Adult ADHD in the Arab World: A review

Introduction: Attention Deficit Hyperactivity Disorder (ADHD) has been mainly studied in children, even though it persists into adulthood; only recently has adult ADHD received the required attention. ADHD research in Arab speaking countries is relatively scarce. Objectives: This scoping review has as objectives to provide a comprehensive overview of adult ADHD research in the 22 Arab countries, to identify gaps in the literature and inform future research. Methods: The scoping review is underpinned by the five-stage framework of Arksey and O'Malley. Eight electronics databases were searched for published and unpublished literature as well as conference proceedings from conception date of databases until February 2018. Results: The literature search yielded 2,792 citations after removal of duplicates, out of which 11 articles and conference proceedings were included. Publications were concentrated in the 21st century. ADHD diagnosis and sample differed between each study, where a variety of screening and diagnostic tools were used among clinical and community samples. National prevalence of adult ADHD only exists for Lebanon and Iraq as they are part of the World Mental Health (WMH) Surveys initiative. Also, adult ADHD is highly comorbid with bipolar and substance use disorder and related entities. Conclusions: This is the first methodologically rigorous scoping review focusing solely on adult ADHD in the Arab region. We found that adult ADHD is quite prevalent in the Arab World where studied, linked to serious impairment, and is highly comorbid, yet it is under-researched and undertreated across the Middle East and North Africa.

Abortion induces reactivation of inflammation in relapsing-remitting multiple sclerosis

ObjectiveTo investigate clinical and radiological outcomes of women with relapsing-remitting multiple sclerosis (RRMS) undergoing abortion.MethodsAn independent, multicentre retrospective study was conducted collecting data from eight Italian MS centres. We compared the preconception and postabortion annualised relapse rate (ARR) and number of Gadolinium enhancing (Gd+) lesions, by analyses of covariance. Variables associated with postabortion clinical and MRI activity were investigated using Poisson regression models; each abortion was considered as a statistical unit.ResultsFrom 1995 to 2017, we observed 188 abortions (17 elective) in 153 women with RRMS. Abortions occurred after a mean time of 9.5 (4.4) weeks from estimated conception date. In 86 events out of 188, conception happened during treatment with disease modifying drugs. The mean postabortion ARR (0.63±0.74) was significantly increased (p=0.037) compared with the preconception year (0.50±0.71) as well as the postabortion mean number of new Gd+ lesions (0.77±1.40 vs 0.39±1.04; p=0.004). Higher likelihood of relapses was predicted by higher preconception ARR, discontinuation of preconception treatment and elective abortion; the occurrence of new Gd+ lesions was associated with higher preconception number of active lesions, discontinuation of preconception treatment, shorter length of pregnancy maintenance and elective abortion.ConclusionsAbortion was associated with clinical and radiological inflammatory rebound remarkably in the first 12 months postevent. Deregulated proinflammatory processes arising at the early stages of pregnancy might play a role both in MS reactivation and abortion. Women with MS should be counselled about these risks of abortion and followed up accordingly.

Conception, fetal growth, and calving seasonality of harbor porpoise (Phocoena phocoena) in the Salish Sea waters of Washington, USA, and southern British Columbia, Canada

We evaluated harbor porpoise (Phocoena phocoena (Linnaeus, 1758)) strandings in the Salish Sea to determine calving seasonality (1980–2015). A total of 443 strandings were analyzed, of which 134 were calves and 53 were neonates. Stranded calves were reported every month, but peaked in July, August, and September. Based on fetal size and an estimated fetal growth rate of 80 mm/month, mean (±SD) conception date (and range) was back-calculated to 11 October ± 30 days (16 August – 31 December) and was later than in most other studies. Using mean (±SD) length at birth (80 ± 5.8 cm), gestation was estimated to be approximately 10.8 months. Estimated birthing period was 16 July – 27 November, with a mean (±SD) birth date of 10 September (±30.7 days) and a birth length of 80.0 cm. Estimated pregnancy rate (0.28–0.29) is lower than reported in other areas and is likely an underestimate due to missed early embryos, poor postmortem condition of a large proportion of the stranded adult females, and potential biases related to the animals that strand and are available. This study of harbor porpoise reproduction and calving in the Salish Sea is the first assessment of calving seasonality for this species in the northeast Pacific Ocean.

An examination of factors potentially influencing birth distributions in golden snub-nosed monkeys (Rhinopithecus roxellana)

Many species of primates are considered seasonal breeders, but the set of factors, such as food availability, day length and temperature, that influence the timing of reproductive events for both wild and captive individuals remains unclear. Here, we examine the role of factors in shaping breeding patterns inRhinopithecus roxellana, a temperate colobine primate. We used circular statistics to describe and compare the patterns of reproductive seasonality among individuals in 13 captive groups and two free ranging but provisioned groups at various locations throughout China. Almost 90% of births occurred in March, April and May in adult females residing in both free ranging (n = 131) and captive groups (n = 407). Births occurred principally in 2–4 months prior to the peak of food availability, while conceptions occurred in 1–2 months after the peak of food availability in free ranging but provisioned groups. Day length (latitude) had a significant effect on the timing of reproduction. However, females that experienced a wide variation of temperature between the lowest and highest monthly average temperature had a later conception date. These results support that day length and temperature might be factor influencing the timing of reproductive activity.

8 ANTI-MÜLLERIAN HORMONE AT WEANING AND BREEDING AS A PREDICTOR OF BEEF HEIFER FERTILITY

This study examined the relationship between serum anti-Müllerian hormone (AMH) concentration at weaning and breeding to determine if either or both measures could predict subsequent fertility of beef heifers. Blood was collected from 71 Angus based heifers at ~7 and 14 months of age and serum stored frozen (−20°C) until analysis for AMH, using bovine AMH ELISA kits (AL115; Ansh Laboratories, Webster, TX, USA). Before breeding, transrectal ultrasonography was used to determine cyclic status of heifers. Heifers received 25 mg of prostaglandin F2α (PGF) and those detected in oestrus were AI ~12 h after detected oestrus. Heifers not detected in oestrus after 7 days received a second PGF injection and oestrus detection and AI continued for 4 days. Ten days later, the heifers were exposed to fertile bulls for a 45-days breeding season. At 50 to 60 days after insemination, transrectal ultrasonography was used to identify pregnant heifers and to confirm conception date based on fetal size. At 60 days after bull removal, ultrasonography was performed to determine pregnancy in heifers conceiving during the breeding season and confirm continuing pregnancy in heifers previously identified as pregnant. Based on fetal size at ultrasonography, the oestrous cycle after initiation of breeding when conception occurred was estimated. For comparison, AI pregnancies were considered cycle 1, and pregnancies initiated during subsequent 21-day intervals of the breeding season were classified as cycles 2, 3, and 4, respectively. For analysis, frequency distribution was used to assign serum AMH concentration measured at weaning, breeding, and the change from weaning to breeding, into quartiles. Comparisons were then made via Chi-squared analysis for heifers in each quartile that were cyclic at synchronization, detected in oestrus, conceived after AI, pregnant at the end of the breeding season, and the estimated cycle that conception occurred. Comparison of heifers based on serum AMH quartiles at weaning failed (P ≥ 0.35) to detect any effect of AMH on subsequent heifer cyclicity at breeding, oestrous response after synchronization, AI conceptions, overall pregnancy rate, or estimated oestrous cycle of the breeding season when conception occurred. Based on AMH concentration at breeding, heifers in the lowest quartile (Q1) had a lower (10%; P = 0.02) AI conception rate than heifers in other quartiles (43 to 73%), and conceived at a later oestrous cycle (P = 0.03) in the breeding season. Comparison of heifers based on the change in AMH concentrations from weaning to breeding revealed that none of the heifers in the lowest quartile (Q1) conceived after AI, compared with 80% in the highest quartile (Q4; P < 0.001). Heifers in the lowest quartile also conceived at a later oestrous cycle in the breeding season than heifers in the other quartiles (P = 0.01). Results indicate that either AMH concentration at breeding or the change in AMH from weaning to breeding can identify beef heifers more likely to conceive to AI and to conceive early in the breeding season.

Natality of Yearling Coyotes in West Virginia

Minimal information is available regarding the reproduction of coyotes (Canis latrans) in the Mid-Atlantic region, which includes the states of Delaware, Maryland, North Carolina, Pennsylvania, Virginia, and West Virginia. Since reproductive information is useful to assess populations and determine management strategies and because this information is unavailable for the Mid-Atlantic, we examined uterine tracts of 66 female coyotes collected from February to May 2010 for fetuses. We measured fetuses using a digital caliper and approximated dates of conception and parturition. Nine (13.6%) female coyotes were pregnant with visible fetuses; seven of these females were yearlings (1.5–2.5 y old). Average litter size of yearling coyotes was 5.4 (SE = 0.48). We estimated an average conception date of 2 February and an average parturition date of 6 April. Conception and parturition dates were within the reported range for coyotes, though one female successfully bred in early January, which is earlier than reported in the literature. The relatively high proportion (30.4%) of yearling females breeding in West Virginia may reflect abundant food resources, low density of coyotes, increasing human-caused mortality, or a combination of these factors. Reproductive information reported here will be helpful in monitoring coyote population trends and in the assessment of management strategies.

Effect of conception date and hind nutrition on fetal growth trajectory and gestation length of red deer (Cervus elaphus)

This study tested the hypothesis that the negative association between gestation length and conception date in red deer is mediated by nutrition. Twenty-eight pregnant red deer were randomly allocated to four groups according to a 2 × 2 factorial design, with the factors conception date (14 March, E; 28 April, L) and level of nutrition (ad libitum, H; restricted, R). Animals were housed indoors in individual pens from early winter until calving and offered daily an ad libitum pelleted ration. The daily ration was then restricted from late winter in ER (134 days post-conception) and LR (89 days post-conception) groups, so that these hinds did not experience a seasonal increase in food intake. X-Ray computed tomography scans were taken at Days 120, 150, 180 and 210 of gestation (mid–late gestation) to estimate weight of various conceptus components. Growth rate of the total fetus was significantly higher in LH than in other treatments (P < 0.01) between Days 180 and 210 of gestation. Birthweight was not significantly different (P > 0.05) between treatments or calf sex. Birthweight was associated directly with change in hind liveweight (P = 0.03) and body condition score during the third trimester of pregnancy (P = 0.01), but was not significantly associated with gestation length (P = 0.34). Gestation length was 4.4 days longer in LR than LH hinds (P = 0.03) and was negatively associated with both food intake (P = 0.03) and LW gain (P = 0.02) during the final trimester of gestation. Feeding late-conceiving hinds an ad libitum diet of high-quality food during the third trimester of gestation maximises fetal growth and shortens gestation length.