This chapter reviews the application of forensic statistical methods related issues such as: methods of deciphering evidence, DNA profile matching, searching a database of DNA profiles, scientific reliability, discrimination in presentation of statistical evidence in legal settings, assumptions in underlying statistical analysis when evidence is presented, precision & accuracy, role of using extreme values in evidence, and decision analysis in forensic science. The emphasis of the chapter is on concepts from statistical application, nature, and use of evidences in everyday clinical practice and in the court of law. Another goal of the chapter is to serve as a central reference to access of information about resources related to this topic.