Malignant neoplasms associated with HIV infection. Problems and solutions (problem outline)

HIV infection refers to socially significant diseases. As a result of the wide coverage of effective antiretroviral therapy for people living with HIV, the rates of AIDS-related mortality have significantly decreased. At the same time, there was a noticeable increase in morbidity and mortality from other non-AIDS-related diseases, not the last place in this list is occupied by malignant neoplasms. A decrease in the frequency of AIDS-associated tumors and an increase in the proportion of AIDS-unassociated tumors are significant changes in the structure of malignant neoplasms. There is a complex relationship between HIV-induced immune suppression, chronic antigenic stimulation and concomitant oncogenic viral infections, which increases the risk of developing malignant tumors in these patients. People living with HIV have higher rates of cancer mortality associated with both the lack of adequate antitumor therapy, complications of treatment, and the existence of a direct relationship between immunosuppression and tumor progression. This article analyzes the problems that arise in the treatment of oncological HIV-infected patients, and offers specific practical steps to solve complex interdisciplinary problems.

Evolution and Sustainability: What Is It Difference?

This article is devoted to the fundamental interdisciplinary problems of evolution and sustainability. From a contemporary standpoint, the author assesses the persisting notions of social and, in particular, economic evolution. An appropriate alternative to these notions presents the framework concept of integrative sustainable development, enshrined in the UN Agenda 2030. Based on the recognized integrative vision of the sustainability problem, it is advisable to extend this concept to the entire process of transformation of society as a social system. It can be named sustainable overall social transformation (SOST). The fundamental properties of SOST and the role of key actors in its provision are revealed. As follows from the study, the current implementation of SOST will be largely associated with non-evolutionary changes. The final conclusion concerns the substantial difference between the sustainable and the preferable evolutionary trajectories of the overall social transformation in the long run. Received: 4 August 2021 / Accepted: 6 October 2021 / Published: 5 November 2021

Preface The 5th International Conference in The Era of Uncertainty (ICPEU) 2021

We would like to thank everyone for your enthusiasm and participation in the 5th International Conference on Planning in the Era of Uncertainty at Universitas Brawijaya. ICPEU is a biennial event held by Department of Regional and Urban Planning – Universitas Brawijaya (Malang, Indonesia) since 2013. The conference series has focused on the discussion of sustainable development since the very beginning, as we truly believe that this topic is very relevant to what we, in the field of planning, face at the moment and in the future. In 2013, we started off the discussion with a big question, can planning theory be applied thoroughly in practice? It was a very memorable discussion as we explored many interdisciplinary problems and solutions in planning. We then developed our topic to sustainable development in 2015 as we considered this as an underlying topic for all relevant problems and solutions. Again, the discussion was remarkable. Papers from different countries participated in the event. In 2017, we started publishing our papers on IOP Proceedings, which is a Scopus-indexed form of publication. And in 2019, we raised the topic of bridging the rural-urban development gap-strengthening sustainability goals. We believe that this event at this moment will be more successful than our predecessors. The 5th ICPEU was held on 19th July 2021 with the topic “Rural-Urban Connectivity”. This topic addressed a concern about spatial equality and sustainability with particular relevance to the pandemic situation. This year, ICPEU was held in a completely different way due to the pandemic. Covid-19 pandemic and travel restrictions did not demotivate us to strengthen our academic community and organize the conference. The current information technology in the form of video conference (webinar) helped us to tackle the distance obstacle. This virtual platform gave us three benefits i.e., 1) made the overall presentations and discussions more efficient, 2) the technology gave us opportunity to effectively communicate with the keynote speakers as well as made all sessions enjoyable for them, and 3) reached more participants. This year we had in total 250 participants including the presenters We organize the conference in the form of plenary session by presenting eight keynote speakers. They talked about the concept and practices of sustainability in a broad range of disciplines including social capital, disaster management, infrastructure, regional development and public policy. The keynote speaker’s session was followed by panel sessions. All panel presenters had 15 minutes to share their ideas continued with 5 minutes discussion for each presentation. Regarding the panel session, we have received papers from Australia, Thailand, Malaysia, Singapore, Japan, and also Indonesia, discussing and showcasing multi-level efforts in achieving sustainable development from different perspectives. In short, the response that we received has been overwhelmingly positive. We received a total of 83 extended abstracts for this event, and unfortunately, we can only accept 70 selected ones to be published in our upcoming publications. We would like to thank our invaluable sponsors, Universitas Brawijaya, the Faculty of Engineering, PLN UP3 Malang, and Bantex Indonesia for their supports that have allowed us to organize this event. Thank you to Hastirin Widi Astuti, S.Pd, M.A (TESOL) for the proofreading and editing services so that we can make prepare these articles for publication. Therefore, I would like to congratulate all authors that have made it this far. Lastly, we would like to acknowledge fellow colleagues who have made this conference successful: Prof. Ir. Hadi Suyono, S.T., MT., Ph.D., IPU., ASEAN Eng. (Dean of the Engineering Faculty, Universitas Brawijaya), Dr. Ir. Abdul Wahid Hasyim, MSP (Head of the Regional and Urban Planning Department, Universitas Brawijaya), The keynote speakers: Prof. Kiyoshi Kobayashi and Prof. Kenichiro Onitsuka (Kyoto University – Japan), Prof. Murakami Keisuke (University of Miyazaki – Japan), Prof. Joe Ravetz (University of Manchester – UK), Dr. Suprapedi. M.Eng (Ministry of Village, Development of Disadvantaged Regions, and Transmigration – Indonesia), Ir. Mochamad Basoeki Hadimoeljono, M.Sc., Ph.D. (Ministry of Public Works and Housing – Indonesia), Dr. Emil Elestianto Dardak, M. Sc. (Vice Governor of East Java Province – Indonesia), and Dr. Tech. Christia Meidiana (Universitas Brawijaya – Indonesia) List of titles Steering Committee, Organizing Committee, Technical Assitance, Documentation Keynote Speech, Parallel Session are available in this Pdf.

FEATURES OF FORMATION OF PROFESSIONAL COMPETENCE OF FUTURE DOCTORS IN MODERN CONDITIONS

IFNMU actively uses educational innovations in various pedagogical processes, determining adequate mechanisms for the transformation of higher education. After all, innovative education is a constant desire to re-evaluate values, preserve those that are of undeniable importance, and discard those that are already outdated. In the practice of IFNMU, the diversification of educational technologies allows effectively combine them through the modernization of traditional education and its reorientation to distance education. With this approach, teachers focus on the personal development of future professionals, the ability to master new experiences of creative and critical thinking, finding solutions to educational problems. Therefore, we consider the innovative educational technology as a general didactic process, which consists in using a set of methods and techniques of joint activities of the subjects of the educational process aimed at achieving the goal of learning, personality development and creative and professional acquisition of knowledge and competencies in accordance with the tasks of training specialists of modern times. The process of forming the professional competence of future doctors consists of a set of consistent, purposeful actions that contribute to the renewal, modification of purpose, content, organization, forms and methods of teaching and education, adaptation of the educational process to new socio-historical conditions. Innovations in medical education do not arise spontaneously, but arise as a result of systematic scientific research, analysis, generalization of pedagogical experience. The basis of these processes is the implementation of the achievements of psychological and pedagogical science in practice, study, generalization and dissemination of advanced domestic and foreign pedagogical experience in training doctors. At the present stage, the integration of knowledge in pedagogical theory is seen as a synthesis of interacting sciences on the basis of some basic discipline. The mechanism of interdisciplinary integration is to implement the explanatory, constructive and prognostic functions of academic disciplines, in their transformation into a methodological, theoretical and technological means of building holistic models of the researched phenomena and processes, solving cognitive and professional problems. As the practical experience of synchronizing the study of related educational material from different courses has shown, as well as the maximum use of multidisciplinary knowledge to study complex objects and concepts of medicine is an important condition for the effectiveness of the educational process. Productive integration of knowledge covers such ways as solving interdisciplinary problems, performing complex practical tasks, conducting educational and research observations, conducting lectures and practical classes, applying problem situations in one discipline to classes in another.

Directions of scientific research in the Ural Branch of the RAS (scientometric analysis of publications)

Compliance of studies with the priority directions of scientific development in the country is an important factor in realizing the research potential of scholars. The article analyzes the directions of scientific research held in the Ural Branch of the Russian Academy of Sciences (UB RAS) organizations and their interdisciplinary interactions in the context of RF priority areas of science and technology development. The research bases on the content analysis of strategic documents at the national and federal levels, programs for the development of the scientific sphere (Forecast of scientific and technological development of the Russian Federation for the period up to 2030) and the analysis of scientific activities of the institutes of the Ural Branch based on scientometric data (Scopus).It is revealed that the leading research directions of Ural scientists enter scientific fields, which, due to the Forecast, are promising for science and technology development. These areas include “Materials Science”, “Biochemistry and Molecular Biology”, “Medicine”, “Immunology and Microbiology”, “Pharmacology, Toxicology, Pharmacy”, “Energy”.Fundamental scientific fields, not dir ectly reflected in the key areas of science and technology development, contribute to their development through the established interdisciplinary ties. They include “Physics and Astronomy”, “Chemistry”, “Engineering”, “Mathematics” and others. Researches on interdisciplinary problems have greater potential for international cooperation.

Social and identification status of communication studies

The collective monograph is devoted to interdisciplinary problems of communication in a modern multimodal society. A number of aspects outlining the status of communication studies as a scientific, practical and social phenomenon are discussed. The authors ask questions about the influence of digitalization on interpersonal and intercultural communication in the modern world, consider the philosophical and cultural meanings of the communicative self-identity of peoples from the positions of national and state ideologies, touch upon the problems of communication in various spheres and discourses: professional, media, political, scientific, educational and social. The monograph also touches on the linguo-axiological, image and linguistic-cultural aspects of communicative processes. The study consists of seven chapters that reveal the authors ' views on the current state and prospects for the development of communicative science and humanities in general. It is addressed to representatives of the scientific community - scientists, graduate students, undergraduates, as well as anyone interested in the issues of communication studies as an important and complex social phenomenon.

Transformed Shell Structures Determined by Regular Networks as a Complex Material for Roofing

The article presents a comprehensive extension of the proprietary basic method for shaping innovative systems of corrugated shell roof structures by means of a specific complex material that comprises regular transformable shell units limited by spatial quadrangles. The units are made up of nominally plane folded sheets transformed into shell shapes. The similar shell units are regularly and effectively arranged in the three-dimensional space in an orderly manner with a universal regular reference surface, polyhedral network, and polygonal network. The extended method leads to the increase in the variety of the designed complex shell roof forms and plane-walled elevation forms of buildings. For this purpose, the rules governing the creation of the continuous roof shell structures of many shells arranged in different unconventional visually attractive patterns and their discontinuous regular modifications are sought. To obtain several novel groups of similar unconventional parametric roof forms, single division coefficients and double division coefficients are used. The easy and intuitive modifications of the positions of the vertices belonging to the polygonal network on the side edges of the polyhedral network accomplished by means of a parametric algorithm allow one to adjust the geometry of the complete shell units to the geometric and material constraints related to the orthotropic properties of the transformed sheeting by means of these coefficients. The innovative approach to the shaping of the diverse unconventional roof structures requires the solving of many interdisciplinary problems in the field of mathematics, civil engineering, construction, morphology, architecture, mechanics, computer visualization, and programming.

Intellectual property: search of the optimum model of legal protection

In the conditions of informatization of social processes and their globalization, the most important common basement and the engine of economic welfare of citizens is knowledge. The value of knowledge for the development of the state and society is confirmed in the Association Agreement, signed by Ukraine and the European Union, that describe the specific tasks for achieving the proper and effective level of protection and protection of intellectual property rights. The implementation of these tasks at the state level regarding the issues of legal protection of intellectual property is already taking place, but the implemented measures are caused controversial attitudes in society about their effectiveness. The reason for such a society's assessment of the state of legal protection of intellectual property lies, first of all, in insufficient scientific and legal development of interdisciplinary problems of legal protection of intellectual property considering modern conditions of informatization of society and globalization of this process with the justification of approaches to constructing an optimal model of such protection within the legal system of our country. The scientific work, which is proposed for the reader's attention, is devoted to consideration of the mentioned problem.

The role of mathematics in transdisciplinarity content of modern education

Introduction. In the context of modernisation in modern education, a deeper (by contrast to interdisciplinary) transdisciplinary level of cognition is becoming prevalent. Transdisciplinary level generates a universal methodology capable of addressing the complex multi-factorial interdisciplinary problems of nature and society. The result is transdisciplinary branches of science such as cybernetics, disaster theory, synergetics, artificial intelligence, big data, etc. All these concepts have been developed on the basis of the achievements of mathematics over the past 70-80 years, the era of mathematical sciences. As a consequence, mathematics has become the basis of the language of information technologies and processes, and, thereby, this science has given rise to a global digital transformation of society based on the use of the unique computer capabilities.The aim of the present research was to explore the role of mathematics in the transdisciplinary trend in updating the content of education with a view to bringing education to a higher (by contrast to interdisciplinary) level, based on the inclusion of modern mathematical theories and methods in the content of education and their applications depending on the direction and profile of the student training.Methodology and research methods. In the course of research, the systemic, cultural, and meta-subject approaches were employed to analyse the role of mathematics in education and to solve the transdisciplinary problems of education content modernisation (based on the most striking manifestations of modern mathematical culture). As a result of the synthesis of these approaches, a holistic scientific worldview emerges, which not only goes beyond the traditional disciplines and methods, but also appears above them.Results and scientific novelty. The analysis of transdisciplinary trend in postindustrial education was carried out. Mathematical and pedagogical aspects of the implementation of systemic, cultural and meta-subject approaches were investigated in order to achieve a higher level of educational process. At the same time, the authors justified the use of mathematical modelling, discrete mathematics, computational processes and artificial intelligence in the training, i.e. formation of a new superdisciplinary way of thinking in students, acquisition of a general cultural cognitive strategy to perform professional and transprofessional tasks.Practical importance. The findings of the current publication contribute to the realisation of the transdisciplinary trend in the content of student training, and will be of interest to both educational theorists and teachers, who train students in many fields. Moreover, this work will be useful for all those interested in the future advancement of the system of education.

Spationomy Simulation Game—Playful Learning in Spatial Economy Higher Education

Simulation games, as a method of playful learning, have been used for more than 70 years in various disciplines with the economy as a leading application field. Their development has been tied with advances in computer science, and nowadays, hundreds of simulation games exist. However, simulation games are not just useful for encouraging disciplinary knowledge production; they also promise to be effective tools for interdisciplinary collaboration. To further explore these promises, we report on the design and playing of a simulation game on the boundary of geoinformatics and business and economics; an interdisciplinary field we have termed Spationomy. Within this game, students from different disciplinary (and cultural) backgrounds applied their knowledge and skills to tackle interdisciplinary problems. In this paper, we also analyze students’ feedback on the game to complement this aspect. The main goal is to discuss the design process that went into creating the game as well as experiences from play sessions in relation to this increase of interdisciplinary knowledge among students. In the end, we present a new gaming concept based on real-world data that can be played in other interdisciplinary situations. Here, students´ feedback on individual features of the game helped to identify future directions in the development of our simulation game.