The predicted lifetime costs and health consequences of calcium and vitamin D supplementation for fracture prevention—the impact of cardiovascular effects

2016 ◽  
Vol 27 (6) ◽  
pp. 2089-2098 ◽  
Author(s):  
G. Hagen ◽  
T. Wisløff ◽  
I. S. Kristiansen
Keyword(s):  
Vitamin D ◽  
Cardiovascular Effects ◽  
Fracture Prevention ◽  
Vitamin D Supplementation ◽  
Health Consequences ◽  
Lifetime Costs ◽  
The Impact

scholarly journals Vitamin D and Blood Parameters

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1017
Author(s):  
Thomas Müller ◽  
Lutz Lohse ◽  
Andreas Blodau ◽  
Katja Frommholz
Keyword(s):  
Vitamin D ◽  
Mean Corpuscular Volume ◽  
Plasma Concentrations ◽  
Blood Parameters ◽  
Vitamin D Supplementation ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Volume ◽  
Corpuscular Haemoglobin ◽  
Mean Corpuscular Haemoglobin ◽  
The Impact

Background: Vitamin D has a steroid- and an anabolic-resembling chemical structure. Vitamin D is essential for many processes in the human body after hydroxylation. Aims of the Study: To investigate the impact of 25-hydroxy-vitamin D plasma concentrations on the blood parameters number of erythrocytes, hematocrit, mean corpuscular hemoglobin and mean corpuscular volume. Methods: Serial assessments were done in 290 patients with multiple sclerosis and repeated after a mean interval of 245 days. A recommendation for vitamin D supplementation was given in case of a concentration lower than 20 ng/mL combined with a prescription of a formulation containing vitamin D but not vitamin K. Results: There was a fall of vitamin D in 119 subjects and a rise in 164, while no change appeared in 7 participants. When vitamin D values went down between both assessments moments, the computed increase of mean corpuscular haemoglobin was significantly lower compared with the rise of mean corpuscular haemoglobin associated with a vitamin D elevation. When vitamin D declined, the computed fall of mean corpuscular volume fall was significantly lower compared with the decrease of mean corpuscular volume, when vitamin D rose. Positive correlations were found between differences of vitamin D and mean corpuscular haemoglobin, respectively mean corpuscular volume. Inverse relations appeared between disparities of vitamin D and erythrocytes, respectively haematocrit. Conclusions: The elevation of vitamin D plasma levels provides enhanced preconditions for a better tissue oxygenation on a cellular level.

scholarly journals Vitamin D status and its determinants in Pre Diabetic pregnant mothers attending tertiary care centre in Tamilnadu, India

2020 ◽  
Vol 11 (1) ◽  
pp. 617-622
Author(s):  
Kavitha Durairaj ◽  
Muthulakshmi M ◽  
Venkataraman P ◽  
Murali R ◽  
Rukumani J ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Infection Type ◽  
Tertiary Care ◽  
Challenge Test ◽  
Vitamin D Supplementation ◽  
Ultraviolet B ◽  
Oral Glucose ◽  
College Hospital ◽  
The Impact

Vitamin D is a vital nutrient factor in the healthiness of the mother and infant. Vitamin D is mainly amalgamated in the skin following exposure to ultraviolet B radiation. Insufficiency of vitamin D in Pregnancy had been related to various sicknesses, such as respiratory infection, type 1 diabetes mellitus, high risk of childhood wheezing. The aim of this study was to investigate the impact of Vitamin D supplementation on the incidence of pregestational diabetes in pregnant women referred to antenatal clinics in SRM Medical College hospital, Tamilnadu, India. 200 pregnant women were recruited, and oral glucose challenge test (OGCT), serum calcium and 25(OH) D were determined. Participants were in the age group of 18 to 35 years, with a mean age of 26.29. Among the participants, 59% were multiparous. The present study showed that a high prevalence of vitamin D deficiency (61.5%) and insufficiency (34%) in pregnant women before supplementation with a mean of 16.84. Vitamin D supplementation during the early weeks of pregnancy might help in the improvement of maternal and child health.

scholarly journals The impact of 1-year vitamin D supplementation on vitamin D status in athletes: a dose–response study

2016 ◽  
Vol 70 (9) ◽  
pp. 1009-1014 ◽  
Author(s):  
E M P Backx ◽  
M Tieland ◽  
K Maase ◽  
A K Kies ◽  
M Mensink ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dose Response ◽  
Vitamin D Supplementation ◽  
Vitamin D Status ◽  
Dose Response Study ◽  
The Impact

Vitamin D Supplementation Is Associated with a Reduction in Self-Reported Falls among Older Adults with Previous Fall History – Feasibility Study

2021 ◽  
pp. 1-7
Author(s):  
S.D. Anton ◽  
R.T. Mankowski ◽  
P. Qiu ◽  
L. You ◽  
B.A. Bensadon ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Handgrip Strength ◽  
Vitamin D Supplementation ◽  
Blood Levels ◽  
Timed Up And Go ◽  
Vitamin D Levels ◽  
Falls In Older Adults ◽  
One Year ◽  
The Impact

Background: Vitamin D insufficiency contributes to muscle weakness and a higher risk of falls in older adults. Objectives: This study explored the impact of vitamin D supplementation on self-reported falls and physical function in older adults with low vitamin D levels and a recent fall history. Materials and Methods: Twenty-five older adults ≥ 70 years with two or more falls during the past year, low vitamin D blood levels (≥10 ng/ml and < 30 ng/mL), and slow gait speed (1.2 m/s) participated in a 6-month vitamin D supplementation (800 IU/day) study. A modified version of the Morse Fall Scale questionnaire was used to assess frequency of falls over one-year prior to study enrollment. Functional outcomes (short physical performance battery, handgrip strength, gait Timed Up and Go, and six-minute walk), and vitamin D levels were assessed at baseline and 6-month follow-up. Results: Based on diaries and pill counts, participants were generally adherent to the intervention (6 of 7 days per week). Supplementation with 800 IU/day of vitamin D for 6 months increased blood vitamin D levels from 23.25±4.8 ng/ml to 29.13±6.9 ng/ml (p<0.001). Self-reported number of falls decreased from an average of 3.76 ± 2.2 falls in one-year to 0.76 ± 1.4 falls (p <0.0001) over the 6-month intervention. No changes in functional outcome measures were observed. Conclusions: Vitamin D supplementation at the currently recommended dose of 800 IU/day increased blood vitamin D levels and reduced frequency of falls in older adults with low vitamin D levels and a recent fall history.

scholarly journals Vitamin D/CD46 Crosstalk in Human T Cells in Multiple Sclerosis

2020 ◽  
Vol 11 ◽  
Author(s):  
Justin Killick ◽  
Joanne Hay ◽  
Elena Morandi ◽  
Sonja Vermeren ◽  
Saniya Kari ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
T Cells ◽  
T Cell ◽  
Chronic Inflammatory Disease ◽  
Vitamin D Supplementation ◽  
Type I ◽  
T Cell Migration ◽  
The Impact

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), in which T-cell migration into the CNS is key for pathogenesis. Patients with MS exhibit impaired regulatory T cell populations, and both Foxp3+ Tregs and type I regulatory T cells (Tr1) are dysfunctional. MS is a multifactorial disease and vitamin D deficiency is associated with disease. Herein, we examined the impact of 1,25(OH)2D3 on CD4+ T cells coactivated by either CD28 to induce polyclonal activation or by the complement regulator CD46 to promote Tr1 differentiation. Addition of 1,25(OH)2D3 led to a differential expression of adhesion molecules on CD28- and CD46-costimulated T cells isolated from both healthy donors or from patients with MS. 1,25(OH)2D3 favored Tr1 motility though a Vitamin D-CD46 crosstalk highlighted by increased VDR expression as well as increased CYP24A1 and miR-9 in CD46-costimulated T cells. Furthermore, analysis of CD46 expression on T cells from a cohort of patients with MS supplemented by vitamin D showed a negative correlation with the levels of circulating vitamin D. Moreover, t-Distributed Stochastic Neighbor Embedding (t-SNE) analysis allowed the visualization and identification of clusters increased by vitamin D supplementation, but not by placebo, that exhibited similar adhesion phenotype to what was observed in vitro. Overall, our data show a crosstalk between vitamin D and CD46 that allows a preferential effect of Vitamin D on Tr1 cells, providing novel key insights into the role of an important modifiable environmental factor in MS.

scholarly journals Vitamin D and Cardiovascular Risk: Which Implications in Children?

2020 ◽  
Vol 21 (10) ◽  
pp. 3536 ◽  
Author(s):  
Silvia Savastio ◽  
Erica Pozzi ◽  
Francesco Tagliaferri ◽  
Roberta Degrandi ◽  
Roberta Cinquatti ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cardiovascular Risk ◽  
Pediatric Patients ◽  
Cardiovascular Effects ◽  
Vitamin D Supplementation ◽  
Risk Markers ◽  
Randomized Controlled ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Lipid Parameters

Vitamin D (25OHD) pleiotropic effects are widely recognized and studied. Recently, vitamin D cardiovascular effects are gaining interest, especially in children, although the studies present conflicting data. Some randomized controlled trials (RCTs) have demonstrated that cardiovascular risk markers, such as lipid parameters, inflammation markers, blood pressure, and arterial stiffness, are unaffected by vitamin D supplementation. By contrast, other studies show that low vitamin D levels are associated with higher risk of cardiovascular disease (CVD) and mortality, and support that increased risk of these diseases occurs primarily in people with vitamin D deficiency. An update on these points in pediatric patients is certainly of interest to focus on possible benefits of its supplementation.

scholarly journals Effects of Preventive Nutrition Interventions among Adolescents on Health and Nutritional Status in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis

Nutrients ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 49 ◽  
Author(s):  
Rehana A Salam ◽  
Jai K Das ◽  
Wardah Ahmed ◽  
Omar Irfan ◽  
Sana Sadiq Sheikh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Folic Acid ◽  
Nutritional Status ◽  
Iron Supplementation ◽  
Vitamin D Supplementation ◽  
Micronutrient Supplementation ◽  
Middle Income ◽  
Total Body ◽  
The Impact ◽  
Quality Evidence

The objective of this review was to assess the impact of preventive nutrition interventions on health and nutritional status of adolescents aged 10–19 years in low- and middle-income countries (LMICs). We searched the databases until 5 February 2019 without any restrictions on publication, date, language, or publication status. A total of 10 studies (15 papers) including 10,802 participants assessing the impact of micronutrient supplementation/fortification were included in this review. We did not find any study assessing the impact of nutrition education and counseling or macronutrient supplementation among adolescents. Among primary outcomes, we are uncertain of the effect of iron supplementation with or without folic acid on anemia (daily supplementation; relative risk (RR): 1.04, 95% confidence interval (CI) 0.42, 2.57; one study; 1160 participants; low-quality evidence; weekly supplementation; RR: 1.07, 95% CI: 0.46, 2.52; one study; 1247 participants; low-quality evidence). We are also uncertain of the effect of various micronutrient supplementation/fortification on body mass index (BMI) (calcium/vitamin D supplementation; (MD: −0.01 kg/m2; 95% CI: −1.20, 1.17; two studies; 730 participants; I2 94%; very-low-quality evidence, iron supplementation with or without folic acid; MD: 0.47 kg/m2; 95% CI: −0.17, 1.11; two studies; 652 participants; I2 37%; very-low-quality evidence, zinc supplementation; MD: 0.35 kg/m2; 95% CI: −0.15, 0.85; one study; 382 participants; very-low-quality evidence) and multiple micronutrient (MMN) fortification; MD: 0.23 kg/m2, 95% CI: −0.11, 0.57; two studies; 943 participants; I2 22%; very-low-quality evidence). None of the included studies reported any other primary outcomes including morbidity or adverse effects. Among secondary outcomes, iron supplementation with or without folic acid may improve hemoglobin concentrations, and calcium/vitamin D supplementation may improve serum 25(OH)D levels, while calcium only supplementation and calcium and vitamin D supplementation may marginally improve total body bone mineral density (BMD). We are uncertain of the effect of MMN fortification on hemoglobin concentrations, calcium supplementation on total body bone mineral content (BMC), calcium + vitamin D supplementation on total body BMC, and zinc supplementation on zinc levels. There is limited evidence of micronutrient supplementation/fortification among adolescents, especially adolescent boys, on health and nutritional status in LMICs. These findings should be interpreted with caution due to the low quality and limited number of studies.

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