scholarly journals Circadian rhythms influence cardiovascular disease differently in males and females: role of sex and gender

2018 ◽  
Vol 5 ◽  
pp. 30-37 ◽  
Author(s):  
W Glen Pyle ◽  
Tami A Martino
Keyword(s):  
Cardiovascular Disease ◽  
Circadian Rhythms ◽  
Sex And Gender ◽  
Males And Females ◽  
And Gender

scholarly journals The role of sex and gender in neuropsychiatric disorders

2016 ◽  
Vol 18 (4) ◽  
pp. 351-352 ◽  
Keyword(s):  
Clinical Symptoms ◽  
Age Of Onset ◽  
Brain Diseases ◽  
Sex And Gender ◽  
Neuropsychiatric Diseases ◽  
Resilience Factors ◽  
Males And Females ◽  
And Gender ◽  
And Function

The prevalence, age of onset, and clinical symptoms of many neuropsychiatric diseases substantially differ between males and females. Factors influencing the relationships between brain development and function and sex or gender may help us understand the differences between males and females in terms of risk or resilience factors in brain diseases.

scholarly journals Elucidating the Relationship Between Insomnia, Sex, and Cardiovascular Disease

2020 ◽  
Vol 4 ◽  
pp. 247028972098001
Author(s):  
Rebecca Leeds ◽  
Ari Shechter ◽  
Carmela Alcantara ◽  
Brooke Aggarwal ◽  
John Usseglio ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Sex Differences ◽  
Cardiovascular Health ◽  
Future Research ◽  
Sex And Gender ◽  
Men And Women ◽  
Sex Research ◽  
And Gender ◽  
The Relationship ◽  
Cvd Mortality

Sex differences in cardiovascular disease (CVD) mortality have been attributed to differences in pathophysiology between men and women and to disparities in CVD management that disproportionately affect women compared to men. Similarly, there has been investigation of differences in the prevalence and presentation of insomnia attributable to sex. Few studies have examined how sex and insomnia interact to influence CVD outcomes, however. In this review, we summarize the literature on sex-specific differences in the prevalence and presentation of insomnia as well as existing research regarding the relationship between insomnia and CVD outcomes as it pertains to sex. Research to date indicate that women are more likely to have insomnia than men, and there appear to be differential associations in the relation between insomnia and CVD by sex. We posit potential mechanisms of the relationship between sex, insomnia and CVD, discuss gaps in the existing literature, and provide commentary on future research needed in this area. Unraveling the complex relations between sex, insomnia, and CVD may help to explain sex-specific differences in CVD, and identify sex-specific strategies for promotion of cardiovascular health. Throughout this review, terms “men” and “women” are used as they are in the source literature, which does not differentiate between sex and gender. The implications of this are also discussed.

Role of Screening Tests in the Detection and Management of Blood Pressure Abnormalities Among Young Population

Angiology ◽  
2016 ◽  
Vol 68 (5) ◽  
pp. 441-446 ◽  
Author(s):  
Mehmet Karaduman ◽  
Mustafa Aparci ◽  
Murat Unlu ◽  
Cengiz Ozturk ◽  
Sevket Balta ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Heart Rate ◽  
Medical Records ◽  
Screening Tests ◽  
Young Population ◽  
Males And Females ◽  
Apparently Healthy

The prevalence of hypertension is increasing among young population worldwide. So there is an interest in detecting prehypertension and hypertension in childhood. We determined blood pressure (BP) recorded at a screening test in a young population. We retrospectively evaluated the medical records including systolic blood pressure (SBP), diastolic blood pressure (DBP), weight, height, and body mass index (BMI) of 685 male and 130 female apparently healthy adolescents. We evaluated the prevalence of BP categories: normotension, prehypertension, and hypertension. The prevalence of normotension (n = 369), prehypertension (n = 333), and hypertension (n = 113) was 45.3%, 40.9% and 13.9%, respectively; prehypertension and hypertension were significantly higher among males. The prevalence of prehypertension and hypertension was significantly higher among overweight males and females. The BMI significantly correlated with SBP, DBP, and heart rate among both genders. The prevalence of prehypertension and hypertension is high among Turkish adolescents. Screening tests focused on BP and BMI measurement may help detect the young population at risk of hypertension and cardiovascular disease in the future.

Ageing and gender

2020 ◽  
pp. 41-68
Author(s):  
Chris Gilleard ◽  
Paul Higgs
Keyword(s):  
Social Reproduction ◽  
Later Life ◽  
Social Imaginary ◽  
Financial Assets ◽  
Sex And Gender ◽  
Men And Women ◽  
The Social ◽  
And Gender ◽  
Bonding Capital

This chapter begins by considering the distinction between sex and gender. The latter constitutes the source of the social division between men and women considered as social beings. It serves as both a reflection of division and inequality and a source of difference and identity. The chapter then explores the framing of this division in terms of patriarchy and the inequalities that are organised by and structured within the relations of work and of social reproduction. It focuses next upon the consequences of such a division, first in terms of both financial assets and resources and then in terms of social relational capital, drawing upon Putnam’s distinction between bridging and bonding capital. It then considers other sources of difference that become more salient in later life, in terms of health illness and longevity. The chapter ends with the role of gender in representing later life, and the role of later life in representing gender. It concludes by distinguishing between gender as a structure shaping third age culture, and gender as a constituent in the social imaginary of the fourth age.

scholarly journals Sex and Gender Disparities in Melanoma

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1819 ◽  
Author(s):  
Maria Bellenghi ◽  
Rossella Puglisi ◽  
Giada Pontecorvi ◽  
Alessandra De Feo ◽  
Alessandra Carè ◽  
...  
Keyword(s):  
X Chromosome ◽  
Immune Surveillance ◽  
Lower Limbs ◽  
Sex And Gender ◽  
System A ◽  
Total Incidence ◽  
Sex Disparities ◽  
And Gender ◽  
Anatomic Localization

Worldwide, the total incidence of cutaneous melanoma is higher in men than in women, with some differences related to ethnicity and age and, above all, sex and gender. Differences exist in respect to the anatomic localization of melanoma, in that it is more frequent on the trunk in men and on the lower limbs in women. A debated issue is if—and to what extent—melanoma development can be attributed to gender-specific behaviors or to biologically intrinsic differences. In the search for factors responsible for the divergences, a pivotal role of sex hormones has been observed, although conflicting results indicate the involvement of other mechanisms. The presence on the X chromosome of numerous miRNAs and coding genes playing immunological roles represents another important factor, whose relevance can be even increased by the incomplete X chromosome random inactivation. Considering the known advantages of the female immune system, a different cancer immune surveillance efficacy was suggested to explain some sex disparities. Indeed, the complexity of this picture emerged when the recently developed immunotherapies unexpectedly showed better improvements in men than in women. Altogether, these data support the necessity of further studies, which consider enrolling a balanced number of men and women in clinical trials to better understand the differences and obtain actual gender-equitable healthcare.

scholarly journals Reconstructing sexual divisions of labor from fingerprints on Ancestral Puebloan pottery

2019 ◽  
Vol 116 (25) ◽  
pp. 12220-12225 ◽  
Author(s):  
John Kantner ◽  
David McKinney ◽  
Michele Pierson ◽  
Shaza Wester
Keyword(s):  
Material Culture ◽  
Chaco Canyon ◽  
Economic Systems ◽  
Sex And Gender ◽  
Pottery Production ◽  
Left Behind ◽  
Ancestral Puebloan ◽  
The Us ◽  
Males And Females ◽  
And Gender

An understanding of the division of labor in different societies, and especially how it evolved in the human species, is fundamental to most analyses of social, political, and economic systems. The ability to reconstruct how labor was organized, however, especially in ancient societies that left behind few material remains, is challenged by the paucity of direct evidence demonstrating who was involved in production. This is particularly true for identifying divisions of labor along lines of age, sex, and gender, for which archaeological interpretations mostly rely upon inferences derived from modern examples with uncertain applicability to ancient societies. Drawing upon biometric studies of human fingerprints showing statistically distinct ridge breadth measurements for juveniles, males, and females, this study reports a method for collecting fingerprint impressions left on ancient material culture and using them to distinguish the sex of the artifacts’ producers. The method is applied to a sample of 985 ceramic sherds from a 1,000-y-old Ancestral Puebloan community in the US Southwest, a period characterized by the rapid emergence of a highly influential religious and political center at Chaco Canyon. The fingerprint evidence demonstrates that both males and females were significantly involved in pottery production and further suggests that the contributions of each sex varied over time and even among different social groups in the same community. The results indicate that despite long-standing assumptions that pottery production in Ancient Puebloan societies was primarily a female activity, labor was not strictly divided and instead was likely quite dynamic.

scholarly journals Genetics, Epigenetics, and Gender Impact in Axial-Spondyloarthritis Susceptibility: An Update on Genetic Polymorphisms and Their Sex Related Associations

2021 ◽  
Vol 12 ◽  
Author(s):  
Maria Sole Chimenti ◽  
Carlo Perricone ◽  
Arianna D’Antonio ◽  
Mario Ferraioli ◽  
Paola Conigliaro ◽  
...  
Keyword(s):  
Epigenetic Modification ◽  
Chromosome Instability ◽  
Epigenetic Factors ◽  
Biological Drugs ◽  
Specific Expression ◽  
Previous Infection ◽  
Inflammatory Bowel ◽  
Males And Females ◽  
And Gender

Spondyloarthritis (SpA) is a group of chronic inflammatory rheumatic disease that can be divided into predominantly axial or predominantly peripheral involvement, with or without associated psoriasis, inflammatory bowel disease or previous infection. Axial SpA (axSpA) encompasses ankylosing spondylitis (AS) with radiological sacroiliitis, and a type without radiographic sacroiliitis, called “non-radiographic axial SpA” (nr-axSpA). Males and females show large differences in their susceptibility to SpA, such as distinctions in clinical patterns, phenotypes and in therapeutical response, particularly to TNF inhibitors (TNFi). Several studies indicate that AS women have doubled risk to failure TNFi compared with males. This diversity in drugs’ efficacy among women and men may be caused by differences in the balance of sex hormones and in gene-specific expression likely triggered by X-chromosome instability and gene-specific epigenetic modifications. Evidence reported that polymorphisms in microRNAs on X- and other chromosomes, such as miR-146a, miR-155, miR-125a-5p, miR-151a-3p and miR-22-3p, miR-199a-5p could be involved in the different clinical presentation of SpA, as well as disease activity. In addition, association with non−response to TNFi treatment and presence of IRAK3 and CHUCK genes in SpA patients was recently detected. Finally, polymorphisms in genes involved in IL-23/IL-17 pathway, such as in drug pharmacodynamics and pharmacokinetics may have a role in response to TNFi, IL17i, and IL23i. A major understanding of genomic variability could help in the development of new therapeutic targets or in taking advantages of different mechanisms of action of biological drugs. Moving from the multifactorial etiology of disease, the present review aims at evaluating genetic and epigenetic factors and their relationship with sex and bDMARDs response, helping to investigate the different expression among males and females of genes on X- and other chromosomes, as well as mi-RNA, to highlight relationships between sex and occurrence of specific phenotypes and symptoms of the disease. Moreover, the role of the epigenetic modification in relation to immune-regulatory mechanisms will be evaluated.

scholarly journals The role of sex and gender in the changing levels of anxiety and depression during the COVID-19 pandemic: A cross-sectional study

2021 ◽  
Vol 17 ◽  
pp. 174550652110629
Author(s):  
Hoda Seens ◽  
Shirin Modarresi ◽  
James Fraser ◽  
Joy C MacDermid ◽  
David M Walton ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Anxiety And Depression ◽  
Generalized Anxiety ◽  
Sex And Gender ◽  
Health Questionnaire ◽  
Cross Sectional ◽  
Maximum Score ◽  
Patient Health ◽  
And Gender

Background: Several studies have assessed the impact of the COVID-19 pandemic on anxiety and depression, but have not focused on the role of sex and gender. This study compared changes in the levels of anxiety and depression (pre- and post-COVID) experienced by individuals of various sexes and genders. Methods: We used a cross-sectional online survey that assessed pre- and post-COVID symptoms of anxiety (Generalized Anxiety Disorder-2) and depression (Patient Health Questionnaire-9). General linear modeling (fixed model factorial analysis of variance) was used to evaluate changes in anxiety and depression between pre- and post-pandemic periods and explore differential effects of sex and gender on those changes. Results: Our study included 1847 participants from 43 countries and demonstrated a percentage increase of 57.1% and 74.2% in anxiety and depression, respectively. For the Generalized Anxiety Disorder-2 scale (maximum score 6), there was a mean increase in anxiety by sex for male, female, and other of 1.0, 1.2, and 1.4, respectively; and by gender for man, woman, and others of 0.9, 1.3, and 1.6, respectively. For the Patient Health Questionnaire-9 (maximum score 27), there was a mean increase in depressive symptoms by sex for male, female, and other of 3.6, 4.7, and 5.5 respectively; and by gender for man, woman, and others of 3.3, 4.8, and 6.5, respectively. Conclusion: During COVID-19, there was an increase in anxiety and depressive symptoms for all sexes and genders, with the greatest increases reported by those identifying as non-male and non-men.

scholarly journals The Role of the Addressee and Gender Diversity in Greeting Behavior in the Saudi Context

2020 ◽  
Vol 13 (6) ◽  
pp. 1
Author(s):  
Huda A. Almushayqih
Keyword(s):  
Mixed Method ◽  
Gender Diversity ◽  
Mixed Method Study ◽  
Qualitative And Quantitative ◽  
Greeting Behavior ◽  
Males And Females ◽  
Similarities And Differences ◽  
And Gender ◽  
Practical Implications

The current paper investigates verbal and nonverbal greeting behaviors in the Saudi context. The study aims to identify how Saudi males and females greet their parents, grandparents, siblings, and friends, and what role the addressee plays on the performance of the greeting behavior. The study further distinguishes the similarities and differences between Saudi males and females in their greeting behavior. This study is a mixed method study that adopts qualitative and quantitative methodologies. The participants of the study are 72 Saudi adults, 50 females and 22 males. The findings show that Saudis accommodate their greeting behavior according to their addressee’s gender, age, social (familial) status, and social distance. Moreover, the findings revealed that males and females vary in the way they greet their relatives and friends. This variation is interpreted in the light of previous studies. This study provides some practical implications for the successful and meaningful greeting as well as successful interactions. 

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