Waning of SARS-CoV-2 booster viral-load reduction effectiveness

The BNT162b2 COVID-19 vaccine has been shown to reduce viral load of breakthrough infections (BTIs), an important factor affecting infectiousness. This viral-load protective effect has been waning with time post the second vaccine and later restored with a booster shot. It is currently unclear though for how long this regained effectiveness lasts. Analyzing Ct values of SARS-CoV-2 qRT-PCR tests of over 22,000 infections during a Delta-variant-dominant period in Israel, we found that this viral-load reduction effectiveness significantly declines within months post the booster dose. Adjusting for age, sex and calendric date, Ct values of RdRp gene initially increased by 2.7 [CI: 2.3-3.0] relative to unvaccinated in the first month post the booster dose, yet then decayed to a difference of 1.3 [CI: 0.7-1.9] in the second month and became small and insignificant in the third to fourth months. The rate and magnitude of this post-booster decline in viral-load reduction effectiveness mirror those observed post the second vaccine. These results suggest rapid waning of the booster's effectiveness in reducing infectiousness, possibly affecting community-level spread of the virus.

Occurrence of pressure-forced meteotsunami events in the eastern Yellow Sea during 2010–2019

This study examined the occurrence of meteotsunamis in the eastern Yellow Sea and the conceptual framework of a monitoring/warning system. Using 1 min intervals of mean-sea-level pressure and sea-level observations from 89 meteorological stations and 16 tide gauges between 2010 and 2019, a total of 42 pressure-forced meteotsunami events were classified. Most meteotsunamis (71 %) displayed a distinct seasonal pattern occurring from March to June, and intense meteotsunamis typically occurred at harbor tide gauges. The occurrence characteristics of the meteotsunamis were examined to improve the meteotsunami monitoring/warning system. Air pressure disturbances with speeds of 11–26 m s−1 and NNW–SW directions were conducive to meteotsunami generation. Most meteotsunamis (88 %), as well as strong meteotsunamis with a wave height exceeding 40 cm (19 %), had dominant period bands of less than 30 min, containing the resonant periods of harbors in the eastern Yellow Sea. Thus, the eastern Yellow Sea is a harbor-meteotsunami-dominated environment, characterized by frequent meteotsunami occurrences and local amplification in multiple harbors. This study can provide practical guidance on operation periods, potential hot spots, and risk levels to monitoring/warning system operators in the eastern Yellow Sea.

Institutional complexity and family business development: a case study of the Charoen Pokphand group

Purpose With features of both “family” and “business,” family businesses must seek a balance between the emotional aspect of “family” and the economic aspect of “business” in its organizational and decision-making processes to ensure the sustainability of the family’s entrepreneurship. This study aims to focus on how internal institutional complexity combined evolves alongside the growth of the family business. Design/methodology/approach The research looks, from the perspective of institutional logic, into the Charoen Pokphand Group, which is an epitome of overseas Chinese family businesses and proceeds to build a model of family business growth in the context of institutional complexity. Findings The research finds that as a family business grows, institutional complexity inside the organization would change from aligned period to sustaining period and then to dominant period. Then further elucidates the process of proactive response in different stages of the development of a family business. Attaching equal importance to the cultivation of entrepreneurship and to the continuation of family values and culture is the crucial mechanism by which Chinese family businesses seek a balance between family logic and business logic. Originality/value This paper unveils the change of institutional complexity in the evolution of family businesses and the process of action of its agency as an organization, and simultaneously partly reveals the features of entrepreneurship that overseas Chinese family businesses have as they grew, which is of positive significance for exploring and building a path of growth unique to Chinese family businesses.

Reconstruction of Copper Smelting Technology Based on 18–20th-Century Slag Remains from the Old Copper Basin, Poland

This research was conducted on historical copper slags from Leszczyna and Kondratów in Lower Silesia, Poland. The area, formerly known as the Old Copper Basin, was a mining and smelting centre between the 18th and 20th centuries, with a dominant period in the 19th century. Cu-carbonates and residual chalcocite dominate local strata-bound copper deposits. Ore bodies are restricted to carbonate strata. A geochemical and mineralogical study of slag samples from four research sites allowed us to establish that a low amount of sulphur in slags results from S-poor ores, and pyrite with gypsum was implemented as reducing agents. Arkose sandstones served as a flux. During smelting, oxygen availability was limited, and temperature exceeded 1200 °C (18th- and 19th-century smelting) and 1400 °C (20th-century smelting). Calculated viscosity indexes mark the low efficiency of metal separation between the silicate and metallic phases. The skeletal and dendritic form of the crystals proved that slag melt was relatively rapidly cooled after formation, usually in air conditions. We estimated that approx. 2000 m3 of slag was created during the leading smelter (Stilles Glück) activity. The research provided various details of the historical copper smelting technological process in Leszczyna and Kondratów.

Suppression of fibrillation consisting of stable rotors by periodic pacing

Recent experimental studies have shown that a sequence of low-energy electrical far-field pulses is able to terminate fibrillation with substantially lower per-pulse energy than a single high-energy electric shock (see S. Luther et al. Nature 475 (7355), 235-239). During this low-energy antifibrillation pacing (LEAP) procedure only tissue near sufficiently large conduction heterogeneities, such as large coronary arteries, is activated. In order to understand the mechanism behind LEAP, We have carried out a statistical study of resetting a medium filled by one or more stable spirals (“rotors”) in a two-dimensional electrophysiological model of cardiac tissue perforated by blood vessels to the resting state (“defibrillation”). We found the highest success probabilities for this defibrillation for underdrive pacing with periods 10 – 20 percent larger than the dominant period of the stable rotors in the unperturbed dynamics. If a sufficiently large number pulses is applied and an optimal pacing period chosen, the energy per pulse required for successful defibrillation is about 75 - 80 percent lower than the energy needed for single-shock defibrillation. Optimal conditions to control and suppress fibrillation based on stable rotors, hence, are similar to the ones in found for the case of an electrophysiological model displaying spatiotemporal chaos (“electrical turbulence”) in an earlier study (see P. Buran et al. Chaos 27, 113110 (2017)). The optimal pacing period is found to increase with increasing strength of the electrical field strength used in the model. The success probability also increases strongly until the fourth or fifth pulse administered, which is strongly correlated to an observed increase of the fraction of re-excitable tissue with each subsequent pulse. Monitoring the fraction of excitable tissue in the model as key quantity of the excitable medium, moreover, enabled us to successfully predict the optimal pacing period for defibrillation.

Deciphering organization of GOES-16 green cumulus through the empirical orthogonal function (EOF) lens

A subset of continental shallow convective cumulus (Cu) cloud fields has been shown to have distinct spatial properties and to form mostly over forests and vegetated areas, thus referred to as “green Cu” (Dror et al., 2020). Green Cu fields are known to form organized mesoscale patterns, yet the underlying mechanisms, as well as the time variability of these patterns, are still lacking understanding. Here, we characterize the organization of green Cu in space and time, by using data-driven organization metrics and by applying an empirical orthogonal function (EOF) analysis to a high-resolution GOES-16 dataset. We extract, quantify, and reveal modes of organization present in a green Cu field, during the course of a day. The EOF decomposition is able to show the field's key organization features such as cloud streets, and it also delineates the less visible ones, as the propagation of gravity waves (GWs) and the emergence of a highly organized grid on a spatial scale of hundreds of kilometers, over a time period that scales with the field's lifetime. Using cloud fields that were reconstructed from different subgroups of modes, we quantify the cloud street's wavelength and aspect ratio, as well as the GW-dominant period.

LOCAL GEOLOGY AND SITE CLASS ASSESSMENT BASED ON MICROTREMOR DATA IN NORTH LOMBOK

Lombok Island is an active seismic area in Indonesia potentially hit by an earthquake due to located between two earthquake generators from the south and the North. Several large earthquakes rocked Lombok, an earthquake with a magnitude of 6.4 on July 29, 2018, and 7.0 on August 5, 2018. This study aims to determine the characteristics of the local site effect based on the dominant frequency value ( ), soil amplification ( ), sediment layer thickness (d), , dominant period (T0), and seismic vulnerability index ( ) and to comprehend the soil class (site class) based on the thickness of the sediment layer (d), and in the North Lombok region. The data used is secondary data from microtremor signal recordings in North Lombok Regency in 2018. Data processing used Geopsy software, and microtremor data were analyzed using the HVSR method. From processing the HVSR data, the dominant frequency value about (0.8 - 18) Hz, amplification value (1.7 – 9.7), dominant period value (0.05 – 1.2) seconds, seismic vulnerability index value (0.4 – 71) , and the value of in the study area (20.05 – 287.04) m/s. Based on microtremor analysis, the local site effect indicates that alluvium rocks caused stronger earthquake vibrations and more damage. Whereas the Kalibabak and Lekopiko formations caused fewer earthquake vibrations and less wear. Based on the dominant period and , area study classify as Site Class IV class E and Site Class III class D Copyright © 2021 IPR. All rights reserved.

Damping effect on seismic input energy and its verification by shake table tests

Seismic input energy per unit mass ( EI/m) imparted into a structure is a function of earthquake (duration, frequency content, amplitude etc.), soil (shear velocity, dominant period etc.) and the structural (vibrational periods etc.) characteristics. Generally, the damping properties of the structure is assumed negligible for seismic input energy. Most of the existing spectral equations derived for SDOF systems generally use a constant damping ratio of 5%. In this study, the damping effect on EI/m is investigated experimentally and numerically on SDOF systems with distinct damping ratios. Experimental investigation and numerical computations proved that seismic input energy is very sensitive to variation of damping within the vicinity of fundamental frequencies. Specifically, up to 50% increment was observed in the plateau region of the input energy spectrum, where maximum EI/m values occur, by variation of damping from 2% to 10%. Hence, a novel damping modification factor ( DMF), which could be utilized for existing energy spectra, is proposed in this paper. Validation studies of the proposed DMF are achieved through the various energy spectra found in the literature.

On the geometric André–Oort conjecture for variations of Hodge structures

Let 𝕍 {{\mathbb{V}}} be a polarized variation of integral Hodge structure on a smooth complex quasi-projective variety S. In this paper, we show that the union of the non-factor special subvarieties for ( S , 𝕍 ) {(S,{\mathbb{V}})} , which are of Shimura type with dominant period maps, is a finite union of special subvarieties of S. This generalizes previous results of Clozel and Ullmo (2005) and Ullmo (2007) on the distribution of the non-factor (in particular, strongly) special subvarieties in a Shimura variety to the non-classical setting and also answers positively the geometric part of a conjecture of Klingler on the André–Oort conjecture for variations of Hodge structures.

Testing the application of Permutation Entropy to characterize the precursory phase of volcanic eruptions

<p>Permutation Entropy (PE) has been suggested to be a promising tool for the prediction of volcanic eruptions. It is a robust yet simple tool to quantify the complexity of time series. The application has been used in the biomedical and econophysics fields and recently was adopted to find precursors of volcano eruptions and to identify tremor episodes. However, in the different eruption cases, the temporal variation of PE was found behaving in different ways. For example, a gradual drop of PE was observed few days prior to the 1996 Gjalp eruption while it remained high prior to the 2012 Copahua eruption. Our final aim is to quantify what features in the PE can be interpreted as eruption precursors and whether this is applicable to different eruptions from the same or different volcanoes. In calculating the PE, the determination of two key inputs, namely the delay time and the embedding dimension, is crucial as PE depends strongly on those parameters. Here we present several tests on different types of synthetic signals with different signal to noise ratios to determine the most suitable input parameters. We found that when the delay time is much shorter than or equal to the dominant period of the signal, the value of PE will be strongly influenced by the noise. Thus, the value of the delay time should be chosen in between. Furthermore, the embedding dimension should not be smaller than 5 to be able to identify the characteristic of the underlying signal. Finally, we show the application of this method to the seismic data during the dike formation and the effusive eruption at Holuhraun, Iceland, in 2014-2015.</p>