VOCABULARY OF YAMSKOY [COACHMAN’s] AND IZVOZNY [CABMAN’s] CARRIER’S TRADE: HISTORICO-DERIVIATIONAL ASPECT

Based on the material from the Russian commercial written records of the XVI-XVII centuries, this article examines semantic and derivational features of the vocabulary of the yamskoy [coachman’s] and izvoznyi [cabman’s] carrier’s trade. In terms of content, the words of these two professional spheres have much in common since the main occupation of yamshchiki [coachmen] and izvozchiki [cabmen] was transportation of people or goods by horse; here are used the names of characters, vehicles, travel modes, types of transported objects. The history of fixing of the words yamshchik [coachman] and izvozchik [cabman] in the Russian language reflects the universal pattern of changing the names of persons ending in -nik by the nouns ending in -shchik /chik ( yamnik - yamshchik [coachman], izvoznik - izvozchik [cabman]). At the same time, the categorical difference in the original names that were at the beginning of the word-formation chains caused a difference in the semantic development of the names of doers: in one case, this is a spatial nomination of yama [Russian word for a ‘pit’] denoting a "station on the road" (> yamchi, yamskoy > yamshchik [coachman]); in another one it is a designation of a movement in space izvoziti [Russian obsolete word for ‘to carry’] (> izvoz > izvozchik [cabman]). In this regard, the names of persons right from the beginning differed in their conceptual representations of the doers: yamshchik [coachman] is the one who moves along the road, and izvozchik [cabman] is the one who “carries” something both on land and on water (like a carrier). Different communicative spheres of yamskoy [coachman’s] (gonny [riding fast] ) and izvozny [cabman’s] carrier’s trade gave birth to specific names of transportation: gon’ba [fast ride] and izvoz [carriage], which had clear internal forms: the first one was motivated by the verb gonyati [Russian obsolete word for ‘to ride fast", and the second one - by the verb izvoziti [Russian obsolete word for ‘to carry outwards’] (cargo, goods).

“IMPATIENT MAN” RASKOLNIKOV AND MYSTERIOUS RUSSIA (ABOUT LITURGICS OF “CRIME AND PUNISHMENT” BY F.M. DOSTOEVSKY)

The article regards “Crime and Punishment” from the perspective of temple-related poetics which encompasses a universal pattern of both dogmatic and mystic Orthodox teaching about the Universe. It has enabled us to trace the connection between the novel itself and the Orthodox church service. Liturgics of the novel reveals itself through poetization of church services and sacraments. Among the sacraments mentioned above Confession and the Blessed Sacrament reflected in the Marmeladov’s storyline are of symbolic nature. Christ proves to be the most mysterious central image of the novel. Dostoevsky reproduces the Evangelic Image of Christ through the liturgic “listening” of the paroemia about the resurrection of Lazarus. The image of the priest which penetrates through the whole novel is associated with the iconography of the image of Christ. Liturgics of “Crime and Punishment” is supported by numerous evangelic images, in particular by the analogy of coffin-like room of Raskolnikov with shelters of the possessed, with the poetics of the New Testament related names and objects. The image of the Orthodox Church with its gleaming dome (the Church Raskolnikov is trying to sever all ties with) is regarded as a substantial image of particular relevance associated with the “Crime” of the novel. Exacerbation of the “spiritual impatient man” fades away in the Divine love which is reflected in love of his family and dear ones, in liturgic support of Christian symbols up to Epilogue (the most repeated symbols include images of cross, icon, grave candle, pray), motives of the sign of the cross, his mother’s blessing, cheerful acceptance of other’s person guilt. The studying of “Crime of Punishment” in the context of temple-related poetics has allowed us to define trans-historic nature of liturgic storylines. A striking point in this case could be “zaraisky storyline” which is connected with the colourman Mikolay, a native of Ryazan who reproduces the image of the Cup as Unity in Christ and as self-giving love. “Zaraisky storyline” connects “Crime and Punishment” with tragic events of the 13th century, with the cycle of stories about Nicola Zaraisky which tell about the invasion of Batu Khan and about the destruction of natives of Ryazan for the sake of faith as a reflection of the national ideal. Liturgucs of “Crime and Punishment” is strengthened by the hidden autobiographic storyline which turns the first of the Dostoevsky’s five novels into the novel-penitence.

Examination of Electrolyte Replacements in the ICU Utilizing MIMIC-III Dataset Demonstrates Redundant Replacement Patterns

Electrolyte repletion in the ICU is one of the most ubiquitous tasks in critical care, involving significant resources while having an unclear risk/benefit ratio. Prior data indicate most replacements are administered while electrolytes are within or above reference ranges with little effect on serum post-replacement levels and potential harm. ICU electrolyte replacement patterns were analyzed using the MIMIC-III database to determine the threshold governing replacement decisions and their efficiency. The data of serum values for potassium, magnesium, and phosphate before and after repletion events were evaluated. Thresholds for when repletion was administered and temporal patterns in the repletion behaviors of ICU healthcare providers were identified. Most electrolyte replacements happened when levels were below or within reference ranges. Of the lab orders placed, a minuscule number of them were followed by repletion. Electrolyte repletion resulted in negligible (phosphate), small (potassium), and modest (magnesium) post-replacement changes in electrolyte serum levels. The repletion pattern followed hospital routine work and was anchored around shift changes. A subset of providers conducting over-repletion in the absence of clinical indication was also identified. This pattern of behavior found in this study supports previous studies and may allude to a universal pattern of over-repletion in the ICU setting.

The “Cairé” and “The Ghost of Komat” Textual Landscapes and Cultural Heritage in Argentinean and Slovenian Folktales

The present article proposes a comparative approach to Argentinean and Slovenian tales that share thematic features with ATU 326 (“The youth who wanted to learn what fear is”) from the standpoint of the fictional construction of verbal landscapes. The comparison is oriented to identifying similar narrative patterns dealing not only with thematic tale types but also with structural and stylistic features, along with changing details. The thematic, structural, and stylistic features common to different versions conform to a narrative matrix, which acts as a pretext to be recreated in diverse narrative contexts. The changing details give new meanings to universal pattern connected with the cultural heritage of different local contexts, such as the Argentinean and the Slovenian ones.

The functional brain favours segregated modular connectivity at old age unless affected by neurodegeneration

Brain’s modular connectivity gives this organ resilience and adaptability. The ageing process alters the organised modularity of the brain and these changes are further accentuated by neurodegeneration, leading to disorganisation. To understand this further, we analysed modular variability—heterogeneity of modules—and modular dissociation—detachment from segregated connectivity—in two ageing cohorts and a mixed cohort of neurodegenerative diseases. Our results revealed that the brain follows a universal pattern of high modular variability in metacognitive brain regions: the association cortices. The brain in ageing moves towards a segregated modular structure despite presenting with increased modular heterogeneity—modules in older adults are not only segregated, but their shape and size are more variable than in young adults. In the presence of neurodegeneration, the brain maintains its segregated connectivity globally but not locally, and this is particularly visible in dementia with Lewy bodies and Parkinson’s disease dementia; overall, the modular brain shows patterns of differentiated pathology.

Male-Female Disparities in Years of Potential Life Lost Attributable to COVID-19 in the United States: A State-by-State Analysis

Males are at higher risk relative to females of severe outcomes following COVID-19 infection. Focusing on COVID-19-attributable mortality in the United States (U.S.), we quantified and contrasted years of potential life lost (YPLL) attributable to COVID-19 by sex based on data from the U.S. National Center for Health Statistics as of 31 March 2021, specifically by contrasting male and female percentages of total YPLL with their respective percent population shares and calculating age-adjusted male-to-female YPLL rate ratios, both nationally and for each of the 50 states and the District of Columbia. Using YPLL before age 75 to anchor comparisons between males and females and a novel Monte Carlo simulation procedure to perform estimation and uncertainty quantification, our results reveal a near-universal pattern across states of higher COVID-19-attributable YPLL among males compared to females. Furthermore, the disproportionately high COVID-19 mortality burden among males is generally more pronounced when measuring mortality burden in terms of YPLL compared to death counts, reflecting dual phenomena of males dying from COVID-19 at higher rates and at systematically younger ages relative to females. The U.S. COVID-19 epidemic also offers lessons underscoring the importance of cultivating a public health environment that recognizes sex-specific needs as well as different patterns in risk factors, health behaviors, and responses to interventions between men and women. Public health strategies incorporating focused efforts to increase COVID-19 vaccinations among men are particularly urged.

GOOD BAD TIME

The article discloses the axiological potential of the qualitative metaphor of time on the example of emotive prose and poetry of German-speaking authors. Time as an abstract notion is rendered metaphorically. Metaphor, taken as an image, is a universal pattern that is used to form emotional and evaluative categories. It encompasses an image representation, evaluation information and attitude expression, both positive and negative. There is an attempt to assess the correlation between ameliorative and pejorative evaluation of time in poetry and emotive prose discourse in the German-language literature. However, besides positive and negative modes, evaluation may also have some other semantic features, which can contribute to its more detailed classification. We analyzed the possibility of using the classification by N.D. Arutyunova to identify and distribute these semantic features among the suggested sets.

A model of active transcription hubs that unifies the roles of active promoters and enhancers

An essential questions of gene regulation is how large number of enhancers and promoters organize into gene regulatory loops. Using transcription-factor binding enrichment as an indicator of enhancer strength, we identified a portion of H3K27ac peaks as potentially strong enhancers and found a universal pattern of promoter and enhancer distribution: At actively transcribed regions of length of ∼200–300 kb, the numbers of active promoters and enhancers are inversely related. Enhancer clusters are associated with isolated active promoters, regardless of the gene's cell-type specificity. As the number of nearby active promoters increases, the number of enhancers decreases. At regions where multiple active genes are closely located, there are few distant enhancers. With Hi-C analysis, we demonstrate that the interactions among the regulatory elements (active promoters and enhancers) occur predominantly in clusters and multiway among linearly close elements and the distance between adjacent elements shows a preference of ∼30 kb. We propose a simple rule of spatial organization of active promoters and enhancers: Gene transcriptions and regulations mainly occur at local active transcription hubs contributed dynamically by multiple elements from linearly close enhancers and/or active promoters. The hub model can be represented with a flower-shaped structure and implies an enhancer-like role of active promoters.

Following Majority Rule versus Deferring to Elders: Educational Background Shapes Group Decision Preference in Burmese Children

Previous studies showed that most children believe majority rule is the right decision rule, and prefer it to authority rule when making group decisions among peers. Yet, these were conducted mostly in Western or similar populations. Here, we conducted experiments with fifty-one Burmese children (4 to 11 years old) at three types of educational institutions: international schools, a monastery school and a day-care centre for street children. In the experiment, children were asked whether they prefer majority or authority rule in a hypothetical story. The result showed the educational institution influences the proportion choosing majority rule, suggesting that preference for majority rule may not be a universal pattern and decision preference may be shaped by cultural factors.