scholarly journals Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice

2021 ◽  
Vol 33 (6) ◽  
pp. 1264-1266
Author(s):  
Yingga Wu ◽  
Baoguo Li ◽  
Li Li ◽  
Sharon E. Mitchell ◽  
Cara L. Green ◽  
...  
Keyword(s):  
Weight Loss ◽  
Food Intake ◽  
Mtor Signaling ◽  
Low Protein ◽  
Protein Diets

Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice

2021 ◽  
Author(s):  
Yingga Wu ◽  
Baoguo Li ◽  
Li Li ◽  
Sharon E. Mitchell ◽  
Cara L. Green ◽  
...  
Keyword(s):  
Weight Loss ◽  
Food Intake ◽  
Mtor Signaling ◽  
Low Protein ◽  
Protein Diets

scholarly journals Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Joanna Moro ◽  
Catherine Chaumontet ◽  
Patrick C. Even ◽  
Anne Blais ◽  
Julien Piedcoq ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Dietary Protein ◽  
Protein Deficiency ◽  
Protein Diet ◽  
Growing Rats ◽  
Low Protein ◽  
Protein Diets

AbstractTo study, in young growing rats, the consequences of different levels of dietary protein deficiency on food intake, body weight, body composition, and energy balance and to assess the role of FGF21 in the adaptation to a low protein diet. Thirty-six weanling rats were fed diets containing 3%, 5%, 8%, 12%, 15% and 20% protein for three weeks. Body weight, food intake, energy expenditure and metabolic parameters were followed throughout this period. The very low-protein diets (3% and 5%) induced a large decrease in body weight gain and an increase in energy intake relative to body mass. No gain in fat mass was observed because energy expenditure increased in proportion to energy intake. As expected, Fgf21 expression in the liver and plasma FGF21 increased with low-protein diets, but Fgf21 expression in the hypothalamus decreased. Under low protein diets (3% and 5%), the increase in liver Fgf21 and the decrease of Fgf21 in the hypothalamus induced an increase in energy expenditure and the decrease in the satiety signal responsible for hyperphagia. Our results highlight that when dietary protein decreases below 8%, the liver detects the low protein diet and responds by activating synthesis and secretion of FGF21 in order to activate an endocrine signal that induces metabolic adaptation. The hypothalamus, in comparison, responds to protein deficiency when dietary protein decreases below 5%.

scholarly journals Problems in estimating the extent of coprophagy in the rat

1989 ◽  
Vol 62 (3) ◽  
pp. 551-561 ◽  
Author(s):  
Gladys Fajardo ◽  
H. Hörnicke
Keyword(s):  
Food Intake ◽  
Dry Matter ◽  
Ingestion Rate ◽  
Pantothenic Acid ◽  
Egg Albumin ◽  
Low Protein ◽  
Quantitative Estimates ◽  
Complete Diet ◽  
Collection Period ◽  
Protein Diets

The quantity of re-ingested faeces was calculated by comparing faecal dry matter of unrestricted rats and coprophagy-restricted rats after correcting for differences in food intake. Due to high day-to-day variations of produced and re-ingested faeces it was not possible to calculate precisely the extent of coprophagy of an individual rat at a particular day with this difference method. Reliable quantitative estimates require at least two rats and a collection period of 7 d. When fed on a nutritionally complete diet, rats re-ingested 0-11 % of their faeces. When fed on low-protein diets (66 g egg albumin/kg) or diets diluted with 200 g cellulose/kg, coprophagy was not significantly increased. A high re-ingestion rate (6–25 %) was observed with thiamin and pantothenic acid deficiencies. After re-ingestion of faeces had been prevented for 1 week, the amount of faeces re-ingested during the subsequent week without tail-cups was increased twofold. It is concluded that rats are able to regulate the amount of faeces eaten precisely according to their requirements.

Free-feeding patterns of rats: effects of pyrogen and dietary protein content

1975 ◽  
Vol 228 (4) ◽  
pp. 1284-1287 ◽  
Author(s):  
PM Leung ◽  
BA Horwitz
Keyword(s):  
Food Intake ◽  
Body Temperature ◽  
Heat Production ◽  
Dietary Protein ◽  
Low Protein ◽  
Bacterial Pyrogen ◽  
Free Feeding ◽  
High Protein Diets ◽  
Protein Diets ◽  
Voluntary Food Intake

Infusion of bacterial pyrogen (Priomen) was accompanied by an increase in body temperature, an increase in heat production, and a decrease in the voluntary food intake ofrats fed high-as well as low-protein diets. The magnitude of this pyrogen-induced depression of food intake was comparable for both diets. However, in rats fed high-protein diets, this decrease was additive to that normally seen following administration of such diets. These data indicate that the control of food intake cannot be explained in terms of a behavioral the more regulatory response.

COMPARATIVE EFFECTS OF SUCROSE AND CORNSTARCH IN LOW-PROTEIN DIETS FED TO RATS EXPOSED TO COLD

1965 ◽  
Vol 43 (2) ◽  
pp. 241-249
Author(s):  
J. R. Beaton ◽  
J. F. Sangster
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Body Weight Gain ◽  
Young Male ◽  
Male Rats ◽  
Low Protein ◽  
Environmental Temperatures ◽  
Protein Diets ◽  
Starch Diet

Young male rats were fed one of three low-protein (5% casein) diets differing in the source of carbohydrate (sucrose, equal parts sucrose and cornstarch, or cornstarch) or a 20% casein (sucrose) diet at environmental temperatures of 24 °C or 5 °C. Replacement of sucrose with starch appeared to have a small but significant effect in increasing body weight gain for 15 days (but not the next 28 days) at 24 °C and also in animals exposed to cold for 28 days after a 15-day feeding period at 24 °C. In disagreement with results reported by Andik et al., cold exposure, although significantly increasing body weight gain and food intake in rats fed the 5% casein – starch diet, did not elicit a weight gain as great as that observed in 20% casein-fed animals at either 24 °C or 5 °C. The 24-hour food intake following a 24-hour fast exceeded the intake on the day before fasting on all diets for animals maintained at 5 °C but not 24 °C. The immediate ([Formula: see text] hour) and 24-hour food intakes of rats at 5 °C exceeded those of comparable dietary groups at 24 °C. At 5 °C, the 24-hour food intake, following the fast, of rats fed the 5% casein – starch diet exceeded that of the 20% casein-fed controls.

Relationship Between Food Intake and Osmotic Effect of Dietary Carbohydrate

1958 ◽  
Vol 193 (3) ◽  
pp. 483-487 ◽  
Author(s):  
A. E. Harper ◽  
H. E. Spivey
Keyword(s):  
Food Intake ◽  
Moisture Content ◽  
Osmotic Pressure ◽  
Stomach Contents ◽  
Dry Weight ◽  
Dietary Carbohydrate ◽  
Osmotic Effect ◽  
Low Protein ◽  
Stomach Volume ◽  
Protein Diets

The objective of this study was to determine whether differences in the food intake and in the rate of gain of rats fed on low protein diets containing different carbohydrates could be related to differences in the osmotic effects of the various carbohydrates. Rate of gain, food intake, stomach volume, dry weight and moisture content of the stomach contents, and the rate of stomach emptying were determined in rats at intervals after feeding low protein diets containing various carbohydrates. There was an inverse relationship between the capacity of the dietary carbohydrate to exert osmotic pressure and the food intake and rate of gain of rats fed for a single interval each day but the positions of glucose and sucrose in the series were reversed under conditions of ad libitum feeding. There was a direct relationship between the capacity of the dietary carbohydrate to exert osmotic pressure and the stomach volume and moisture content of the stomach contents. Rats could be trained to consume an adequate quantity of a diet in a limited time more readily if the osmotic capacity of the dietary carbohydrate was low.

scholarly journals Food Intake, Energy Balance and Serum Leptin Concentrations in Rats Fed Low-Protein Diets

2000 ◽  
Vol 130 (3) ◽  
pp. 514-521 ◽  
Author(s):  
Fangyan Du ◽  
D. Allan Higginbotham ◽  
B. Douglas White
Keyword(s):  
Energy Balance ◽  
Food Intake ◽  
Serum Leptin ◽  
Low Protein ◽  
Protein Diets

Enzyme supplementation of low or high crude protein concentration diets for broiler chickens

1990 ◽  
Vol 51 (2) ◽  
pp. 399-404 ◽  
Author(s):  
D. Pettersson ◽  
H. Graham ◽  
P. Åman
Keyword(s):  
Growth Rate ◽  
Food Intake ◽  
High Protein Diet ◽  
Conversion Ratio ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Food Conversion ◽  
Low Protein ◽  
Enzyme Supplementation ◽  
Protein Diets

ABSTRACTPrevious investigations have established that supplementing broiler chicken diets with appropriate endosperm cell wall degrading enzymes can improve nutrient digestion, and indicated that this could allow lower protein diets to be used. In this study the effect of enzyme supplementation on the productive value of low (192 g/kg dry matter (DM)) and high (227 g/kg DM) protein diets was studied. The diets employed were based on barley, wheat and rye, and the two enzyme preparations used, Glucanase GP 5000® and Novozym-343®, contained β3-glucanase and arabinoxylanase activities.The high protein diet gave a higher incidence of sticky droppings, but resulted in a higher growth rate and improved food conversion ratio than the low protein diet. Enzyme supplementation reduced the incidence of sticky droppings and also improved growth rate, food intake and food conversion efficiency for both diets, with the Glucanase GP 5000 preparation generally being more effective. Enzyme supplementation improved growth rate on the low protein diet to a level equal to or better than that on the high protein diet, although this was achieved by a better food intake and an inferior food conversion ratio. This study demonstrated that supplementation with appropriate enzymes could allow a reduction in dietary protein level without affecting broiler growth rate.

Sign in / Sign up

Export Citation Format

Share Document