Practical Approach for Apps Design in Compliance With Accessibility, Usability, and User Experience

There is a huge proliferation of digital products on the market today for both large enterprises and small businesses. Most of these companies have experienced the development of software products for the mobile market and have been faced with the major challenge of capturing the customer's attention. There is a great focus on making a great first impact and providing the audience with the best possible digital experience. Accordingly, issues related to usability, accessibility, and user experience are extremely relevant. This chapter addresses how these practices can be used in practice by building an app that offers car cleaning services. Several approaches based on building app interfaces that increase user engagement and retention levels are explored and discussed.

The Future of Learning

The unexpected discomfort caused by Covid-19 pandemic and all the consequent government restrictions on travels and social distancing have pushed all the Training Organizations worldwide into an unusual challenge, being forced to support their Customers from afar. This work aims to thoroughly analyze the success of the Remote Learning methodology, highlighting key factors impacting the learning curve, and to share effective improvement ideas for this approach to deliver training focused on technical and human skills. Many companies reacted to this situation by investing largely in and increasing the adoption of digital technologies to facilitate internal and external communications and more specifically to support Remote Learning. However, despite the prompt response, many Training Organizations found themselves delivering their products through a series of trials, mistakes and lesson learned on methodology and tools. The detection of few but significant improvements increased effectiveness and improved interaction in our Remote Classes. The improvement actions concerned learning how to make the most of the available digital technologies and identifying the most effective applications for sharing documents and interacting with participants; at the same time, a great focus on the human skills approach was crucial to learn how to promote trust, motivation and interaction between our staff and Customers’ personnel. In this perspective, Operator Training Simulations (OTS) and Remote VR Training have emerged as one of the best applications to increase the attendees’ learning curve and help develop Customers’ personnel skills. Our study, however, isn't all about bright stars. The feedback told us that some Customers still prefer to take in-person training classes rather than remote ones. Sometimes this relates with biases against remote or digital activities, but it often applies where hard activities need to be performed.

Three decades of Cdk5

Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function. The mechanisms underlying the modulation of Cdk5, its modes of action, and its effects on the nervous system have been a great focus in the field for nearly three decades. In this review, we provide an overview of the discovery and regulation of Cdk5, highlighting recent findings revealing its role in neuronal/synaptic functions, circadian clocks, DNA damage, cell cycle reentry, mitochondrial dysfunction, as well as its non-neuronal functions under physiological and pathological conditions. Moreover, we discuss evidence underscoring aberrant Cdk5 activity as a common theme observed in many neurodegenerative diseases.

Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration

The reconstruction of large bone defects remains a crucial challenge in orthopedic surgery. The current treatments including autologous and allogenic bone grafting and bioactive materials have their respective drawbacks. While mesenchymal stem cell (MSC) therapy may address these limitations, growing researches have demonstrated that the effectiveness of MSC therapy depends on paracrine factors, particularly exosomes. This aroused great focus on the exosome-based cell-free therapy in the treatment of bone defects. Exosomes can transfer various cargoes, and noncoding RNAs are the most widely studied cargo through which exosomes exert their ability of osteoinduction. Here, we review the research status of the exosome-derived noncoding RNAs in bone regeneration, the potential application of exosomes, and the existing challenges.

Organic-inorganic nanohybrids based on AIE luminogens-functional polymer and CdTe/ZnS QDs: morphologies, optical properties, and applications

Nano-light materials have attracted a great focus on materials research due to their excellent fluorescent properties. The hybrid assembly of various nano-optical materials combines advantages of themselves, extending the boundary...

New trends in visual inspection of buildings and structures: Study for the use of drones

Visual inspection is a very simple, non-destructive technique and usual in diagnosing buildings and structures’ conditions. It also plays an important role in the rapid assessment of constructive problems as well as in the definition of an appropriate way for eventual remedial interventions. However, the use of this methodology often meets difficulties, especially when places to be inspected are difficult to access; it involves security risks for inspectors or even when a reactive inspection of urgent nature becomes unfeasible due to the high costs and the necessary means involved. In this context, the introduction of new technologies, such as drones, can bring substantial benefits. Currently, great focus has been put on this type of device as an emerging technology in the construction industry. This article treats about a reflexion on the adaptability and versatility of using drones, within a framework for monitoring the condition of buildings’ envelope, just as for other kinds of structures (e.g. bridges, viaducts, dams, chimneys, etc.). The interest lies, for now, in devices with a multirotor configuration, integrating high-definition cameras for both photography and video. In order to verify these assumptions, several field tests are being performed, of which some examples are presented.

THE DOMINANT FACTORS OF LECTURER'S RESEARCH PRODUCTIVITY USING AHP: CASE STUDY OF CATHOLIC UNIVERSITY OF DE LA SALLE MANADO-INDONESIA

Higher education places a great emphasis on research. In order to remain competitive, Catholic universities also place a great focus on research. The quality and quantity of lecturer research is one of the determining factors in the ranking of a tertiary institution. An evaluation of lecturer research productivity requires an instrument to measure lecturer research activities and understand determinants. Lecturer productivity involves many complex factors that are both objective and subjective, and is considered part of multi-criteria decision making. This study uses the AHP approach to determine the weights of the criteria and sub-criteria and their dominant factors. This method is used to evaluate the productivity of lecturers at Unika De La Salle Manado and has implications and applications for all universities.

Interleukin 6 and Interleukin 17a Enhance Proliferation and Differentiation of Murine Osteoblast and Human Foetal Osteoblast Cell Lines

Introduction: Cytokines have been gaining great focus due to their role in enhancing osseointegration as well as their potential in bone reconstruction. Osseointegration often faces complications in its compatibility with the implant due to rejection by the recipients own immune system. Therefore, extensive studies are being carried out to enhance osteoblast development to minimize such complication. The aim of this study was to determine the effect of different concentrations of Interleukin 6 (IL-6) and Interleukin 17a (IL-17A) in the proliferation and differentiation of murine and human osteoblasts. Methods: Various concentrations (5, 10, 25 and 50 ng/ml) of rIL-6 and rIL-17A were tested on both murine osteoblast (MC3T3-E1) and human feotal osteoblast (hFOB) cell lines using [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] (MTS) and alkaline phosphatise (ALP) assays. MTS was carried out at 24, 48, 72, 96 and 120 hours while ALP assay was done on day 1, 3, 7, 10 and 14. Results: MC3T3-E1 cells showed steadier proliferation and differentiation compared to hFOB. Both cell lines expressed responses in dose-dependent manner. The concentration of 10ng for IL-6 and IL-17A in the case of MC3T3-E1 cell line was found to be the most suitable for further studies. Conclusion: IL-6 and IL-17A enhance proliferation and ALP activity of both MC3T3-E1 and hFOB cell lines.

The Toyota Way to Effective Strategy Deployment: How Organizations Can Focus Energy on Key Priorities Through Hoshin Kanri to Achieve the Business Goals

Purpose: The motivation behind this article is to provide a lot of rules to be utilized in lean strategy standards and instruments in modern associations. This article expects to feature the pretended by lean strategy technique for vital strategic planning and management, especially in reference to the Hoshin Kanri strategy deployment system. This article is addressing a gap in the knowledge of effective Hoshin Kanri process over the association. Methodology/Design/Approach: A systematic literature review using the MEDLINE, EMBASE, Scopus and Emerald databases, resulting in the selection of high-quality papers with a great focus on the Toyota Way. Originally/Value: This article review subjects driven and finished up by Toyota that are required to implement strategies and adjust objectives all over the association. The article centers around the Hoshin Kanri deployment process. It underlines the significance of leadership/pioneering and the helpfulness of utilizing the right daily training practice to help lean progress and improve strategy execution in the whole association. This is the first article to comprehensively review Hoshin Kanri with reference to the Toyota business practice. Findings: Hoshin Kanri might be successfully utilized for deploying strategies and to improve correspondence from top to down, which must be accomplished if experts are to be adequately prepared and frontline staff is to be engaged in daily, continuous improvement efforts.

Is there any Threshold in the Causal Association of Mother’s Education with Child’s Health? A Case study of Pakistan

Past studies failed to solve the problem of nonlinearity and threshold in the association of mother education with infants’ health. This research diagnoses and investigates the existence of threshold. Successive eight educational plans during 1955-1998 in Pakistan record a large variation in the educational policies and investment and a great focus on primary schooling. It motivates us to select Pakistan and construct the instrument for purging the coefficients of mother education from endogeneity bias along with the threshold impact. IV regression outcomes disclose that only 11-16 years of mother education has significant impact on infants’ health outcomes, implying a threshold level at 6-10 years schooling. Thus, it is argued that low cognitive capability via lower level of education, poor educational quality, ineffective education for health even in the text books of 6-10 years of education leads to a threshold in the relationship of mother education with child nutrition.