scholarly journals Aqueous extract of dried flower buds of Syzygium aromaticum inhibits inflammation and oxidative stress

2012 ◽  
Vol 3 (3) ◽  
pp. 323 ◽  
Author(s):  
Shakir Ali ◽  
TijjaniSalihu Shinkafi ◽  
Indusmitha Routray ◽  
Tasleem Ahmad ◽  
Amena Mahmood
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Syzygium Aromaticum ◽  
Flower Buds ◽  
And Oxidative Stress

scholarly journals Aqueous extract of Pterocarpus santalinoides DC stem bark prevents L-NAME-induced hypertension in rat

2021 ◽  
Vol 10 (3) ◽  
pp. 166-172
Author(s):  
Chinte Yamjom Ramatou ◽  
◽  
Ngo Lemba Thom Esther ◽  
Florence Tsofack Ngueguim ◽  
Yannick Bekono Fouda ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Rate ◽  
Aqueous Extract ◽  
Hdl Cholesterol ◽  
Experimental Period ◽  
Stem Bark ◽  
Renal Markers ◽  
Induced Hypertension ◽  
And Oxidative Stress ◽  
Pterocarpus Santalinoides

Background: Pterocarpus santalinoides stem bark is commonly used in Cameroonian medicine to treat many diseases including hypertension. Thus, this study was aimed to evaluate preventive effects of aqueous extract of Pterocarpus santalinoides (AEPS) stem bark on NG-Nitro-L-arginine-methyl ester (LNAME)-induced hypertension in rat. Methods: Normotensive rats received L-NAME (25 mg/kg intraperitoneally) concomitantly with AEPS (50, 100 and 200 mg/kg) or captopril (20 mg/kg) orally during 3 weeks. At the end of experimental period, arterial pressure and heart rate were recorded by invasive method. After sacrifice, blood, aorta and heart were harvested for biochemical analysis on homogenate. Results: Intraperitoneal injection of L-NAME induced in rat a significant increase (p < 0.001; p < 0.01; p < 0.05) of blood pressure, heart rate, malondialdehyde, total cholesterol, triglycerides, LDL-cholesterol, hepatic and renal markers functions. L-NAME also decreased significantly (p < 0.001; p < 0.01; p < 0.05) the levels of HDL-cholesterol, nitrites, glutathione, superoxide dismutase and catalase activities as compared to control rats. The AEPS prevented significantly the increase (p < 0.001) of hemodynamic parameters induced by L-NAME and various modifications of biochemical parameters (lipid profile, hepatic and renal markers functions) and oxidative stress markers evaluated. Conclusion: This study shows that the aqueous extract of Pterocarpus santalinoides prevents hypertension, dyslipidemia and oxidative stress induced by L-NAME in rat by attenuating endothelial dysfunction, liver and kidney’s damages

scholarly journals SEED EXTRACT OF ABELMOSCHUS MOSCHATUS MEDIK REVERSES NAF-INDUCED BEHAVIORAL CHANGES THROUGH NEURODEGENERATION AND OXIDATIVE STRESS IN BRAIN OF RAT

2017 ◽  
Vol 10 (10) ◽  
pp. 165 ◽  
Author(s):  
Kurmeti Sudhakar ◽  
Mesram Nageshwar ◽  
Pratap Reddy K
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Cell Structure ◽  
Ethanol Extract ◽  
Treated Group ◽  
Seed Extract ◽  
Stress Markers ◽  
Congo Red Staining ◽  
And Oxidative Stress ◽  
Number Of Cells

  Objective: This study reports protective effect of Abelmoschus moschatus seed extract against sodium fluoride-induced neurodegeneration through oxidative stress, neurohistological, and behavioral observations in Wistar rats.Methods: A total of 20 Wistar rats (around 250 g) were randomly classified into four groups, namely, control, fluoride (NaF), fluoride + A. moschatus seed aqueous extract (AMAE), and fluoride + A. moschatus seed ethanol extract (AMEE). The control group animals received normal tap water, fluoride group received fluoridated water at the rate of 40 mg/kg b. wt., 3rd group rats treated with fluoride (40 mg/kg b. wt.) + AMAE (300 mg/kg b. wt.), and 4th group rats treated with fluoride (40 mg/kg b. wt.) + AMEE (300 mg/kg b. wt.). Neurobehavioral responses of rotarod, hot plate, and maze learning tests and oxidantive stress markers including lipid peroxidation (LPO), GSH levels, superoxide dismutase, CAT, and GSH peroxidase (GPx) activities, and also histology with H and E as well as congo red staining were studied in control, fluoride, and A. moschatus seed extract treated against fluoride groups.Results: Decreased neurobehavioral responses with rotarod, hot plate, and maze and enhanced LPO (p<0.05) levels were found in fluoride received animals. Whereas, the superoxide dismutase (SOD), CAT, GSH, and GPx were decreased (p<0.05) in NaF treatment. The rats received seed extract along with NaF showed significant reversal of behavioral and oxidative stress markers and the effect of ethanol extract was more pronounced than aqueous extract. The fluoride-treated group showed disturbed cell structure and reduced number of cells in H and E as well as congo red staining which was reversed in cell morphology and restored cell number in seed extract against NaF-treated group. As a result of increased LPO, decreased antioxidant system, and decreased number of cells, neurodegeneration was observed resulting in the disturbance in functions associated with reported behavior.Conclusion: Okra with high antioxidants activity, seed extract showed reversal of LPO levels and antioxidant status in the brain tissue. And also plant extract administered rats displayed normal cell structure and number of cells than only fluoride received group. Therefore, the aqueous and ethanolic extract of A. moschatus plant seeds has neuroprotective effects against fluoride-induced motor, nociceptive, learning behavior, and on histological structure of brain through antioxidant mechanism. The ethanol extract has shown more efficacy than aqueous extract.

Houttuynia cordata aqueous extract attenuated glycative and oxidative stress in heart and kidney of diabetic mice

2015 ◽  
Vol 55 (2) ◽  
pp. 845-854 ◽  
Author(s):  
Cheng-chin Hsu ◽  
Hui-ting Yang ◽  
Jing-jing Ho ◽  
Mei-chin Yin ◽  
Jen-ying Hsu
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Diabetic Mice ◽  
Houttuynia Cordata ◽  
And Oxidative Stress

scholarly journals Effect of Carthamus Tinctorius Safflower Aqueous Extract Against Nickel Chloride Induces Hematotoxicity and Immunotoxicity in Adult Male Rabbits

2017 ◽  
Vol 30 (3) ◽  
pp. 19
Author(s):  
Layla Abd-Al-Sattar Sadiq Laylani
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Blood Cells ◽  
Hematological Parameters ◽  
Nickel Chloride ◽  
Carthamus Tinctorius ◽  
Stress Factors ◽  
Control Group ◽  
Immunological Parameters ◽  
And Oxidative Stress

  This study was designed to show, the role of Carthamus tinctorius safflower aqueous extract against toxicity of nickel chloride (NiCl2). Twenty male, rabbits were used and divided into four groups (with 5 rabbits in each group); group (control group) received normal diet, group II received orally 100mg/kg NiCl2 for six weeks, group III received 100mg/kg NiCl2 and 100mg/kg extract six weeks, group IV received 100mg/kg NiCl2 and 200mg/ kg extract six weeks. Hematological parameters showed (RBC (Red blood cells), Hb (Hemoglobin), PCV (Packed cells volume) decreased and WBC (White blood cells) increased) significant changes (P < 0.05) compared with control group. Immunological parameters (IgG, IgA and IgM increased) and oxidative stress factors (MDA increased and GSH decreased) show significant changes (P < 0.05) compared with control group. While, safflower aqueous adverse the negative effects of NiCl2 and causing ameliorative effects on all hematological parameters, hematological immunological parameters and oxidative stress factors showed no significant changes (P < 0.05) compared with control group. It was concluded that flower extract of Carthamus tinctorius has been antioxidant role against nickel chloride toxicity in rabbits.  

scholarly journals Centella asiaticaAttenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Nelli Giribabu ◽  
Nelli Srinivasarao ◽  
Somesula Swapna Rekha ◽  
Sekaran Muniandy ◽  
Naguib Salleh
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Centella Asiatica ◽  
Diabetic Rats ◽  
Activity Levels ◽  
Lipid Peroxidation Product ◽  
Histopathological Changes ◽  
Markers Of Inflammation ◽  
Leaf Aqueous Extract ◽  
And Oxidative Stress

Diabetes mellitus has been reported to affect functions of the hippocampus. We hypothesized thatCentella asiatica, a herb traditionally being used to improve memory, prevents diabetes-related hippocampal dysfunction. Therefore, the aim of this study was to investigate the protective role ofC. asiaticaon the hippocampus in diabetes.Methods. Streptozotocin- (STZ-) induced adult male diabetic rats received 100 and 200 mg/kg/day body weight (b.w)C. asiaticaleaf aqueous extract for four consecutive weeks. Following sacrifice, hippocampus was removed and hippocampal tissue homogenates were analyzed for Na+/K+-, Ca2+- and Mg2+-ATPases activity levels. Levels of the markers of inflammation (tumor necrosis factor, TNF-α; interleukin, IL-6; and interleukin, IL-1β) and oxidative stress (lipid peroxidation product: LPO, superoxide dismutase: SOD, catalase: CAT, and glutathione peroxidase: GPx) were determined. The hippocampal sections were visualized for histopathological changes.Results. Administration ofC. asiaticaleaf aqueous extract to diabetic rats maintained near normal ATPases activity levels and prevents the increase in the levels of inflammatory and oxidative stress markers in the hippocampus. Lesser signs of histopathological changes were observed in the hippocampus ofC. asiaticaleaf aqueous extract treated diabetic rats.Conclusions.C. asiaticaleaf protects the hippocampus against diabetes-induced dysfunction which could help to preserve memory in this condition.

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