scholarly journals Assessing the Organizational Climate for Translational Research with a New Survey Tool

2020 ◽  
Vol 26 (6) ◽  
pp. 2893-2910 ◽  
Author(s):  
Arno Simons ◽  
Nico Riedel ◽  
Ulf Toelch ◽  
Barbara Hendriks ◽  
Stephanie Müller-Ohlraun ◽  
...  
Keyword(s):  
Organizational Climate ◽  
Translational Research ◽  
Assessment Tool ◽  
Research Integrity ◽  
University Hospital ◽  
Practical Implementation ◽  
Research Practices ◽  
Survey Tool ◽  
Research Climate ◽  
The Impact

AbstractPromoting translational research as a means to overcoming chasms in the translation of knowledge through successive fields of research from basic science to public health impacts and back is a central challenge for research managers and policymakers. Organizational leaders need to assess baseline conditions, identify areas needing improvement, and to judge the impact of specific initiatives to sustain or improve translational research practices at their institutions. Currently, there is a lack of such an assessment tool addressing the specific context of translational biomedical research. To close this gap, we have developed a new survey for assessing the organizational climate for translational research. This self-assessment tool measures employees’ perceptions of translational research climate and underlying research practices in organizational environments and builds on the established Survey of Organizational Research Climate, assessing research integrity. Using this tool, we show that scientists at a large university hospital (Charité Berlin) perceive translation as a central and important component of their work. Importantly, local resources and direct support are main contributing factors for the practical implementation of translation into their own research practice. We identify and discuss potential leverage points for an improvement of research climate to foster successful translational research.

scholarly journals Assessing the organizational climate for translational research with a new survey tool

2019 ◽  
Author(s):  
Arno Simons ◽  
Nico Riedel ◽  
Ulf Toelch ◽  
Barbara Hendriks ◽  
Stephanie Ohlraun ◽  
...  
Keyword(s):  
Organizational Climate ◽  
Translational Research ◽  
Assessment Tool ◽  
University Hospital ◽  
Practical Implementation ◽  
Contributing Factors ◽  
Research Practices ◽  
Survey Tool ◽  
Research Climate ◽  
The Impact

Promoting biomedical translation from bench to bedside and back in organizational settings is a central challenge for research managers and policymakers. For this, organizational leaders need to assess baseline conditions, identify areas needing improvement, and to judge the impact of specific initiatives to sustain or improve translational research practices at their institutions. Currently, there is a lack of such an assessment tool addressing the specific context of translational biomedical research. To close this gap, we have developed and tested a new survey for assessing the organizational climate for translational research. This self-assessment tool measures employees’ perceptions of translational climate and underlying research practices in organizational environments and builds on the established Survey of Organizational Research Climate. Having implemented the new survey in practice, we show that scientists at a large university hospital (Charité Berlin) perceive translation as a central and important component of their work. Importantly, local resources and direct support are main contributing factors for the practical implementation of translation into their own research practice. We identify and discuss potential leverage points for an improvement of research climate to foster successful translational research.

scholarly journals Rethinking success, integrity, and culture in research (Part 2) — A multi-actor qualitative study on problems of science

2020 ◽  
Author(s):  
Noémie Aubert Bonn ◽  
Wim Pinxten
Keyword(s):  
Research Misconduct ◽  
Research Integrity ◽  
Structured Interviews ◽  
Community Members ◽  
Research Practices ◽  
Research Issues ◽  
Questionable Research Practices ◽  
The Rich ◽  
Research Students ◽  
The Impact

ABSTRACTBackgroundResearch misconduct and questionable research practices have been the subject of increasing attention in the past few years. But despite the rich body of research available, few empirical works provide the perspectives of non-researcher stakeholders.MethodsTo capture some of the forgotten voices, we conducted semi-structured interviews and focus groups with policy makers, funders, institution leaders, editors or publishers, research integrity office members, research integrity community members, laboratory technicians, researchers, research students, and former-researchers who changed career to inquire on the topics of success, integrity, and responsibilities in science. We used the Flemish biomedical landscape as a baseline to be able to grasp the views of interacting and complementary actors in a system setting.ResultsGiven the breadth of our results, we divided our findings in a two-paper series with the current paper focusing on the problems that affect the quality and integrity of science. We first discovered that perspectives on misconduct, including the core reasons for condemning misconduct, differed between individuals and actor groups. Beyond misconduct, interviewees also identified numerous problems which affect the integrity of research. Issues related to personalities and attitudes, lack of knowledge of good practices, and research climate were mentioned. Elements that were described as essential for success (in the associate paper) were often thought to accentuate the problems of research climates by disrupting research cultures and research environments. Even though everyone agreed that current research climates need to be addressed, no one felt responsible nor capable of initiating change. Instead, respondents revealed a circle of blame and mistrust between actor groups.ConclusionsOur findings resonate with recent debates, and extrapolate a few action points which might help advance the discussion. First, we must tackle how research is assessed. Second, approaches to promote better science should be revisited: not only should they directly address the impact of climates on research practices, but they should also redefine their objective to empower and support researchers rather than to capitalize on their compliance. Finally, inter-actor dialogues and shared decision making are crucial to building joint objectives for change.Trial registrationosf.io/33v3m

scholarly journals EFFECT OF PREOPERATIVE PREPARATION ON PATIENTS OUTCOME AMONG PATIENTS UNDERGOING SURGICAL OPERATIONS AT ALMIK NIMIR HOSPITAL – SUDAN

2020 ◽  
Vol 8 (8) ◽  
pp. 346-355
Author(s):  
Eied Saber Al amine Ali ◽  
Higazi Mohammed Ahmed Abdallah
Keyword(s):  
Assessment Tool ◽  
Elective Surgery ◽  
Computer Software ◽  
University Hospital ◽  
Care Plan ◽  
Postoperative Phase ◽  
Preoperative Preparation ◽  
Quasi Experimental ◽  
Two Phases ◽  
The Impact

Preoperative preparations of the patients physically and psychologically are the cornerstone of the good outcomes. This prospective quasi-experimental hospital-based study was conducted in Sudan, Shendi city at Elmek Nimer university hospital to evaluate the impact of preoperative preparation on patients outcome among patients undergoing general surgery. In the period of June 2016 to May 2019. The study was included a hundred patients undergoing general elective surgery, data were collected by interviewing questionnaire, anxiety scale, pain assessment tool, postoperative parameter, and patients satisfaction tool, data were collected in two phases (pre& postoperative). The data were analyzed by the computer software program (SPPS) version 20. The results showed that more than two third (79.4%) of the patient had poor knowledge about the importance of preoperative preparations, but improve after implemented program and this was reflected on patient behavior and outcome in the postoperative phase. (70%) had reported no anxiety to mild in the postoperative phase. in regard of postoperative pain, majority of patients (70%) experienced moderate to severe level of pain in the first 4 hours, this level of pain reduce to mild to no pain level in (82%) of patients in next 12hours. Most of the patients had full to good satisfaction regarding preparations and outcome. The study support and justifies the effectiveness of the preoperative preparations on patient outcomes. The study recommended surgical nurses have to provide proper explanation and teaching for elective surgical patients to be adherence with the care plan to promote good surgical outcome.

scholarly journals Explaining variance in perceived research misbehavior - Results from a survey among academic researchers in Amsterdam

2020 ◽  
Author(s):  
Tamarinde Laura Haven ◽  
Joeri K. Tijdink ◽  
Brian C Martinson ◽  
Lex Bouter ◽  
Frans J. Oort
Keyword(s):  
Research Question ◽  
Research Integrity ◽  
Climate Factors ◽  
Measurement Instruments ◽  
Research Practices ◽  
Academic Researchers ◽  
Research Climate ◽  
Academic Organization ◽  
Responsible Research

Breaches of research integrity have sparked interest in the factors that may help explain when research misbehavior is more likely to occur. Often three clusters of factors are distinguished: individual factors, climate factors and publication factors. Our research question is: to what extent can individual, climate and publication factors explain the variance in frequently perceived research misbehaviors? We used validated measurement instruments for these three clusters of factors to survey academic researchers in Amsterdam. Results showed that individual, climate and publication factors combined explain 32% of variance in perceived frequency of research misbehavior. The cluster accounting for the greatest percentage of explained variance was the research climate (23%). The research climate factors included in our study concern perceptions of specific dimensions of the academic organization, such as the existence of research-related norms and socialization activities into responsible research practices within a department, and the quality of resources an institute has available to support researchers in their work. Our results underscore the important role of the research climate in fostering responsible research practices and suggest that the frequency of research misbehaviors might be lowered by putting more emphasis on the socialization into ethical departmental norms and creating an open departmental atmosphere.

Antecedents And Outcomes Of Qwl Among Employees In Banks

2019 ◽  
Vol 118 (7) ◽  
pp. 1-19
Author(s):  
Geethanjali N ◽  
Parveen Roja M ◽  
Lavanya D
Keyword(s):  
Organizational Climate ◽  
Job Stress ◽  
Work Life ◽  
Working Environment ◽  
Quality Of Work Life ◽  
Quality Of Work ◽  
Significant Difference ◽  
Service Productivity ◽  
The Impact

Quality of work life is the major factor to be considered in working environment of any organization. The performance of employees and the organization lies on the ability of the employees based on working environment. The QWL leads to better working environment which improves the performance of organization. The present study has made an attempt to find the level of factors causing QWL and the impact of outcome of QWL in banks. Since the profile of the banks may be associated with the level of outcomes of QWL, the present study has made an attempt to examine it with the help of one way analysis of variance and t-test. The included outcomes of QWL are job satisfaction, job stress, organizational climate, organizational commitment, employees retention behaviour, service quality employees and service productivity of employees. The highly associated determinants of QWL and the significant difference among the PUSBs and PRSBs have been noticed. The significantly associating important profiles of the banks regarding the existence of outcome of QWL are identified.

The Impact of Translational Research in Breast Cancer Care: Can we Improve the Therapeutic Scenario?

2018 ◽  
Vol 18 (6) ◽  
pp. 832-836
Author(s):  
Giuseppe Buono ◽  
Francesco Schettini ◽  
Francesco Perri ◽  
Grazia Arpino ◽  
Roberto Bianco ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Translational Research ◽  
Cell Biology ◽  
Cancer Biology ◽  
Hormone Receptors ◽  
Treatment Strategies ◽  
Growth Factor Receptor ◽  
Molecular Heterogeneity ◽  
Therapeutic Implications ◽  
The Impact

Traditionally, breast cancer (BC) is divided into different subtypes defined by immunohistochemistry (IHC) according to the expression of hormone receptors and overexpression/amplification of human epidermal growth factor receptor 2 (HER2), with crucial therapeutic implications. In the last few years, the definition of different BC molecular subgroups within the IHC-defined subtypes and the identification of the important role that molecular heterogeneity can play in tumor progression and treatment resistance have inspired the search for personalized therapeutic approaches. In this scenario, translational research represents a key strategy to apply knowledge from cancer biology to the clinical setting, through the study of all the tumors “omics”, including genomics, transcriptomics, proteomics, epigenomics, and metabolomics. Importantly, the introduction of new high-throughput technologies, such as next generation sequencing (NGS) for the study of cancer genome and transcriptome, greatly amplifies the potential and the applications of translational research in the oncology field. Moreover, the introduction of new experimental approaches, such as liquid biopsy, as well as new-concept clinical trials, such as biomarker-driven adaptive studies, may represent a turning point for BC translational research. </P><P> It is likely that translational research will have in the near future a significant impact on BC care, especially by giving us the possibility to dissect the complexity of tumor cell biology and develop new personalized treatment strategies.

Understanding the Impact of Bullying in a Unionized U.S. Public Sector Workforce

2019 ◽  
Vol 68 (3) ◽  
pp. 139-153 ◽  
Author(s):  
Mazen El Ghaziri ◽  
Shellie Simons ◽  
Jane Lipscomb ◽  
Carla L. Storr ◽  
Kathleen McPhaul ◽  
...  
Keyword(s):  
Public Sector ◽  
Organizational Climate ◽  
Negative Impact ◽  
Multinomial Logistic Regression ◽  
Female Gender ◽  
Bargaining Unit ◽  
Organizational Level ◽  
Organizational Impact ◽  
Cross Sectional ◽  
The Impact

Background: Workplace Bullying (WPB) can have a tremendous, negative impact on the victims and the organization as a whole. The purpose of this study was to examine individual and organizational impact associated with exposure to bullying in a large U.S. unionized public sector workforce. Methods: A cross-sectional Web-based survey was conducted among 16,492 U.S. state government workers. Survey domains included demographics, negative acts (NAs) and bullying, supportiveness of the organizational climate, and individual and organizational impacts of bullying. Multinomial logistic regression was used to assess the impact among respondents who reported exposure to bullying. Findings: A total of 72% participants responded to the survey (n = 11,874), with 43.7% (n = 5,181) reporting exposure to NAs and bullying. A total of 40% (n = 4,711) participants who experienced WPB reported individual impact(s) while 42% ( n = 4,969) reported organization impact(s). Regular NA was associated with high individual impact (negatively impacted them personally; odds ratio [OR] = 5.03) when controlling for other covariates including: female gender (OR =1.89) and job tenure of 6 to 10 years (OR = 1.95); working in a supportive organizational climate and membership in a supportive bargaining unit were protective of high impact (OR = 0.04 and OR = 0.59, respectively). High organizational impact (transferring to another position) was associated with regular NA and bullying (OR = 16.26), female gender (OR = 1.55), providing health care and field service (OR = 1.68), and protective effect of organizational climate (OR = 0.39). We found a dose-response relationship between bullying and both individual and organizational-level impact. Conclusion/Application to Practice: Understanding the impacts of WPB should serve to motivate more workplaces and unions to implement effective interventions to ameliorate the problem by enhancing the organizational climate, as well as management and employee training on the nature of WPB and guidance on reporting.

scholarly journals Outcomes of COVID-19 Hospitalized Patients Previously Treated with Renin-Angiotensin System Inhibitors

2020 ◽  
Vol 9 (11) ◽  
pp. 3472 ◽  
Author(s):  
Elena-Mihaela Cordeanu ◽  
Lucas Jambert ◽  
Francois Severac ◽  
Hélène Lambach ◽  
Jonathan Tousch ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
Severe Pneumonia ◽  
University Hospital ◽  
Angiotensin System ◽  
Angiotensin Converting Enzyme 2 ◽  
Renin Angiotensin ◽  
Previously Treated ◽  
The Impact ◽  
Harmful Effects ◽  
Observation Period

(1) Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) penetrates respiratory epithelium through angiotensin-converting enzyme-2 binding, raising concerns about the potentially harmful effects of renin–angiotensin system inhibitors (RASi) on Human Coronavirus Disease 2019 (COVID-19) evolution. This study aimed to provide insight into the impact of RASi on SARS-CoV-2 outcomes in patients hospitalized for COVID-19. (2) Methods: This was a retrospective analysis of hospitalized adult patients with SARS-CoV-2 infection admitted to a university hospital in France. The observation period ended at hospital discharge. (3) Results: During the study period, 943 COVID-19 patients were admitted to our institution, of whom 772 were included in this analysis. Among them, 431 (55.8%) had previously known hypertension. The median age was 68 (56–79) years. Overall, 220 (28.5%) patients were placed under mechanical ventilation and 173 (22.4%) died. According to previous exposure to RASi, we defined two groups, namely, “RASi” (n = 282) and “RASi-free” (n = 490). Severe pneumonia (defined as leading to death and/or requiring intubation, high-flow nasal oxygen, noninvasive ventilation, and/or oxygen flow at a rate of ≥5 L/min) and death occurred more frequently in RASi-treated patients (64% versus 53% and 29% versus 19%, respectively). However, in a propensity score-matched cohort derived from the overall population, neither death (hazard ratio (HR) 0.93 (95% confidence interval (CI) 0.57–1.50), p = 0.76) nor severe pneumonia (HR 1.03 (95%CI 0.73–1.44), p = 0.85) were associated with RASi therapy. (4) Conclusion: Our study showed no correlation between previous RASi treatment and death or severe COVID-19 pneumonia after adjustment for confounders.

scholarly journals Development of a Rapid Risk and Impact Assessment Tool to Enhance Response to Environmental Emergencies in the Early Stages of a Disaster: A Tool Developed by the European Multiple Environmental Threats Emergency NETwork (EMETNET) Project

2021 ◽  
Author(s):  
Emma-Jane Goode ◽  
Eirian Thomas ◽  
Owen Landeg ◽  
Raquel Duarte-Davidson ◽  
Lisbeth Hall ◽  
...  
Keyword(s):  
Public Health ◽  
Impact Assessment ◽  
Assessment Tool ◽  
The European Union ◽  
Protection Mechanism ◽  
Environmental Threats ◽  
Environmental Disasters ◽  
Early Stages ◽  
Potential Risks ◽  
The Impact

AbstractEvery year, numerous environmental disasters and emergencies occur across the globe with far-reaching impacts on human health and the environment. The ability to rapidly assess an environmental emergency to mitigate potential risks and impacts is paramount. However, collating the necessary evidence in the early stages of an emergency to conduct a robust risk assessment is a major challenge. This article presents a methodology developed to help assess the risks and impacts during the early stages of such incidents, primarily to support the European Union Civil Protection Mechanism but also the wider global community in the response to environmental emergencies. An online rapid risk and impact assessment tool has also been developed to promote enhanced collaboration between experts who are working remotely, considering the impact of a disaster on the environment and public health in the short, medium, and long terms. The methodology developed can support the appropriate selection of experts and assets to be deployed to affected regions to ensure that potential public health and environmental risks and impacts are mitigated whenever possible. This methodology will aid defensible decision making, communication, planning, and risk management, and presents a harmonized understanding of the associated impacts of an environmental emergency.

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