How can experiments play a greater role in public policy? Twelve proposals from an economic model of scaling

2020 ◽  
Vol 5 (1) ◽  
pp. 2-49 ◽  
Author(s):  
OMAR AL-UBAYDLI ◽  
MIN SOK LEE ◽  
JOHN A. LIST ◽  
CLAIRE L. MACKEVICIUS ◽  
DANA SUSKIND

AbstractPolicymakers are increasingly turning to insights gained from the experimental method as a means to inform large-scale public policies. Critics view this increased usage as premature, pointing to the fact that many experimentally tested programs fail to deliver their promise at scale. Under this view, the experimental approach drives too much public policy. Yet, if policymakers could be more confident that the original research findings would be delivered at scale, even the staunchest critics would carve out a larger role for experiments to inform policy. Leveraging the economic framework of Al-Ubaydli et al. (2019), we put forward 12 simple proposals, spanning researchers, policymakers, funders and stakeholders, which together tackle the most vexing scalability threats. The framework highlights that only after we deepen our understanding of the scale-up problem will we be on solid ground to argue that scientific experiments should hold a more prominent place in the policymaker's quiver.

Author(s):  
Joshua Kotin

This book is a new account of utopian writing. It examines how eight writers—Henry David Thoreau, W. E. B. Du Bois, Osip and Nadezhda Mandel'shtam, Anna Akhmatova, Wallace Stevens, Ezra Pound, and J. H. Prynne—construct utopias of one within and against modernity's two large-scale attempts to harmonize individual and collective interests: liberalism and communism. The book begins in the United States between the buildup to the Civil War and the end of Jim Crow; continues in the Soviet Union between Stalinism and the late Soviet period; and concludes in England and the United States between World War I and the end of the Cold War. In this way it captures how writers from disparate geopolitical contexts resist state and normative power to construct perfect worlds—for themselves alone. The book contributes to debates about literature and politics, presenting innovative arguments about aesthetic difficulty, personal autonomy, and complicity and dissent. It models a new approach to transnational and comparative scholarship, combining original research in English and Russian to illuminate more than a century and a half of literary and political history.


Author(s):  
S. Pragati ◽  
S. Kuldeep ◽  
S. Ashok ◽  
M. Satheesh

One of the situations in the treatment of disease is the delivery of efficacious medication of appropriate concentration to the site of action in a controlled and continual manner. Nanoparticle represents an important particulate carrier system, developed accordingly. Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. Nanoparticles could be polymeric or lipidic (SLNs). Industry estimates suggest that approximately 40% of lipophilic drug candidates fail due to solubility and formulation stability issues, prompting significant research activity in advanced lipophile delivery technologies. Solid lipid nanoparticle technology represents a promising new approach to lipophile drug delivery. Solid lipid nanoparticles (SLNs) are important advancement in this area. The bioacceptable and biodegradable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. Supplemented with small size which prolongs the circulation time in blood, feasible scale up for large scale production and absence of burst effect makes them interesting candidates for study. In this present review this new approach is discussed in terms of their preparation, advantages, characterization and special features.


2020 ◽  
Vol 27 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Niaz Ahmad ◽  
Muhammad Aamer Mehmood ◽  
Sana Malik

: In recent years, microalgae have emerged as an alternative platform for large-scale production of recombinant proteins for different commercial applications. As a production platform, it has several advantages, including rapid growth, easily scale up and ability to grow with or without the external carbon source. Genetic transformation of several species has been established. Of these, Chlamydomonas reinhardtii has become significantly attractive for its potential to express foreign proteins inexpensively. All its three genomes – nuclear, mitochondrial and chloroplastic – have been sequenced. As a result, a wealth of information about its genetic machinery, protein expression mechanism (transcription, translation and post-translational modifications) is available. Over the years, various molecular tools have been developed for the manipulation of all these genomes. Various studies show that the transformation of the chloroplast genome has several advantages over nuclear transformation from the biopharming point of view. According to a recent survey, over 100 recombinant proteins have been expressed in algal chloroplasts. However, the expression levels achieved in the algal chloroplast genome are generally lower compared to the chloroplasts of higher plants. Work is therefore needed to make the algal chloroplast transformation commercially competitive. In this review, we discuss some examples from the algal research, which could play their role in making algal chloroplast commercially successful.


2020 ◽  
Vol 13 (1) ◽  
pp. 272
Author(s):  
Aaron C. Sparks ◽  
Heather Hodges ◽  
Sarah Oliver ◽  
Eric R. A. N. Smith

In many public policy areas, such as climate change, news media reports about scientific research play an important role. In presenting their research, scientists are providing guidance to the public regarding public policy choices. How do people decide which scientists and scientific claims to believe? This is a question we address by drawing on the psychology of persuasion. We propose the hypothesis that people are more likely to believe local scientists than national or international scientists. We test this hypothesis with an experiment embedded in a national Internet survey. Our experiment yielded null findings, showing that people do not discount or ignore research findings on climate change if they come from Europe instead of Washington-based scientists or a leading university in a respondent’s home state. This reinforces evidence that climate change beliefs are relatively stable, based on party affiliation, and not malleable based on the source of the scientific report.


2021 ◽  
Vol 102 (8) ◽  
pp. 8-13
Author(s):  
Thomas Hatch

Taking advantage of the possibilities for learning outside of school requires us to build on what we know about why it is so hard to sustain and scale up unconventional educational experiences within conventional schools. To illustrate the opportunities and challenges, Thomas Hatch describes a large-scale approach to project-based learning developed in a camp in New Hampshire and incorporated in a Brooklyn school, a trip-based program in Detroit, and Singapore’s systemic embrace of learning outside school. By understanding the conditions that can sustain alternative instructional practices, educators can find places to challenge the boundaries of schooling and create visions of the possible that exceed current constraints.


Electronics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 219
Author(s):  
Phuoc Duc Nguyen ◽  
Lok-won Kim

People nowadays are entering an era of rapid evolution due to the generation of massive amounts of data. Such information is produced with an enormous contribution from the use of billions of sensing devices equipped with in situ signal processing and communication capabilities which form wireless sensor networks (WSNs). As the number of small devices connected to the Internet is higher than 50 billion, the Internet of Things (IoT) devices focus on sensing accuracy, communication efficiency, and low power consumption because IoT device deployment is mainly for correct information acquisition, remote node accessing, and longer-term operation with lower battery changing requirements. Thus, recently, there have been rich activities for original research in these domains. Various sensors used by processing devices can be heterogeneous or homogeneous. Since the devices are primarily expected to operate independently in an autonomous manner, the abilities of connection, communication, and ambient energy scavenging play significant roles, especially in a large-scale deployment. This paper classifies wireless sensor nodes into two major categories based the types of the sensor array (heterogeneous/homogeneous). It also emphasizes on the utilization of ad hoc networking and energy harvesting mechanisms as a fundamental cornerstone to building a self-governing, sustainable, and perpetually-operated sensor system. We review systems representative of each category and depict trends in system development.


2021 ◽  
pp. 037957212098250
Author(s):  
Jennifer K. Foley ◽  
Kristina D. Michaux ◽  
Bho Mudyahoto ◽  
Laira Kyazike ◽  
Binu Cherian ◽  
...  

Background: Micronutrient deficiencies affect over one quarter of the world’s population. Biofortification is an evidence-based nutrition strategy that addresses some of the most common and preventable global micronutrient gaps and can help improve the health of millions of people. Since 2013, HarvestPlus and a consortium of collaborators have made impressive progress in the enrichment of staple crops with essential micronutrients through conventional plant breeding. Objective: To review and highlight lessons learned from multiple large-scale delivery strategies used by HarvestPlus to scale up biofortification across different country and crop contexts. Results: India has strong public and private sector pearl millet breeding programs and a robust commercial seed sector. To scale-up pearl millet, HarvestPlus established partnerships with public and private seed companies, which facilitated the rapid commercialization of products and engagement of farmers in delivery activities. In Nigeria, HarvestPlus stimulated the initial acceptance and popularization of vitamin A cassava using a host of creative approaches, including “crowding in” delivery partners, innovative promotional programs, and development of intermediate raw material for industry and novel food products. In Uganda, orange sweet potato (OSP) is a traditional subsistence crop. Due to this, and the lack of formal seed systems and markets, HarvestPlus established a network of partnerships with community-based nongovernmental organizations and vine multipliers to popularize and scale-up delivery of OSP. Conclusions: Impact of biofortification ultimately depends on the development of sustainable markets for biofortified seeds and products. Results illustrate the need for context-specific, innovative solutions to promote widespread adoption.


2020 ◽  
Vol 11 (1) ◽  
pp. 109
Author(s):  
Jana Korytárová ◽  
Vít Hromádka

This article deals with the partial outputs of large-scale infrastructure project risk assessment, specifically in the field of road and motorway construction. The Department of Transport spends a large amount of funds on project preparation and implementation, which however, must be allocated effectively, and with knowledge of the risks that may accompany them. Therefore, documentation for decision-making on project financing also includes their analysis. This article monitors the frequency of occurrence of individual risk factors within the qualitative risk analysis, with the support of the national risk register, and identifies dependent variables that represent part of the economic cash flows for determining project economic efficiency. At the same time, it compares these dependent variables identified by sensitivity analysis with critical variables, followed by testing the interaction of the critical variables’ effect on the project efficiency using the Monte Carlo method. A partial section of the research was focused on the analysis of the probability distribution of input variables, especially “the investment costs” and “time savings of infrastructure users” variables. The research findings conclude that it is necessary to pay attention to the setting of statistical characteristics of variables entering the economic efficiency indicator calculations, as the decision of whether or not to accept projects for funding is based on them.


Author(s):  
Marta Mattoso ◽  
Claudia Werner ◽  
Guilherme Horta Travassos ◽  
Vanessa Braganholo ◽  
Eduardo Ogasawara ◽  
...  

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