scholarly journals Sarcoma of the breast: breast cancer history as etiologic and prognostic factor—A population-based case–control study

2020 ◽  
Vol 183 (3) ◽  
pp. 669-675 ◽  
Author(s):  
Fredrik Karlsson ◽  
Fredrik Granath ◽  
Karin E. Smedby ◽  
Jan Zedenius ◽  
Robert Bränström ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Strong Association ◽  
Population Based ◽  
Mesenchymal Tumors ◽  
Cancer History ◽  
Angiosarcoma Of The Breast ◽  
History Of ◽  
And Gender ◽  
Breast Breast Cancer ◽  
Control Study

Abstract Purpose Sarcomas of the breast account for about 1% of all breast malignancies. The aim of this national survey was to explore etiologic and prognostic factors. Methods Utilizing national Swedish registers, all patients registered with mesenchymal tumors in the breast during the period 1993–2013 (n = 344) were identified and compared to up to ten age and gender matched controls. Cancer history was retrieved for cases and controls. Conditional Poisson regression models were used for calculation of odds ratios. Results Previous breast cancer was overrepresented among patients with angiosarcoma. The highest risk occurred ≥ 5 years after treatment for breast cancer (OR 73.9, 95% confidence interval, CI, 25.4–215; P < 0.001). An increase in incidence of angiosarcoma was observed during the study period (1.10, 95% CI 1.05–1.16; P < 0.001). The overall incidence of breast sarcoma increased from 1.52 to 2.04 cases per million per year. Angiosarcoma of the breast was associated with a significant excess mortality compared to age-matched controls (HR 4.65, 95% CI 3.01–7.19; P < 0.001). Conclusions Angiosarcoma increased in incidence and displayed a more severe clinical course, with significantly shorter survival. The strong association between a history of breast cancer 5 years or more prior to the diagnosis of angiosarcoma points to radiotherapy as a contributing factor.

scholarly journals Thyroid disorders and breast cancer risk in Asian population: a nationwide population-based case–control study in Taiwan

BMJ Open ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. e020194 ◽  
Author(s):  
Chien-Hsiang Weng ◽  
Yi-Huei Chen ◽  
Ching-Heng Lin ◽  
Xun Luo ◽  
Tseng-Hsi Lin
Keyword(s):  
Breast Cancer ◽  
Index Date ◽  
Case Control Study ◽  
Asian Population ◽  
Population Based ◽  
Case Control ◽  
Thyroid Disorders ◽  
Increased Risk ◽  
History Of ◽  
Control Study

ObjectiveTo evaluate whether hyperthyroidism or hypothyroidism increases the risk of subsequent breast cancer in an Asian population.DesignNationwide population-based case–control study.SettingAll healthcare facilities in Taiwan.ParticipantsA total of 103 466 women (mean age 53.3 years) were enrolled.Methods51 733 adult women with newly diagnosed primary breast cancer without a previous cancer history between 2006 and 2011 were identified and included in our study. 51 733 women with no cancer diagnosis prior to the index date were age matched as controls. Diagnosis of hyperthyroidism or hypothyroidism prior to the diagnosis of breast cancer or the same index date was identified, age, histories of thyroid disease treatment, oestrogen use and radioactive iodine treatment were adjusted.Main outcome measuresTo identify risk differences in developing breast cancer among patients with a medical history of hyperthyroidism or hypothyroidism.ResultsThere was a significantly increased risk of breast cancer in women with hyperthyroidism under the age of 55 years (age <45: OR 1.16, P=0.049; age 45–55: OR 1.15, P=0.019). Patients with hypothyroidism also showed an increased risk of breast cancer (OR 1.19, P=0.029) without statistical significance after stratification by age group (age <45, 45–55, >55 years). Treatment for thyroid disorders did not alter the association in subgroup analyses (P=0.857; 0.262, respectively).ConclusionsAsian women under 55 years of age with history of hyperthyroidism have a significantly increased risk of breast cancer regardless of treatment. Women with history of hypothyroidism may also have an increased risk.

scholarly journals Prevalence of risk factors for breast cancer in women aged 30 years and above in Mumbai

2018 ◽  
Vol 5 (2) ◽  
pp. 647
Author(s):  
Padmavathi V. Dyavarishetty ◽  
Shobha S. Kowli
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Risk Factor ◽  
Population Based ◽  
Individual Risk ◽  
Age At Menarche ◽  
Cross Sectional ◽  
Cancer History ◽  
Increasing Trend ◽  
History Of

Background: Even though there is an increasing trend of breast cancer, women still do not perceive themselves at risk. Poor awareness about the disease and its risk factors and the absence of population based screening contribute to delayed diagnosis. The objective of the study was to assess the prevalence of various risk factors for breast cancer in women aged 30 years and above. Methods: The cross-sectional study using convenience sampling of all women aged 30 years and above was conducted in Mumbai. Of the 2430 women enumerated in the study area, 1158 women participated in the study. Risk factors for breast cancer assessed included age at menarche; age at first child birth; breastfeeding; use of oral contraceptive pills, age of menopause, first degree relatives with history of breast cancer, history of current and past breast cancer; history of any previous breast related abnormalities. Results: 15.5% of the women had atleast one risk factor for breast cancer. The prevalence of individual risk factors was below 6%. Conclusions: Prevalence of the risk factors for breast cancer is not very high, but never the less, the increasing trend of breast cancer in the country makes it imperative to introduce population based screening for all women with or without risk factor. 

Reproductive Factors and Risk of Breast Cancer by Tumour Subtypes Among Ghanaian Women: A Population-Based Case-Control Study

2019 ◽  
Author(s):  
Jonine Figueroa ◽  
Brittny C. Davis Lynn ◽  
Lawrence Edusei ◽  
Nicholas Titiloye ◽  
Ernest Adjei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Reproductive Factors ◽  
Population Based ◽  
Case Control ◽  
Ghanaian Women ◽  
Control Study

scholarly journals MEDALT: single-cell copy number lineage tracing enabling gene discovery

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Fang Wang ◽  
Qihan Wang ◽  
Vakul Mohanty ◽  
Shaoheng Liang ◽  
Jinzhuang Dou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Cell ◽  
Copy Number ◽  
Speciation Analysis ◽  
Population Based ◽  
Lineage Tracing ◽  
Breast Cancer Patients ◽  
Lineage Tree ◽  
History Of ◽  
A Cell

AbstractWe present a Minimal Event Distance Aneuploidy Lineage Tree (MEDALT) algorithm that infers the evolution history of a cell population based on single-cell copy number (SCCN) profiles, and a statistical routine named lineage speciation analysis (LSA), whichty facilitates discovery of fitness-associated alterations and genes from SCCN lineage trees. MEDALT appears more accurate than phylogenetics approaches in reconstructing copy number lineage. From data from 20 triple-negative breast cancer patients, our approaches effectively prioritize genes that are essential for breast cancer cell fitness and predict patient survival, including those implicating convergent evolution.The source code of our study is available at https://github.com/KChen-lab/MEDALT.

scholarly journals Diet and cancer in Northeast Brazil: evaluation of eating habits and food group consumption in relation to breast cancer

2008 ◽  
Vol 24 (4) ◽  
pp. 820-828 ◽  
Author(s):  
Flávia Emília Leite de Lima ◽  
Maria do Rosário Dias de Oliveira Latorre ◽  
Maria José de Carvalho Costa ◽  
Regina Mara Fisberg
Keyword(s):  
Breast Cancer ◽  
Dairy Products ◽  
Case Control Study ◽  
Eating Habits ◽  
Strong Association ◽  
Food Group ◽  
Northeast Brazil ◽  
Food Groups ◽  
Diet And Cancer ◽  
Control Study

A hospital-based case-control study was performed from August 2002 to November 2003 in Northeast Brazil. Eighty-nine women were recruited with histologically confirmed breast cancer (age 30-80 years), matched for age with 94 controls. Food consumption of cases and controls was evaluated by foods and food groups, categorized in consumption tertiles. Odds ratio (OR) and 95% confidence intervals (95%CI) were obtained through unconditional logistic regression. Intake of fruits and juices, beans, and dairy products showed a strong association with reduced risk of breast cancer. Consumption of red and fried meat was positively associated with risk of breast cancer (red meat - OR = 4.30; 95%CI: 1.74-10.67; p for trend = 0.00). No association was observed in vegetable and sausage meat groups and breast cancer. Red and fried meat may be risk factors, and intake of fruit, beans, and dairy products may protect against breast cancer.

Immune-response against Streptococcus pyogenes in the development of abdominal aortic aneurysm – A population-based case-control study

VASA ◽  
2008 ◽  
Vol 37 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Wanhainen ◽  
Rasmussen ◽  
Björck ◽  
Björck
Keyword(s):  
Immune Response ◽  
Abdominal Aortic Aneurysm ◽  
Streptococcus Pyogenes ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Abdominal Aortic ◽  
History Of ◽  
Antibody Levels ◽  
Control Study

Background: In a population-based case-control study the association between antibodies to Streptococcus pyogenes antigens and the development of abdominal aortic aneurysm (AAA) was analysed. Patients and methods: Forty-two patients with screening-detected AAA were compared to 100 age- and sex matched controls with normal aortas. Antibodies against three recently characterized cell wall-attached proteins of S. pyogenes (SclA, SclB and GRAB) were analysed in plasma samples obtained at screening (current), and in samples obtained from a study conducted 12 years previously on the same population (historical). Results: Historical antibody levels against the S. pyogenes antigen GRAB were significantly higher in AAA patients compared with controls (0.25 vs 0.17, p = 0.021). A similar trend was observed in current GRAB antibody levels (0.23 vs 0.17, p = 0.072). GRAB-antibody levels at age 60 years retained the association with AAA in a logistic regression model after adjustment for a history of atherosclerosis (OR 20.2, p = 0.022), current smoking (OR 21.4, p = 0.025) and family history of AAA (OR 12.9, p = 0.053). Current and historical antibody levels against SclA and SclB in AAA patients were similar to those in controls. Conclusions: The results indicate that the immune response against S. pyogenes protein GRAB may be involved in the pathogenesis of AAA.

MnSOD polymorphism and breast cancer in a population-based case–control study

2003 ◽  
Vol 199 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Kathleen M Egan ◽  
Patricia A Thompson ◽  
Linda Titus-Ernstoff ◽  
Jason H Moore ◽  
Christine B Ambrosone
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Mnsod Polymorphism ◽  
Control Study
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