Social injustice leads to profoundly increased rates of illness and premature death in low- and middle-income countries related to inadequate public health services and medical care, internal factors such as extreme poverty and unaccountable governments, and external factors such as debt, structural adjustment policies, and trade barriers. This chapter describes the impact of social injustice on public health in low- and middle-income countries, including issues related to endemic and epidemic diseases and health risks associated with poverty, living conditions, occupational health and safety, and violence. It discusses what needs to be done, including promoting approaches that focus on poor people, promoting and protecting human rights, improving healthcare systems, improving education and health literacy, increasing foreign assistance, reducing the import of hazards into these countries, preventing violence, promoting representative government, changing international economic policies, and promoting sustainable development. Text boxes address trafficking in persons, hunger and malnutrition, and the import of hazardous substances from high-income countries to low- and middle-income countries.