Planned and/or unplanned developments in the setting, which are directly or indirectly in connection to a certain profession or are of multidisciplinary character, have impact on initiation and steering of the course and direction of research campaigns of “vigilant” professional analysts and/or researchers of a profession, i.e. professions. It was the occurrence of the “vicious infection - SARS CoV 2” at the territory of Planet Earth which also initiated the subject professional research in the area of applied thermal engineering within two partial units which may be in interaction with the infection, i.e. which may also be in causal connection: “applied thermal engineering in building stock (only business and residential buildings)”- “sophisticated thermotechnical system integrated in a business or residential building”- “pathogenic microorganisms”. When general, professional and/or scientific public was faced with occurrence of plentitude of information, misinformation, interpretations, misconceptions, and/or ambiguities in the “black box of SARS CoV 2 pandemic”, the subject research was initiated in an analytical and principled manner with application of methods of analysis based on the “logic of rational action” in the given area. The aspects of the approach are adapted to the subject of the research, imperatively and consecutively imposed by the need for analysis and evaluation of causality between the given partial units and pathogenic microorganisms. In relation to the accepted partial units in the stage of utilization of the existing business or residential building for the dedicated purpose, the findings point that, inter alia, if such buildings were constructed as a result of conscientious, competent, responsible, and highly professional work of multidisciplinary builders and if they comprise adequate integrated sophisticated thermotechnical systems which have systematic, functional, and operating capability and which achieve satisfactory target function of the system, they do not “generate” pathogenic microorganisms, do not participate in their transfer, do not intensify their pathogenic properties and activity, do not contribute to occurrence of pandemics, do not jeopardize human health, and do not cause their mortality, etc. but are basically also not intended to “destroy” pathogenic microorganisms reaching the system from the outside and/or treated limited closed spaced within the building frequented by people off their working activities and/or pursuing their working activities, individually or in groups. Depending on the type of the current sophisticated thermotechnical system in the building, if necessary, it is possible to perform interventions aimed at reconstruction so as to “immunize” the system in a manner which may be recognized and designed by professional, competent, experienced, and dedicated thermal engineers. It needs to be noted that the subject exploration is conducted for deontological reasons, with the aim to promote theory and practice in the given.