Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients

Western diets are typically low in ω-3 fatty acids, and high in saturated and ω-6 fatty acids. There is a need to increase dietary ω-3 fatty acid content. Chia (Salvia hispanica L.) has the highest botanical source of alpha-linolenic acid (ALA) known, and recently has been receiving more attention because of this. Feeding ALA to animals has been shown to increase the ω-3 fatty acid content of the foods they produce, and hence offers consumers an easy way to increase their intake of ω3 fatty acids without altering their diet. Broilers were fed rapeseed, flaxseed, chia seed and chia meal to assess the ability of these feed ingredients to increase the ω-3 fatty acid content of the meat, and also to determine whether any negative effects on bird production would arise. Flaxseed produced significantly (P < 0.05) lower body weights, weight gains and poorer conversion ratios than did the other feeds. Except in the case of the chia meal with the dark meat, the chia seed significantly (P < 0.05) reduced the saturated fatty acid (SFA) content of the white and dark meats compared with the control diet. Adding ALA increased the ALA, LCω-3 fatty acid and total polyunsaturated fatty acid (PUFA) ω-3 fatty acid content of both meat types, except in the case of the white meat of the birds fed rapeseed. Chia seed gave the highest total PUFA ω-3 increase, yielding 157 and 200% increases for the dark and white meat, respectively, compared with the control. The ω-6:ω-3 and SFA:ω-3 ratios dramatically improved in both types of meat when chia seed, chia meal or flaxseed was added to the diet. The study also showed that not all ALA-rich seeds are biologically equivalent sources in terms of producing ω-3 enriched broiler meat. Chia proved to be superior to the other sources examined in this trial. Key words: Chia seed, flaxseed, rapeseed, omega-3, alpha-linolenic, broiler meat, fatty acid

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Effect of Omega-3 fatty acids on blood pressure and serum lipids in continuous ambulatory peritoneal dialysis patients

Journal of Research in Pharmacy Practice ◽

10.4103/2279-042x.162356 ◽

2015 ◽

Vol 4 (3) ◽

pp. 135 ◽

Cited By ~ 5

Author(s):

Shahram Taheri ◽

Nooshin Keyvandarian ◽

Mojgan Mortazavi ◽

SayedMohsen Hosseini ◽

AfsoonEmami Naini

Keyword(s):

Blood Pressure ◽

Fatty Acids ◽

Peritoneal Dialysis ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Serum Lipids ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Dialysis Patients

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Variation in fatty acid content and composition among Iranian fennel landraces

10.22541/au.161435697.70652571/v1 ◽

2021 ◽

Author(s):

Keivan Bahmani ◽

Ali Izady- Darbandi ◽

Azam Akbari ◽

Ryan Warner

Keyword(s):

Fatty Acids ◽

Oleic Acid ◽

Fatty Acid ◽

Linoleic Acid ◽

Acid Content ◽

Fatty Acid Content ◽

Seed Mass ◽

Oleic Acid Content ◽

High Linoleic Acid ◽

Early Maturing

One of the factors determining drug quality in bitter fennel is the types and quantities of fatty acids stored in the seeds. We measured the fatty acid content of 50 Iranian fennel landraces. Fatty acid concentration of the 50 fennel landraces ranged from 9.5 to 23% of seed mass, and the highest amounts of fatty acid content among the early maturing races belonged to Hamedan and Arak (19.5 and 18.5%, respectively), among the medium maturing races to Marvdasht, Kohn and Meshkin Shahr (23, 20.5 and 19%, respectively), and among the late-maturing races to Sari (21%). The highest fatty acid yields belonged to Fasa (65.3 ml/m2) among the early maturing races, Meshkin Shahr and Moqhan (92.5 and 85.4 ml/m2) among the medium maturing races, and Sari (71.4 ml/m2) among the late-maturing races. The main compositions of fatty acids, measured in twelve of the landraces, were oleic acid (52-64%), linoleic acid (26-39%), palmitic acid (0.3-4.1%), stearic acid (1.3-2.4%), linolenic acid (0.6-3.6%) and myristic acid (0.35-1.07%). It was observed that landraces with high oleic acid content originated from regions with a dry and warm climate, while landraces with high linoleic acid content originated from regions with a humid and cool climate. Understanding relationships between the fatty acid profile and landrace origin climate may improve the efficiency of identifying landraces with specific fennel chemotypes. In conclusion, these results indicate that some of these fennel landraces have the potential to be complementary sources of certain fatty acids, such as oleic and linoleic acids.

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Effects of An Omega 3 Fatty Acid Supplement Consumption On Platelet Aggregation Tests in Patients Low Grade Lymphoproliferative Disorders.

Blood ◽

10.1182/blood.v114.22.5076.5076 ◽

2009 ◽

Vol 114 (22) ◽

pp. 5076-5076

Author(s):

Gabriela Ballester ◽

Alexander Salazar ◽

Theodor Witte ◽

Elaine Hardman ◽

Doreen Griswold ◽

...

Keyword(s):

Fatty Acids ◽

Fatty Acid ◽

Fatty Acid Content ◽

Lymphoproliferative Disorders ◽

Low Grade ◽

Base Line ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Normal Range ◽

Omega 3 Fatty Acid

Abstract Abstract 5076 Introduction Omega 3 fatty acids, when supplemented to cell culture or in the diet of tumor bearing animals, have been shown to sensitize mouse leukemias and lymphomas or multiple human solid tumor types to chemotherapy drugs. Enhanced chemosensitivity has been associated with suppression of nuclear factor kappa B (NFkB) activation and increased susceptibility to lipid peroxidation. Some investigators have expressed concerns over a possible bleeding diathesis related to the chronic consumption of these supplements. Patients and Methods We have initiated a pilot study in patients with low grade lymphoproliferative disorders to determine omega 3 fatty acids supplements tolerance; correlation of oral supplementation with incorporation of omega 3 fatty acids in blood cell membranes and in-vitro sensitivity of leukemia cells to chemotherapy. Omega 3 capsules, containing 1250 mg total oil, 60% of which is omega 3 were administered 3 times daily. Doses were escalated after the first month to 6 capsules per day and to 9 capsules after the second month, if there was good tolerance. As part of safety monitoring, platelet aggregation studies were done at base line and at 6 months, utilizing a Siemens Dade PFA-100 analyzer. Fatty acid composition of red blood cells was assessed using gas chromatography. Results Eight patients with Chronic Lymphocytic Leukemia (Rai stage 0-1, no requiring therapy) have been accrued to date. Six of the 8 patients were also receiving aspirin at the time of study. A dose-related increase in the omega 3 fatty acid content of both red blood cells and leukocytes was documented. The total omega 3 content of red cells was about 80% over base line after 3 capsules per day for one month; after 6 capsules per day the total omega 3 content of erythrocytes was about 160% over baseline. The omega 3 content of leukocytes after supplementation was much more variable ranging from -0.5% to 280% over baseline after 3 capsules per day and 37% to 416% over baseline after 6 capsules per day. Baseline Collagen/ADP aggregation was within the normal range in all patients: mean 72.4 sec (range 59-110) (normal- 70-118), no significant changes were noted at 6 months: mean 69.2 sec (range: 59-85). Baseline Collagen/EPI aggregation was elevated in 2 patients (>300 sec), the remaining patients had normal values with a mean of 100.3 sec (normal range: 74-193). At 6 months, Collagen/EPI aggregation showed a mean value of 129.3 sec (range 110-158), representing a mean 29.6% increase over baseline. Omega3 fatty acid supplements were generally well tolerated. Currently, 6 patients are up to 6 capsules/day and 2 are at 9 capsules/day. Two patients had Grade I intermittent diarrhea (1 patient at 6 capsules/day); 1 patient noted hand bruising. Conclusions Clearly, humans can consume enough omega 3 supplements to elicit biological activity as shown by the increase in fatty acid content of erythrocytes and leukocytes. No changes in Collagen/ADP aggregation was noted after 6 months of supplementation. A mild increase in Collagen/EPI aggregation is reported, with values that remained within the normal range, even in patients also medicated with aspirin. Studies are in progress to determine effects on NFkB activity and lipid peroxidation. Disclosures No relevant conflicts of interest to declare.

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Variability of Essential and Nonessential Fatty Acids of Irish Rapeseed Oils as an Indicator of Nutritional Quality

International Journal of Food Science ◽

10.1155/2022/7934565 ◽

2022 ◽

Vol 2022 ◽

pp. 1-10

Author(s):

Rebecca Coughlan ◽

Siobhan Moane ◽

Tracey Larkin

Keyword(s):

Fatty Acids ◽

Fatty Acid Composition ◽

Oleic Acid ◽

Fatty Acid ◽

Linoleic Acid ◽

Acid Composition ◽

Acid Content ◽

Fatty Acid Content ◽

The Third ◽

Saturated Fatty Acid Content

The low saturated fatty acid content of rapeseed oil has resulted in it being classed as one of the most health-benefiting culinary oils. This study determines whether Irish rapeseed oils contain identical fatty acid profiles or whether distinct profiles exist between producers and producers’ successive oil batches. The fatty acid content of Irish rapeseed oils was determined in terms of the desirable MUFA and PUFA and saturated content of these oils. The fatty acid composition demonstrated significant differences in individual unsaturated fatty acid content, while total saturation had insignificant differences. Saturated fatty acid content ranged from 6.10 to 15.8%, while unsaturated fatty acids ranged from 84.20 to 90.10%. Moreover, individual fatty acid content exhibited significant differences ( p < 0.05 ). Oleic acid (C18:1), linoleic acid (C18:2), and stearic acid (C18:0) contents were considered significantly different from other fatty acids detected. The third successive batch from each producer exhibited lower oleic acid content, and the third batch contained higher linoleic acid content, at the same time maintaining a desirable unsaturated fatty acid composition. Studies suggest that differences in the fatty acid composition may be due to cultivation practices such as climate, soil composition, sowing and harvesting, processing techniques, and oxidation reactions.

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FUNCTIONAL DRINK TECHNOLOGY WITH CHIA SEEDS

Grain Products and Mixed Fodder’s ◽

10.15673/gpmf.v21i1.2093 ◽

2021 ◽

Vol 21 (1) ◽

pp. 20-30

Author(s):

Wang Haiyan ◽

Melnyk Oksana ◽

Li Bo

Keyword(s):

Fatty Acids ◽

Fatty Acid ◽

Organic Acids ◽

Human Body ◽

Acid Content ◽

Unsaturated Fatty Acids ◽

Fatty Acid Content ◽

Omega 3 ◽

Chia Seed ◽

Functional Drink

This article mainly introduces the necessity of the emergence of functional foods and the current market development. Using chia seeds as the characteristic raw material, adding apple juice and hawthorn juice, it is developed to be suitable for subhealthy people, obese people, diabetes and cardiovascular patients.Functional beverages refer to beverages that regulate human body functions to a certain extent by adjusting the composition and content ratio of nutrients in the beverage. In recent research hotspots, chia seeds are often developed and applied by nutritionists or other nutrition enthusiasts because of their rich nutritional value. Chia seeds are rich in a variety of unsaturated fatty acids, accounting for about 80% of the total fatty acid content, of which omega-3 and omega-6 unsaturated fatty acids are the most content, 68% is α-linolenic acid, which is the most abundant omega-3 fatty acid content of the food. Each 100g of chia seeds contains about 16-25g of protein and about 26-40g of dietary fiber, including all 8 amino acids needed by the human body. In addition, it is also rich in vitamins and minerals, as well as a variety of natural antioxidant ingredients, with high-quality antioxidant functions. This makes the ability of chia seeds to maintain blood sugar stability, protect the heart, cerebrovascular, and promote gastrointestinal motility and bone health cannot be underestimated.Hawthorn contains a large amount of vitamin C, carotene, organic acids and other nutrients, combined with cellulose, pectin and organic acids in apples, can further assist chia seeds to improve gastrointestinal conditions and promote gastrointestinal motility, while soluble fiber Vegetarian can regulate blood sugar.This article chooses apple and hawthorn as flavor bases, oligosaccharides (FOS) as sweeteners, resistant starch and guar gum as composite stabilizers, to produce a chia seed functional drink to reduce weight and improve heart and brain Vascular health problems. In the extremely poor analysis of the orthogonal test results of the chia seed functional drink, the best sample formula.

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THE CONTENT OF FATTY ACIDS IN INDONESIA’S FISH OIL

Jurnal Ilmu dan Teknologi Kelautan Tropis ◽

10.28930/jitkt.v6i1.8635 ◽

2014 ◽

Vol 6 (1) ◽

Author(s):

Indra T Maulana ◽

Sukraso Sukraso ◽

Sophi Damayanti

Keyword(s):

Fatty Acids ◽

Fatty Acid ◽

Fish Oil ◽

Acid Content ◽

Fatty Acid Content ◽

Acid Value ◽

Buffer Size ◽

Fish Oils ◽

Omega 3 ◽

Peroxide Values

<p>Study of fatty acid content was conducted in six Indonesian fish oils taken from Surabaya, Sorong, Garut, Banyuwangi, and fish oil standard. The acid and peroxide values were a main parameters which affecting the quality of the fish oil. These parameters were set using the method stated on the SNI No. 01-3555-1998. The oil containing omega-3 such as EPA and DHA is beneficial for health. The study of fatty acid content in six fish oils were analyzed by GCMS Shimadzu QP 2010 ULTRA with FID Detector. RTX-5 were used as a column (diphenyl dimethyl polysiloxane as a solid buffer, size length 30 m, diameter 0,25 mm, and He as a gas mobile phase). The results showed that acid values for oil 1, 2, 3, 4, 5, and 6 were 0.55%, 0.50%, 0.48%, 0.55%, 0.48%, and 0.58%, respectively. While the peroxide values were 5.67, 4.72, 4.45,5.01, 4.85, and 5.27 meq/kg, respectively. GCMS analysis showed that fish oil 1, 2, 3, and 4 very dominant containing squalene of 29.45%, 32.34%, 21.07%, and 43.49%, respectively. While oil 6 contained EPA of 8.97% and DHA 6.56%, and that was the highest compared with other oils. However, oil 6 also contained a trans fatty acids i.e., elaidic acid of 26.8% and trans-13-docosanoic acid of 0.9%. For comparison, natural oil 5 was rich of linoleic acid (39.58%). The GCMS's analysis results proved that the oil 6 made from lemuru had a big potency to be developed for an Indonesian fish oil export comodity.</p> <p>Keywords: fish oil, EPA, DHA, squalena, GCMS, acid value, peroxide value</p>

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