Abstract #1093204: Correlation of Triglyceride Glucose Index With Metabolic Parameters: Initial Insights From Newly Diagnosed Type 2 Diabetics in India

Background: Diabetes mellitus (DM) is a major health problem with long-term microvascular and macrovascular complications responsible for the majority of its mortality and morbidity. The development and progression of diabetic complications are strongly related to the degree of glycemic control. The purpose of this study was to study, the incidence of retinopathy in newly diagnosed diabetics and its association with various risk factors with a special stress on role of HbA1c levels. Methods: We analysed 300 newly diagnosed type2 diabetics (diagnosed within 6 months). Patients were subject to detailed history, examination (including retinal examination), and investigations including serum creatinine, urinary micro-albumin, 24 hours urinary protein, HbA1c and ultrasonography. Results: Incidence of retinopathy in newly diagnosed type 2 diabetics was 30% (91/300). With increase in HbA1c, the incidence of retinopathy increased. All results were statistically proven. Conclusion: Incidence of retinopathy in newly diagnosed type2 diabetics is as high as 30%. Glycemic control is the an important factor contributing to development of this microvascular complications in diabetic patients. DOI: http://dx.doi.org/10.3329/bjms.v14i1.16535 Bangladesh Journal of Medical Science Vol.14(1) 2015 p.39-42

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Newly Diagnosed Type 2 Diabetics Have The Lowest Body Mass Index Change Among Rural Populations Of Sweden And The United States

The Internet Journal of Health ◽

10.5580/e59 ◽

2006 ◽

Vol 5 (1) ◽

Cited By ~ 1

Keyword(s):

United States ◽

Body Mass Index ◽

Body Mass ◽

The United States ◽

Rural Populations ◽

Newly Diagnosed ◽

Body Mass Index Change ◽

Index Change ◽

Type 2 Diabetics

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Lipid profile abnormalities in newly diagnosed type 2 diabetics: a cross-sectional study

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20193620 ◽

2019 ◽

Vol 6 (5) ◽

pp. 1452

Author(s):

Monica A. ◽

Dhivya P.

Keyword(s):

Cardiovascular Disease ◽

Lipid Profile ◽

Cross Sectional Study ◽

South Indian Population ◽

Newly Diagnosed ◽

Sectional Study ◽

Cross Sectional ◽

Type 2 Diabetics ◽

Very High

Background: India is fast becoming the diabetes capital of the World. A direct atherogenic effect of triglyceride rich particles has been noted. This study assesses the lipid profile abnormalities in newly diagnosed type 2 diabetes mellitus. Since dyslipidemia is a risk factor for cardiovascular disease, such assessment will enable better recognition, prevention and management of cardiovascular mortality and morbidity.Methods: The study was conducted over a period of one year at a tertiary care hospital in South India. A cross-sectional study of 100 newly diagnosed type 2 diabetics in a rural South-Indian population was done. Results: In our study, 55 (55%) participants had high triglycerides and 45 (45%) had normal triglycerides. Among the 55 participants with abnormal triglycerides, 34% had borderline high levels (150-199mg/dl), 18% had high levels (200-499 mg/dl) and 3% participants had very high triglycerides (≥500 mg/dl). 26% male and 29% female participants had above normal triglyceride levels. In our study, 25% had borderline high cholesterol levels and 5% had high total Cholesterol. 39% of participants had near optimal levels of LDL, 19% had borderline high levels of LDL, 7% had high levels of LDL and 4% had very high levels of LDL. Significantly higher levels of triglycerides and LDL were noted.Conclusions: Deranged lipid profiles are quite prevalent in type 2 diabetics with females having higher triglyceride levels. Recognition of such elevated triglyceride levels in even newly diagnosed type 2 diabetics will help in better prevention of associated cardiovascular disease.

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Association of vitamin-D deficiency with oxidative stress in newly diagnosed type 2 diabetes

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20175132 ◽

2017 ◽

Vol 5 (12) ◽

pp. 5221

Author(s):

Bairapogu John Pradeep Kumar ◽

Maliyannar Itaggappa ◽

Kamandalagondi Vasudevareddy Thimmaraju

Keyword(s):

Oxidative Stress ◽

Type 2 Diabetes ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Oxidative Stress Markers ◽

Newly Diagnosed ◽

Stress Markers ◽

Type 2 Diabetics ◽

Vitamin D Levels

Background: According to a recent World Health Organization (WHO) report, India, with 32 million diabetic individuals, currently has the highest incidence of diabetes worldwide; these numbers are predicted to increase to 80 million by the year 2030. Deficiency of vitamin D has been associated with increased risk of developing Type 2 diabetes mellitus (DM) and cardiovascular diseases. Vitamin D deficiency is highly prevalent in our country. About 70% of adults in both rural and urban areas were found showing manifestations of vitamin D deficiency. Therefore, we designed this study to assess the vitamin D status of the study population by measuring serum 25(OH) D levels, and its association with oxidative stress markers in type 2 diabetes mellitus.Methods: This is a cross sectional study with Group 1 (n=147): Newly diagnosed type 2 diabetics and Group 2 (n=147): Apparently healthy individuals. Blood was collected by venipuncture. 5ml of blood was collected and allowed to clot. Serum was separated and stored in refrigerator to estimate the oxidative stress markers and vitamin D levels. Estimation of vitamin D levels and oxidative stress markers were carried out by commercially available kits.Results: Vitamin D levels are significantly low in newly diagnosed type 2 diabetics when compared to controls (p < 0.000), whereas the FBG levels are significantly high in newly diagnosed type 2 diabetics when compared to controls (p < 0.000). The TAOS levels are significantly low in newly diagnosed type 2 diabetics when compared to controls (p <0.000), whereas the MDA levels are significantly high in newly diagnosed type 2 diabetics when compared to controls (p < 0.000). The oxidative stress marker TAOS (r = 0.71; p < 0.000), was positively correlated and MDA (r = - 0.85; p < 0.000), was negatively with Vitamin D in newly diagnosed type 2 diabetics.Conclusions: From this study, it is concluded that, lower levels of vitamin D is associated with increased oxidative stress. Therapeutic interventions to increase the vitamin D levels and reduce the oxidative stress should be included as a part of treatment inn newly diagnosed type diabetics.

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