Assessment of strategies for the formation of stable suspensions of titanium dioxide nanoparticles in aqueous media suitable for the analysis of biological fluids

2020 ◽  
Vol 412 (7) ◽  
pp. 1469-1481
Author(s):  
Samantha Salou ◽  
Ciprian-Mihai Cirtiu ◽  
Dominic Larivière ◽  
Normand Fleury
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Biological Fluids ◽  
Aqueous Media

scholarly journals Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine

2020 ◽  
Author(s):  
Daniel Ziental ◽  
Beata Czarczynska-Goslinska ◽  
Dariusz T. Mlynarczyk ◽  
Arleta Glowacka-Sobotta ◽  
Beata Stanisz ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Metallic Nanoparticles ◽  
Malignant Tumors ◽  
Uv Light ◽  
Titanium Dioxide Nanoparticles ◽  
Aqueous Media ◽  
Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Tio2 Nps ◽  
Wide Range

Metallic nanoparticles (NPs), among polymeric NPs, liposomes, micelles, quantum dots, dendrimers, or fullerenes, are becoming more and more important due to their potential use in the novel medical therapies. Titanium dioxide (titanium(IV) oxide, titania, TiO2) is an inorganic compound that owes its recent rise in scientific interest to photoactivity. After the illumination in aqueous media with UV light, TiO2 produces an array of reactive oxygen species (ROS). The capability to produce ROS and thus induce cell death has found application in the photodynamic therapy (PDT) for the treatment of a wide range of maladies, from psoriasis to cancer. Titanium dioxide NPs were studied as photosensitizing agents in the treatment of malignant tumors as well as in photodynamic inactivation of antibiotic-resistant bacteria. Both TiO2 NPs themselves, as well as their composites with other molecules, can be successfully used as photosensitizers in PDT. Moreover, various organic compounds can be grafted on TiO2 NPs, leading to hybrid materials. These nanostructures can reveal increased light absorption allowing their further use in targeted therapy in medicine. In order to improve efficient anticancer therapy, many approaches utilizing titanium dioxide were tested. The most significant studies are discussed in this review.

scholarly journals Finding Nano: Challenges Involved in Monitoring the Presence and Fate of Engineered Titanium Dioxide Nanoparticles in Aquatic Environments

Water ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 734
Author(s):  
Simone Heilgeist ◽  
Ryo Sekine ◽  
Oz Sahin ◽  
Rodney A. Stewart
Keyword(s):  
Titanium Dioxide ◽  
Tio2 Nanoparticles ◽  
Inductively Coupled Plasma ◽  
Titanium Dioxide Nanoparticles ◽  
Aqueous Media ◽  
Experimental Studies ◽  
Aquatic Environments ◽  
Nano Tio2 ◽  
Icp Ms ◽  
Modelling Studies

In recent years, titanium dioxide (TiO2) has increasingly been used as an inorganic ultraviolet (UV) filter for sun protection. However, nano-TiO2 may also pose risks to the health of humans and the environment. Thus, to adequately assess its potential adverse effects, a comprehensive understanding of the behaviour and fate of TiO2 in different environments is crucial. Advances in analytical and modelling methods continue to improve researchers’ ability to quantify and determine the state of nano-TiO2 in various environments. However, due to the complexity of environmental and nanoparticle factors and their interplay, this remains a challenging and poorly resolved feat. This paper aims to provide a focused summary of key particle and environmental characteristics that influence the behaviour and fate of sunscreen-derived TiO2 in swimming pool water and natural aquatic environments and to review the current state-of-the-art of single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) approaches to detect and characterise TiO2 nanoparticles in aqueous media. Furthermore, it critically analyses the capability of existing fate and transport models to predict environmental TiO2 levels. Four particle and environmental key factors that govern the fate and behaviour of TiO2 in aqueous environments are identified. A comparison of SP-ICP-MS studies reveals that it remains challenging to detect and characterise engineered TiO2 nanoparticles in various matrices and highlights the need for the development of new SP-ICP-MS pre-treatment and analysis approaches. This review shows that modelling studies are an essential addition to experimental studies, but they still lack in spatial and temporal resolution and mostly exclude surface transformation processes. Finally, this study identifies the use of Bayesian Network-based models as an underexplored but promising modelling tool to overcome data uncertainties and incorporates interconnected variables.

scholarly journals Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 387 ◽  
Author(s):  
Daniel Ziental ◽  
Beata Czarczynska-Goslinska ◽  
Dariusz T. Mlynarczyk ◽  
Arleta Glowacka-Sobotta ◽  
Beata Stanisz ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Malignant Tumors ◽  
Uv Light ◽  
Titanium Dioxide Nanoparticles ◽  
Metal Oxide Nanoparticles ◽  
Aqueous Media ◽  
Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Photosensitizing Agents ◽  
Wide Range

Metallic and metal oxide nanoparticles (NPs), including titanium dioxide NPs, among polymeric NPs, liposomes, micelles, quantum dots, dendrimers, or fullerenes, are becoming more and more important due to their potential use in novel medical therapies. Titanium dioxide (titanium(IV) oxide, titania, TiO2) is an inorganic compound that owes its recent rise in scientific interest to photoactivity. After the illumination in aqueous media with UV light, TiO2 produces an array of reactive oxygen species (ROS). The capability to produce ROS and thus induce cell death has found application in the photodynamic therapy (PDT) for the treatment of a wide range of maladies, from psoriasis to cancer. Titanium dioxide NPs were studied as photosensitizing agents in the treatment of malignant tumors as well as in photodynamic inactivation of antibiotic-resistant bacteria. Both TiO2 NPs themselves, as well as their composites and combinations with other molecules or biomolecules, can be successfully used as photosensitizers in PDT. Moreover, various organic compounds can be grafted on TiO2 nanoparticles, leading to hybrid materials. These nanostructures can reveal increased light absorption, allowing their further use in targeted therapy in medicine. In order to improve efficient anticancer and antimicrobial therapies, many approaches utilizing titanium dioxide were tested. Results of selected studies presenting the scope of potential uses are discussed in this review.

scholarly journals Salt Stress Mitigation via the Foliar Application of Chitosan-Functionalized Selenium and Anatase Titanium Dioxide Nanoparticles in Stevia (Stevia rebaudiana Bertoni)

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4090
Author(s):  
Morteza Sheikhalipour ◽  
Behrooz Esmaielpour ◽  
Gholamreza Gohari ◽  
Maryam Haghighi ◽  
Hessam Jafari ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Salt Stress ◽  
Titanium Dioxide Nanoparticles ◽  
Chitosan Nanoparticles ◽  
Stevia Rebaudiana ◽  
High Salt ◽  
Steviol Glycosides ◽  
Rebaudioside A ◽  
Tio2 Nps ◽  
Stevia Rebaudiana Bertoni

High salt levels are one of the significant and major limiting factors on crop yield and productivity. Out of the available attempts made against high salt levels, engineered nanoparticles (NPs) have been widely employed and considered as effective strategies in this regard. Of these NPs, titanium dioxide nanoparticles (TiO2 NPs) and selenium functionalized using chitosan nanoparticles (Cs–Se NPs) were applied for a quite number of plants, but their potential roles for alleviating the adverse effects of salinity on stevia remains unclear. Stevia (Stevia rebaudiana Bertoni) is one of the reputed medicinal plants due to their diterpenoid steviol glycosides (stevioside and rebaudioside A). For this reason, the current study was designed to investigate the potential of TiO2 NPs (0, 100 and 200 mg L−1) and Cs–Se NPs (0, 10 and 20 mg L−1) to alleviate salt stress (0, 50 and 100 mM NaCl) in stevia. The findings of the study revealed that salinity decreased the growth and photosynthetic traits but resulted in substantial cell damage through increasing H2O2 and MDA content, as well as electrolyte leakage (EL). However, the application of TiO2 NPs (100 mg L−1) and Cs–Se NPs (20 mg L−1) increased the growth, photosynthetic performance and activity of antioxidant enzymes, and decreased the contents of H2O2, MDA and EL under the saline conditions. In addition to the enhanced growth and physiological performance of the plant, the essential oil content was also increased with the treatments of TiO2 (100 mg L−1) and Cs–Se NPs (20 mg L−1). In addition, the tested NPs treatments increased the concentration of stevioside (in the non-saline condition and under salinity stress) and rebaudioside A (under the salinity conditions) in stevia plants. Overall, the current findings suggest that especially 100 mg L−1 TiO2 NPs and 20 mg L−1 Cs–Se could be considered as promising agents in combating high levels of salinity in the case of stevia.

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