrosis is a poor indicator for the effect on conduction. Ideally, an assessment of cardiac fibrosis should exclude fibrous tissue that does not affect conduction and differentiate between the various types that do; in this article, we highlight practical solutions for histological analysis that meet these requirements.

Knee osteoarthritis severity concerning neutrophil-lymphocyte ratio

Osteoarthritis (OA) is a disease with a significant inflammatory component. Neutrophil-lymphocyte ratio (NLR) level is a marker to determine inflammation. The study aimed to evaluate the association between the severity of knee OA and NLR. A case-control study was conducted in Al-Zahrawi from June 2017 to June 2018. A total of 100 knees OA were recruited and 50 healthy subjects as a control group. NLR was significantly higher in knee OA than controls, the mean value was (2.19±0.72) and (1.97±0.88), respectively. Older age, chronic pain, prolong the onset of diagnosis and high NLR were significantly associated with severe OA. Knee OA had higher NLR compared to healthy people. Higher NLR is associated with the severity of knee OA and it is a poor indicator.

Comparative Analysis of Equivalent Material based on MFI

Polymers of the same family show distinct behavior with each other and because of this, the end prediction after molding the part is very difficult. Simulations result does not always match the product. For close substitution in absence of exactly known material composition, the equivalent grade of the same MFI may be used. However, the MFI is a poor indicator of the rheological behavior to be comprehend for accurate simulation. This research analyzes the appropriate parameters for the rheology of polymers, in the same class that are appropriate.

Hierarchical genetic structuring in the cool boreal kelp, Laminaria digitata: implications for conservation and management

Kelp are foundation species threatened by ongoing warming trends and increased harvesting pressure. This emphasizes the need to study genetic structure over various spatial scales to resolve demographic and genetic processes underpinning resilience. Here, we investigate the genetic diversity in the kelp, Laminaria digitata, in previously understudied southern (trailing-edge) and northern (range-centre) regions in the Northeastern Atlantic Ocean. There was strong hierarchical spatial structuring with significantly lower genetic variability and gene flow among southern populations. As these span the area of the Hurd’s deep Pleistocene glacial refuge, the current low variation likely reflects a fraction of previous levels that has been eroded at the species southern edge. Northern variability and private alleles also indicate contributions from cryptic northern glacial refugia. Contrary to expectations of a positive relationship between neutral genetic diversity and resilience, a previous study reported individuals from the same genetically impoverished southern populations to be better adapted to cope with thermal stress than northern individuals. This not only demonstrates that neutral genetic diversity may be a poor indicator of resilience to environmental stress but also confirms that extirpation of southern populations will result in the loss of evolved, not just potential, adaptations for resilience.

Seizure onset location shapes dynamics of initiation

ObjectiveIctal electrographic patterns are widely thought to reflect underlying neural mechanisms of seizures. Here we studied the degree to which seizure patterns are consistent in a given patient, relate to particular brain regions and if two candidate biomarkers (high-frequency oscillations, HFOs; infraslow activity, ISA) and network activity, as assessed with cross-frequency interactions, can discriminate between seizure types.MethodsWe analyzed temporal changes in low and high frequency oscillations recorded during seizures, as well as phase-amplitude coupling (PAC) to monitor the interactions between delta/theta and ripple/fast ripple frequency bands at seizure onset.ResultsSeizures of multiple pattern types were observed in a given patient and brain region. While there was an increase in HFO rate across different electrographic patterns, there are specific relationships between types of HFO activity and onset region. Similarly, changes in PAC dynamics were more closely related to seizure onset region than they were to electrographic patterns while ISA was a poor indicator for seizure onset.ConclusionsOur findings suggest that the onset region sculpts neurodynamics at seizure initiation and that unique features of the cytoarchitecture and/or connectivity of that region play a significant role in determining seizure mechanism.SignificanceClinicians should consider more than just overt electrographic patterns when considering seizure mechanisms and regions of onset. Examination of onset pattern in conjunction with the interactions between different oscillatory frequencies in the context of different brain regions might be more informative and lead to more reliable clinical inference as well as novel therapeutic approaches.