Post-earthquake fire (PEF) is one of the most complicated problems resulting from earthquake, presenting a serious risk to urban buildings. As most standards and codes ignore the possibility of PEF, buildings are too weak under PEF loads. This chapter is to investigate the effects of PEF loads on partially damaged RC buildings located in urban regions. To do that, a methodology named sequential analysis is introduced here via which the structural performance at various performance levels is evaluated under fire and PEF scenarios. Numerically, in order to simulate the earthquake loads, conventional pushover analysis is employed, with an explanation presented in the chapter to introduce the pushover analysis, its advantages and its limitations. To simulate the fire loads, standard fire curve (ISO 834) is used for simplicity.