scholarly journals Overview on developed synthesis procedures of coumarin heterocycles

2020 ◽  
Vol 17 (12) ◽  
pp. 3031-3094 ◽  
Author(s):  
Masoud Mohammadi Zeydi ◽  
Seyed Jafar Kalantarian ◽  
Zahra Kazeminejad
Keyword(s):  
Biological Properties ◽  
Synthesis Methods ◽  
Green Solvent ◽  
Green Condition ◽  
Pharmaceutical Properties ◽  
Coumarin Ring

Abstract Considering highly valuable biological and pharmaceutical properties of coumarins, the synthesis of these heterocycles has been considered for many organic and pharmaceutical chemists. This review includes the recent research in synthesis methods of coumarin systems, investigating their biological properties and describing the literature reports for the period of 2016 to the middle of 2020. In this review, we have classified the contents based on co-groups of coumarin ring. These reported methods are carried out in the classical and non-classical conditions particularly under green condition such as using green solvent, catalyst and other procedures.

scholarly journals Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1719 ◽  
Author(s):  
Deepak Gupta ◽  
Deepak Bhatia ◽  
Vivek Dave ◽  
Vijaykumar Sutariya ◽  
Sheeba Varghese Gupta
Keyword(s):  
Selection Criteria ◽  
Opposite Effect ◽  
Biological Properties ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Salt Form ◽  
Pharmaceutical Ingredients ◽  
Selection Processes ◽  
Salt Selection ◽  
Pharmaceutical Properties ◽  
Salt Forms

The physicochemical and biological properties of active pharmaceutical ingredients (APIs) are greatly affected by their salt forms. The choice of a particular salt formulation is based on numerous factors such as API chemistry, intended dosage form, pharmacokinetics, and pharmacodynamics. The appropriate salt can improve the overall therapeutic and pharmaceutical effects of an API. However, the incorrect salt form can have the opposite effect, and can be quite detrimental for overall drug development. This review summarizes several criteria for choosing the appropriate salt forms, along with the effects of salt forms on the pharmaceutical properties of APIs. In addition to a comprehensive review of the selection criteria, this review also gives a brief historic perspective of the salt selection processes.

scholarly journals ROLE OF NANOTECHNOLOGY IN DENTAL SCIENCES: A REVIEW

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Ramakoteswara Rao N ◽  
Kranthi kiran Reddy E ◽  
Leena Gahane ◽  
SV Ranganayakulu
Keyword(s):  
Materials Science ◽  
Biological Properties ◽  
Synthesis Methods ◽  
Nano Technology ◽  
New Science ◽  
Physical Chemical ◽  
Health Related ◽  
Nano Science ◽  
Physical And Chemical

Nano technology is the multi disciplinary science and technology, which has emerged as new science exploiting specific phenomena and direct manipulation of materials on nanoscale. Nanotechnology deals with the physical, chemical, and biological properties of structures and their parts at nanoscale dimensions. It's established on the concept by creating functional structures by controlling corpuscles and molecules on a one-by-one basis by different physical and chemical synthesis methods. Developments in materials science and, nano biotechnology is especially forestalled to provide elevates in dental sciences and initiations in oral health-related diagnostic and therapeutical methods. Keywords: Nano Science, dentistry, Nanocomposite, Nanorobots, Nanomaterials.

Cyclodextrins as multifunctional excipients

2019 ◽  
Vol 6 ◽  
pp. 67-76
Author(s):  
Magdalena Paczkowska ◽  
Judyta Cielecka-Piontek
Keyword(s):  
Chemical Stability ◽  
Biological Properties ◽  
Base Hydrolysis ◽  
Active Pharmaceutical Ingredients ◽  
Acid Base ◽  
Pharmaceutical Ingredients ◽  
Dry Mixing ◽  
Pharmaceutical Properties ◽  
Permeability Studies ◽  
Hydrolysis Conditions

Cyclodextrins are pharmaceutical excipients which can form inclusion complexes. They are mainly used to increase the solubility of active pharmaceutical ingredients, which causes increased bioavailability. In addition, they can mask the taste and smell, affect the modification of biological properties and increase its chemical stability. The aim of the studies was to determine the possibility of using cyclodextrins as substances modifying chemical stability of model labile active pharmaceutical ingredients for which the susceptibility to degradation in acid-base hydrolysis (meropenem), thermolysis (meropenem), oxidation (cetirizine) or photolysis (rutin) has been previously proven. The extension of the research was a parallel assessment of the effect of cyclodextrin on selected physicochemical and biological properties important due to the possibility of modifying the pharmaceutical properties of selected model labile active pharmaceutical ingredients. In the first stage, preparations of labile systems of active pharmaceutical ingredients with β-cyclodextrin were carried out using kneading and dry mixing methods. Next, the identity of the obtained systems was confirmed using spectral (UV, FT-IR, Raman, XRPD), thermal (DSC) and microscopic (SEM) methods. The analytical methods (UV method for meropenem, HILIC for cetirizine and UHPLC-DAD for rutin) have been developed and validated to assess the changes in the concentration of model labile active pharmaceutical ingredients during stability, solubility and permeability studies through artificial biological membranes. The conducted research confirms the possibility of modifying the chemical stability of labile active pharmaceutical ingredients under acid- -base hydrolysis conditions, thermolysis, oxidation and photolysis. They also confirm the beneficial effect of the presence of inclusion systems based on cyclodextrin systems on parameters for other pharmaceutical properties of active substances, especially such as dissolution dynamics, dissolution rate, permeability and eventually bioavailability.

scholarly journals Isolation and Partial Purification of Bioactive Compounds from Sponge Sigmadocia Fibulata (Schmidt) Collected from West Coast of Mumbai, India

2021 ◽  
Vol 14 (3) ◽  
pp. 1675-1684
Author(s):  
Bhadekar N. S ◽  
Zodape G.V
Keyword(s):  
Bioactive Compounds ◽  
West Coast ◽  
Acid Methyl Ester ◽  
Biological Properties ◽  
Partial Purification ◽  
Acid Metabolite ◽  
Fatty Acid Metabolite ◽  
Plant Metabolite ◽  
Pharmaceutical Properties ◽  
Layer Chromatography

The sponge Sigmadocia fibulata (Schmidt) was collected during low tides from West Coast of Mumbai. Crude extract was obtained by taking 10 gram of sponge samples in10 ml of methanol. The preparative TLC (Thin Layer Chromatography) was performed by using Toluene: Ethyl acetate: Diethylamine (7:2:1) (v/v). The isolated compounds were subjected to GC-MS and FTIR analysis. The structural properties of bio active compounds were determined.From the structural determination it was confirmed that S. fibulata contains bioactive compounds as Triacontanoic acid, methyl ester – (Skin irritant), Hexadecanoic acid, 2- hydroxyl- (hydroxymethyl) ethyl ester – (Fatty acid, Metabolite and Irritant) and 2-Nitro-1, 3-bis-oclyoxy-benzene, (A natural product found in Neolitsea daibuensis. It has a role as a plant metabolite and an algal metabolite). From their biological properties it was confirmed that S. fibulata contains bio active compound, which has biomedical and pharmaceutical properties.

scholarly journals Nanoremediation: Tiny objects solving Huge environmental problems

2020 ◽  
Vol 14 ◽  
Author(s):  
Andrea Rónavári ◽  
Zoltán Kónya
Keyword(s):  
Iron Nanoparticles ◽  
State Of The Art ◽  
Current Knowledge ◽  
Biological Properties ◽  
High Reactivity ◽  
Synthesis Methods ◽  
Inorganic Contaminants ◽  
Chlorinated Organic ◽  
Zero Valent Iron Nanoparticles ◽  
Effective Use

Background:: The application of zero valent iron nanoparticles (nZVI) to remediate soil and groundwater has gained increased attention within the last decade, primarily due to its high reactivity, cost effectiveness and potential to treat a broad range of contaminants (e.g. chlorinated organic solvents, inorganic anions, or metals). Objective:: In this paper, the state of the art of the applicability of nanomaterials especially the most frequently used nZVI in soil and groundwater is presented. The purpose of this article is to give an overview of the current knowledge pertaining to the synthesis, employment, limitations, and risk of iron nanoparticles. Methods:: Therefore, the authors have reviewed and discussed the recent patents and papers related to the developments and approaches made on the synthesis of iron nanoparticles emphasizing the justification of green synthesis methods. The studies related to the effective use of nanoparticles in remediating organic and inorganic contaminants are addressed. The potential limitations, challenges, and risks of this innovative nanoremediation technology are also discussed. Results:: Studies suggest that nZVI have successfully been applied in nanoremediation, however little is known about the particles’ fate and impacts. Additionally, it has already been proven that synthesis and modification can largely determine the physicochemical and biological properties of the particles. Conclusion:: This review corroborates the suitability of nanoparticles in the remediation of contaminated media, simultaneously highlighting the work still needed to optimize the syntheses and careful use of such materials, concluding that comprehensive screenings should be performed prior nZVI applications to assess their behavior and impact on the environment and living systems.

scholarly journals Cinnoline Scaffold—A Molecular Heart of Medicinal Chemistry?

Molecules ◽  
2019 ◽  
Vol 24 (12) ◽  
pp. 2271 ◽  
Author(s):  
Marta Szumilak ◽  
Andrzej Stanczak
Keyword(s):  
Clinical Trials ◽  
Significant Contribution ◽  
Biological Properties ◽  
Research Groups ◽  
Antitumor Activities ◽  
Pharmacological Activities ◽  
Lead Compounds ◽  
Pharmacokinetic Properties ◽  
Structural Subunit ◽  
Pharmaceutical Properties

The cinnoline nucleus is a very important bicyclic heterocycle that is used as the structural subunit of many compounds with interesting pharmaceutical properties. Cinnoline derivatives exhibit broad spectrum of pharmacological activities such as antibacterial, antifungal, antimalarial, anti-inflammatory, analgesic, anxiolytic and antitumor activities. Some of them are under evaluation in clinical trials. In the present review, we have compiled studies focused on the biological properties of cinnoline derivatives conducted by many research groups worldwide between 2005 and 2019. Comprehensive and target oriented information clearly indicate that the development of cinnoline based molecules constitute a significant contribution to the identification of lead compounds with optimized pharmacodynamic and pharmacokinetic properties.

SPIONs and magnetic hybrid materials: Synthesis, toxicology and biomedical applications

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ralf P. Friedrich ◽  
Christina Janko ◽  
Harald Unterweger ◽  
Stefan Lyer ◽  
Christoph Alexiou
Keyword(s):  
Hybrid Materials ◽  
Biomedical Applications ◽  
Volume Ratio ◽  
Superparamagnetic Iron Oxide ◽  
Biological Properties ◽  
Magnetic Drug Targeting ◽  
Synthesis Methods ◽  
Materials Synthesis ◽  
Low Toxicity ◽  
Review Reports

Abstract In the past decades, a wide variety of different superparamagnetic iron oxide nanoparticles (SPIONs) have been synthesized. Due to their unique properties, such as big surface-to-volume ratio, superparamagnetism and comparatively low toxicity, they are principally well suited for many different technical and biomedical applications. Meanwhile, there are a numerous synthesis methods for SPIONs, but high requirements for biocompatibility have so far delayed a successful translation into the clinic. Moreover, depending on the planned application, such as for imaging, magnetic drug targeting, hyperthermia or for hybrid materials intended for regenerative medicine, specific physicochemical and biological properties are inevitable. Since a summary of all existing SPION systems, their properties and application is far too extensive, this review reports on selected methods for SPION synthesis, their biocompatibility and biomedical applications.

scholarly journals Nanostructured titanium dioxide for use in bone implants: a short review

Cerâmica ◽  
2020 ◽  
Vol 66 (380) ◽  
pp. 440-450
Author(s):  
I. A. Bezerra Neta ◽  
M. F. Mota ◽  
H. L. Lira ◽  
G. A. Neves ◽  
R. R. Menezes
Keyword(s):  
Titanium Dioxide ◽  
State Of The Art ◽  
Short Review ◽  
Biological Properties ◽  
High Specific Surface Area ◽  
Synthesis Methods ◽  
Bone Implants ◽  
Nanostructured Tio2 ◽  
Support Cell ◽  
Insight Into

Abstract Titanium dioxide (TiO2) based nanostructured materials have shown great potential for use in implants thanks to their excellent physicochemical properties, such as high specific surface area, ability to elicit positive cell response, and stability in body fluids. However, there are few studies in the literature that focus on the use of nanostructured TiO2 to support cell growth and bone regeneration. The purpose of this survey is to review the state of the art of TiO2 for use in bone implants, as well as provide insight into its characteristics and synthesis methods. Studies of the biological properties of nanostructured TiO2 are described, establishing its potential for the biomedical field.

scholarly journals New Approaches in Synthesis and Characterization Methods of Iron Oxide Nanoparticles

2022 ◽  
Author(s):  
Cristina Chircov ◽  
Bogdan Stefan Vasile
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Recent Progress ◽  
Biological Properties ◽  
Synthesis And Characterization ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Synthesis Methods ◽  
Characterization Methods ◽  
Molecular Separation

Recent years have witnessed an extensive application of iron oxide nanoparticles within a wide variety of fields, including drug delivery, hyperthermia, biosensing, theranostics, and cell and molecular separation. Consequently, synthesis and characterization methods have continuously evolved to provide the possibility for controlling the physico-chemical and biological properties of the nanoparticles to better suit the envisaged applications. In this manner, this chapter aims to provide an extensive overview of the most recent progress made within the processes of iron oxide nanoparticle synthesis and characterization. Thus, the chapter will focus on novel and advanced approaches reported in the literature for obtaining standardized nanoparticles with controllable properties and effects. Specifically, it will emphasize the most recent progress made within the microwave-assisted, microfluidics, and green synthesis methods, as they have shown higher capacities of controlling the outcome nanoparticle properties.

Synthesis Method and Investigation of o-, m-, p-Nitrophenylarsonic Acid Properties

2019 ◽  
Vol 16 (11) ◽  
pp. 4481-4485
Author(s):  
Farid Dgamaletdinovich Yambyshev
Keyword(s):  
Diazonium Salt ◽  
Synthesis Method ◽  
Cardiac Activity ◽  
Biological Properties ◽  
Biologically Active ◽  
Synthesis Methods ◽  
Acid Sodium Salt ◽  
Wide Range ◽  
Compound Synthesis ◽  
Interesting Object

The importance of studying arylated arsenic derivatives is conditioned by a number of reasons. In particular, as biologically active substances, they attract attention in terms of their fungicidal activity and stimulating effect on cardiac activity. Besides, they serve as an interesting object for intermolecular interaction study conditioned by the H-bond. Finally, as the main starting products, they are the source of a wide range of arsenic-organic compound synthesis, including aromatic primary, secondary arsinghalides, tertiary asymmetric arsines and their derivatives. The aim of the present work was to study the possibility of diazonium salt use obtained from weakly basic arylamines in a strongly acidic medium for arylation of arsinic acid sodium salt. This article discusses the methods for the synthesis of arylated arsenic derivatives containing the substituents in the benzene ring that affect the electronic structure, reactivity, and biological properties of the compounds. They studied the ability of an arsenic atom to transit from a four-coordinate state to a five-coordinate state with the formation of strong monohydrates. They showed the disadvantages and positive aspects of the already known and used synthesis methods. The most practical version of arylated arsenic compound synthesis has been tested and recommended.

Sign in / Sign up

Export Citation Format

Share Document