Common techniques and methods for screening of natural products for developing of anticancer drugs

2021 ◽  
pp. 323-353
Author(s):  
Monika Singh ◽  
Sukanya Patra ◽  
Rajesh Kumar Singh
Keyword(s):  
Natural Products ◽  
Anticancer Drugs

scholarly journals Natural Products Targeting the Mitochondria in Cancers

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 92
Author(s):  
Yue Yang ◽  
Ping-Ya He ◽  
Yi Zhang ◽  
Ning Li
Keyword(s):  
Natural Products ◽  
Anticancer Drugs ◽  
Web Of Science ◽  
Keyword Search ◽  
Biological Activities ◽  
Natural Compounds ◽  
New Drugs ◽  
Antitumor Effects ◽  
Regulate Cell Growth ◽  
Anticancer Drug Discovery

There are abundant sources of anticancer drugs in nature that have a broad prospect in anticancer drug discovery. Natural compounds, with biological activities extracted from plants and marine and microbial metabolites, have significant antitumor effects, but their mechanisms are various. In addition to providing energy to cells, mitochondria are involved in processes, such as cell differentiation, cell signaling, and cell apoptosis, and they have the ability to regulate cell growth and cell cycle. Summing up recent data on how natural products regulate mitochondria is valuable for the development of anticancer drugs. This review focuses on natural products that have shown antitumor effects via regulating mitochondria. The search was done in PubMed, Web of Science, and Google Scholar databases, over a 5-year period, between 2015 and 2020, with a keyword search that focused on natural products, natural compounds, phytomedicine, Chinese medicine, antitumor, and mitochondria. Many natural products have been studied to have antitumor effects on different cells and can be further processed into useful drugs to treat cancer. In the process of searching for valuable new drugs, natural products such as terpenoids, flavonoids, saponins, alkaloids, coumarins, and quinones cover the broad space.

Discovery of anticancer drugs from antimalarial natural products: a MEDLINE literature review

2012 ◽  
Vol 17 (17-18) ◽  
pp. 942-953 ◽  
Author(s):  
Robert Duffy ◽  
Christine Wade ◽  
Raymond Chang
Keyword(s):  
Natural Products ◽  
Literature Review ◽  
Anticancer Drugs

scholarly journals Marine Natural Products: A Source of Novel Anticancer Drugs

Marine Drugs ◽  
2019 ◽  
Vol 17 (9) ◽  
pp. 491 ◽  
Author(s):  
Shaden A. M. Khalifa ◽  
Nizar Elias ◽  
Mohamed A. Farag ◽  
Lei Chen ◽  
Aamer Saeed ◽  
...  
Keyword(s):  
Natural Products ◽  
Anticancer Drugs ◽  
Marine Natural Products ◽  
Molecular Mechanisms ◽  
Biological Effects ◽  
Marine Organisms ◽  
New Drugs ◽  
Bioactive Metabolites ◽  
Chemical Structures ◽  
The Impact

Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.

scholarly journals The Contribution of Natural Products as Source of New Anticancer Drugs: Studies Carried Out at the National Experimental Oncology Laboratory from the Federal University of Ceará

2010 ◽  
Vol 2 (1) ◽  
Author(s):  
Letícia V. Costa-Lotufo ◽  
Raquel C. Montenegro ◽  
Ana Paula N. N. Alves ◽  
Socorro V. F. Madeira ◽  
Cláudia Pessoa ◽  
...  
Keyword(s):  
Natural Products ◽  
Anticancer Drugs ◽  
New Anticancer Drugs

scholarly journals Selective Killing Natural Products and Drugs in Oral Cancer Treatments

2016 ◽  
pp. 1-2
Author(s):  
Hsueh-Wei Chang
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Side Effects ◽  
Oral Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Cancer Treatments ◽  
Normal Cells ◽  
Killing Effect ◽  
Anticancer Drug Discovery

Most cancer drugs are effective to kill cancer cells but also harm normal cells. Drugs and natural products with the selective killing effect may be helpful to solve this problem. The side effects of many anticancer drugs are partly derived from its damage to both cancer and normal cells without selection. This problem raises the need of anticancer drug discovery with the selective killing effect.

scholarly journals Quinonoids: Therapeutic Potential for Lung Cancer Treatment

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Hua-Zhong Ying ◽  
Chen-Huan Yu ◽  
Hao-Kun Chen ◽  
Huan-Huan Zhang ◽  
Jie Fang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Natural Products ◽  
Anticancer Drugs ◽  
Therapeutic Potential ◽  
Invasion And Migration ◽  
Anticancer Effects ◽  
Incidence And Mortality ◽  
High Incidence ◽  
Underlying Mechanisms ◽  
And Migration

Lung cancer is the leading cause of cancer-related deaths worldwide. Owing to its high incidence and mortality, the development and discovery of novel anticancer drugs is of great importance. In recent years, many breakthroughs have been achieved in the search for effective anticancer substances from natural products. Many anticancer drugs used clinically and proven to be effective are derived from natural products. Quinonoids, including naphthoquinones, phenanthrenequinones, benzoquinones, and anthraquinones, constitute a large group of natural bioactive compounds that widely exist in higher and lower plant species. Given that most of these compounds possess anticancer effects, they are applied in many cancer studies, especially in lung cancer research. They can promote apoptosis, induce autophagy, and inhibit proliferation, angiogenesis, and cell invasion and migration. Some drugs can enhance anticancer effects when combined with other drugs. Thus, quinonoids have broad application prospects in the treatment of lung cancer. Here, we summarize the previous studies on the antilung cancer activities of quinonoids together with their underlying mechanisms and analyze the common research targets with different effects so as to provide references for the discovery of quinonoids against lung cancer.

The Role of Bacterial Natural Products in Predator Defense

Synlett ◽  
2018 ◽  
Vol 29 (05) ◽  
pp. 537-541 ◽  
Author(s):  
Pierre Stallforth ◽  
Martin Klapper ◽  
Johannes Arp ◽  
Markus Günther
Keyword(s):  
Molecular Weight ◽  
Natural Products ◽  
Anticancer Drugs ◽  
Soil Bacteria ◽  
Therapeutic Use ◽  
Low Molecular Weight ◽  
Active Compounds ◽  
Predator Defense ◽  
Predator Prey

Bacterially produced natural products, i.e., low molecular weight metabolites, or derivatives thereof, constitute most of the commercially available antibiotics as well as a large proportion of anticancer drugs. While indispensable as therapeutically active compounds, the ecological roles of many of these bacterial natural products remain poorly understood. Here, we discuss these metabolites in light of ­microbial predator defense: soil bacteria are constantly threatened by a variety of predators and the secretion of low molecular weight toxins enables the producing bacteria to kill or deter the predator. Conversely, a deeper understanding of these microbial predator–prey interactions can lead to the discovery of novel compounds, which in turn can be of therapeutic use.

Potential Role of In vitro-In vivo Correlations (IVIVC) for the Development of Plant Derived Anticancer Drugs

2020 ◽  
Vol 21 ◽  
Author(s):  
A.Mohamed Sheik Tharik ◽  
S.B. Santhosh ◽  
Murugesan Susitra Manjari ◽  
S.N. Meyyanathan
Keyword(s):  
Natural Products ◽  
Anticancer Drugs ◽  
Internal Control ◽  
Anticancer Agents ◽  
Scale Up ◽  
Primary Source ◽  
New Drugs

Background: Conventional medicines, along with herbal formulations of Chinese, serves as the primary source and hub of active new drugs where the initial research concentrate in the extraction and isolation of bioactive lead com-pound(s) to treat several diseases largely for cancer. Plant-derived natural products and their analogs reveal a significant source of several clinically useful anticancer agents. Herbs and herbal derived active compounds play an unavoidable role in the treatment, drug discovery and delivery for decades,as evidenced by numerous existing marked drugs and various cancer-related molecular targets in clinical development. Objective: Solubility, resistance and metabolic limitations of the drugcan be overcome by suitable molecular modifications; Due to enhancements in tumor targeting technology, some agents which failed in earlier clinical studies are also stimulating renewed interest. In this connection, In Vitro In Vivo Correlation (IVIVC) plays an important role in the development of dosage forms in the field of pharmaceutical technology. Conclusion: IVIVC tool fastens and improves the drug development process and product quality, which is also utilized in internal control for scale-up, to improve formulations and alternativeproduction processes. Most importantly, this IVIVC tool lessens the quantity of human studies during new pharmaceuticals developments. In this review, we would like to grab the attention of readers to the importance and significance of IVIVC for natural products of anticancer drugs examples such as Docetaxel, Etoposide phosphate, 6-Gingerol, Capsaicin, etc.

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