Telephone-Based Reminder To Improve Safety After Percutaneous Coronary Intervention

Introduction: Dual Antiplatelet Therapy (DAPT) is a class I guideline indication after Percutaneous Coronary Intervention (PCI). Our population is high-risk for low medication adherence. With a multidisciplinary team we developed a telephone-based intervention to improve DAPT adherence post-PCI. Methods: Patients undergoing PCI at our center were contacted by nursing staff via telephone at 1 week, 30 days, and 60 days post-procedure. Calls included a reminder of the importance of DAPT and elicited any patient concerns. Concerns were relayed to the team who could take appropriate action. For patients filling their medications at any pharmacies within our closed system the proportion of days covered (PDC) was calculated. These were compared to data for patients undergoing PCI in the seven months prior to program initiation. Information on interventions performed as a result of calls was also collected. Results: During the study period, 452 patients underwent PCI. Of these, 70% were contacted and 244 filled their prescription at our system pharmacies. Twelve-month median PDC was 74%, with 45% of patients having PDC >80%. There was no significant difference when compared to the group prior to the intervention, median PDC 79% and 50% of patients having PDC >80%. In 26 patients calls led to interventions, removing barriers that would have otherwise prevented continued adherence. Conclusion: A telephone-based reminder system led to directed interventions in nearly 1 in 10 patients contacted. It was not able to significantly improve PDC when compared to a contemporary sample. This highlights the difficulty in using PDC to detect barriers to adherence.

Atlas of Micromorphological Degradation of Archaeological Birch Bark

In this paper we present an atlas of micromorphological degradation of archaeological birch bark for the first time. We analysed the morphology of 13 samples extracted from ice-logged, waterlogged and cave-retrieved objects dated from the Neolithic to the Middle Age by means of light microscopy (LM) and transmission electron microscopy (TEM). We then compared their morphology to that of a contemporary sample, both intact and decayed. In all samples, 13 morphological characteristics that can be associated with fungal, bacterial, chemical, mechanical and light degradation are defined and described, and example LM and TEM images are provided. This novel atlas provides conservator-restorers a much-needed tool to relate the macroscopic appearance to the microscopic structure of birch bark objects. The most important macroscopic features allowing estimation of the state of preservation at the cell level are colour changes, loss of pliability, presence of delamination and increased brittleness. Colour change and delamination can be connected to microscopic features, and microscopic analysis can trace whether they were caused by biotic, chemical or physical decay. However, increased brittleness cannot be connected to a specific microscopic feature.

Measuring Social and Emotional Wellbeing in Aboriginal Youth Using Strong Souls: A Rasch Measurement Approach

Currently, there are few robustly evaluated social and emotional wellbeing (SEWB) measures available for use with Aboriginal youth in research, policy, and practice. As such, this study used a Rasch measurement approach to examine the psychometric properties of Strong Souls, a 25-item self-reported SEWB instrument, created for use with Aboriginal youth in the Northern Territory. Our sample (N = 154) included youth (15–25 years old) living on Whadjuk (metropolitan Western Australia; N = 91) and Kamilaroi countries (rural New South Wales; N = 63). Using Rasch modelling techniques, evidence for multidimensionality in the scale was observed, resulting in subsequent analyses conducted separately on two subscales: Psychological Distress and Resilience. The Resilience subscale did not meet the Rasch model assumptions, with poor person and item separation and reliability indexes suggesting the scale was not reliably differentiating between participants’ Resilience scores. The Psychological Distress subscale had mixed separation and reliability index results, with good construct validity implied but poorer ability to target the distress of participants. Our findings provide novel evidence demonstrating the functioning of Strong Souls in a contemporary sample of Aboriginal youth, suggesting further modifications of the instrument are required before it can be used with confidence as a reliable measure in this population group.

Geopsychology of instrumental aggression: daily concurrence of global terrorism and solar-geomagnetic activity (1970-2018)

Formal scientific study of the geopsychology of human aggression dates back at least a century and has consistently demonstrated a positive association between solar-geomagnetic activity and aggressive behaviour. Advances in the theories, methodologies, and practical applications of geopsychology could therefore contribute to collective efforts to comprehend, to forecast, and to develop interventions for aggressive behaviours such as those seen in terrorism. This requires a rigorous and precise estimate of the magnitude of association between solar-geomagnetic activity and aggression using a representative, contemporary sample of strictly-operationalized behaviour. Here we show that days in recent history (1970-2018) with the lowest levels of instrumental human aggression (number of casualty-associated terrorism incidents) also had the lowest levels of solar and geomagnetic activity, and that stepwise increases in human aggression were mirrored by progressive increases in solar activity. We used Bayesian methods robust to outliers and heterogeneity of variance to analyze the most comprehensive and contemporary global database of terrorism incidents available, which included more than 106,000 unique instances of instrumental aggression spanning 48 years. We conclude that there is a small, nonzero promotional effect of solar-geomagnetic activity on terrorism-related aggression. This may reflect the fact that solar-geomagnetic activity serves as a zeitgeber that coordinates the expression of instrumental aggression across an aggregation of susceptible individuals. We propose that many behaviours – even instrumental acts such as terrorism which are presumed to involve a degree of planning and intention – may be subject to subtle geopsychological induction or suppression.

Biomarkers of Inflammation and Risk of Hospitalization for Heart Failure in Patients With Atrial Fibrillation

Background Hospitalization for heart failure (HF) is very common in patients with atrial fibrillation (AF). We hypothesized that biomarkers of inflammation can identify patients with AF at increased risk of this important complication. Methods and Results Patients with established AF were prospectively enrolled. Levels of hs‐CRP (high‐sensitivity C‐reactive protein) and interleukin‐6 were measured from plasma samples obtained at baseline. We calculated an inflammation score ranging from 0 to 4 (1 point for each biomarker between the 50th and 75th percentile, 2 points for each biomarker above the 75th percentile). Individual associations of biomarkers and the inflammation score with HF hospitalization were obtained from multivariable Cox proportional hazards models. A total of 3784 patients with AF (median age 72 years, 24% prior HF) were followed for a median of 4.0 years. The median (interquartile range) plasma levels of hs‐CRP and interleukin‐6 were 1.64 (0.81–3.69) mg/L and 3.42 (2.14–5.60) pg/mL, respectively. The overall incidence of HF hospitalization was 3.04 per 100 person‐years and increased from 1.34 to 7.31 per 100 person‐years across inflammation score categories. After multivariable adjustment, both biomarkers were significantly associated with the risk of HF hospitalization (per increase in 1 SD, adjusted hazard ratio [HR], 1.22; 95% CI, 1.11–1.34 for log‐transformed hs‐CRP; adjusted HR, 1.48; 95% CI, 1.35–1.62 for log‐transformed interleukin‐6). Similar results were obtained for the inflammation score (highest versus lowest score, adjusted HR, 2.43; 95% CI, 1.80–3.30; P value for trend <0.001). Conclusions Biomarkers of inflammation strongly predicted HF hospitalization in a large, contemporary sample of patients with AF. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02105844.

Non-random errors and their importance in testing of hypotheses

Increasing numbers of non-random errors are observed in contemporary sample surveying – in particular, those resulting from no response or faulty measutrements (imprecise statistical observation). Until recently, the consequences of these kinds of errors have not been widely discussed in the context of the testing of hypoteses. Researchers focused almost entirely on sampling errors (random errors), whose magnitude decreases as the size of the random sample grows. In consequence, researchers who often use samples of very large sizes tend to overlook the influence random and non-random errors have on the results of their study. The aim of this paper is to present how non-random errors can affect the decision-making process based on the classical hypothesis testing procedure. Particular attention is devoted to cases in which researchers manage samples of large sizes. The study proved the thesis that samples of large sizes cause statistical tests to be more sensitive to non-random errors. Systematic errors, as a special case of non-random errors, increase the probability of making the wrong decision to reject a true hypothesis as the sample size grows. Supplementing the testing of hypotheses with the analysis of confidence intervals may in this context provide substantive support for the researcher in drawing accurate inferences.

A First Step, a Second Chance: Public Support for Restoring Rights of Individuals with Prior Convictions

Recent federal and state-level justice reforms have centered on “legal reintegration” (e.g., permitting expungement for a greater range of crimes and rights restoration). While scholarship has tapped public opinion of this approach, much of it predates recent reentry efforts. We see an opportunity to extend this literature by focusing on a contemporary sample ( N = 374) of residents living in Virginia, a state that recently considered such reforms. Results suggest most of the public supports expungement reform, but less than 40% support rights restoration generally, with approval levels dependent on specific type of restoration. Divides are explained by socio-demographic factors, particularly political ideology and race, as well as crime-related views. Implications are discussed.

Power and limits of selection genome scans on temporal data from a selfing population

Tracking genetic changes of populations through time allows a more direct study of the evolutionary processes acting on the population than a single contemporary sample. Several statistical methods have been developed to characterize the demography and selection from temporal population genetic data. However, these methods are usually developed under the assumption of outcrossing reproduction and might not be applicable when there is substantial selfing in the population. Here, we focus on a method to detect loci under selection based on a genome scan of temporal differentiation, adapting it to the particularities of selfing populations. Selfing reduces the effective recombination rate and can extend hitch-hiking effects to the whole genome, erasing any local signal of selection on a genome scan. Therefore, selfing is expected to reduce the power of the test. By means of simulations, we evaluate the performance of the method under scenarios of adaptation from new mutations or standing variation at different rates of selfing. We find that the detection of loci under selection in predominantly selfing populations remains challenging even with the adapted method. Still, selective sweeps from standing variation on predominantly selfing populations can leave some signal of selection around the selected site thanks to historical recombination before the sweep. Under this scenario, ancestral advantageous alleles at low frequency leave the strongest local signal, while new advantageous mutations leave no local footprint of the sweep.

In Other … Romanian Words. Practical Considerations on Translating

The present article evolved from a series of short Romanian translations based on the German version of Adam Fletcher’s book entitled “How to be German in 50 new steps/ Wie man Deutscher wird. In 50 neuen Schritten” (2016). Spanning more than three months, the outcomes of the translating process were rendered concrete with the collective contribution of five Erasmus students[1] at Leipzig University, Germany, all of whom (their teacher included) are native speakers of the Romanian language. Frequently employing a combination of free and formal translation-styles, the team of translators-to-be strove to retain all the meanings, be they propositional or expressive, presupposed or evoked, or those generated by idioms, fixed expressions and non-equivalence in the original text. They provided alternative translations, mostly differing on the levels of lexis, grammar and register, but eventually negotiated the best one, which naturally became the final translated text, as much as possible freed from any traces of “translationese” and suitable for any authentic contemporary sample of Romanian language. [1] I am grateful to Patricia Gheorghe and Ramona Băcănaru (Technical University of Civil Engineering of Bucharest), Andreea Tufeanu (University of Bucharest), Denisa Urs and Paula Heredea (University of Oradea), for their major role throughout the whole process of translation and for all their pertinent observations on the source and target texts.