The relationship between nutritional status, performance status and survival time in patients with pancreatic cancer

2018 ◽  
Vol 37 ◽  
pp. S80
Author(s):  
D.Hopanci Bicakli ◽  
S.C. Guney ◽  
R. Uslu ◽  
A. Coker
Keyword(s):  
Pancreatic Cancer ◽  
Nutritional Status ◽  
Survival Time ◽  
Performance Status ◽  
The Relationship

The Relationship Between Nutritional Status, Performance Status, and Survival Among Pancreatic Cancer Patients

2019 ◽  
Vol 72 (2) ◽  
pp. 202-208 ◽  
Author(s):  
Derya Hopanci Bicakli ◽  
Ruchan Uslu ◽  
Sedat Can Güney ◽  
Ahmet Coker
Keyword(s):  
Pancreatic Cancer ◽  
Nutritional Status ◽  
Cancer Patients ◽  
Performance Status ◽  
The Relationship

scholarly journals Malnutrition among rural and urban children in Lesotho: related hazard and survival probabilities

2003 ◽  
Vol 8 (3) ◽  
Author(s):  
Zeleke Worku
Keyword(s):  
Nutritional Status ◽  
Survival Time ◽  
Full Text ◽  
Urban Children ◽  
Survival Probabilities ◽  
Several Variables ◽  
Rural And Urban ◽  
Nutritional Status Of Children ◽  
The Relationship

The relationship between the survival time of children and several variables that affect the survival and nutritional status of children under the age of five years in the Maseru District of Lesotho was investigated. Opsomming Die verhouding tussen die oorlewingstyd van kinders en verskeie veranderlikes wat die oorlewings- en voedingstatus van kinders onder die ouderdom van vyf jaar affekteer is in die Maseru-distrik in Lesotho nagevors. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

Correlation Between Baseline Methylmalonic Acid Status and Mucositis Severity in the PROPEL Study: Implications for Vitamin Prophylaxis.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 1681-1681 ◽  
Author(s):  
Barbara Pro ◽  
Bertrand Coiffier ◽  
Steven M. Horwitz ◽  
Adam Boyd ◽  
Ellen Neylon ◽  
...  
Keyword(s):  
Folic Acid ◽  
Nutritional Status ◽  
Vitamin B12 ◽  
Research Funding ◽  
Statistical Significance ◽  
Performance Status ◽  
Vitamin Supplementation ◽  
Slope Estimate ◽  
Baseline Values ◽  
The Relationship

Abstract Abstract 1681 Poster Board I-707 Background The rationally designed antifolate, pralatrexate, has high affinity for reduced folate carrier-1 (RFC-1) and was designed to be retained longer within cancer cells due to efficient polyglutamation by folylpolyglutamyl synthetase (FPGS). Prophylactic vitamin supplementation with folic acid and vitamin B12 is often used by physicians to minimize toxicities seen with antifolate chemotherapy (Scagliotti GV, JCO 2003; 21:1556). Nutritional status is a concern for cancer patients in general, and particularly for patients with aggressive disease that have been treated previously. In the PROPEL study, a pivotal international multi-center Phase 2 study of pralatrexate in patients with relapsed or refractory peripheral T-cell lymphoma (PTCL), patients were treated with pralatrexate and received folic acid and vitamin B12 supplementation. Patients in PROPEL had been treated with a median of three prior regimens, and an overall response rate of 28% by independent central review was observed. The most common grade 3-4 toxicities were thrombocytopenia (32%) and mucositis (22%). This report includes analyses of baseline MMA, Hcy, and RBC folate levels and their association with thrombocytopenia or mucositis in the PROPEL trial. Methods Patients received pralatrexate 30 mg/m2 IV weekly for 6 weeks in 7-week cycles and supplementation with vitamin B12 (1 mg IM q8-10 wks) and folic acid (1.0-1.25 mg PO daily). Eligibility criteria included histologically confirmed PTCL, disease progression after ≥ 1 prior treatment, and ECOG performance status £ 2. MMA, Hcy and RBC folate levels were measured at baseline, prior to vitamin initiation. A linear model was used to estimate the relationship (slope) between each of these baseline values and the maximum grade of mucositis and thrombocytopenia. Results Of the 115 patients enrolled, 111 were evaluable for safety and 109 were evaluable for response. Eighty-nine had baseline MMA levels, 91 had baseline Hcy levels, and 75 had baseline RBC folate levels before initiation of vitamin supplementation. Baseline values are summarized by the highest grade of thrombocytopenia or mucositis in the Table. The linear relationship between maximum mucositis grade on study (0 vs 1-2 vs 3-4) and baseline MMA was statistically significant (slope estimate = 43.3 nmol/L, p = 0.039). In addition, there was a trend for increasing MMA and increasing severity of thrombocytopenia that did not meet statistical significance (slope estimate = 17.6 μmol/L, p = 0.267). No other significant relationships were noted. Conclusions In the subset of relapsed or refractory PTCL patients tested for MMA levels in the PROPEL study, higher levels of baseline MMA were associated with increased severity of mucositis. There was an association between MMA and severity of thrombocytopenia that did not reach statistical significance. RBC folate and Hcy were not predictive of the severity of mucositis and thrombocytopenia in this analysis. Because patients with relapsed or refractory PTCL may have poor nutritional status, all patients treated with pralatrexate, including those with elevated MMA, should be supplemented with vitamins. Additional studies may be warranted to define the relationship between MMA levels and the development of mucositis and thrombocytopenia among patients treated with pralatrexate. Disclosures Pro: Allos Therapeutics, Inc: Research Funding. Horwitz:Allos Therapeutics, Inc: Consultancy, Research Funding. Boyd:Allos Therapeutics, Inc.: Employment. Fruchtman:Allos Therapeutics, Inc.: Employment.

scholarly journals Clinical Significance of Serum NEDD9 Levels in Patients with Pancreatic Cancer

Biomolecules ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 169 ◽  
Author(s):  
Cigdem Usul Afsar ◽  
Mehmet Karabulut ◽  
Senem Karabulut ◽  
Safiye Tokgoz Ozal ◽  
Murat Cikot ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Performance Status ◽  
Progression Free Survival ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Serum Samples ◽  
Baseline Serum ◽  
Free Survival ◽  
The Relationship

Introduction: Pancreatic cancer (PC) is a lethal malignancy. Various diagnostic, predictive, and prognostic biomarkers have been evaluated. This study was conducted to investigate the serum levels of neural precursor cell expressed developmentally downregulated protein 9 (NEDD9) in patients with PC and the relationship between tumor progression and known prognostic parameters. Materials and Methods: Serum samples were obtained on first admission before any treatment. Serum NEDD9 levels were determined using enzyme-linked immunosorbent assay (ELISA). Age- and sex-matched healthy controls were included in the analysis. Results: In a three year period, 32 patients with a pathologically-confirmed diagnosis of PC were enrolled in this study. The median age at diagnosis was 61 years, range 38 to 84 years; the majority of the patients in the group were men (n = 20, 62.5%). The tumor was located in the head of pancreas in 21 (65.6%) patients. Forty-one percent of 17 metastatic patients who received palliative CTx (chemotherapy) were CTx-responsive. The baseline serum NEDD9 levels were significantly higher in patients with PA than in the control group (p = 0.03). Median OS of the whole group were 27 ± 7.3 weeks. Alcohol intake, performance status, and LDH levels were found to be significant prognostic factors (p = 0.006, p < 0.001, and p < 0.001, respectively). However, serum NEDD9 levels had no significantly effect on progression free survival (PFS) and overall survival (OS) (p = 0.71 and p = 0.58, respectively). Conclusions: NEDD9 is identified as a secretory biomarker for PC but it has no prognostic role.

scholarly journals Survival analysis and factors affecting survival in patients with pancreatic cancer.

2020 ◽  
Vol 7 (2) ◽  
pp. 412-418
Author(s):  
Özgür Önal ◽  
Servet Derya Yılmaz ◽  
Hande Nur Eroğlu ◽  
İsmet Eroğlu ◽  
Murat Koçer
Keyword(s):  
Pancreatic Cancer ◽  
Alcohol Use ◽  
Survival Time ◽  
Performance Status ◽  
Eastern Cooperative Oncology Group ◽  
Laboratory Data ◽  
Disease Stage ◽  
Ecog Performance Status ◽  
Risk Of Death ◽  
History Of

Objective: The study aims to investigate the effects of clinicopathological characteristics and laboratory data at the time of diagnosis and of the administered treatments on survival in patients with pancreatic cancer. Material and Methods: In this retrospective cohort study, we included the patients who presented to the Medical Oncology Outpatient Clinic of Isparta Süleyman Demirel University Medical Faculty Hospital and were diagnosed with pancreatic cancer between January 1, 2010 and December 31, 2017. Results: A total of 124 patients were examined. The median survival time was 6.97 (%95 CI:4.663-9.270) months, and the 5-year survival rate was 8%. The survival time was shorter in patients diagnosed with adenocarcinoma (HR: 5.350), history of alcohol use (HR: 2.195), an Eastern Cooperative Oncology Group (ECOG) performance score of >2 (HR:2.763), Ca 19-9 value >400 (HR:1.790). Stages 2, 3 and 4 posed 2.034, 3.175 and 6.023 times higher risk of death than stage 1, respectively. Considering the adjuvant chemotherapy group as reference, risk of death was 1.250 times higher for those who received palliative chemotherapy and 2.314 times higher for those who did not receive chemotherapy. Conclusion: In conclusion, history of alcohol use, Ca 19-9 level, ECOG performance status, disease stage, histopathological subtype of the disease, and whether the patient received chemotherapy or radiotherapy affect survival in patients with pancreatic cancer.   

The Relationship between Nutritional Knowledge and Attitudes toward Food Intake and Nutritional Status of People with HIVAIDS

2019 ◽  
Vol 22 (11) ◽  
pp. 213-223
Author(s):  
Meirina Dwi Larasati ◽  
Nurul Dwi Anggriyani ◽  
Susi Tursilowati ◽  
Ria Ambarwati ◽  
Yuniarti Yuniarti
Keyword(s):  
Food Intake ◽  
Nutritional Status ◽  
Nutritional Knowledge ◽  
Knowledge And Attitudes ◽  
The Relationship

scholarly journals Cohort study of the overall survival of patients with pancreatic cancer in a hospital of specialties of Quito-Ecuador in the period 2007–2017

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Andrés Moreno Roca ◽  
Luciana Armijos Acurio ◽  
Ruth Jimbo Sotomayor ◽  
Carlos Céspedes Rivadeneira ◽  
Carlos Rosero Reyes ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cohort Study ◽  
Survival Time ◽  
Univariate Analysis ◽  
Rank Test ◽  
Kaplan Meier ◽  
Significant Difference ◽  
Icd 10 ◽  
The Difference ◽  
Clinical Records

Abstract Objectives Pancreatic cancers in most patients in Ecuador are diagnosed at an advanced stage of the disease, which is associated with lower survival. To determine the characteristics and global survival of pancreatic cancer patients in a social security hospital in Ecuador between 2007 and 2017. Methods A retrospective cohort study and a survival analysis were performed using all the available data in the electronic clinical records of patients with a diagnosis of pancreatic cancer in a Hospital of Specialties of Quito-Ecuador between 2007 and 2017. The included patients were those coded according to the ICD 10 between C25.0 and C25.9. Our univariate analysis calculated frequencies, measures of central tendency and dispersion. Through the Kaplan-Meier method we estimated the median time of survival and analyzed the difference in survival time among the different categories of our included variables. These differences were shown through the log rank test. Results A total of 357 patients diagnosed with pancreatic cancer between 2007 and 2017 were included in the study. More than two-thirds (69.9%) of the patients were diagnosed in late stages of the disease. The median survival time for all patients was of 4 months (P25: 2, P75: 8). Conclusions The statistically significant difference of survival time between types of treatment is the most relevant finding in this study, when comparing to all other types of treatments.

Mid upper arm circumference as an alternative measure to assess the nutritional status of adolescents: a study in India based on NFHS-4 data

2021 ◽  
pp. 1-12
Author(s):  
Aparna Roy ◽  
T. V. Sekher
Keyword(s):  
Nutritional Status ◽  
Sensitivity And Specificity ◽  
Measurement Data ◽  
Anthropometric Measurement ◽  
Alternative Measure ◽  
Upper Arm ◽  
Male Adolescents ◽  
Arm Circumference ◽  
Mid Upper Arm Circumference ◽  
The Relationship

Abstract Use of body mass index (BMI) to assess the nutritional status of adolescents requires many resources, especially for country-level assessment. This study aimed to determine the relationship between BMI and mid upper arm circumference (MUAC) among adolescent males and females in India and to examine whether MUAC effectively represents the nutritional status of adolescents. The study utilized anthropometric measurement data collected by India’s National Family Health Survey-4 (2015–16). The weighted sample for analysis included 91,315 female and 14,893 male adolescents. The BMI and MUAC measurements showed a positive correlation in both female and male adolescents. Using BMI-for-age Z-score classifications, 12.7% of the adolescents were undernourished. Using MUAC (in cm) as per NACS (Nutrition Assessment, Counselling, and Support) guidelines and Mramba et al. (2017) classified 22.9% and 3.7% of the adolescents as undernourished respectively. Finally, using the MUAC-for-age Z-score classification, 98.4% of adolescents were determined to be normal and 1.7% undernourished. Sensitivity and specificity tests of the MUAC cut-offs, in comparison with BMI cut-offs, showed that all three MUAC cut-off classifications had high specificity (NACS cut-off: 81.3%; Mramba et al. cut-off (cm): 97.7%; Mramba et al. cut-off (Z-score): 99.1%). The NACS cut-off had moderately high sensitivity (52.2%) but the Mramba et al. cut-offs had low sensitivity (13.3% for the centimetre cut-off and 6.6% for the Z-score cut-off). Sensitivity and specificity tests proved the relationship between BMI and MUAC, and that MUAC represents adolescent nutritional status with considerable efficiency. With further research, it may be established that MUAC is a better and promising measure of adolescent nutrition, having the advantage of needing fewer resources for data collection. The MUAC has the potential to offer a simple and low-resource alternative to BMI to assess nutritional status among adolescents in poor countries.

scholarly journals The significance of exosomal RNAs in the development, diagnosis, and treatment of pancreatic cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zheng Zhao ◽  
Guiping Zhao ◽  
Shuyue Yang ◽  
Shengtao Zhu ◽  
Shutian Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Immune Escape ◽  
Diagnosis And Treatment ◽  
Circular Rnas ◽  
Molecular Heterogeneity ◽  
Bioactive Constituents ◽  
Functional Connections ◽  
Non Coding Rnas ◽  
The Relationship ◽  
Exosomal Rnas

AbstractExosomes are single-membrane, secreted organelles with a diameter of 30–200 nm, containing diverse bioactive constituents, including DNAs, RNAs, proteins, and lipids, with prominent molecular heterogeneity. Extensive studies indicate that exosomal RNAs (e.g., microRNAs, long non-coding RNAs, and circular RNAs) can interact with many types of cancers, associated with several hallmark features like tumor growth, metastasis, and resistance to therapy. Pancreatic cancer (PaCa) is among the most lethal cancers worldwide, emerging as the seventh foremost cause of cancer-related death in both sexes. Hence, revealing the specific pathogenesis and improving the clinical diagnosis and treatment process are urgently required. As the study of exosomes has become an active area of research, the functional connections between exosomes and PaCa have been deeply investigated. Among these, exosomal RNAs seem to play a significant role in the development, diagnosis, and treatment of PaCa. Exosomal RNAs delivery ultimately modulates the various features of PaCa, and many scholars have interpreted how exosomal RNAs contribute to the proliferation, angiogenesis, migration, invasion, metastasis, immune escape, and drug resistance in PaCa. Besides, recent studies emphasize that exosomal RNAs may serve as diagnostic and prognostic biomarkers or therapeutic targets for PaCa. In this review, we will introduce these recent insights focusing on the discoveries of the relationship between exosomal RNAs and PaCa, and the potentially diagnostic and therapeutic applications of exosomes in PaCa.

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