Marine resources and cancer therapy: from current evidence to challenges for functional foods development

2022 ◽  
Author(s):  
Beatriz de la Fuente ◽  
Houda Berrada ◽  
Francisco J Barba
Keyword(s):  
Cancer Therapy ◽  
Functional Foods ◽  
Current Evidence ◽  
Marine Resources

scholarly journals Assessment of Dietary Patterns Represents a Potential, Yet Variable, Measure of Inflammatory Status: A Review and Update

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Mariana C. Calle ◽  
Catherine J. Andersen
Keyword(s):  
Chronic Disease ◽  
Systemic Inflammation ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Functional Foods ◽  
Disease Risk ◽  
Current Evidence ◽  
Low Grade ◽  
Inflammatory Status ◽  
Anti Inflammatory

Chronic low-grade, systemic inflammation is a well-characterized risk factor in the development of chronic metabolic diseases, such as cardiovascular disease, type 2 diabetes, and metabolic syndrome. Diet could be an effective strategy for reducing inflammation associated with chronic disease. While anti-inflammatory properties of isolated dietary bioactive and functional foods have been routinely studied, the evaluation of dietary patterns on inflammation warrants further review—especially given the recent inclusion of dietary pattern recommendations into dietary guidelines and policies. Therefore, the objective of this narrative review is to examine current evidence linking diet to low-grade, systemic inflammation within the context of chronic disease. Specifically, we provide an update on the findings from human trials that have characterized anti-inflammatory properties of dietary patterns, defined by various methods and indexes. Given the complexity of interpreting results from dietary pattern analysis, we further present recent evidence on the anti-inflammatory roles of isolated bioactive nutrients and functional foods that are common components of distinct dietary patterns, in addition to considerations for interpreting dietary pattern research, population-specific dietary recommendations, and future studies. Overall, we observe a vast range of variability in the evidence from observational studies that have evaluated the relationships between healthy dietary patterns and inflammatory markers. These studies highlight the need for additional intervention studies with study designs that account for metabolic status, diversity in populations, breadth of inflammatory measurements, fasting vs. postprandial effects of diet, and control of confounding factors (e.g., genotype, microbiome profiles, and dietary adherence) in order to better understand the effect that diet has, as a whole, on inflammation. These strategies will help to strengthen diet recommendations aimed at reducing inflammation and chronic disease risk.

scholarly journals The Prognostic Value of CD133 in Predicting the Relapse and Recurrence Pattern of High-Grade Gliomas on MRI: A Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Mahdi Abdoli Shadbad ◽  
Negar Hosseinkhani ◽  
Zahra Asadzadeh ◽  
Oronzo Brunetti ◽  
Nicola Silvestris ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Prognostic Value ◽  
Tumor Recurrence ◽  
Meta Analysis ◽  
Therapy Resistance ◽  
Current Evidence ◽  
High Grade ◽  
Tumor Relapse ◽  
High Grade Gliomas ◽  
Cd133 Protein

BackgroundCancer stem cells have been implicated in tumor relapse, tumor invasion, and cancer therapy resistance in high-grade gliomas; thus, characterizing cancer stem cell-related markers can help determine the prognosis of affected patients. Preclinical studies have reported that CD133 is implicated in tumor recurrence and cancer therapy resistance in high-grade gliomas; however, clinical studies have reported inconclusive results regarding its prognostic value in patients with high-grade gliomas.MethodsWe systematically searched the PubMed, Scopus, Web of Science, and Embase databases to obtain peer-reviewed studies published before March 10, 2021. Then, we conducted the current systematic review and meta-analysis based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statements. By applying the random-effect model, the effect size of studies investigating the progression-free survival (PFS), time to local recurrence (TTL), and time to distant recurrence (TTD) were calculated using RevMan version 5.4. The heterogeneity between the included studies was studied by the I2 index and Cochran’s Q test. Egger test was performed on funnel plots to investigate the potential asymmetry and publication bias among the included studies using CMA version 2.ResultsWith the 10% cut-off, CD133 protein overexpression is associated with the inferior PFS of patients with high-grade gliomas. Increased CD133 protein expression is associated with sooner distant tumor recurrence on MRI in glioblastoma patients and patients with high-grade gliomas and improved TTL on MRI in glioblastoma patients.ConclusionBased on the current evidence from 1086 patients with high-grade gliomas, CD133 overexpression is a valuable marker to predict tumor relapse and tumor recurrence patterns in patients with high-grade gliomas.

scholarly journals Real Impact of Novel Immunotherapy Drugs in Cancer. The Experience of 10 Last Years

Toxins ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 149
Author(s):  
Andreas Koulouris ◽  
Christos Tsagkaris ◽  
Michail Nikolaou
Keyword(s):  
Cancer Therapy ◽  
Cancer Immunotherapy ◽  
Treatment Modalities ◽  
Current Evidence ◽  
Research Opportunities ◽  
Current State ◽  
Prospective Research ◽  
The Impact ◽  
Intense Research

Intense research on immunotherapy has been conducted during recent years. As advances in the field have started changing the landscape of cancer therapy, it is necessary to assess the impact of immunotherapeutic modalities in the treatment of various cancers. Ten years ago, in 2011, ipilimumab was the first of the newest immunotherapeutic drugs against cancer to be approved by the FDA. Then several drugs followed and formed a therapeutic arsenal to fight cancer. Initial studies were performed on metastatic patients, but there are currently several studies in patients with potentially curable cancers. All these developments have created a new environment for oncology which we will present in this article. This review examines the current evidence related to the impact of immunotherapy on various cancers and discusses its potential clinical and research implications, including its effectiveness in comparison to other treatment modalities (chemotherapy, radiotherapy), its toxicity and prospective research opportunities. While constant updates and further research is critical to understand the impact of immunotherapy in cancer therapy, not only does it seem to be important to assess the current state of knowledge highlighting the success but also to determine the challenging aspects of cancer immunotherapy.

Current Evidence and Future Perspectives About Herbal Therapeutics for Cancer Therapy

2021 ◽  
pp. 1-29
Author(s):  
David Paul ◽  
A. Parag ◽  
K. S. Aswathi ◽  
Dinesh Kumar Chellappan ◽  
Somasundaram Arumugam ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Current Evidence ◽  
Future Perspectives

scholarly journals Photobiomodulation for Taste Alteration

Encyclopedia ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 240-248
Author(s):  
Marwan El Mobadder ◽  
Samir Nammour
Keyword(s):  
Biological Activity ◽  
Cancer Therapy ◽  
Therapeutic Effect ◽  
Near Infrared ◽  
Current Evidence ◽  
Or Management ◽  
Oral Complications ◽  
Infrared Wavelengths ◽  
Oral Complication ◽  
Taste Alteration

Photobiomodulation (PBM) therapy employs light at red and near-infrared wavelengths to modulate biological activity. The therapeutic effect of PBM for the treatment or management of several diseases and injuries has gained significant popularity among researchers and clinicians, especially for the management of oral complications of cancer therapy. This entry focuses on the current evidence on the use of PBM for the management of a frequent oral complication due to cancer therapy—taste alteration.

scholarly journals Aerobic exercise in anthracycline-induced cardiotoxicity: a systematic review of current evidence and future directions

2017 ◽  
Vol 312 (2) ◽  
pp. H213-H222 ◽  
Author(s):  
Joseph J. Chen ◽  
Pei-Tzu Wu ◽  
Holly R. Middlekauff ◽  
Kim-Lien Nguyen
Keyword(s):  
Systematic Review ◽  
Side Effects ◽  
Cancer Therapy ◽  
Cancer Survivors ◽  
Aerobic Exercise ◽  
Pediatric Population ◽  
Childhood Cancer Survivors ◽  
Cardiovascular Complications ◽  
Current Evidence ◽  
Cancer Therapies

Cancer and cardiovascular disease are major causes of morbidity and mortality worldwide. Older cancer patients often wrestle with underlying heart disease during cancer therapy, whereas childhood cancer survivors are living long enough to face long-term unintended cardiac consequences of cancer therapies, including anthracyclines. Although effective and widely used, particularly in the pediatric population, anthracycline-related side effects including dose-dependent association with cardiac dysfunction limit their usage. Currently, there is only one United States Food and Drug Administration-approved drug, dexrazoxane, available for the prevention and mitigation of cardiotoxicity related to anthracycline therapy. While aerobic exercise has been shown to reduce cardiovascular complications in multiple diseases, its role as a therapeutic approach to mitigate cardiovascular consequences of cancer therapy is in its infancy. This systematic review aims to summarize how aerobic exercise can help to alleviate unintended cardiotoxic side effects and identify gaps in need of further research. While published work supports the benefits of aerobic exercise, additional clinical investigations are warranted to determine the effects of different exercise modalities, timing, and duration to identify optimal aerobic training regimens for reducing cardiovascular complications, particularly late cardiac effects, in cancer survivors exposed to anthracyclines.

Maritime Coastal and Island Societies of Australia and New Guinea

2021 ◽  
Author(s):  
Michael Rowland ◽  
Ben Shaw ◽  
Sean Ulm
Keyword(s):  
Late Holocene ◽  
New Guinea ◽  
Cultural Development ◽  
Current Evidence ◽  
Marine Resources ◽  
Long Distance ◽  
Mobile Populations ◽  
Multidisciplinary Studies ◽  
Abundance And Distribution ◽  
Vast Area

Coasts, islands, and marine resources played a central role in the dispersal of people into and across Sahul (the combined landmass of New Guinea and Australia). This vast area spans tropical and temperate latitudes, with changes in the abundance and distribution of coastal resources having greatly influenced how people used these landscapes. Little is known of early coastal and island occupation in the millennia after colonisation because sites of this antiquity are now under water, and most islands formed in the Holocene following the postglacial rise in sea level. Current evidence indicates that small, mobile populations harvested nearshore shellfish and fish by 44–42 ka, with long-distance sea voyaging and interisland trade apparent by 25–20 ka. Increasingly intensive coast and island use is evident by the Mid-Holocene, with specialised maritime economies emerging in tropical latitudes throughout the Late Holocene. Although large gaps remain in our understanding of coastally oriented lifeways, multidisciplinary studies are increasingly challenging global paradigms about the antiquity and importance of marine resources on human cultural development.

scholarly journals Prediction of mucositis risk secondary to cancer therapy: a systematic review of current evidence and call to action

2020 ◽  
Vol 28 (11) ◽  
pp. 5059-5073
Author(s):  
H. R. Wardill ◽  
◽  
S. T. Sonis ◽  
N. M. A. Blijlevens ◽  
Y. Z. A. Van Sebille ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Therapy ◽  
Current Evidence ◽  
Call To Action

Inhibiting CDK in Cancer Therapy: Current Evidence and Future Directions

2017 ◽  
Vol 13 (1) ◽  
pp. 21-38 ◽  
Author(s):  
Smruthi Vijayaraghavan ◽  
Stacy Moulder ◽  
Khandan Keyomarsi ◽  
Rachel M. Layman
Keyword(s):  
Cancer Therapy ◽  
Current Evidence ◽  
Future Directions

The Tempo and mode(S) of Prebiotic Evolution

1997 ◽  
Vol 161 ◽  
pp. 419-429 ◽  
Author(s):  
Antonio Lazcano
Keyword(s):  
Origin Of Life ◽  
Organic Compounds ◽  
Biological Evolution ◽  
Current Evidence ◽  
Early Diversification ◽  
Time Period ◽  
The Galaxy ◽  
History Of ◽  
Widespread Phenomenon ◽  
The Origin Of Life

AbstractDifferent current ideas on the origin of life are critically examined. Comparison of the now fashionable FeS/H2S pyrite-based autotrophic theory of the origin of life with the heterotrophic viewpoint suggest that the later is still the most fertile explanation for the emergence of life. However, the theory of chemical evolution and heterotrophic origins of life requires major updating, which should include the abandonment of the idea that the appearance of life was a slow process involving billions of years. Stability of organic compounds and the genetics of bacteria suggest that the origin and early diversification of life took place in a time period of the order of 10 million years. Current evidence suggest that the abiotic synthesis of organic compounds may be a widespread phenomenon in the Galaxy and may have a deterministic nature. However, the history of the biosphere does not exhibits any obvious trend towards greater complexity or «higher» forms of life. Therefore, the role of contingency in biological evolution should not be understimated in the discussions of the possibilities of life in the Universe.

Sign in / Sign up

Export Citation Format

Share Document