Houttuynia cordata aqueous extract attenuated glycative and oxidative stress in heart and kidney of diabetic mice

2015 ◽  
Vol 55 (2) ◽  
pp. 845-854 ◽  
Author(s):  
Cheng-chin Hsu ◽  
Hui-ting Yang ◽  
Jing-jing Ho ◽  
Mei-chin Yin ◽  
Jen-ying Hsu
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Diabetic Mice ◽  
Houttuynia Cordata ◽  
And Oxidative Stress

scholarly journals Erratum to: Houttuynia cordata aqueous extract attenuated glycative and oxidative stress in heart and kidney of diabetic mice

2017 ◽  
Vol 56 (5) ◽  
pp. 2007-2007 ◽  
Author(s):  
Cheng-chin Hsu ◽  
Hui-ting Yang ◽  
Jing-jing Ho ◽  
Mei-chin Yin ◽  
Jen-ying Hsu
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Diabetic Mice ◽  
Houttuynia Cordata ◽  
And Oxidative Stress

scholarly journals Coptisine Attenuates Diabetes—Associated Endothelial Dysfunction through Inhibition of Endoplasmic Reticulum Stress and Oxidative Stress

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4210
Author(s):  
Yan Zhou ◽  
Chunxiu Zhou ◽  
Xutao Zhang ◽  
Chi Teng Vong ◽  
Yitao Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Vascular Function ◽  
Inflammatory Responses ◽  
Therapeutic Potential ◽  
Ex Vivo ◽  
Diabetic Mice ◽  
And Oxidative Stress

Coptisine is the major bioactive protoberberine alkaloid found in Rhizoma Coptidis. Coptisine reduces inflammatory responses and improves glucose tolerance; nevertheless, whether coptisine has vasoprotective effect in diabetes is not fully characterized. Conduit arteries including aortas and carotid arteries were obtained from male C57BL/6J mice for ex vivo treatment with risk factors (high glucose or tunicamycin) and coptisine. Some arterial rings were obtained from diabetic mice, which were induced by high-fat diet (45% kcal% fat) feeding for 6 weeks combined with a low-dose intraperitoneal injection of streptozotocin (120 mg/kg). Functional studies showed that coptisine protected endothelium-dependent relaxation in aortas against risk factors and from diabetic mice. Coptisine increased phosphorylations of AMPK and eNOS and downregulated the endoplasmic reticulum (ER) stress markers as determined by Western blotting. Coptisine elevates NO bioavailability and decreases reactive oxygen species level. The results indicate that coptisine improves vascular function in diabetes through suppression of ER stress and oxidative stress, implying the therapeutic potential of coptisine to treat diabetic vasculopathy.

scholarly journals Aqueous extract of Pterocarpus santalinoides DC stem bark prevents L-NAME-induced hypertension in rat

2021 ◽  
Vol 10 (3) ◽  
pp. 166-172
Author(s):  
Chinte Yamjom Ramatou ◽  
◽  
Ngo Lemba Thom Esther ◽  
Florence Tsofack Ngueguim ◽  
Yannick Bekono Fouda ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Rate ◽  
Aqueous Extract ◽  
Hdl Cholesterol ◽  
Experimental Period ◽  
Stem Bark ◽  
Renal Markers ◽  
Induced Hypertension ◽  
And Oxidative Stress ◽  
Pterocarpus Santalinoides

Background: Pterocarpus santalinoides stem bark is commonly used in Cameroonian medicine to treat many diseases including hypertension. Thus, this study was aimed to evaluate preventive effects of aqueous extract of Pterocarpus santalinoides (AEPS) stem bark on NG-Nitro-L-arginine-methyl ester (LNAME)-induced hypertension in rat. Methods: Normotensive rats received L-NAME (25 mg/kg intraperitoneally) concomitantly with AEPS (50, 100 and 200 mg/kg) or captopril (20 mg/kg) orally during 3 weeks. At the end of experimental period, arterial pressure and heart rate were recorded by invasive method. After sacrifice, blood, aorta and heart were harvested for biochemical analysis on homogenate. Results: Intraperitoneal injection of L-NAME induced in rat a significant increase (p < 0.001; p < 0.01; p < 0.05) of blood pressure, heart rate, malondialdehyde, total cholesterol, triglycerides, LDL-cholesterol, hepatic and renal markers functions. L-NAME also decreased significantly (p < 0.001; p < 0.01; p < 0.05) the levels of HDL-cholesterol, nitrites, glutathione, superoxide dismutase and catalase activities as compared to control rats. The AEPS prevented significantly the increase (p < 0.001) of hemodynamic parameters induced by L-NAME and various modifications of biochemical parameters (lipid profile, hepatic and renal markers functions) and oxidative stress markers evaluated. Conclusion: This study shows that the aqueous extract of Pterocarpus santalinoides prevents hypertension, dyslipidemia and oxidative stress induced by L-NAME in rat by attenuating endothelial dysfunction, liver and kidney’s damages

scholarly journals Aqueous extract of dried flower buds of Syzygium aromaticum inhibits inflammation and oxidative stress

2012 ◽  
Vol 3 (3) ◽  
pp. 323 ◽  
Author(s):  
Shakir Ali ◽  
TijjaniSalihu Shinkafi ◽  
Indusmitha Routray ◽  
Tasleem Ahmad ◽  
Amena Mahmood
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Syzygium Aromaticum ◽  
Flower Buds ◽  
And Oxidative Stress

scholarly journals SEED EXTRACT OF ABELMOSCHUS MOSCHATUS MEDIK REVERSES NAF-INDUCED BEHAVIORAL CHANGES THROUGH NEURODEGENERATION AND OXIDATIVE STRESS IN BRAIN OF RAT

2017 ◽  
Vol 10 (10) ◽  
pp. 165 ◽  
Author(s):  
Kurmeti Sudhakar ◽  
Mesram Nageshwar ◽  
Pratap Reddy K
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Cell Structure ◽  
Ethanol Extract ◽  
Treated Group ◽  
Seed Extract ◽  
Stress Markers ◽  
Congo Red Staining ◽  
And Oxidative Stress ◽  
Number Of Cells

  Objective: This study reports protective effect of Abelmoschus moschatus seed extract against sodium fluoride-induced neurodegeneration through oxidative stress, neurohistological, and behavioral observations in Wistar rats.Methods: A total of 20 Wistar rats (around 250 g) were randomly classified into four groups, namely, control, fluoride (NaF), fluoride + A. moschatus seed aqueous extract (AMAE), and fluoride + A. moschatus seed ethanol extract (AMEE). The control group animals received normal tap water, fluoride group received fluoridated water at the rate of 40 mg/kg b. wt., 3rd group rats treated with fluoride (40 mg/kg b. wt.) + AMAE (300 mg/kg b. wt.), and 4th group rats treated with fluoride (40 mg/kg b. wt.) + AMEE (300 mg/kg b. wt.). Neurobehavioral responses of rotarod, hot plate, and maze learning tests and oxidantive stress markers including lipid peroxidation (LPO), GSH levels, superoxide dismutase, CAT, and GSH peroxidase (GPx) activities, and also histology with H and E as well as congo red staining were studied in control, fluoride, and A. moschatus seed extract treated against fluoride groups.Results: Decreased neurobehavioral responses with rotarod, hot plate, and maze and enhanced LPO (p<0.05) levels were found in fluoride received animals. Whereas, the superoxide dismutase (SOD), CAT, GSH, and GPx were decreased (p<0.05) in NaF treatment. The rats received seed extract along with NaF showed significant reversal of behavioral and oxidative stress markers and the effect of ethanol extract was more pronounced than aqueous extract. The fluoride-treated group showed disturbed cell structure and reduced number of cells in H and E as well as congo red staining which was reversed in cell morphology and restored cell number in seed extract against NaF-treated group. As a result of increased LPO, decreased antioxidant system, and decreased number of cells, neurodegeneration was observed resulting in the disturbance in functions associated with reported behavior.Conclusion: Okra with high antioxidants activity, seed extract showed reversal of LPO levels and antioxidant status in the brain tissue. And also plant extract administered rats displayed normal cell structure and number of cells than only fluoride received group. Therefore, the aqueous and ethanolic extract of A. moschatus plant seeds has neuroprotective effects against fluoride-induced motor, nociceptive, learning behavior, and on histological structure of brain through antioxidant mechanism. The ethanol extract has shown more efficacy than aqueous extract.

PP2Cm overexpression alleviates MI/R injury mediated by a BCAA catabolism defect and oxidative stress in diabetic mice

2020 ◽  
Vol 866 ◽  
pp. 172796 ◽  
Author(s):  
Kun Lian ◽  
Xiong Guo ◽  
Qin Wang ◽  
Yi Liu ◽  
Ru-Tao Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Mice ◽  
And Oxidative Stress
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