Conclusion:
Stroke is a complex disease caused by genetic and environmental factors, and its etiological
mechanism has not been fully clarified yet, which brings great challenges to its effective prevention
and treatment. MAPK signaling pathway regulates gene expression of eukaryotic cells and basic cellular
processes such as cell proliferation, differentiation, migration, metabolism and apoptosis, which are
considered as therapeutic targets for many diseases. Up to now, mounting evidence has shown that
MAPK signaling pathway is involved in the pathogenesis and development of ischemic stroke. However,
the upstream kinase and downstream kinase of MAPK signaling pathway are complex and the
influencing factors are numerous, the exact role of MAPK signaling pathway in the pathogenesis of
ischemic stroke has not been fully elucidated. MAPK signaling molecules in different cell types in the
brain respond variously after stroke injury, therefore, the present review article is committed to summarizing
the pathological process of different cell types participating in stroke, discussed the mechanism
of MAPK participating in stroke. We further elucidated that MAPK signaling pathway molecules
can be used as therapeutic targets for stroke, thus promoting the prevention and treatment of stroke.