In evolution towards a successful mobile communications, the radio technology plays major role and the chosen radio technology should be spectrally efficient, robust and reliable. OFDM provided the much needed spectral efficiency, reliability, robustness and scalability for LTE, compared to the previous access methods such as TDMA, FDMA, and CDMA. For 5G, we should look for more spectrally efficient and massively scalable radio technology to cater to IoT and high bandwidth applications. The objective of this chapter is to introduce the 5G radio system, its challenges from both user and network perspective, and the key disruptive technologies for 5G – such as carrier aggregation, waveform engineering, full duplex, Multi-RAT, flexible networks, and Massive MIMO. Finally, the chapter discusses the current developments in 5G radio research.