Innovative Research on Solfeggio and Ear Training Teaching of Natural Artistic Conception Music

Solfeggio and ear training is the most important basic link in music education. Solfeggio and ear training education traditionally follows the mode of manual teaching with piano performance. With the progress of computer technology, more and more Solfeggio and ear training software began to appear, which not only had a certain impact on the traditional teaching, but also triggered the thinking and exploration of software application. Among them, Ear Master from Denmark is the most mainstream Solfeggio and ear training software in the current market. Because of its relatively perfect design and relatively powerful function, it has great application value in the current Solfeggio teaching practice. Although the subjective and objective deficiencies of Ear Master determine its role and positioning in teaching practice. The results show that Solfeggio and ear training can play a positive role as long as they are well used and follow certain principles. The research results can promote the development and improvement of traditional Solfeggio and ear training teaching.

Research On the Optimization of Community Governance System-Taking the “volunteer + community” Service Model in “COVID-19” Epidemic Prevention and Control as an Example

Community governance is the basic link of social governance and occupies an important position in the national governance system. This paper mainly discusses from three aspects: First, the effectiveness and deficiency of community governance in epidemic prevention and control; Second, the “volunteer + community” service model mechanism; The third is the way to optimize community governance in the post epidemic period.

Stage stratification of pregnant women at risk of preeclampsia

Introduction. Pre-eclampsia (PE) continues to be the leading problem in obstetrics. The existing methods for predicting PE show insufficient efficiency, and therefore the search for new predictors of PE remains relevant.The goal of the study. To develop a method for staged stratification of pregnant women to the risk of PE according on the basis of the revealed dismetabolic features of the pathogenesis of this complication of gestation.Material and methods. A dynamic clinical and laboratory examination of 180 pregnant women with independent factors of high risk of PE was carried out. PE was revealed in 89 women who made up group I. Group II (control) consisted of 30 healthy pregnant women with the physiological gestation.Results and discussion. A statistically significant increase in diabetogenic and atherogenic changes characteristic of physiological pregnancy, changes in hormonal, endothelial-hemostasiological, pro-inflammatory and placental parameters aimed at the energy and plastic supply of the fetus was revealed in women with PE. The results of laboratory examination, statistical data processing showed that the most significant pathogenetic mechanisms of development of PE are pathological insulin resistance (IR) and hyperinsulinemia (HI), which act as the basic link and initiate atherogenic transformation of the lipid profile, pro-inflammatory and immunometabolic disorders, prothrombotic status, hyperleptinemia, hyperuricemia, antiangiogenic state and endothelial dysfunction, which indicates a pronounced pathogenetic and clinical similarity of PE and metabolic syndrome. The revealed features of the pathogenesis of PE were reflected in the method of staged risk stratification of pregnant women: the models for assessing the individual risk of PE implementation included the levels of insulin, PlGF, PAMG-1, and TNF-α at 11–14 weeks of gestation; levels of insulin, uric acid, TNF-α, and mean platelet volume at 18-21 weeks of gestation (I trimester – AUC = 0.886, Se = 86.7%, Sp = 84.3%; II trimester - AUC = 0.874, Se = 83.3%, Sp = 87.2%, р < 0.001).Conclusion. Practical application of the developed pathogenetically substantiated method of staged stratification of pregnant women by the risk of PE implementation will justify the appointment and enhancement of preventive measures, reduce the incidence of severe and complicated forms of PE, and improve gestational and perinatal outcomes.

RESEARCH ON THE INNOVATION OF TEACHING MODE OF VOCATIONAL AND TECHNICAL EDUCATION

Vocational and technical education group is the main training object of new high-quality talents in our school, and teaching is the basic link of Vocational and technical education. The current teaching mode of Vocational and technical education has the disadvantages of emphasizing theory and neglecting practice. Therefore, it is necessary to discuss the teaching mode of Vocational and technical education in our school. Based on the current situation of the teaching mode of Vocational and technical education in our school, this paper puts forward the teaching and assessment mode of “combining theory with practice” and “combining thinking cultivation with practice”.

Mitochondrial dysfunction associated with AC mode of chemotherapy intake

Since the establishment of the anthracycline drugs cardiotoxigenic effect, the most widely accepted mechanistic base for their iatrogenic cardiotoxicity was connected with excessive and inadequate intensification of LPO. However, ineffectiveness of the antioxidant and multivitamin regimens of cardio-protection caused the necessity of finding new pathogenic targets, exposure to which will prevent the development of cardiovascular symptoms. Such a target became the nuclear topoisomerases, the study results of which served as the foundation for the creation of dexrazoxan, the only drug with this regard approved by the FDA. However, our interest was attracted towards the mitochondrial topoisomerases, since the integrity of the mitochondrial apparatus of cardiomyocytes is the basic link in maintaining the physiological morpho-functional balance of cardiomyocytes. At the same time, it is established that in the cell doxorubicin is predominantly accumulated in the mitochondria, which also makes emphasizes onto the prospects of studying this issue. Purpose Purpose of the study was to investigate the influence of AC mode of chemotherapy (adriamicin (doxorubicin) + cyclophosphomide) on the mitochondrial topoisomerases levels. Methods 60 inbred mice of the C57BL/6J line with genotype a,H-2b were used. The experimental animals were divided into 2 groups: in the first group polychemotherapy in AC mode was applied; in the second group (placebo group) saline solution was used. Doxorubicin (Sigma Aldrich) was administered at a dose of 4 mg/kg and cyclophosphamid (Sigma Aldrich) at a dose of 2 mg/kg were administered intravenously. There were 4 courses conducted with the intervals of 21 days between them. The study results were recorded in 6 days after the last cycle of chemotherapy. The total duration of experiment was 90 days. The following types of topoisomerases have been studied: Top2β, Top3α, and Top1mt. Results The results of the first group showed a decrease in the Top2β level by 2.4±0.4%, Top3α - by 0.7±0.5, and Top1mt - by 49.5±11.7% (p=0.05). When analyzing the results of the second group no statistically significant changes were recorded. Conclusion The fact of AC mode of chemotherapy administered should be taken as a predictor of destabilization of the mitochondrial topoisomerases signaling, in particular of the Top1mt, which in turn, causes the development of mitochondrial dysfunction and results the energy imbalance in cardiomyocytes. Funding Acknowledgement Type of funding source: None

ASSESSMENT OF THE CURRENT STATE OF MANAGEMENT OF THE OPERATION OF THE HOUSING STOCK

The housing stock is the most important national treasure, all Russian society and government bodies are interested in its growth and preservation. The very sphere associated with the management of the operation of the housing stock is constantly developing and requires improvement at all levels of management. The managing organization, as an executor of housing and communal services, is the basic link between consumers and contractors of these services, as well as providers of communal resources. Bearing responsibility to citizens for the uninterrupted and high-quality provision of housing and communal services, the managing organization constitutes the economic core of the entire economy. Therefore, an assessment of the current state of management of the operation of the housing stock will make it possible to develop directions for improving the activities of managing organizations, which will help to increase the efficiency of their activities and the level of quality of services provided for managing the operation of the housing stock. In the article, the author’s attention is drawn to the dynamics of indicators of the housing stock and its components in the Russian Federation. The features of the housing stock as a management object are presented. The analysis of: financial indicators of the activities of enterprises for managing the operation of the housing stock in Russia (balanced financial result; profitability of works, services; return on assets; autonomy ratio; ratio of own circulating assets; current liquidity ratio); indicators for payment for services provided by enterprises for managing the operation of the housing stock (accrued housing payments to the population; actually paid by the population for housing payments; actual level of housing payments by the population; arrears of the population for housing payments); indicators of debt on financial obligations of enterprises carrying out activities for the management of the operation of the housing stock. Highlighted the problems that the owners of the housing stock in the event of arrears in payment for services.

The Robustness of the Gray Level Co-Occurrence Matrices and X-Ray Computed Tomography Method for the Quantification of 3D Mineral Texture

Mineral textural quantification methods have become critical in both geosciences and mineral processing as mineral texture is a critical factor contributing to ore variability. However, the lack of objective mineral texture classification has made quantification difficult. The aim of this study is therefore to investigate the robustness of applying the gray level co-occurrence matrices (GLCM) to 3-dimensional (3D) gray scale images measured by X-ray computed tomography (XCT) for the quantification of mineral texture in 3D. The data quality of the GLCM outputs like statistics, heat maps and histograms in response to changes in XCT conditions such as artefacts, resolution, and calibration was tested. The response of the GLCM outputs with respect to different mineral texture types with anisotropic features and inter-sample variability was also explored. The methodology included testing core sizes of 26, 19, 14, and 6 mm diameter. Calibration was tested using copper and tungsten wires. The study demonstrated the versatility of the method for different sample types. Inter-sample calibration and optimal scanning conditions (quality and integrity) were also demonstrated, and a basic link between the 3D GLCM statistical descriptors with the mineral texture features of rocks was established. The 3D mineral texture method can potentially bypass the XCT segmentation process for direct automation of 3D mineral texture information.

AGRICULTURE OF THE KEMEROVO REGION

<p>The article presents the characteristics of modern agriculture, which is the basic link of the agroindustrial complex of the Kemerovoregion. It examines the factors that determine its specialization and the main industry of rural economy of Kuzbass. Agriculture plays an important role in ensuring food security in the region. The leading industry is beef farming, beef and dairy cattle, arable farming and grain growing. The Kemerovoregion achieves self-suffi in many agricultural products, some products are exported outside of the region. Prospects of development of agricultural production in Kuzbass are associated with the development of private fodder industry based on the cultivation of forage crops and legumes for intensive and industrial pig, poultry, and beef and dairy cattle breeding and production of succulent feeds for dairy and beef cattle. The development of agriculture will lead to the creation of new processing industries, the formation of a developed agro-industrial complex in the region, which will increase the level of socio-economic development of the region.<strong></strong></p>