Development of Muruntau–Myutenbai joint open pit mine

Muruntau open pit mine has been in operation since 1967 and is one of the largest open pit mines in the world. As per the project of mining phase V effective since 2020, it is among the world’s three largest open pit mines. The distribution of ore reserves per horizons is analyzed with regard to nature-and-process zones delineated in Muruntau–Myutenbai joint open pit mine. The project parameters of the pit and the scope of mining operations were determined from the geological and mathematical modeling including the detailed survey data and borehole assay results. The open pit mining scenarios within the project limits of mining phase V up to 2030 are considered. The open pit mining scheduling is performed with regard to operational specifics of the deposit, number of nature-and-process zones and duration of the scheduling period. It is concluded that maintenance of the required gold content of ore to be processed needs stimulation of the annual mining output up to 50–60 Mm3 in the easterly direction of the pit at the preserved production output in all nature-and-process zones. To this effect, it is required to formulate a sustainable action plan, with the assigned performance indicators, with regard to the Extra Activity Progr am to Improve Production of Precious Metals at Navoi Mining and Metallurgical Combinat over the period to 2026 and further on to 2040. The authors appreciate participation of Head of a Department at VNIPIpromtekhnologii, Candidate of Engineering Sciences A. V. Seleznev in this study.

UJI AKTIVITAS EKSTRAK DAUN MBOA (Melastomata malabatricum) TERHADAP HAMA GUDANG Callosobruchus sp (COLEOPTERA:BRUCHIDAE) PADA KACANG HIJAU (Phaseolus radiata L.)

Activity Test Extract Mboa Leaf (Melastomata Malabatrikum) against warehouse pest Callosobruchus Sp (Coleoptera : Bruchidae) Green bean (Phaseolus Radiata L.). Green beans are an important crop in the tropics and have long cultivated in Indonesia. Green bean production in quantity and quality is strongly influenced by the presence of pest and diseases. The damage caused by insects ensued can reach 70% (Kartasapoetra, 1987). Given the magnitude percentage damage inflicted by insects CallosobbrushusSp is a necessary control measure. This study aims to determine the activity of leaf extract Mboa (M. Mallabatricum) against warehouse pest Callosobruchus Sp. This study uses a CDR with four treatments (M25, M50, M75, M100) and repeated 10 times. The result showed extra activity Mboa leaves (M. Mallabatricum) against Callosobruchus Sp to test a contact poison can cause Callosobruchus Sp morality above 80% seen in the treatment of M50, M75, and M100 of 9.987%. repellant test showed a decrease traffic to continue successive treatment – participated in treatments M25 (61%), M50 (46%), M75 (43%), M100(34%) and mortality due to neurological disorders for M25 (7.34%), M50 (7.99%), M75 (8.54%), and M100 (9.21%). An antibody test can suppress high levels of oviposition in each treatment. M25 (31.21%), M50 (71.01%), M75(79.5%), and M100 (87.22%).

Docking Assisted Prediction and Biological Evaluation of Sideritis L. Components with PTP1b Inhibitory Action and Probable Anti-Diabetic Properties

Background: The main characteristic of Diabetes type II is the impaired activation of intracellular mechanisms triggered by the action of insulin. PTP1b is a Protein Tyrosine Phosphatase that dephosphorylates insulin receptor causing its desensitization. Since inhibition of PTP1b may prolong insulin receptor activity, PTP1b has become a drug target for the treatment of Diabetes II. Although a number of inhibitors have been synthesized during the last decades, the research still continues for the development of more effective and selective compounds. Moreover, several constituents of plants and edible algae with PTP1b inhibitory action have been found, adding this extra activity at the pallet of properties of the specific natural products. Objective: Sideritis L. (Lamiaceae) is a herbal plant growing around the Mediterranean sea which is included in the Mediterranean diet for centuries. The present study is the continuation of a previous work where the antioxidant and anti-inflammatory activities of the components of Sideritis L. were evaluated and aimed to investigate the potential of some sideritis’s components to act as PTP1b inhibitors, thus exhibiting the beneficial effect in the treatment of diabetes II. Methods: Docking analysis was done to predict PTP1b inhibitory action. Human recombinant PTP1b enzyme was used for the evaluation of the PTP1b inhibitory action, while inhibition of the human LAR and human T-cell PTP was tested for the estimation of the selectivity of the compounds. Conclusion: Docking analysis effectively predicted inhibition and mode of inhibitory action. According to the experimental results, four of the components exhibited PTP1b inhibitory action. The most active ones were acetoside, which acted as a competitive inhibitor, with an IC50 of 4 µM and lavandufolioside, which acted as an uncompetitive inhibitor, with an IC50 of 9.3 µM. All four compounds exhibited increased selectivity against PTP1b.

“You Must Do Something”

Yale’s football team is supported by Yale students through attendance at practices and games and paying subscriptions that help with the team’s costs. To fellow students, Camp seems “in love with the game”; he is often seen handling and passing the large oval rugby ball, and he holds a ball while studying to build his grip. He also plays baseball, and in 1878, after being challenged to participate in Yale’s annual intramural track event and then practicing with typical seriousness of purpose, he wins the hurdles race. Camp also writes poetry and submits it for publication in the Yale Lit. All in all, he fits naturally in a student body that expects students to work at some extra activity and do it with all their might.

Pendidikan akhlak mulia pada sekolah menengah pertama Bina Anak Soleh Tuban

Pendidikan akhlak mulia selama ini lebih menekankan pada aspek pengetahuan dari pada aspek sikap dan aplikasinya. Fenomena tawuran pelajar dan pergaulan bebas menjadi bukti. Sekolah Islam berasrama dengan kurikulum khasnya dianggap berhasil mengelola pendidikan karakter akhlak mulia. Namun belum semua sekolah mampu mengelolanya secara efektif. Penelitian ini bertujuan mengetahui dan menggali data mengenai bagaimana perencanaan, implementasi, evaluasi, dan pengelolaan asrama (boarding school system) pendidikan akhlak mulia dilakukan. Penelitian menggunakan pendekatan kualitatif, merupakan studi kasus SMP BAS school boarding sistem Tuban. Temuan penelitian menunjukkan bahwa sekolah melakukan perencanaan program diawali dengan penetapan visi dan misi, tujuan, standart kelulusan, menyusun kurikulum terpadu mengintegrasikan antara kurikulum nasional dan kurikulum khas pondok pesantren dengan penekanan pada pendidikan akhlak mulia. evaluasi dilakukan terus menerus terhadap seluruh aspek kegiatan siswa. Keberhasilan ditandai adanya perubahan perilaku siswa seperti disiplin, rajin ibadah, taat, jujur, dan berprestasi. Masyarakat makin percaya dan lembaga makin berkembang. Salah satu rekomendasi penelitian agar semua pemangku kepentingan komitmen terhadap rencana, menjadi contoh dan melakukan pembinaan terus menerus serta menjalin kemitraan.Kata kunci: pengelolaan, pendidikan, akhlak mulia GOOD MANNERS EDUCATION AT YUNIOR HIGH SCHOOL TUBANAbstractGood manner education tends to emphasize on knowledge but weak on attitude and its application. The phenomenon of students do juvenile delinquency, promiscuity, and abuse of drugs. Islamic boarding schools with integrating curriculum of national and local /manhaj tarbiyah emphasizes on Islamic religion subjects and good manner values to students. However, many schools have not succeded in managing good manner education yet. This study is aimed to know and find out data about planning, implementation, evaluation, and management school boarding of good manner eduction as a case study of qualitative research in SMP BAS school boarding system Tuban. The study finds that the planning program is formulated in school vision and mission, gol, standart graduation, develop integrated curriculum, and actualizes in active learning process, develop students’ extra activity, religious habit and leadership. Evaluation conducted on whole activities continuously. The success of managerial implementation has been indicated by students’ attitude changes such as disciplinary, obedience, learning achievement, and less violence. For making effective good manner education program should involve of parents community, togetherness and commitment.Keywords: managing, good manner, islamic based

Sniff-Like Patterned Input Results in Long-Term Plasticity at the Rat Olfactory Bulb Mitral and Tufted Cell to Granule Cell Synapse

During odor sensing the activity of principal neurons of the mammalian olfactory bulb, the mitral and tufted cells (MTCs), occurs in repetitive bursts that are synchronized to respiration, reminiscent of hippocampal theta-gamma coupling. Axonless granule cells (GCs) mediate self- and lateral inhibitory interactions between the excitatory MTCs via reciprocal dendrodendritic synapses. We have explored long-term plasticity at this synapse by using a theta burst stimulation (TBS) protocol and variations thereof. GCs were excited via glomerular stimulation in acute brain slices. We find that TBS induces exclusively long-term depression in the majority of experiments, whereas single bursts (“single-sniff paradigm”) can elicit both long-term potentiation and depression. Statistical analysis predicts that the mechanism underlying this bidirectional plasticity involves the proportional addition or removal of presynaptic release sites. Gamma stimulation with the same number of APs as in TBS was less efficient in inducing plasticity. Both TBS- and “single-sniff paradigm”-induced plasticity depend on NMDA receptor activation. Since the onset of plasticity is very rapid and requires little extra activity, we propose that these forms of plasticity might play a role already during an ongoing search for odor sources. Our results imply that components of both short-term and long-term olfactory memory may be encoded at this synapse.

Estudio de la situación socioeconómica y académica del docente de la Facultad de Medicina de la Universidad Peruana Cayetano Heredia.

One hundred and twenty one teachers, 51.3% of the total of the faculty of medicine Alberto Hurtado of UPCH were surveyed in order to determine some social, economic and academia characteristics. We found: age average, 49.4 yr;89.3%male; 87.6% were married; 85.8% lived in middle and high social level areas; average of children 2.8; 8.3% were full-time teachers; average of years in teaching 19.5 yr; 95.9% were attracted for teaching; 85.1% would not abandon teaching; 42.4% were satisfied; 52.9% had training in teaching methods; 54.5% were doing research; 55.9% had published; 90.0% belong to the Ministry of Health-Hospitals; 79.2% do private practice; 75.0% own a house; 52.5% had other member of their family working and 72.5% had private practice as the main income. We concluded that our teaching staff belongs in average, to the middle class, doteaching as an extra activity, have interest and experience in teaching but do not have enough pedagogical education and that research and publications could increase.

Architectural communication: Intra and extra activity of architecture

Apart from a brief overview of architectural communication viewed from the standpoint of theory of information and semiotics, this paper contains two forms of dualistically viewed architectural communication. The duality denotation/connotation (?primary? and ?secondary? architectural communication) is one of semiotic postulates taken from Umberto Eco who viewed architectural communication as a semiotic phenomenon. In addition, architectural communication can be viewed as an intra and an extra activity of architecture where the overall activity of the edifice performed through its spatial manifestation may be understood as an act of communication. In that respect, the activity may be perceived as the ?behavior of architecture?, which corresponds to Lefebvre?s production of space.

Chaperone-like activity of alpha-crystallin is enhanced by high-pressure treatment

α-Crystallin, an oligomeric protein in vertebrate eye lens, is a member of the small heat-shock protein family. Several papers pointed out that its chaperone-like activity could be enhanced by increasing the temperature. We demonstrate in the present study that structural perturbations by high hydrostatic pressures up to 300MPa also enhance this activity. In contrast with temperature-induced changes, the pressure-induced enhancement is reversible. After pressure release, the extra activity is lost with a relaxation time of 2.0±0.5h. Structural alterations contributing to the higher activity were studied with IR and fluorescence spectroscopy, and light-scattering measurements. The results suggest that while the secondary structure barely changes under pressure, the interactions between the subunits weaken, the oligomers dissociate, the area of accessible hydrophobic surfaces significantly increases and the environment of tryptophan residues becomes slightly more polar. It seems that structural flexibility and the total surface area of the oligomers are the key factors in the chaperone capacity, and that the increase in the chaperone activity does not require the increase in the oligomer size as was assumed previously [Burgio, Kim, Dow and Koretz (2000) Biochem. Biophys. Res. Commun. 268, 426—432]. After pressure release, the structure of subunits are reorganized relatively quickly, whereas the oligomer size reaches its original value slowly with a relaxation time of 33±4 h. In our interpretation, both the fast and slow structural rearrangements have an impact on the functional relaxation.

Use of Prolonged Standing for Individuals With Spinal Cord Injuries

Background and Purpose. Prolonged standing in people with spinal cord injuries (SCIs) has the potential to affect a number of health-related areas such as reflex activity, joint range of motion, or well-being. The purpose of this study was to document the patterns of use of prolonged standing and their perceived effects in subjects with SCIs. Subjects. The subjects were 152 adults with SCIs (103 male, 49 female; mean age=34 years, SD=8, range=18–55) who returned mailed survey questionnaires. Methods. A 17-item self-report survey questionnaire was sent to the 463 members of a provincial spinal cord support organization. Results. Survey responses for 26 of the 152 respondents were eliminated from the analysis because they had minimal effects from their injuries and did not need prolonged standing as an extra activity. Of the 126 remaining respondents, 38 respondents (30%) reported that they engaged in prolonged standing for an average of 40 minutes per session, 3 to 4 times a week, as a method to improve or maintain their health. The perceived benefits included improvements in several health-related areas such as well-being, circulation, skin integrity, reflex activity, bowel and bladder function, digestion, sleep, pain, and fatigue. The most common reason that prevented the respondents from standing was the cost of equipment to enable standing. Discussion and Conclusion. Considering the many reported benefits of standing, this activity may be useful for people with SCI. This study identified a number of body systems and functions that may need to be investigated if clinical trials of prolonged standing in people with SCI are undertaken.