Production methods and characterization of porous Mg and Mg alloys for biomedical applications

2017 ◽  
pp. 25-82 ◽  
Author(s):  
A. Vahidgolpayegani ◽  
C. Wen ◽  
P. Hodgson ◽  
Y. Li
Keyword(s):  
Biomedical Applications ◽  
Mg Alloys ◽  
Production Methods

scholarly journals The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles

Polymers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 3302
Author(s):  
Antony V. Samrot ◽  
Sree K. Samanvitha ◽  
N. Shobana ◽  
Emilin R. Renitta ◽  
Puvanesvaran Senthil Kumar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Fatty Acid ◽  
Zeta Potential ◽  
Hydroxy Fatty Acid ◽  
Biomedical Applications ◽  
Physicochemical Characteristics ◽  
Production Methods ◽  
Solvent Diffusion ◽  
Storage Granules

Polyhydroxyalkanoates (PHAs) are storage granules found in bacteria that are essentially hydroxy fatty acid polyesters. PHA molecules appear in variety of structures, and amongst all types of PHAs, polyhydroxybutyrate (PHB) is used in versatile fields as it is a biodegradable, biocompatible, and ecologically safe thermoplastic. The unique physicochemical characteristics of these PHAs have made them applicable in nanotechnology, tissue engineering, and other biomedical applications. In this review, the optimization, extraction, and characterization of PHAs are described. Their production and application in nanotechnology are also portrayed in this review, and the precise and various production methods of PHA-based nanoparticles, such as emulsion solvent diffusion, nanoprecipitation, and dialysis are discussed. The characterization techniques such as UV-Vis, FTIR, SEM, Zeta Potential, and XRD are also elaborated.

Preparation and Characterization of Chitosan-Based Scaffolds for Biomedical Applications

2006 ◽  
Vol 514-516 ◽  
pp. 1005-1009 ◽  
Author(s):  
José V. Araújo ◽  
J.A. Lopes da Silva ◽  
Margarida M. Almeida ◽  
Maria Elisabete V. Costa
Keyword(s):  
Biomedical Applications ◽  
Freeze Drying ◽  
Average Pore Size ◽  
Composite Scaffolds ◽  
Average Pore ◽  
Chitosan Matrix ◽  
Freeze Dried ◽  
Porous Chitosan ◽  
Interconnected Structure

Porous chitosan/brushite composite scaffolds were prepared by a freeze-drying technique, starting from brushite suspensions in chitosan solutions. The obtained scaffolds showed a regular macroporous and interconnected structure with brushite particles uniformly distributed in the chitosan matrix. The variation of the brushite concentration affected the microstructure of the final freeze-dried scaffold, in particular, its porosity and its average pore size. The yield strengths of the composite scaffolds could also be improved by the increase of the brushite content.

scholarly journals Synthesis and characterization of novel protein nanodots as drug delivery carriers with an enhanced biological efficacy of melatonin in breast cancer cells

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9076-9085
Author(s):  
Kanchan Yadav ◽  
Megha Das ◽  
Nurul Hassan ◽  
Archana Mishra ◽  
Jayeeta Lahiri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Live Cell Imaging ◽  
Biomedical Applications ◽  
Breast Cancer Cells ◽  
Cell Imaging ◽  
Synthesis And Characterization ◽  
Novel Protein

A novel nanodot-using protein has been synthesized for the live cell imaging and drug delivery of melatonin in breast cancer cells. Its unique properties hold potential for various biomedical applications in the field of bioimaging and drug delivery.

scholarly journals Layer-by-Layer Self-Assembly Composite Coatings for Improved Corrosion and Wear Resistance of Mg Alloy for Biomedical Applications

Coatings ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 515
Author(s):  
Tongfang Liu ◽  
Song Rui ◽  
Sheng Li
Keyword(s):  
Wear Resistance ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Composite Coatings ◽  
Covalent Bond ◽  
Mg Alloys ◽  
Mg Alloy ◽  
Layer By Layer ◽  
Corrosion Propagation ◽  
Chemical Linkage

Mg alloys are promising biomedical metal due to their natural degradability, good processability, and favorable mechanical properties. However, the poor corrosion resistance limits their further clinical applications. In this study, the combined strategies of surface chemical treatment and layer-by-layer self-assembly were used to prepare composite coatings on Mg alloys to improve the biocorrosion resistance. Specially, alkalized AZ91 Mg alloy generated chemical linkage with silane via Si–O–Mg covalent bond at the interface. Subsequently, Si–OH group from silane formed a crosslinked silane layer by Si–O–Si network. Further chemical assembly with graphene oxide (GO), lengthened the diffusion pathway of corrosive medium. The chemically assembled composite coatings could firmly bond to Mg alloy substrate, which persistently and effectively acted as compact barriers against corrosion propagation. Improved biocorrosion resistance of AZ91 Mg alloy with self-assembly composite coatings of silane/GO was subsequently confirmed by immersion tests. Besides, the Mg alloy exhibited good wear resistance due to outside layer of GO with a lubricant effect. Cell viability of higher than 75% had also been found for the alloy with self-assembly composite coatings, which showed good cytocompatibility.

Characterization of a calcium phosphate–TiO2 nanotube composite layer for biomedical applications

2011 ◽  
Vol 31 (5) ◽  
pp. 906-914 ◽  
Author(s):  
A. Roguska ◽  
M. Pisarek ◽  
M. Andrzejczuk ◽  
M. Dolata ◽  
M. Lewandowska ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biomedical Applications ◽  
Composite Layer ◽  
Tio2 Nanotube

Preparation and characterization of poly (ethylene glycol) grafted Ca-alginate fibers by γ-irradiation for biomedical applications

2013 ◽  
Vol 27 (2) ◽  
pp. 216-226 ◽  
Author(s):  
Md. Kamal Khan ◽  
Mohammed Mizanur Rahman ◽  
Bodrun Nesa ◽  
Romana Nasrin ◽  
Swajal Molla ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Poly Ethylene Glycol ◽  
Γ Irradiation ◽  
Alginate Fibers ◽  
Poly Ethylene ◽  
Ca Alginate

scholarly journals Characterization of Epigallocatechin-Gallate-Grafted Chitosan Nanoparticles and Evaluation of Their Antibacterial and Antioxidant Potential

Polymers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1375
Author(s):  
María J. Moreno-Vásquez ◽  
Maribel Plascencia-Jatomea ◽  
Saúl Sánchez-Valdes ◽  
Judith C. Tanori-Córdova ◽  
Francisco J. Castillo-Yañez ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Food Packaging ◽  
Inhibitory Concentration ◽  
Antioxidant Activities ◽  
Bacterial Species ◽  
Chitosan Nanoparticles ◽  
Epigallocatechin Gallate ◽  
Antioxidant Power ◽  
Ferric Reducing Antioxidant Power

Nanoparticles based on chitosan modified with epigallocatechin gallate (EGCG) were synthetized by nanoprecipitation (EGCG-g-chitosan-P). Chitosan was modified by free-radical-induced grafting, which was verified by Fourier transform infrared (FTIR). Furthermore, the morphology, particle size, polydispersity index, and zeta potential of the nanoparticles were investigated. The grafting degree of EGCG, reactive oxygen species (ROS) production, antibacterial and antioxidant activities of EGCG-g-chitosan-P were evaluated and compared with those of pure EGCG and chitosan nanoparticles (Chitosan-P). FTIR results confirmed the modification of the chitosan with EGCG. The EGCG-g-chitosan-P showed spherical shapes and smoother surfaces than those of Chitosan-P. EGCG content of the grafted chitosan nanoparticles was 330 μg/g. Minimal inhibitory concentration (MIC) of EGCG-g-chitosan-P (15.6 μg/mL) was lower than Chitosan-P (31.2 μg/mL) and EGCG (500 μg/mL) against Pseudomonas fluorescens (p < 0.05). Additionally, EGCG-g-chitosan-P and Chitosan-P presented higher Staphylococcus aureus growth inhibition (100%) than EGCG at the lowest concentration tested. The nanoparticles produced an increase of ROS (p < 0.05) in both bacterial species assayed. Furthermore, EGCG-g-chitosan-P exhibited higher antioxidant activity than that of Chitosan-P (p < 0.05) in 2,2′-azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and ferric-reducing antioxidant power assays. Based on the above results, EGCG-g-chitosan-P shows the potential for food packaging and biomedical applications.

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