Metabolic Syndrome in Humans and Horses: The Relationship Between Obesity and Insulin Resistance

2016 ◽  
pp. 149-166
Author(s):  
Teresa A. Burns ◽  
Ramiro E. Toribio
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
The Relationship

scholarly journals The Relationship between Epicardial Adipose Tissue Thickness and Serum Interleukin-17a Level in Patients with Isolated Metabolic Syndrome

Biomolecules ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 97 ◽  
Author(s):  
Esra Demir ◽  
Nazmiye Harmankaya ◽  
İrem Kıraç Utku ◽  
Gönül Açıksarı ◽  
Turgut Uygun ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue ◽  
Control Group ◽  
Model Assessment ◽  
Tissue Thickness ◽  
The Metabolic Syndrome ◽  
Epicardial Adipose Tissue Thickness ◽  
The Relationship

In this study, it was aimed to investigate the relationship between the epicardial adipose tissue thickness (EATT) and serum IL-17A level insulin resistance in metabolic syndrome patients. This study enrolled a total of 160 subjects, of whom 80 were consecutive patients who applied to our outpatient clinic and were diagnosed with metabolic syndrome, and the other 80 were consecutive patients who were part of the control group with similar age and demographics in whom the metabolic syndrome was excluded. The metabolic syndrome diagnosis was made according to International Diabetes Federation (IDF)-2005 criteria. EATT was measured with transthoracic echocardiography (TTE) in the subjects. IL-17A serum levels were determined using the ELISA method. Fasting blood glucose, HDL, triglyceride, and fasting insulin levels were significantly higher in the metabolic syndrome group compared to the control group. In addition, the metabolic syndrome group had significantly higher high-sensitivity C-reactive protein (hs-CRP) and Homeostatic Model Assessment Insulin Resistance (HOMA-IR) levels than the control group. Similarly, serum IL-17A levels were significantly elevated in the metabolic syndrome group compared to the control group statistically (p < 0.001). As well, EATT was higher in the metabolic syndrome than the control group. Conclusion: By virtue of their proinflammatory properties, EATT and IL-17 may play an important role in the pathogenesis of the metabolic syndrome.

scholarly journals Metabolic aspects of the relationship of asthma and obesity

2019 ◽  
Vol 15 (4) ◽  
pp. 9-14 ◽  
Author(s):  
Oxana Y. Kytikova ◽  
Marina V. Antonyuk ◽  
Tatyana A. Gvozdenko ◽  
Tatyana Р. Novgorodtseva
Keyword(s):  
Nitric Oxide ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Common Mechanism ◽  
The Metabolic Syndrome ◽  
Duration Of Hospitalization ◽  
Mechanisms Of Formation ◽  
Relationship Of ◽  
The Relationship

Asthma and obesity are serious medical and social world problems, and their combined course is characterized by a decrease in the quality of life, an increase in the frequency and duration of hospitalization. The present review summarizes the current views on the mechanisms of formation of asthma phenotype combined with obesity, role of leptin and adiponectin imbalance in the development of systemic inflammation in obesity in the pathophysiology of asthma, its interrelations with metabolic syndrome. We present data that shows that syndrome is closely related not only to the debut of asthma, but also to a decrease in its control. Along with obesity, the role of other components of metabolic syndrome, in particular insulin resistance, as a predictor of asthma development is considered. Insulin resistance may be the most likely factor in the relationship between asthma and obesity, independent of other components of the metabolic syndrome. Insulin resistance associated with obesity can lead to disruption of nitric oxide synthesis. We reveal common mechanism of metabolic disorders of nitric oxide and arginine in metabolic syndrome and asthma and show that insulin resistance treatment can be therapeutically useful in patients with asthma in combination with obesity.

The Relationship of the Hypertension, Insulin Resistance, and Metabolic Syndrome in the Serum Uric Acid Level

2004 ◽  
Vol 34 (9) ◽  
pp. 874 ◽  
Author(s):  
Tae Woo Yoo ◽  
Ki Chul Sung ◽  
Young Choon Kim ◽  
Sang Tai Hwang ◽  
Se Yong Oh ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Relationship Of ◽  
The Relationship

scholarly journals Reduced insulin resistance partly mediated the association of high dietary magnesium intake with less metabolic syndrome in a large Chinese population

2020 ◽  
Author(s):  
Na Yang ◽  
Liyun He ◽  
Yuxiu Li ◽  
Lingling Xu ◽  
Fan Ping ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Chinese Population ◽  
Survey Methods ◽  
Negative Relationship ◽  
Mediation Effect ◽  
Nutrition Survey ◽  
Magnesium Intake ◽  
Dietary Magnesium ◽  
The Relationship

Abstract Background High dietary magnesium intake may reduce insulin resistance (IR) and metabolic syndrome (MetS). However, previous studies were inconsistent in Asian population and there have been no study about the mediation of IR in the relationship between dietary magnesium intake and MetS. Thus, this cross-sectional analysis aimed to evaluate the association between dietary magnesium intake, IR and MetS using data from China Health and Nutrition Survey. Methods Dietary magnesium intake was defined as daily dietary magnesium intake divided by body weight. Logistic regression analysis was used to calculate the odds ratio (OR) for IRand the prevalence of MetS across the quartile categories of dietary magnesium intake. Results 8,254 participants were included in final analysis. We found a significant negative association between dietary magnesium intake and IR, the multivariable-adjusted OR for HOMA-IR comparing the highest to the lowest quartile of dietary magnesium intake was 0.435 (95% confidence intervals (CI) 0.376 to 0.502). The prevalence of the MetS was 33.5%, 24.9%, 18.4% and 13.4% for increasing quartiles of dietary magnesium intake (p <0.001). The direct effect and indirect effect of dietary magnesium on MetS was found significant, and the calculated percentage of mediation was 23.0%. Conclusion Our study demonstrated a significant and independent negative relationship among weight adjusted dietary magnesium intake, HOMA-IR and MetS in a large Chinese population. IR partly mediated the relationship between dietary magnesium intake and MetS.Keywords: diet magnesium intake; metabolic syndrome; insulin resistance; Chinese population; mediation effect

scholarly journals C1q/TNF-Related Protein5 (CTRP5) as a Biomarker to Predict Metabolic Syndrome and Each of Its Components

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Feiyu Jiang ◽  
Min Yang ◽  
Xili Zhao ◽  
Rui Liu ◽  
Gangyi Yang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Multiple Stepwise Regression Analysis ◽  
Glucose And Lipid Metabolism ◽  
Study Population ◽  
The Relationship

Objective. C1q/TNF-related protein5 (CTRP5) is a member of the C1q/tumor necrosis factor α- (TNF-α-) related protein family and has been reported to be associated with the regulation of glucose and lipid metabolism. However, the clinical association between CTRP5 and metabolic syndrome (MetS) has not been reported. The aim of the current study is to investigate the association between CTRP5 and MetS by a cross-sectional study. Methods. We performed a cross-sectional study in a Chinese population including 89 controls and 88 MetS individuals. Serum CTRP5 concentrations were determined by ELISA. The relationship between circulating CTRP5 and MetS and insulin resistance (IR) was assessed by Spearman’s correlation and multiple stepwise regression analysis. Results. Circulating CTRP5 concentrations were markedly decreased in MetS individuals relative to normal adults. Overweight/obese individuals (BMI ≥ 25 kg/m2) showed a lower serum CTRP5 level than lean subjects (BMI < 25 kg/m2) in the study population (124.1 (99.12–147.37) vs. 103.9 (79.15–124.25) μg/L; P<0.01). Circulating CTRP5 was found to be correlated negatively with BMI, FAT%, FBG, WHR, SBP, HbA1c, TG, 2-hour blood glucose after glucose overload (2-hOGTT), FIns, and HOMA-IR and positively with HDL-C (P<0.05 or P<0.01). Binary logistic regression revealed that serum CTRP5 levels were associated with MetS. In addition, serum CTRP5 levels gradually decreased with the increase in MetS components. Conclusions. Circulating CTRP5 is relative to the elevated risk of MetS in humans and may be in part through the effect of insulin resistance. This trial is registered with ChiCTR-OCS-13003185.

scholarly journals Obesity, metabolic syndrome, male hypogonadism and cardiovascular risk

2013 ◽  
pp. 234-238
Author(s):  
Giovanni Corona ◽  
Francesco Lotti ◽  
Alessandra Sforza ◽  
Mario Maggi ◽  
Valerio Chiarini
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Sexual Dysfunction ◽  
Large Body ◽  
Surrogate Marker ◽  
Male Hypogonadism ◽  
Disease States ◽  
Increased Risk ◽  
Diabetic Population ◽  
The Relationship

Background: A large body of evidences indicates that sexual dysfunction, and in particular erectile dysfunction (ED), may represent an early surrogate marker of different disease states such as diabetes mellitus, hypertension, metabolic syndrome (MetS) and depression. Furthermore, it has been suggested that ED could also be considered the first sign of a forthcoming coronary heart disease (CHD) and an efficient predictor of silent CHD in a diabetic population, independently of glycometabolic control and ED severity. Hypogonadism is frequently associated with MetS both in subjects with or without ED, insulin resistance being the putative pathogenetic link. In subjects with ED hypogonadism can exacerbate sexual dysfunction because of its typical symptoms, such as decreased sexual desire and mood disturbances. However, hypogonadism per se has been associated with an increased risk of cardiovascular and overall mortality. Aim of the study: In this review, a comprehensive literature search was carried out, in order to discuss the relationship between insulin resistance, ED, MetS and hypogonadism, focusing on their possible involvement in the development of cardiovascular diseases.

scholarly journals EFFECT OF DYSLIPIDAEMIA AND INSULIN RESISTANCE ON THE COURSE OF ALOPECIA AREATA ASSOCIATED WITH METABOLIC SYNDROME

2021 ◽  
pp. 18-22
Author(s):  
I.I. Horda ◽  
◽  
S.V. Vozianova ◽  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Carbohydrate Metabolism ◽  
Metabolic Disorders ◽  
Blood Lipids ◽  
Severe Form ◽  
High Density Lipoproteins ◽  
Homa Index ◽  
Mild Form ◽  
The Relationship

Alopecia areata (AA) is a tissue-specific disease of the hair follicles, manifested by foci of alopecia on a scalp and other areas of skin. The objective of our study was to evaluate the values of blood lipids and carbohydrate metabolism in patients with АА associated with metabolic syndrome (MS) to determine the relationship between disease severity and metabolic disorders. Materials and methods. Clinical and anamnestic characteristics and laboratory values of lipid spectrum and carbohydrate metabolism were analysed in 50 patients with AA associated with MS. Results. As a result of the study, the following regularities have been established: values of blood lipids (cholesterol, triglycerides, high-density lipoproteins) and carbohydrate metabolism (blood glucose, glycosylated haemoglobin, HOMA index) statistically significantly deteriorate with increasing number of the MS components (p <0.05); in patients with mild AA there is a statistically significantly (p <0.05) smaller number of MS components compared with patients with moderate to severe forms (φemp=2,645 < φcr=1,64); HOMA index increases statistically significantly with increasing severity of the disease: by 14.14% in patients with moderate form compared with patients with mild form, and in the presence of severe form by 28.31% compared with patients with moderate and by 46.46% compared with patients with mild forms of AA (p <0.05); the rate of triglycerides in the blood increases statistically significantly depending on the severity of AA: by 36.17% in patients with moderate form and by 41.78% in patients with severe form compared with mild form of AA (p <0.05); the content of high-density lipoproteins in the blood decreases statistically significantly depending on the severity of AA: by 2.12% in patients with moderate form compared with mild form and by 9.53% in patients with severe form compared with moderate form (p <0.05); no relationship has been found between the severity of MS, given the number of its components, and the stage of AA: active and chronic. Conclusions. As a result of the study, the relationship between the severity of AA and the severity of metabolic disorders in the presence of MS in patients has been established. An important area is the study of correction of dyslipidaemia and insulin resistance in a comprehensive therapy of AA associated with MS.

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