Non-Metallic Technology Deployment for the Next Generation of ADNOC Production Facilities

Industry-wide, the degradation and corrosion of steel infrastructure and the associated maintenance to prevent or mitigate this, poses a heavy environmental and operational burden across many industry segments. To address these challenges, ADNOC Group Technology, led by our Non-Metallic Steering Committee and ADNOC Upstream, in partnership with several selected specialist product companies, is deploying a range of innovative solutions as pilot trials within a holistic R&D program – which is aiming to transform our production and processing facilities, with a close focus on integrity management – and specifically we are assessing the deployment of non-metallic pipelines, storage and process vessels as well as downhole tubing and casing. Focusing specifically on flowlines and pipelines - traditional steel pipes used in the oil patch are burdensome to store, transport and install, as well as susceptible to degradation, corrosion-driven wall loss in challenging operational environments, such as those found Onshore and Offshore Abu Dhabi. This vulnerability results in increased operating risks as facilities mature, adding cost and time for inspection, maintenance and eventually - replacements that will lead to production deferrals or interruptions. A range of non-metallic pipeline technologies are being assessed and piloted in this program, including stand-alone extruded polymeric pipe and liners, Reinforced Thermoplastic Pipe (RTP) used Onshore and Offshore, specialized non-metallic flexible pipelines for Offshore including Thermoplastic Composite Pipe (TCP) and downhole tubulars. The methodology involves placing segments of RTP into live pipeline systems for a finite duration of operation – usually one year – and then removing sections to assess any degradation in performance, or capability of the RTP during that time. These test results will be the subject of a further publication at the end of this trial period. In this paper, we will focus on RTP piloting Onshore and specifically mention a unique trial in an ultra-sour gas field, where the technology has already delivered the required performance: safely transporting gas with levels of H2S up to 10% by volume. This trial also proves that specifically engineered non-metallic products may be successfully operated at the high temperature and high pressure (HPHT) levels that are characteristic of our reservoirs.

Status, reporting completeness and methodological quality of pilot randomised controlled trials in acupuncture: protocol for a systematic review

IntroductionTo date, there has been a lack of knowledge about the status, reporting completeness and methodological quality of pilot trials in the acupuncture field. Thus, this systematic review protocol aims to: (1) investigate publication trends and aspects of feasibility evaluated in acupuncture pilot trials; (2) identify the proportion of acupuncture pilot trials that lead to definitive trials and (3) assess the reporting completeness and methodological quality of pilot trials in acupuncture.Methods and analysisStudies of acupuncture pilot randomised controlled trials published from 2011 to 2021 will be retrieved in seven databases in January 2022, including PubMed, Web of Science, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang Database and Chinese Biomedical Literature Database. The methodological quality and reporting completeness of all included studies will be assessed using the risk of bias 2.0 tool (RoB 2) and the Consolidated Standards of Reporting Trials (CONSORT) extension to randomised pilot and feasibility trials, respectively. For the primary analysis, publication trends, aspects of feasibility and the proportion of pilot trials that lead to definitive trials will be analysed. A quantitative analysis of the methodological quality and reporting completeness of the included trials will be implemented by calculating the percentage of items reported in each domain of RoB 2 and CONSORT. The secondary analysis will adopt a regression analysis to identify factors associated with the reporting completeness.Ethics and disseminationEthical approval is not required for this study. This study is planned to be submitted to a peer-reviewed academic journal.

Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis

Knee osteoarthritis is the most prevalent joint disease and a frequent cause of pain, functional loss and disability. Conventional treatments have demonstrated only modest clinical benefits whereas cell-based therapies have shown encouraging results, but important details, such as dose needed, long-term evolution or number of applications required are scarcely known. Here we have reanalyzed results from two recent pilot trials with autologous bone marrow-derived mesenchymal stromal cells using the Huskisson plot to enhance quantification of efficacy and comparability. We find that cell doses of 10, 40 and 100 million autologous cells per knee provided quite similar healing results and that much of the effect attained 1 year after cell application remained after 2 and 4 years. These results are encouraging because they indicate that, apart from safety and simplicity: (i) the beneficial effect is both significant and sizeable, (ii) it can be achieved with a single injection of cells, and (iii) the effect is perdurable for years.Trial registration: EudraCT 2009-017405-11; NCT02123368. Registered 25 April 2014—Prospectively registered, https://clinicaltrials.gov/ct2/show/NCT02123368?term=02123368&draw=2&rank=1

The Relationship Between COVID 19 Anxiety and Dementia Caregivers Burden and Suffering

The impact of COVID-19 on dementia caregivers is gaining new interest. It is unknown how the pandemic has impacted caregivers’ burden and existential suffering. Analyses were performed on data for dementia caregivers (n=89) enrolled in the Indiana University Telephone Acceptance and Commitment Therapy for Caregivers (TACTICs) pilot trials. Individuals were primary caregivers of a family member with dementia and had clinically significant anxiety measured by a GAD-7 score >10 or between 5-9 with reported interference in life. COVID-19 anxiety was measured using the NIH CoRonavIruS Health Impact Survey (CRISIS) questions. Caregivers were on average 55.2 years of age with 56.2% being child or child-in-law, 71.9% were white and 24.7% were Black. Mean burden scores, measured by the Zarit Burden Index, were higher (44.29) compared to means reported across the literature (26.7) indicating the sample experienced higher than normal levels of burden. Mean existential suffering scores measured by the subscale of Experience of Suffering Scale were lower (9.37) compared to means across the literature (11.5) indicating that overall participants experienced lower levels of existential suffering compared to those in previous studies. A significant relationship was found between COVID-19 anxiety and burden levels (x2= 9.07, p<0.05), with higher levels of COVID-19 anxiety associated with greater burden. A non-significant relationship was found between COVID-19 anxiety and existential suffering (x2=5.99, p=0.11). Results highlight the impact of COVID-19 anxiety as an external stressor on dementia caregiving. and the importance of considering context of external stressors when implementing intervention protocols for caregivers of individuals with dementia.

Recent development in biogeotechnology and its engineering applications

Microbial geotechnology or biogeotechnology is a new branch of geotechnical engineering. It involves the use of microbiology for traditional geotechnical applications. Many new innovative soil improvement methods have been developed in recent years based on this approach. A proper understanding of the various approaches and the performances of different methods can help researchers and engineers to develop the most appropriate geotechnical solutions. At present, most of the methods can be categorized into three major types, biocementation, bioclogging, and biogas desaturation. Similarities and differences of different approaches and their potential applications are reviewed. Factors affecting the different processes are also discussed. Examples of up-scaled model tests and pilot trials are presented to show the emerging applications. The challenges and problems of biogeotechnology are also discussed.

Focal Prostate Stereotactic Body Radiation Therapy With Correlative Pathological and Radiographic-Based Treatment Planning

IntroductionAdvances in multiparametric MRI (mpMRI) combining anatomic and functional imaging can accurately identify foci of adenocarcinoma within the prostate, offering the possibility of partial gland therapy. We performed tandem prospective pilot trials to investigate the feasibility of focal prostate SBRT (f-SBRT) based on correlating diagnostic mpMRI and biopsies with confirmatory pathology in treatment planning.Materials and MethodsPatients with pathologic focal Gleason 6–7 disease and a corresponding PIRADS 4–5 lesion on mpMRI underwent targeted and comprehensive biopsies using MRI/ultrasound fusion under electromagnetic sensor navigation. After rigorous analysis for imaging biopsy concordance, five of 18 patients were eligible to proceed to f-SBRT. Chi-squared test was used for differences from expected outcomes, and concordance was estimated with binomial distribution theory and Wilson’s method.ResultsSix patients had Gleason 6 and 12 had Gleason 3 + 4 disease (mean PSA: 5.8 ng/ml, range: 2.2–8.4). Absolute concordance was 43.8% (95% CI: 0.20, 0.64). Patterns of discordance included additional sites of ipsilateral disease, bilateral disease, and negative target. Five were upstaged to a new NCCN risk category necessitating treatment escalation. The five patients with concordant pathology completed three-fraction f-SBRT with sparing of the surrounding normal structures (including contralateral neurovascular bundle), with no reported grade 2+ toxicities and favorable PSA responses (mean: 41% decrease).ConclusionsOn our pilot trials of f-SBRT planning using rigorous imaging and pathology concordance, image-guided confirmatory biopsies frequently revealed additional disease, suggesting the need for caution in partial-gland therapy. For truly focal disease, f-SBRT provided excellent dosimetry, minimal toxicity, and encouraging biochemical response. Clinical Trial Registration: www.clinicaltrials.gov, NCT02681614; NCT02163317.

A Study of Treatment of Industrial Acidic Wastewaters with Stainless Steel Slags Using Pilot Trials

Different stainless steel slags have been successfully employed in previous experiments, for the treatment of industrial acidic wastewaters. Although, before this technology can be implemented on an industrial scale, upscaled pilot experiments need to be performed. In this study, the parameters of the upscale trials, such as the volume and mixing speeds, are firstly tested by dispersing a NaCl tracer in a water bath. Mixing time trials are used to maintain constant mixing conditions when the volumes are increased to 70, 80 and 90 L, compared to the 1 L laboratory trials. Subsequently, the parameters obtained are used in pH buffering trials, where stainless steel slags are used as reactants, replicating the methodology of previous studies. Compared to laboratory trials, the study found only a minor loss of efficiency. Specifically, in previous studies, 39 g/L of slag was needed to buffer the pH of the acidic wastewaters. To reach similar pH values within the same time span, upscaled trials found a ratio of 43 g/L and 44 g/L when 70 and 90 L are used, respectively. Therefore, when the kinetic conditions are controlled, the technology appears to be scalable to higher volumes. This is an important finding that hopefully promotes further investments in this technology.