Prognostic factors and risk factors for development and recurrence of sinonasal papillomas: potential role of different HPV subtypes

2019 ◽  
Vol 277 (3) ◽  
pp. 767-775 ◽  
Author(s):  
A. Pähler vor der Holte ◽  
I. Fangk ◽  
S. Glombitza ◽  
L. Wilkens ◽  
H. J. Welkoborsky
Keyword(s):  
Risk Factors ◽  
Prognostic Factors ◽  
Potential Role

scholarly journals Towards a Consensus on Alzheimer’s Disease Comorbidity?

2021 ◽  
Vol 10 (19) ◽  
pp. 4360
Author(s):  
Iska Avitan ◽  
Yudit Halperin ◽  
Trishna Saha ◽  
Naamah Bloch ◽  
Dana Atrahimovich ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Potential Role ◽  
Oxygen Species ◽  
Degenerative Diseases ◽  
Comorbid Diseases

Alzheimer’s disease (AD) is often comorbid with other pathologies. First, we review shortly the diseases most associated with AD in the clinic. Then we query PubMed citations for the co-occurrence of AD with other diseases, using a list of 400 common pathologies. Significantly, AD is found to be associated with schizophrenia and psychosis, sleep insomnia and apnea, type 2 diabetes, atherosclerosis, hypertension, cardiovascular diseases, obesity, fibrillation, osteoporosis, arthritis, glaucoma, metabolic syndrome, pain, herpes, HIV, alcoholism, heart failure, migraine, pneumonia, dyslipidemia, COPD and asthma, hearing loss, and tobacco smoking. Trivially, AD is also found to be associated with several neurodegenerative diseases, which are disregarded. Notably, our predicted results are consistent with the previously published clinical data and correlate nicely with individual publications. Our results emphasize risk factors and promulgate diseases often associated with AD. Interestingly, the comorbid diseases are often degenerative diseases exacerbated by reactive oxygen species, thus underlining the potential role of antioxidants in the treatment of AD and comorbid diseases.

scholarly journals The Exploration of Poor Ovarian Response–Related Risk Factors: A Potential Role of Growth Differentiation Factor 8 in Predicting Ovarian Response in IVF-ET Patient

2021 ◽  
Vol 12 ◽  
Author(s):  
Long Bai ◽  
Huihui Pan ◽  
Yinjun Zhao ◽  
Qingqing Chen ◽  
Yu Xiang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Growth Factor ◽  
Potential Role ◽  
Transforming Growth Factor ◽  
Ovarian Response ◽  
Poor Ovarian Response ◽  
Aberrant Expression ◽  
Differentiation Factor ◽  
Ivf Et

Controlled ovarian hyperstimulation (COH) is the most common therapeutic protocol to obtain a considerable number of oocytes in IVF-ET cycles. To date, the risk factors affecting COH outcomes remain elusive. Growth differentiation factor 8 (GDF-8), a member of transforming growth factor β (TGF-β) superfamily, has been long discerned as a crucial growth factor in folliculogenesis, and the aberrant expression of GDF-8 is closely correlated with the reproductive diseases. However, less is known about the level of GDF-8 in IVF-ET patients with different ovarian response. In the present study, the potential risk factors correlated with ovarian response were explored using logistic regression analysis methods. Meanwhile, the expression changes of GDF-8 and its responsible cellular receptors in various ovarian response patients were determined. Our results showed that several factors were intensely related to poor ovarian response (POR), including aging, obesity, endometriosis, surgery history, and IVF treatment, while irregular menstrual cycles and PCOS contribute to hyperovarian response (HOR). Furthermore, POR patients exhibited a decrease in numbers of MII oocytes and available embryos, thereby manifesting a lower clinical pregnancy rate. The levels of GDF-8, ALK5, and ACVR2B in POR patients were higher compared with those in control groups, whereas the expression level of ACVR2A decreased in poor ovarian response patients. In addition, clinical correlation analysis results showed that the concentration of GDF-8 was negatively correlated with LH and estradiol concentration and antral follicle count. Collectively, our observations provide a novel insight of ovarian response–associated risk factors, highlighting the potential role of GDF-8 levels in ovarian response during COH process.

scholarly journals Covid-19 and ex-smokers: an underestimated prognostic factor?

2020 ◽  
Vol 90 (3) ◽  
Author(s):  
Pierluigi Carratù ◽  
Roberto Boffi ◽  
Silvano Dragonieri ◽  
Elena Munarini ◽  
Chiara Veronese ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prognostic Factors ◽  
Prognostic Factor ◽  
Protective Factor

Dear Editor, The recent and explosive worldwide outbreak of Covid-19 leads many scientists and clinicians to identify the most responsible triggering risk factors in individuals without comorbidities, as well as potential prognostic factors. A notable field of research has been conducted on the role of smoking, which has been initially hypothesized as being a protective factor for Covid-19....

scholarly journals The Role of MicroRNAs in Selected Forms of Glomerulonephritis

2019 ◽  
Vol 20 (20) ◽  
pp. 5050 ◽  
Author(s):  
Magdalena Nalewajska ◽  
Klaudia Gurazda ◽  
Ewa Styczyńska-Kowalska ◽  
Małgorzata Marchelek-Myśliwiec ◽  
Andrzej Pawlik ◽  
...  
Keyword(s):  
Risk Factors ◽  
Immune System ◽  
Genetic Risk ◽  
Potential Role ◽  
Kidney Diseases ◽  
Diagnostic Techniques ◽  
Targeted Treatments ◽  
Harmful Effects ◽  
Insight Into

Glomerulonephritis (GN) represents a collection of kidney diseases characterized by inflammation within the renal glomeruli and small blood vessels. The lesions that occur in other nephron structures mainly result from the harmful effects of proteinuria. In recent years, an emphasis has been placed on gaining a better insight into the pathogenesis and pathophysiology of GN in order to facilitate diagnoses and provide efficient and targeted treatments of the disease. Owing to the advanced molecular and genetic diagnostic techniques available today, researchers have been able to elucidate that most cases of GN are determined by genetic risk factors and are associated with the abnormal functioning of the immune system (the immunologically mediated forms of GN). MicroRNAs (miRNAs) are a group of single-stranded, non-coding molecules, approximately 20 nucleotides in length, that act as regulatory factors in the post-transcriptional processes capable of regulating the expression of multiple genes. In this paper we present the available research aiming to determine effects of miRNAs on the development and progression of GN and discuss the potential role of miRNAs as new diagnostic markers and therapeutic targets.

scholarly journals BK viremia and polyomavirus nephropathy in 352 kidney transplants; risk factors and potential role of mTOR inhibition

2013 ◽  
Vol 14 (1) ◽  
Author(s):  
Johannes Jacobi ◽  
Antonina Prignitz ◽  
Maike Büttner ◽  
Klaus Korn ◽  
Alexander Weidemann ◽  
...  
Keyword(s):  
Risk Factors ◽  
Potential Role ◽  
Kidney Transplants ◽  
Mtor Inhibition

Risk factors associated with sensitive skin and potential role of lifestyle habits: a cross-sectional study

2017 ◽  
Vol 42 (6) ◽  
pp. 656-658 ◽  
Author(s):  
D. Falcone ◽  
R. J. H. Richters ◽  
N. E. Uzunbajakava ◽  
P. E. J. van Erp ◽  
P. C. M. van de Kerkhof
Keyword(s):  
Risk Factors ◽  
Potential Role ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Sensitive Skin ◽  
Lifestyle Habits ◽  
Cross Sectional ◽  
Factors Associated

scholarly journals Cryptorchidism: Incidence, Risk Factors, and Potential Role of Environment; An Update

2003 ◽  
Vol 24 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Patrick F. Thonneau ◽  
Peggy Candia ◽  
Roger Mieusset
Keyword(s):  
Risk Factors ◽  
Potential Role ◽  
Incidence Risk

scholarly journals The Potential Role of Flavonoids in Ameliorating Diabetic Cardiomyopathy via Alleviation of Cardiac Oxidative Stress, Inflammation and Apoptosis

2021 ◽  
Vol 22 (10) ◽  
pp. 5094
Author(s):  
Fatin Farhana Jubaidi ◽  
Satirah Zainalabidin ◽  
Izatus Shima Taib ◽  
Zariyantey Abd Hamid ◽  
Siti Balkis Budin
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Diabetic Cardiomyopathy ◽  
Mortality Risk ◽  
Potential Role ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Diabetic Patients ◽  
Remedial Actions

Diabetic cardiomyopathy is one of the major mortality risk factors among diabetic patients worldwide. It has been established that most of the cardiac structural and functional alterations in the diabetic cardiomyopathy condition resulted from the hyperglycemia-induced persistent oxidative stress in the heart, resulting in the maladaptive responses of inflammation and apoptosis. Flavonoids, the most abundant phytochemical in plants, have been reported to exhibit diverse therapeutic potential in medicine and other biological activities. Flavonoids have been widely studied for their effects in protecting the heart against diabetes-induced cardiomyopathy. The potential of flavonoids in alleviating diabetic cardiomyopathy is mainly related with their remedial actions as anti-hyperglycemic, antioxidant, anti-inflammatory, and anti-apoptotic agents. In this review, we summarize the latest findings of flavonoid treatments on diabetic cardiomyopathy as well as elucidating the mechanisms involved.

scholarly journals Perioperative Nutritional Aspects in Total Pancreatectomy: A Comprehensive Review of the Literature

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1765
Author(s):  
Niccolò Furbetta ◽  
Annalisa Comandatore ◽  
Desirée Gianardi ◽  
Matteo Palmeri ◽  
Gregorio Di Franco ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pancreatic Cancer ◽  
Prognostic Factors ◽  
Chronic Pancreatitis ◽  
Total Pancreatectomy ◽  
Invasive Procedure ◽  
Review Of The Literature ◽  
Nutritional Factors ◽  
Comprehensive Review

Total pancreatectomy (TP) is a highly invasive procedure often performed in patients affected by anorexia, malabsorption, cachexia, and malnutrition, which are risk factors for bad surgical outcome and even may cause enhanced toxicity to chemo-radiotherapy. The role of nutritional therapies and the association between nutritional aspects and the outcome of patients who have undergone TP is described in some studies. The aim of this comprehensive review is to summarize the available recent evidence about the influence of nutritional factors in TP. Preoperative nutritional and metabolic assessment, but also intra-operative and post-operative nutritional therapies and their consequences, are analyzed in order to identify the aspects that can influence the outcome of patients undergoing TP. The results of this review show that preoperative nutritional status, sarcopenia, BMI and serum albumin are prognostic factors both in TP for pancreatic cancer to support chemotherapy, prevent recurrence and prolong survival, and in TP with islet auto-transplantation for chronic pancreatitis to improve postoperative glycemic control and obtain better outcomes. When it is possible, enteral nutrition is always preferable to parenteral nutrition, with the aim to prevent or reduce cachexia. Nowadays, the nutritional consequences of TP, including diabetes control, are improved and become more manageable.

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